LOCUS       NP_001035493             428 aa            linear   ROD 28-APR-2025
DEFINITION  flotillin-2 isoform 1 [Mus musculus].
ACCESSION   NP_001035493
VERSION     NP_001035493.1
DBSOURCE    REFSEQ: accession NM_001040403.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 428)
  AUTHORS   Moon,S., Zhao,F., Uddin,M.N., Tucker,C.J., Karmaus,P.W. and
            Fessler,M.B.
  TITLE     Flotillin-2 dampens T cell antigen sensitivity and functionality
  JOURNAL   JCI Insight 9 (24), e182328 (2024)
   PUBMED   39499901
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 428)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 428)
  AUTHORS   Yang,Q., Zhang,Z., Chen,Z., Wang,Y., Chen,Y., Zheng,J., Li,R.,
            Li,L., Mo,L., Liang,Q., Chen,F., Wang,J. and Li,X.
  TITLE     Flot2 deficiency facilitates B cell-mediated inflammatory responses
            and endotoxic shock
  JOURNAL   Immunology 170 (4), 567-578 (2023)
   PUBMED   37688314
  REMARK    GeneRIF: Flot2 deficiency facilitates B cell-mediated inflammatory
            responses and endotoxic shock.
REFERENCE   4  (residues 1 to 428)
  AUTHORS   Wisniewski,D.J., Liyasova,M.S., Korrapati,S., Zhang,X.,
            Ratnayake,S., Chen,Q., Gilbert,S.F., Catalano,A., Voeller,D.,
            Meerzaman,D., Guha,U., Porat-Shliom,N., Annunziata,C.M. and
            Lipkowitz,S.
  TITLE     Flotillin-2 regulates epidermal growth factor receptor activation,
            degradation by Cbl-mediated ubiquitination, and cancer growth
  JOURNAL   J Biol Chem 299 (1), 102766 (2023)
   PUBMED   36470425
  REMARK    GeneRIF: Flotillin-2 regulates epidermal growth factor receptor
            activation, degradation by Cbl-mediated ubiquitination, and cancer
            growth.
REFERENCE   5  (residues 1 to 428)
  AUTHORS   Pernot,M., Jaspard-Vinassa,B., Abelanet,A., Rubin,S., Forfar,I.,
            Jeanningros,S., Cetran,L., Yu,M.H., Balse,E., Hatem,S.,
            Dufourcq,P., Couffinhal,T. and Duplaa,C.
  TITLE     Decrease of Pdzrn3 is required for heart maturation and protects
            against heart failure
  JOURNAL   Sci Rep 12 (1), 8 (2022)
   PUBMED   34996942
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 428)
  AUTHORS   Edgar,A.J. and Polak,J.M.
  TITLE     Flotillin-1: gene structure: cDNA cloning from human lung and the
            identification of alternative polyadenylation signals
  JOURNAL   Int J Biochem Cell Biol 33 (1), 53-64 (2001)
   PUBMED   11167132
REFERENCE   7  (residues 1 to 428)
  AUTHORS   Volonte,D., Galbiati,F., Li,S., Nishiyama,K., Okamoto,T. and
            Lisanti,M.P.
  TITLE     Flotillins/cavatellins are differentially expressed in cells and
            tissues and form a hetero-oligomeric complex with caveolins in
            vivo. Characterization and epitope-mapping of a novel flotillin-1
            monoclonal antibody probe
  JOURNAL   J Biol Chem 274 (18), 12702-12709 (1999)
   PUBMED   10212252
REFERENCE   8  (residues 1 to 428)
  AUTHORS   Bickel,P.E., Scherer,P.E., Schnitzer,J.E., Oh,P., Lisanti,M.P. and
            Lodish,H.F.
  TITLE     Flotillin and epidermal surface antigen define a new family of
            caveolae-associated integral membrane proteins
  JOURNAL   J Biol Chem 272 (21), 13793-13802 (1997)
   PUBMED   9153235
REFERENCE   9  (residues 1 to 428)
  AUTHORS   Cho,Y.J., Chema,D., Moskow,J.J., Cho,M., Schroeder,W.T.,
            Overbeek,P., Buchberg,A.M. and Duvic,M.
  TITLE     Epidermal surface antigen (MS17S1) is highly conserved between
            mouse and human
  JOURNAL   Genomics 27 (2), 251-258 (1995)
   PUBMED   7557989
REFERENCE   10 (residues 1 to 428)
  AUTHORS   Bonhomme,F., Catalan,J., Britton-Davidian,J., Chapman,V.M.,
            Moriwaki,K., Nevo,E. and Thaler,L.
  TITLE     Biochemical diversity and evolution in the genus Mus
  JOURNAL   Biochem Genet 22 (3-4), 275-303 (1984)
   PUBMED   6375655
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669840.5, BY204171.1, BC070423.1 and CD774654.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170557.1, AK030199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     Protein         1..428
                     /product="flotillin-2 isoform 1"
                     /note="epidermal surface antigen; membrane component
                     chromosome 17 surface marker 1 homolog"
                     /calculated_mol_wt=46907
     Region          5..427
                     /region_name="YqiK"
                     /note="Uncharacterized membrane protein YqiK, contains
                     Band7/PHB/SPFH domain [Function unknown]; COG2268"
                     /db_xref="CDD:441869"
     Site            405
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14254; propagated from
                     UniProtKB/Swiss-Prot (Q60634.2)"
     CDS             1..428
                     /gene="Flot2"
                     /gene_synonym="Esa; reggie-2"
                     /coded_by="NM_001040403.2:134..1420"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS36237.1"
                     /db_xref="GeneID:14252"
                     /db_xref="MGI:MGI:103309"
ORIGIN      
        1 mgnchtvgpn ealvvsggcc gsdykqyvfg gwawawwcis dtqrisleim tlqprcedve
       61 taegvaltvt gvaqvkimte kellavaceq flgknvqdik nvvlqtlegh lrsilgtltv
      121 eqiyqdrdqf aklvrevaap dvgrmgieil sftikdvydk vdylsslgkt qtavvqrdad
      181 igvaeaerda gireaeckke mldvkfmadt kiadskrafe lqksafseev niktaeaqla
      241 yelqgareqq kirqeeieie vvqrkkqiav eaqeilrtdk eliatvrrpa eaeahriqqi
      301 aegekvkqvl laqaeaekir kigeaeaavi eamgkaeaer mklkaeayqk ygdaakmalv
      361 lealpqiaak isapltkvde ivvlsgdnsk vtsevnrlla elpasvhalt gvdlskipli
      421 knatgaqv
//
