LOCUS       NP_001074654            2726 aa            linear   ROD 06-OCT-2024
DEFINITION  filamin-C isoform 1 [Mus musculus].
ACCESSION   NP_001074654 XP_284175
VERSION     NP_001074654.1
DBSOURCE    REFSEQ: accession NM_001081185.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2726)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 2726)
  AUTHORS   Zhou,X., Fang,X., Ithychanda,S.S., Wu,T., Gu,Y., Chen,C., Wang,L.,
            Bogomolovas,J., Qin,J. and Chen,J.
  TITLE     Interaction of Filamin C With Actin Is Essential for Cardiac
            Development and Function
  JOURNAL   Circ Res 133 (5), 400-411 (2023)
   PUBMED   37492967
  REMARK    GeneRIF: Interaction of Filamin C With Actin Is Essential for
            Cardiac Development and Function.
REFERENCE   3  (residues 1 to 2726)
  AUTHORS   Li-Villarreal,N., Rasmussen,T.L., Christiansen,A.E., Dickinson,M.E.
            and Hsu,C.W.
  TITLE     Three-dimensional microCT imaging of mouse heart development from
            early post-implantation to late fetal stages
  JOURNAL   Mamm Genome 34 (2), 156-165 (2023)
   PUBMED   36595063
  REMARK    Review article
REFERENCE   4  (residues 1 to 2726)
  AUTHORS   Wu,T., Xu,Y., Zhang,L., Liang,Z., Zhou,X., Evans,S.M. and Chen,J.
  TITLE     Filamin C is Essential for mammalian myocardial integrity
  JOURNAL   PLoS Genet 19 (1), e1010630 (2023)
   PUBMED   36706168
  REMARK    GeneRIF: Filamin C is Essential for mammalian myocardial integrity.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 2726)
  AUTHORS   Powers,J.D., Kirkland,N.J., Liu,C., Razu,S.S., Fang,X.,
            Engler,A.J., Chen,J. and McCulloch,A.D.
  TITLE     Subcellular Remodeling in Filamin C Deficient Mouse Hearts Impairs
            Myocyte Tension Development during Progression of Dilated
            Cardiomyopathy
  JOURNAL   Int J Mol Sci 23 (2), 871 (2022)
   PUBMED   35055055
  REMARK    GeneRIF: Subcellular Remodeling in Filamin C Deficient Mouse Hearts
            Impairs Myocyte Tension Development during Progression of Dilated
            Cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2726)
  AUTHORS   Kaput,J., Klein,K.G., Reyes,E.J., Kibbe,W.A., Cooney,C.A.,
            Jovanovic,B., Visek,W.J. and Wolff,G.L.
  TITLE     Identification of genes contributing to the obese yellow Avy
            phenotype: caloric restriction, genotype, diet x genotype
            interactions
  JOURNAL   Physiol Genomics 18 (3), 316-324 (2004)
   PUBMED   15306695
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 2726)
  AUTHORS   Lu,S., Carroll,S.L., Herrera,A.H., Ozanne,B. and Horowits,R.
  TITLE     New N-RAP-binding partners alpha-actinin, filamin and Krp1 detected
            by yeast two-hybrid screening: implications for myofibril assembly
  JOURNAL   J Cell Sci 116 (Pt 11), 2169-2178 (2003)
   PUBMED   12692149
REFERENCE   8  (residues 1 to 2726)
  AUTHORS   van der Flier,A., Kuikman,I., Kramer,D., Geerts,D., Kreft,M.,
            Takafuta,T., Shapiro,S.S. and Sonnenberg,A.
  TITLE     Different splice variants of filamin-B affect myogenesis,
            subcellular distribution, and determine binding to integrin [beta]
            subunits
  JOURNAL   J Cell Biol 156 (2), 361-376 (2002)
   PUBMED   11807098
REFERENCE   9  (residues 1 to 2726)
  AUTHORS   Chiang,W., Greaser,M.L. and Lyons,G.E.
  TITLE     Filamin isogene expression during mouse myogenesis
  JOURNAL   Dev Dyn 217 (1), 99-108 (2000)
   PUBMED   10679933
REFERENCE   10 (residues 1 to 2726)
  AUTHORS   Gariboldi,M., Maestrini,E., Canzian,F., Manenti,G., De Gregorio,L.,
            Rivella,S., Chatterjee,A., Herman,G.E., Archidiacono,N.,
            Antonacci,R. et al.
  TITLE     Comparative mapping of the actin-binding protein 280 genes in human
            and mouse
  JOURNAL   Genomics 21 (2), 428-430 (1994)
   PUBMED   8088838
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC044807.4.
            
            On Feb 6, 2007 this sequence version replaced XP_284175.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2726
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.36 cM"
     Protein         1..2726
                     /product="filamin-C isoform 1"
                     /note="filamin-C; actin-binding protein 280; filamin-2;
                     ABP-280-like protein; actin-binding-like protein"
                     /calculated_mol_wt=290990
     Region          1..260
                     /region_name="Actin-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14315; propagated from
                     UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          23..147
                     /region_name="CH_FLNC_rpt1"
                     /note="first calponin homology (CH) domain found in
                     filamin-C (FLN-C) and similar proteins; cd21310"
                     /db_xref="CDD:409159"
     Site            order(24..29,35..36,39,43,85..88,93..96,98..99,102..103,
                     105,114..122,127,129..130,132..133,136..137,140)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409159"
     Region          151..265
                     /region_name="CH_FLNC_rpt2"
                     /note="second calponin homology (CH) domain found in
                     filamin-C (FLN-C) and similar proteins; cd21314"
                     /db_xref="CDD:409163"
     Site            order(162,166,214,216..217,220..221,223,232..240,247,
                     249..250,252..253,256..257,260)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409163"
     Region          271..369
                     /region_name="Filamin 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          276..372
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          371..469
                     /region_name="Filamin 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          376..472
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          470..566
                     /region_name="Filamin 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          475..568
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          567..659
                     /region_name="Filamin 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          572..662
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          663..759
                     /region_name="Filamin 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          668..762
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          760..862
                     /region_name="Filamin 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          765..865
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          863..961
                     /region_name="Filamin 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          868..964
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          962..1057
                     /region_name="Filamin 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          968..1061
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Site            1003
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          1058..1150
                     /region_name="Filamin 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          1063..1152
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          1151..1245
                     /region_name="Filamin 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          1156..1248
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Site            1162
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14315; propagated from
                     UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          1246..1345
                     /region_name="Filamin 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          1252..1348
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Site            1339
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14315; propagated from
                     UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          1346..1438
                     /region_name="Filamin 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          1351..1440
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          1439..1534
                     /region_name="Filamin 13"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          1444..1537
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          1535..1631
                     /region_name="Filamin 14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          1540..1634
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          1636..1735
                     /region_name="Filamin 15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          1637..1733
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          1736..1759
                     /region_name="Hinge 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          1760..1855
                     /region_name="Filamin 16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          <1792..1856
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          1856..1947
                     /region_name="Filamin 17"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          1863..1949
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          1948..2034
                     /region_name="Filamin 18"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          2037..2129
                     /region_name="Filamin 19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          2042..2131
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Site            2043
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14315; propagated from
                     UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          2163..2244
                     /region_name="Intradomain insert, mediate targeting to Z
                     lines. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          2193..2214
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          2212..2307
                     /region_name="Filamin 20, mediates interaction with XIRP1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00087"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Site            2234
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19131326; propagated from
                     UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Site            2237
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14315; propagated from
                     UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Site            2239
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q14315; propagated from
                     UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          2241..2261
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          <2245..2309
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          2310..2402
                     /region_name="Filamin 21"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          2315..2403
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          2404..2725
                     /region_name="Interaction with INPPL1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          2408..2494
                     /region_name="Filamin"
                     /note="Filamin/ABP280 repeat; pfam00630"
                     /db_xref="CDD:395505"
     Region          2506..2596
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Site            2587
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14315; propagated from
                     UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          2594..2726
                     /region_name="Self-association site, tail.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          2594..2630
                     /region_name="Hinge 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Site            2618
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14315; propagated from
                     UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Site            2621
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14315; propagated from
                     UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Site            2633
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14315; propagated from
                     UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Region          2636..2725
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Site            2715
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14315; propagated from
                     UniProtKB/Swiss-Prot (Q8VHX6.3)"
     Site            2719
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14315; propagated from
                     UniProtKB/Swiss-Prot (Q8VHX6.3)"
     CDS             1..2726
                     /gene="Flnc"
                     /gene_synonym="1110055E19Rik; ABP-280; ABPL; Fln2"
                     /coded_by="NM_001081185.2:307..8487"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39452.1"
                     /db_xref="GeneID:68794"
                     /db_xref="MGI:MGI:95557"
ORIGIN      
        1 mmnnsnysda sglglvdead empstekdla edapwkkiqq ntftrwcneh lkcvgkrltd
       61 lqrdlsdglr liallevlsq krmyrkfhpr pnfrqmklen vsvalefler ehiklvsids
      121 kaivdgnlkl ilgliwtlil hysismpmwe deddedarkq tpkqrllgwi qnkvpqlpit
      181 nfnrdwqdgk algalvdnca pglcpdweaw dpnqpvqnar eamqqaddwl gvpqviapee
      241 ivdpnvdehs vmtylsqfpk aklkpgapvr skqlnpkkai aygpgiepqg ntvlqpahft
      301 vqtvdagvge vlvyiedpeg hteeakvvpn ndkdrtyavs yvpkvaglhk vtvlfagqni
      361 erspfevnvg malgdankvs argpglepvg nvankptyfd iytagagtgd vavvivdpqg
      421 rrdtvevale dkgdntfrct yrpvmegpht vhvafagapi trspfpvhva eacnpnacra
      481 sgrglqpkgv rvkevadfkv ftkgagsgel kvtvkgpkgt eepvkvreag dgvfeceyyp
      541 vvpgkyvvti twggyaiprs pfevqvspea gaqkvrawgp gletgqvgks adfvveaigt
      601 evgtlgfsie gpsqakiecd dkgdgscdvr ywptepgeya vhvicddedi rdspfiahiq
      661 pappdcfpdk vkafgpglep tgcivdrpae ftidaraagk gdlklyaqda dgcpidikvi
      721 pngdgtfrcs yvptkpikht iivswggvnv pkspfrvnvg egshpervkv ygpgvektgl
      781 kaneptyftv dcseagqgdv sigikcapgv vgpveadidf diikndndtf tvkytppgag
      841 hytimvlfan qeipaspfhi kvdpshdask vkaegpglsr tgvevgkpth ftvltkgagk
      901 akldvhfaga akgeavrdfe iidnhdysyt vkytavqqgn mavtvtyggd pvpkspfvvn
      961 vappldlskv kvqglnskva vgqeqafsvn trgaggqgql dvrmtspsrr pipcklepgg
     1021 gaeaqavrym ppeegpykvd itydghpvpg spfavegvlp pdpskvcayg pglkgglvgt
     1081 papfsidtkg agtgglgltv egpceakiec qdngdgscav sylptepgey tinilfaeah
     1141 ipgspfkati qpvfdpskvr asgpglergk ageaatftvd cseageaelt ieilsdagvk
     1201 aevliqnnad gtyhityspa fpgtytitik ygghpipkfp trvhvqpavd tsgikvsgpg
     1261 vephgvlrev tteftvdars ltatggnhvt arvlnpsgak tdtyvtdngd gtyrvqytay
     1321 eegvhlvevl ydevavpksp frvgvtegcd ptrvrafgpg legglvnkan rftvetrgag
     1381 tgglglaieg pseakmsckd nkdgsctvey ipftpgdydv nitfggqpip gspfrvpvkd
     1441 vvdpgkvkcs gpglgtgvra rvpqtftvdc sqagraplqv avlgptgvae pvevrdngdg
     1501 thtvhytpat dgpytvavky adqevprspf kikvlpshda skvrasgpgl nasgipaslp
     1561 veftidarda gqglltvqil dpegkpkkan irdngdgtyt vsylpdmsgr ytitikyggd
     1621 eipyspfrih alptgdaskc lvtvsigghg lgaclgpriq igeetvitvd akaagkgkvt
     1681 ctvstpdgae ldvdvvenhd gtfdiyytap epgkyvitir fggehipnsp fhvlacdplp
     1741 hveepaemlq mrqpyaplrp gtcpthwate epvvpveple smlrpfnlvi pftvqkgelt
     1801 gevrmpsgkt arpnitdnkd gtitvryapt ekglhqmgik ydgnhipgsp lqfyvdains
     1861 rhvsaygpgl shgmvnkpat ftivtkdage gglslavegp skaeitckdn kdgtctvsyl
     1921 ptapgdysii vrfddkhipg spftakitgd dsmrtsqlnv gtstdvslki tegdlsqlta
     1981 sirapsgnee pcllkrlpnr higisftpke vgehvvsvrk sgkhvtnspf kilvgpseig
     2041 daskvrvwgk glsegqtfqv aefivdtrna gygglglsie gpskvdince dmedgtckvt
     2101 ycptepgtyi inikfadkhv pgspftvkvt gegrmkesit rrrqapsiat igstcdlnlk
     2161 ipgnwfqmvs aqerltrtft rsshtytrte rteisktrgg etkrevrvee stqvggdpfp
     2221 avfgdflgre rlgsfgsitr qqegeassqd mtaqvtspsg kteaaeiveg edsaysvrfv
     2281 pqemgphtvt vkyrgqhvpg spfqftvgpl geggahkvra ggtglergva gvpaefsiwt
     2341 reagagglsi avegpskaei afedrkdgsc gvsyvvqepg dyevsikfnd ehipdspfvv
     2401 pvaslsddar rltvtslqet glkvnqpasf avqlngargv idarvhtpsg aveecyvsel
     2461 dsdkhtirfi phengvhsid vkfngahipg spfkirvgeq sqagdpglvs aygpgleggt
     2521 tgvssefivn tqnagsgals vtidgpskvq ldcrecpegh vvtytpmapg nyliaikygg
     2581 pqhivgspfk akvtgprlsg ghslhetstv lvetvtksss srgasyssip kfssdaskvv
     2641 trgpglsqaf vgqknsftvd cskagtnmmm vgvhgpktpc eevyvkhmgn rvynvtytvk
     2701 ekgdyilivk wgdesvpgsp fkvnvp
//
