LOCUS       NM_134080               9083 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus filamin, beta (Flnb), transcript variant 2, mRNA.
ACCESSION   NM_134080 XM_001471989 XM_001472027 XM_001478129 XM_001478141
            XM_904364 XM_990154
VERSION     NM_134080.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9083)
  AUTHORS   Kopsidas,C.A., Lowe,C.C., McDaniel,D.P., Zhou,X. and Feng,Y.
  TITLE     Sustained generation of neurons destined for neocortex with
            oxidative metabolic upregulation upon filamin abrogation
  JOURNAL   iScience 27 (7), 110199 (2024)
   PUBMED   38989458
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9083)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 9083)
  AUTHORS   Huang,W., Zhang,S., Lin,J., Ding,Y., Jiang,N., Zhang,J., Zhao,H.
            and Chen,F.
  TITLE     Rare loss-of-function variants in FLNB cause non-syndromic
            orofacial clefts
  JOURNAL   J Genet Genomics 51 (2), 222-229 (2024)
   PUBMED   37003352
  REMARK    GeneRIF: Rare loss-of-function variants in FLNB cause non-syndromic
            orofacial clefts.
REFERENCE   4  (bases 1 to 9083)
  AUTHORS   Zieba,J., Forlenza,K.N., Heard,K., Martin,J.H., Bosakova,M.,
            Cohn,D.H., Robertson,S.P., Krejci,P. and Krakow,D.
  TITLE     Intervertebral disc degeneration is rescued by TGFbeta/BMP
            signaling modulation in an ex vivo filamin B mouse model
  JOURNAL   Bone Res 10 (1), 37 (2022)
   PUBMED   35474298
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9083)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9083)
  AUTHORS   Saba,L., Bhave,S.V., Grahame,N., Bice,P., Lapadat,R., Belknap,J.,
            Hoffman,P.L. and Tabakoff,B.
  TITLE     Candidate genes and their regulatory elements: alcohol preference
            and tolerance
  JOURNAL   Mamm Genome 17 (6), 669-688 (2006)
   PUBMED   16783646
REFERENCE   7  (bases 1 to 9083)
  AUTHORS   Ficker,M., Powles,N., Warr,N., Pirvola,U. and Maconochie,M.
  TITLE     Analysis of genes from inner ear developmental-stage cDNA
            subtraction reveals molecular regionalization of the otic capsule
  JOURNAL   Dev Biol 268 (1), 7-23 (2004)
   PUBMED   15031101
REFERENCE   8  (bases 1 to 9083)
  AUTHORS   Sheen,V.L., Feng,Y., Graham,D., Takafuta,T., Shapiro,S.S. and
            Walsh,C.A.
  TITLE     Filamin A and Filamin B are co-expressed within neurons during
            periods of neuronal migration and can physically interact
  JOURNAL   Hum Mol Genet 11 (23), 2845-2854 (2002)
   PUBMED   12393796
REFERENCE   9  (bases 1 to 9083)
  AUTHORS   van der Flier,A., Kuikman,I., Kramer,D., Geerts,D., Kreft,M.,
            Takafuta,T., Shapiro,S.S. and Sonnenberg,A.
  TITLE     Different splice variants of filamin-B affect myogenesis,
            subcellular distribution, and determine binding to integrin [beta]
            subunits
  JOURNAL   J Cell Biol 156 (2), 361-376 (2002)
   PUBMED   11807098
REFERENCE   10 (bases 1 to 9083)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ112968.1, AK050046.1, BP765788.1, CD555839.1, AC140322.4,
            BY101832.1, BU055777.1, CV558093.1, CD549389.1, CD546916.1,
            CF165547.1, BU703688.1, CN534523.1, BG076906.2, CF166040.1,
            CF736029.1, CB290081.1, BM950536.1, CF551577.1, BM949278.1,
            CF172628.1, CA537344.1, CB194973.1 and BP753072.1.
            
            On or before Jul 25, 2007 this sequence version replaced
            XM_001471989.1, XM_001472027.1, XM_904364.3, XM_001478129.1,
            XM_001478141.1, XM_990154.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1,
            resulting in an isoform (b) that is shorter than isoform a. This
            gene lacks full-length transcript support, and therefore the exon
            combination of this variant is inferred based on tiled partial
            transcripts and full-length orthologous alignments, e.g., human
            AB191258.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               CJ112968.1         4-363
            361-1179            AK050046.1         1-819
            1180-1326           BP765788.1         489-635
            1327-1678           CD555839.1         117-468
            1679-1805           AC140322.4         98518-98644         c
            1806-1953           BY101832.1         200-347
            1954-2155           BU055777.1         120-321
            2156-2518           CV558093.1         135-497
            2519-2679           AC140322.4         93092-93252         c
            2680-3079           CD549389.1         116-515
            3080-3618           CD546916.1         34-572
            3619-3846           CF165547.1         290-517
            3847-4417           BU703688.1         80-650
            4418-4866           CN534523.1         195-643
            4867-5154           BG076906.2         125-412
            5155-5353           CF166040.1         308-506
            5354-5713           CF736029.1         326-685
            5714-6253           CB290081.1         64-603
            6254-6529           BM950536.1         394-669
            6530-7048           CF551577.1         248-766
            7049-7360           BM949278.1         131-442
            7361-7884           CF172628.1         72-595
            7885-8098           CA537344.1         286-499
            8099-8737           CB194973.1         19-657
            8738-9083           BP753072.1         1-346               c
FEATURES             Location/Qualifiers
     source          1..9083
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 4.59 cM"
     gene            1..9083
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /note="filamin, beta"
                     /db_xref="GeneID:286940"
                     /db_xref="MGI:MGI:2446089"
     exon            1..487
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..7971
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /note="isoform b is encoded by transcript variant 2;
                     filamin-B; actin binding protein 278; beta-filamin;
                     ABP-280-like protein; actin-binding-like protein"
                     /codon_start=1
                     /product="filamin-B isoform b"
                     /protein_id="NP_598841.1"
                     /db_xref="GeneID:286940"
                     /db_xref="MGI:MGI:2446089"
                     /translation="MPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDL
                     SDGLRLIALLEVLSQKRMHHKYHQRPTFRQMKLENVSVALEFLDHESIKLVSIDSKAI
                     VDGNLKLILGLVWTLILHYSISMPVWEDEGDDDAKKQTPKQRLLGWIQNKIPYLPITN
                     FNQNWQDGKALGALVDSCAPGLCPDWESWDPRKPVDNAREAMQQADDWLGVPQVITPE
                     EIIHPDVDEHSVMTYLSQFPKAKLKPGAPLKPKLNPKKARAYGRGIEPTGNMVKQPAK
                     FTVDTISAGQGDVMVFVEDPEGNKEEARVTPDSDKNKTYSVEYLPKVTGLHKVIVLFA
                     GQHISKSPFEVNVDKAQGDASKVTAKGPGLETTGNIANKPTYFDIYTAGAGVGDIGIE
                     VEDPQGKNSVELLVEDRGNQVYRCVYKPVQPGPHVVKVSFAGDAIPKSPFGVQIGEAC
                     NPNACRASGRGLQPKGVRIRETADFKVDTKAAGSGELGVTVKGPKGLEELVKQKGFLD
                     GVYSFEYYPSTPGKYSVAVTWGGHHIPKSPFEVQVGPEAGMQKVRAWGPGLHGGIVGR
                     SADFVVESIGSEVGTLGFAIEGPSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDD
                     EDIKDSPYMAFIHPATGDYNPDLVQAYGPGLEKSGCTINNPAEFIVDPKDAGSAPLKI
                     LAQDGEGQPIDIQMKSRMDGTYACSYTPLKAIKHTIAVVWGGVNIPHSPYRVNIGQGS
                     HPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIKCDARVLSDDEEDVDFD
                     IIHNANDTFTVKYVPPAPGRYTIKVLFASQEIPASPFRVKVDPSHDASKVKAEGPGLS
                     KAGVENGKPTHFTVHTKGAGKAPLNVQFSSPLPGEAVKDLDIIDNYDYSHTVKYTPTQ
                     QGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKINGLENRVEVGKDQEFAIDTNGAG
                     GQGKLDVTILSPSRKVVPCLVAPVAGRECSTAKFIPREEGLFAVDVTYDGHPVPGSPY
                     TVEASLPPDPTKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECS
                     DNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHG
                     KVGEPGILCVDCSEAGPGTLGLEAVSDSGAKAEVSIQNNKDGTYAVTYVPLTAGMYTL
                     TMKYGGELVPHFPAWVKVEPAIDTSGIKAFGPGIEGKDVFREATTDFTVDSRPLTQVG
                     GDHIKAQITNPSGASTECFVKDNADGTYQVEYTPFEKGFHVVEVTYDDVPIPNSPFKV
                     AVTEGCQPSRVHAQGPGLKEAFTNKSNVFTVVTRGAGIGGLGITVEGPSESKINCRDN
                     KDGSCSAEYIPFAPGDYDVNITYGGVHIPGSPFRVPSKDVVDPSKVKIAGPGLSSCVR
                     ACIPQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYIVS
                     VKYADEEIPRSPFKVKVLPTYDASKVTASGPGLSAYGVPASLPVEFAIDARDAGEGLL
                     AVQITDQEGKPQRATVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDNIPLSPYRIRATQ
                     TGDASKCLATGPGIAPTVKTGEEVGFVVDAKTAGKGKVTCVILTPDGTEAEADVIENE
                     DGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVTAMEEAPVTEEAYVPVS
                     DMNGLGFKPFDLVIPFAVRKGEITGTVHMPSGKKATPEIVDNKDGTVTVRYAPTEVGL
                     HEMHIKYRGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAGEGG
                     LDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKITDD
                     NRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNNHIGISFIPR
                     EVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGQGLSEGRTFEMSDFIVDT
                     RDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPF
                     TVKISGEGRVRESITRTSRAPAVATVGSICDLNLKIPEINSSDMSAHVTSPSGHVTEA
                     EIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGP
                     GLERGEAGIPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGN
                     YEVSIKFNDEHIPDSPYLVPVIAPSDDARCLTVLSLQESGLKVNQPASFAIRLNGAKG
                     KIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRV
                     GEPGQAGNPALVSAYGAGLETGTTGIQSEFFINTTQAGPGTLSVTIEGPSKVKMDCQE
                     IPEGYKVMYTPMAPGNYLIGVKYGGPNHISRSPFKAKVTGQRLVSPGSANETSSILVE
                     SVTRSSTETCYSAIPKSSSDASKVTSKGAGLSKAFVGQKSSFLVDCSKAGSNMLLIGV
                     HGPTTPCEEVSMKHVGKQQYNVTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP"
     exon            488..736
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            737..834
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            835..982
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1101
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1179
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1342
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1540
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1678
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1805
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1942
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2136
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2250
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2394
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2518
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2679
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2770
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2940
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3058
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3321
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3919
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            3920..4093
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            4094..4256
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            4257..4417
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            4418..4585
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            4586..4709
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            4710..4866
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            4867..5056
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            5057..5304
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            5305..5343
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            5344..5446
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            5447..5587
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            5588..5716
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            5717..5890
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            5891..6049
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            6050..6253
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            6254..6406
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            6407..6529
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            6530..6796
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            6797..6934
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            6935..7050
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            7051..7183
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            7184..7360
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            7361..7579
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            7580..7783
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     exon            7784..9067
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9046..9051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /note="hexamer: AATAAA"
     polyA_site      9067
                     /gene="Flnb"
                     /gene_synonym="Fln-b"
                     /note="major polyA site"
ORIGIN      
        1 gcgtagcgcg caggcgccag gccaggctac ttcgcgcccg gggacggacg aaggcagtcc
       61 tgatcctgtt gcggctagta tagcagcgct ttctaaccct ctccccactt gcctcagttc
      121 cccttccccg ggcccttggg gcttttcatc tcagtccctg cagctcgttg tttccgcgta
      181 ctctctgcct ccaggatgcc ggtgacggag aaagacctgg cggaggacgc gccgtggaag
      241 aagattcagc agaacacgtt cacgcgctgg tgcaacgagc acctcaagtg tgtgaataaa
      301 cgcatcggga acctgcagac cgacctgagc gacgggctac ggctcatcgc gctgctcgag
      361 gtgctcagcc agaagcgcat gcaccacaag taccatcagc ggcccacctt cagacagatg
      421 aagctggaga atgtgtctgt ggctctggag ttcctagacc acgaaagcat taagctcgtg
      481 tccattgaca gtaaagccat cgtggatggg aacctgaagc tcatcttggg cctggtatgg
      541 actttgatcc ttcactactc catctccatg cccgtatggg aagatgaagg ggatgatgat
      601 gccaagaagc agacaccaaa gcagaggcta ctgggatgga ttcagaacaa gattccatac
      661 ttgcccatca ctaactttaa ccagaactgg caagatggca aagccttagg agccctggta
      721 gacagctgtg ctccaggtct gtgcccagac tgggaatcct gggacccacg gaagccggtg
      781 gataatgccc gagaagccat gcagcaggcc gatgactggc tgggcgtccc acaggtcatc
      841 actcctgagg agattattca cccggacgtg gacgagcact ctgtgatgac ctacctgtct
      901 cagttcccca aagccaagct caagccaggt gctcctctta aacccaaact caacccaaag
      961 aaagcccgag cctatggcag aggaatcgaa cctactggaa acatggtgaa gcagccagcc
     1021 aaattcacgg tagataccat cagcgctgga caaggagatg tgatggtgtt tgttgaggac
     1081 ccagaaggaa acaaggaaga ggcacgtgtg accccagaca gtgacaagaa caagacatac
     1141 tctgtggagt atctgcccaa agtcaccggc ctgcataaag tcatcgtcct ctttgcagga
     1201 cagcacattt ctaagagccc atttgaagtg aatgttgaca aagcccaagg agatgccagc
     1261 aaagtcactg caaaaggccc agggctggaa actacaggga acattgccaa caagcctacc
     1321 tattttgaca tctacacagc tggagctggc gtgggggaca tcggcattga ggtggaggat
     1381 ccccagggca agaacagcgt ggagctgctg gtggaagaca gaggaaacca ggtgtataga
     1441 tgtgtctaca aaccagtgca gcctggcccc catgtggtca aggtctcctt tgctggggat
     1501 gccattccca agagtccctt tggtgtacaa attggggaag cctgcaaccc aaatgcctgc
     1561 agagccagcg gccgaggtct gcagcccaaa ggtgtccgga tccgggagac tgcagacttt
     1621 aaggtggaca ccaaggctgc tggaagcgga gagcttggtg taactgtgaa gggccctaag
     1681 ggcctggagg agctggtcaa acaaaagggc tttctggatg gggtctactc atttgagtac
     1741 taccccagca caccagggaa atacagcgtt gcagttacct ggggggggca ccacattccc
     1801 aagagcccct ttgaagttca agttggccct gaagcaggca tgcagaaagt ccgtgcatgg
     1861 ggccctggac tccacggcgg cattgttggt cggtcagcag attttgtggt ggaatccatt
     1921 ggttctgagg ttggaactct gggatttgcc attgaaggcc cttcccaagc aaagatcgag
     1981 tatgatgatc agaacgatgg ctcgtgtgat gtcaaatact ggcccaagga gcctggagaa
     2041 tacgccgttc acatcatgtg cgacgacgaa gacatcaagg acagcccata catggctttc
     2101 atccaccctg ccacaggaga ctacaaccca gatctagtcc aagcctatgg gccgggtttg
     2161 gagaaatctg gttgtactat caacaaccca gcagagttca ttgtggatcc taaggatgcc
     2221 gggagtgctc ccttaaagat actggcgcag gatggggaag gccagcccat tgacatccag
     2281 atgaagagtc ggatggacgg cacttatgct tgctcatata ccccacttaa agccatcaag
     2341 cacaccatcg ctgtggtctg gggaggtgtg aacataccac acagccccta cagggtcaac
     2401 attgggcaag gtagccatcc ccaaaaggtc aaagtgtttg gcccaggcgt ggagaggagt
     2461 ggtctgaagg caaatgagcc tactcacttt acagtggatt gcacggaggc cggggaaggt
     2521 gatgtcagtg ttggtatcaa gtgcgatgcc cgagttttaa gtgacgatga ggaagatgtc
     2581 gattttgaca ttattcacaa tgccaatgac acattcactg tcaaatacgt acctcctgcc
     2641 cctgggcggt ataccatcaa agttctcttt gcatctcagg aaatccccgc cagccctttc
     2701 agagtcaaag ttgacccttc ccatgacgcc agcaaggtga aggcagaagg ccccgggttg
     2761 agtaaagcag gcgtggaaaa tgggaagcca acccacttca ctgttcacac caagggagcc
     2821 ggaaaagctc cgctcaacgt gcagttcagc agcccccttc ctggggaggc agtgaaggac
     2881 ttggatatca ttgataatta tgactactca catactgtta aatacacccc aacccagcag
     2941 ggcaacatgc aggttctagt gacttatggt ggcgatccca ttcctaaaag tcctttcact
     3001 gtgggcgttg ctgcgccact ggatctgagc aagataaaaa ttaatggact ggaaaacaga
     3061 gttgaggttg gaaaggacca ggaatttgcc attgacacca acggggcagg aggccagggg
     3121 aagctggatg tgaccatcct gagcccttct cggaaggtgg tgccatgctt ggtagcacca
     3181 gtggctggca gggaatgcag cacagccaaa ttcatccctc gggaggaggg gctgtttgct
     3241 gtagatgtga cctatgatgg acacccagtg cccgggagcc cctatactgt ggaggcctca
     3301 ctaccaccag atcccaccaa ggtgaaggcc cacggtcctg gccttgaagg aggtcttgta
     3361 ggcaagcccg ctgagttcac cattgacact aaaggagctg gaactggagg tttgggccta
     3421 actgtggaag gtccatgtga ggccaaaatc gaatgctcgg ataacggtga cgggacctgc
     3481 tccgtctcct accttcccac aaaacccgga gaatactttg tcaacattct ctttgaagaa
     3541 gtccacattc ctggatctcc cttcaaagcc gacattgaaa tgccgtttga cccctctaag
     3601 gttgtagcgt caggaccagg acttgaacac ggaaaagtgg gtgaacccgg aatcctttgc
     3661 gttgattgtt cagaagcagg gcctgggact ctgggccttg aagccgtctc agactcaggg
     3721 gcgaaagctg aagtgtccat ccagaacaat aaagatggca cctacgctgt gacctatgtg
     3781 cctctgacag ctggcatgta cacactgacc atgaagtatg gtggtgagct tgtaccacac
     3841 tttcctgcct gggtcaaggt ggagccagcc atagacacta gtgggatcaa agcctttggg
     3901 ccaggaatcg aaggcaagga cgtgtttcgg gaggccacaa cggacttcac ggttgactcg
     3961 aggcccctta cccaggttgg aggtgaccat atcaaagctc aaattaccaa cccctcgggg
     4021 gcctccaccg agtgctttgt caaggacaat gctgatggga cctatcaggt cgaatacacg
     4081 ccctttgaga aaggtttcca tgtagtggag gtgacatacg atgatgtgcc catcccaaat
     4141 agcccattca aagtggctgt cactgaaggc tgccagccat ctcgggtcca tgcgcaaggc
     4201 cctggactga aagaggcgtt taccaacaaa tctaatgtct tcacagtggt aaccagggga
     4261 gcagggatcg gtgggcttgg cataactgtg gaggggccgt cggagtcaaa gataaactgc
     4321 agagacaaca aggatggcag ctgcagtgct gagtacattc ctttcgctcc aggggattat
     4381 gacgtcaata tcacgtacgg aggcgtccac atccctggca gccccttcag agttccttca
     4441 aaagatgttg tggatcccag caaggtcaag attgctggcc ccggtctgag ctcctgtgtc
     4501 cgagcatgca tcccgcagtc cttcacagtg gacagcagca aggctggcct agctcccctg
     4561 gaagtgaggg tcctgggccc aagaggcctc gtggagccgg tgaatgtggt agataatggg
     4621 gacggcaccc acacagtgac ctacacgcca tctcaggagg ggccctacat tgtttccgtc
     4681 aaatatgctg atgaagagat cccccgaagt ccctttaagg tcaaggttct tcccacatac
     4741 gatgcaagca aagtgacagc ctctgggcct ggcctcagcg cctatggggt acccgccagc
     4801 ctacctgtgg agttcgccat tgatgccaga gatgctggcg aaggcctgct tgctgtccag
     4861 atcacggacc aggagggaaa gcctcaaaga gctactgtcc acgacaacaa agatggcaca
     4921 tatgccgtta cctatatccc tgataagacc ggacgctata tgattggagt cacctatggt
     4981 ggagacaaca ttccactttc tccttaccgt atccgggcca cacagacagg cgatgccagc
     5041 aagtgcttgg ccacaggtcc tggtattgcc cccactgtga aaactggcga ggaggtgggc
     5101 tttgtagtgg acgctaagac tgcagggaag gggaaagtaa cctgcgtgat tctgacccca
     5161 gatggcaccg aggctgaggc tgacgtcatt gaaaatgaag atggcaccta tgacattttc
     5221 tacactgctg ccaagccagg cacctatgtt atctatgtgc gctttggtgg cgttgatatt
     5281 cccaatagcc ccttcacagt catggccacc gatggggaag tcacagccat ggaggaggca
     5341 ccggttacag aagaggccta tgtccctgtg agtgacatga acgggctagg cttcaagccc
     5401 tttgacttgg tgattccatt tgccgtcagg aaaggagaaa ttacaggcac ggtgcatatg
     5461 ccttctggga agaaggctac acctgagatt gtggacaaca aggacggcac ggtcactgtg
     5521 agatacgcgc ccactgaagt cggcctccac gagatgcaca tcaagtacag gggcagccac
     5581 atcccggaga gccccctgca gttctacgtg aactacccca acagtgggag tgtgtctgct
     5641 tatggtccag gccttgtgta tggagtagcc aacaaaactg ccaccttcac cattgtcaca
     5701 gaggatgcgg gagaaggtgg tctggacttg gctattgaag gaccctcgaa agcagagatc
     5761 agctgcattg acaacaaaga cgggacatgt acagtgacct acctacccac cttgccaggg
     5821 gactacagca ttctggtcaa gtacaatgac aaacatattc ctggcagccc cttcactgcc
     5881 aagatcacag atgataacag acgctgctcc caagtgaagc tgggctcagc tgctgacttc
     5941 cttctggaca tcagtgagac agaccttagc acactgacag ccagtatcaa ggccccatct
     6001 ggacgtgacg agccctgtct gctaaagagg ctacccaaca accacattgg catttccttc
     6061 atcccccgag aagtgggtga gcatctagtc agcatcaaga aaaacggtaa ccacgtggcc
     6121 aacagccctg tgtccattat ggtggtccag tctgaaattg gtgatgcacg ccgagccaaa
     6181 gtctatggcc aaggcctgtc agaaggccgg acttttgaga tgtcagactt catcgtggac
     6241 acaagagatg caggctatgg tggcatatcc ttggcagtag aaggacccag caaggtggac
     6301 atccaaacag aggacctgga ggacggcacc tgcaaggtgt cctacttccc cactgtgccc
     6361 ggggtctata tcgtctccac caaatttgct gacgagcatg tgcctggaag cccattcact
     6421 gtgaagatca gtggcgaggg aagagtcaga gagagcatca cccggaccag ccgggctccg
     6481 gctgtggcca cggttggcag tatctgtgac ctgaacctga agatcccgga gatcaacagc
     6541 agtgacatgt ctgcccatgt caccagcccc tctggccatg tcactgaggc agagattgtg
     6601 cccatgggaa agaactctca ctgtgtcaga tttgtgcccc aggagatggg cgttcacact
     6661 gtcagcgtaa agtaccgcgg acagcacgta acaggaagcc cgttccagtt caccgtgggg
     6721 ccccttggcg aagggggtgc ccacaaggtc cgggcaggag gccctggcct ggagagggga
     6781 gaagcaggca tcccagctga gttcagcatc tggacccggg aagcaggtgc tggcggcctc
     6841 tccattgctg ttgagggccc tagtaaggcc gagatcacat tcgatgacca taaaaatggg
     6901 tcatgcggtg tgtcttatat tgcccaagag cctggtaact acgaggtgtc tatcaagttc
     6961 aacgacgagc acatcccgga cagcccttac ctggtgcccg tcatcgcgcc ctcagacgac
     7021 gctcgctgcc tcactgttct gagccttcag gaatcaggat taaaagttaa ccagccagcg
     7081 tcctttgcta taaggttgaa tggtgcgaaa gggaagattg atgcaaaggt gcacagcccc
     7141 tcaggagccg tggaggaatg ccacgtgtct gaactggagc cagataagta tgccgttcgc
     7201 ttcatcccgc atgagaatgg catccacacg atcgatgtca agtttaacgg gagccacgtg
     7261 gtcgggagcc ctttcaaagt acgtgtagga gagcctggcc aggcaggcaa tcctgctcta
     7321 gtgtcagcct acggtgctgg gcttgagacg ggcaccacag gtatccaatc agaattcttc
     7381 atcaatacca ctcaggcagg cccagggaca ttatctgtca ccattgaagg accatccaag
     7441 gtcaaaatgg attgccagga aatcccagag gggtacaaag tcatgtacac tcccatggct
     7501 cctggaaatt acctgattgg tgtcaaatat ggcgggccca accacatctc gaggagtcca
     7561 ttcaaggcca aggtgacagg ccaacgtctg gtcagcccag gctcagccaa cgagacctcc
     7621 tccatcttgg tggagtccgt aaccagatcc tcaacggaaa cgtgctatag cgccattccc
     7681 aagtcgtcct ccgatgccag caaagtgacc tccaagggcg caggcctgtc aaaggctttt
     7741 gtgggccaga agagttcttt cctggtggac tgcagcaaag ctgggtccaa catgctgttg
     7801 attggggtcc atgggcccac caccccctgt gaagaggtct ccatgaagca tgtgggcaag
     7861 caacagtaca acgtcaccta cgtcgtcaag gagaggggcg attacgttct ggctgtgaag
     7921 tggggggaag agcacatccc cggtagcccc tttcatgtca ccgtgcctta aagcatctga
     7981 tagccaatgc tggacgtgtc ccttccggtt gcttttgttg ctagtttgta attcattttt
     8041 tacaatgtcc acagcctgct ggtgggccag cgtccccatc ccaaaccttg ccgctcactc
     8101 caagtgcctt ggtgccctag acttgactcg aggtcatgtg ggacatcttc agaaagcaag
     8161 ctggggccaa aaaagtgcag agccctctgc ccaaatcaag actcttaatt tcaaaggtca
     8221 ttgcagacgg aacaagaaca tggacaggac tgactggctc tcctaagctt ctggtctact
     8281 caagcgataa ccaaacaaga atgtcattgc agaagggggt cctgcacccc acttgccaaa
     8341 gaacagtgca acccactttc ctcaagacta gacaacaaat aagaaagtct gacccagatt
     8401 atactccatg cctgggcttc gtcttggggc cctgatcact ttgacttcat cctaaagcca
     8461 gctctggagc agaaggcatg cagaacactc cataccccat ttttggaatt ctgtacctgc
     8521 ctacttcttt attaacagcc ttgaaggcat gtgctcatgg ccaaatgcag ggcctctgcc
     8581 agctgccccc agagttcatt gcggctgcta aatggcagag accactgata aattatttca
     8641 ggacctcctc cttgcaaaag ctggaaggga tgggtacccc tcttatgacc catgagaggc
     8701 cttaatgacc aagacactag cacgtgcacc cacctgaggt ctctaaaggt tttggtgtaa
     8761 gcattgtcag gctgtcaaat ggctggagcg agtgttacac acacacacac acacacacac
     8821 acacacacac acacacacac acacaatggg gtgtggtggt tctcatgaat gtggcagggg
     8881 tggagtaggt gtcccgcacc aaggcacagc agctggagag gtgtgggtgc taaaagccac
     8941 ctgttaggac ctggagcagc tgaagccgga tgtgaaaggc ggaatagaca cggagaccga
     9001 actggaatca aatgccgact ataaagtgta tcttataact tattaaataa aatgtttgct
     9061 ccataaaaaa aaaaaaaaaa aaa
//
