LOCUS       NM_001404064            8493 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus filamin, alpha (Flna), transcript variant 3, mRNA.
ACCESSION   NM_001404064 XM_006527911
VERSION     NM_001404064.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8493)
  AUTHORS   Binder,M.S., Escobar,I., Xu,Y., Sokolov,A.M., Zhang,L. and
            Bordey,A.
  TITLE     Reducing Filamin A Restores Cortical Synaptic Connectivity and
            Early Social Communication Following Cellular Mosaicism in Autism
            Spectrum Disorder Pathways
  JOURNAL   J Neurosci 44 (39), e1245232024 (2024)
   PUBMED   39164108
  REMARK    GeneRIF: Reducing Filamin A Restores Cortical Synaptic Connectivity
            and Early Social Communication Following Cellular Mosaicism in
            Autism Spectrum Disorder Pathways.
            Erratum:[J Neurosci. 2025 Jan 29;45(5):e2351242024. doi:
            10.1523/JNEUROSCI.2351-24.2024.. PMID: 39843238]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8493)
  AUTHORS   Falace,A., Corbieres,L., Palminha,C., Guarnieri,F.C., Schaller,F.,
            Buhler,E., Tuccari di San Carlo,C., Montheil,A., Watrin,F.,
            Manent,J.B., Represa,A., de Chevigny,A., Pallesi-Pocachard,E. and
            Cardoso,C.
  TITLE     FLNA regulates neuronal maturation by modulating RAC1-Cofilin
            activity in the developing cortex
  JOURNAL   Neurobiol Dis 198, 106558 (2024)
   PUBMED   38852754
  REMARK    GeneRIF: FLNA regulates neuronal maturation by modulating
            RAC1-Cofilin activity in the developing cortex.
REFERENCE   3  (bases 1 to 8493)
  AUTHORS   Kopsidas,C.A., Lowe,C.C., McDaniel,D.P., Zhou,X. and Feng,Y.
  TITLE     Sustained generation of neurons destined for neocortex with
            oxidative metabolic upregulation upon filamin abrogation
  JOURNAL   iScience 27 (7), 110199 (2024)
   PUBMED   38989458
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8493)
  AUTHORS   Ellis,M.L., Terreaux,A., Alwis,I., Smythe,R., Perdomo,J., Eckly,A.,
            Cranmer,S.L., Passam,F.H., Maclean,J., Schoenwaelder,S.M.,
            Ruggeri,Z.M., Lanza,F., Taoudi,S., Yuan,Y. and Jackson,S.P.
  TITLE     GPIbalpha-filamin A interaction regulates megakaryocyte
            localization and budding during platelet biogenesis
  JOURNAL   Blood 143 (4), 342-356 (2024)
   PUBMED   37922495
  REMARK    GeneRIF: GPIbalpha-filamin A interaction regulates megakaryocyte
            localization and budding during platelet biogenesis.
REFERENCE   5  (bases 1 to 8493)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8493)
  AUTHORS   Deussing,J., Roth,W., Rommerskirch,W., Wiederanders,B., von
            Figura,K. and Peters,C.
  TITLE     The genes of the lysosomal cysteine proteinases cathepsin B, H, L,
            and S map to different mouse chromosomes
  JOURNAL   Mamm Genome 8 (4), 241-245 (1997)
   PUBMED   9096102
REFERENCE   7  (bases 1 to 8493)
  AUTHORS   Funke,B., Zuleger,B., Benavente,R., Schuster,T., Goller,M.,
            Stevenin,J. and Horak,I.
  TITLE     The mouse poly(C)-binding protein exists in multiple isoforms and
            interacts with several RNA-binding proteins
  JOURNAL   Nucleic Acids Res 24 (19), 3821-3828 (1996)
   PUBMED   8871564
REFERENCE   8  (bases 1 to 8493)
  AUTHORS   Bae,D.S., Schaefer,M.L., Partan,B.W. and Muglia,L.
  TITLE     Characterization of the mouse DAX-1 gene reveals evolutionary
            conservation of a unique amino-terminal motif and widespread
            expression in mouse tissue
  JOURNAL   Endocrinology 137 (9), 3921-3927 (1996)
   PUBMED   8756567
REFERENCE   9  (bases 1 to 8493)
  AUTHORS   Rivella,S., Tamanini,F., Bione,S., Mancini,M., Herman,G.,
            Chatterjee,A., Maestrini,E. and Toniolo,D.
  TITLE     A comparative transcriptional map of a region of 250 kb on the
            human and mouse X chromosome between the G6PD and the FLN1 genes
  JOURNAL   Genomics 28 (3), 377-382 (1995)
   PUBMED   7490070
REFERENCE   10 (bases 1 to 8493)
  AUTHORS   Gariboldi,M., Maestrini,E., Canzian,F., Manenti,G., De Gregorio,L.,
            Rivella,S., Chatterjee,A., Herman,G.E., Archidiacono,N.,
            Antonacci,R. et al.
  TITLE     Comparative mapping of the actin-binding protein 280 genes in human
            and mouse
  JOURNAL   Genomics 21 (2), 428-430 (1994)
   PUBMED   8088838
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807376.4.
            
            On Apr 7, 2022 this sequence version replaced XM_006527911.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR17253014.3819435.1,
                                    SRR17253011.3614779.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AL807376.4         32115-32219         c
            106-593             AL807376.4         28450-28937         c
            594-842             AL807376.4         25303-25551         c
            843-940             AL807376.4         25114-25211         c
            941-1088            AL807376.4         24878-25025         c
            1089-1207           AL807376.4         24187-24305         c
            1208-1285           AL807376.4         24029-24106         c
            1286-1448           AL807376.4         23773-23935         c
            1449-1649           AL807376.4         23489-23689         c
            1650-1787           AL807376.4         22799-22936         c
            1788-1911           AL807376.4         22591-22714         c
            1912-2048           AL807376.4         22332-22468         c
            2049-2242           AL807376.4         22038-22231         c
            2243-2356           AL807376.4         21720-21833         c
            2357-2500           AL807376.4         21485-21628         c
            2501-2624           AL807376.4         20490-20613         c
            2625-2785           AL807376.4         20242-20402         c
            2786-2876           AL807376.4         20068-20158         c
            2877-3046           AL807376.4         19807-19976         c
            3047-3164           AL807376.4         19508-19625         c
            3165-3427           AL807376.4         19129-19391         c
            3428-4025           AL807376.4         18006-18603         c
            4026-4199           AL807376.4         17742-17915         c
            4200-4362           AL807376.4         17496-17658         c
            4363-4523           AL807376.4         17251-17411         c
            4524-4694           AL807376.4         16990-17160         c
            4695-4818           AL807376.4         16549-16672         c
            4819-4975           AL807376.4         16308-16464         c
            4976-5165           AL807376.4         15535-15724         c
            5166-5189           AL807376.4         15353-15376         c
            5190-5437           AL807376.4         12892-13139         c
            5438-5533           AL807376.4         12687-12782         c
            5534-5636           AL807376.4         12442-12544         c
            5637-5777           AL807376.4         12212-12352         c
            5778-5906           AL807376.4         11767-11895         c
            5907-6080           AL807376.4         11405-11578         c
            6081-6242           AL807376.4         11146-11307         c
            6243-6446           AL807376.4         10707-10910         c
            6447-6599           AL807376.4         10472-10624         c
            6600-6722           AL807376.4         10238-10360         c
            6723-6989           AL807376.4         9877-10143          c
            6990-7127           AL807376.4         9584-9721           c
            7128-7243           AL807376.4         9247-9362           c
            7244-7376           AL807376.4         8588-8720           c
            7377-7553           AL807376.4         7784-7960           c
            7554-7772           AL807376.4         7426-7644           c
            7773-7976           AL807376.4         7138-7341           c
            7977-8493           AL807376.4         5847-6363           c
FEATURES             Location/Qualifiers
     source          1..8493
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.89 cM"
     gene            1..8493
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /note="filamin, alpha"
                     /db_xref="GeneID:192176"
                     /db_xref="MGI:MGI:95556"
     exon            1..105
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            106..593
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..8164
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /note="isoform 3 is encoded by transcript variant 3;
                     filamin-A; actin-binding protein 280; non-muscle filamin;
                     endothelial actin-binding protein; dilated pupils 2"
                     /codon_start=1
                     /product="filamin-A isoform 3"
                     /protein_id="NP_001390993.1"
                     /db_xref="GeneID:192176"
                     /db_xref="MGI:MGI:95556"
                     /translation="MSSSHSRCGQSAAVASPGGSIDSRDAEMPATEKDLAEDAPWKKI
                     QQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQM
                     QLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEED
                     EEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDA
                     SKPVNNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLR
                     PKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTA
                     NNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLE
                     PSGNIANKTTYFEIFTAGAGMGEVEVVIQDPTGQKGTVEPQLEARGDSTYRCSYQPTM
                     EGVHTVHVTFAGVPIPRSPYTVTVGQACNPAACRAIGRGLQPKGVRVKETADFKVYTK
                     GAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPTIPGTYTVTITWGGQNIGRSPF
                     EVKVGTECGNQKVRAWGPGLEGGIVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECD
                     DKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKARGPGL
                     EKTGVAVNKPAEFTVDAKHAGKAPLRVQVQDNEGCSVEATVKDNGNGTYSCSYVPRKP
                     VKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTE
                     AGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPCGAGSYTIMVLFADQA
                     TPTSPIRVKVEPSHDASKVKAEGPGLNRTGVELGKPTHFTVNAKTAGKGKLDVQFSGL
                     AKGDAVRDVDIIDHHDNTYTVKYIPVQQGPVGVNVTYGGDHIPKSPFSVGVSPSLDLS
                     KIKVSGLGDKVDVGKDQEFTVKSKGAGGQGKVASKIVSPSGAAVPCKVEPGLGADNSV
                     VRFVPREEGPYEVEVTYDGVPVPGSPFPLEAVAPTKPSKVKAFGPGLQGGNAGSPARF
                     TIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIP
                     GSPFKAHVAPCFDASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLP
                     AEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGVQCYG
                     PGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTDTYVQDCGDGTYKVE
                     YTPYEEGVHSVDVTYDGSPVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTV
                     ETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGS
                     PFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLV
                     EPVDVVDNADGTQTVNYVPSREGSYSISVLYGEEEVPRSPFKVKVLPTHDASKVKASG
                     PGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVP
                     DVPGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIGPTIQIGE
                     ETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRF
                     GGEHVPNSPFQVTALAGDQPTVQTPLRSQQLAPQYNYPQGSQQTWIPERPMVGVNGLD
                     VTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPSITDNKDGTVTVRYSPSEAGLHEM
                     DIRYDNMHIPGSPLQFYVDYVNCGHITAYGPGLTHGVVNKPATFTVNTKDAGEGGLSL
                     AIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNDQHIPGSPFTARVTGDDSM
                     RMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKET
                     GEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRD
                     AGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSV
                     KVTGEGRVKESITRRRRAPSVANIGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEI
                     VEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGL
                     ERAEVGVPAEFGIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYE
                     VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAI
                     DAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGIYLIDVKFNGTHIPGSPFKIRVGE
                     PGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECP
                     EGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSL
                     TKVATVPQHATSGPGPADVSKVVAKGLGLSKAYVGQKSNFTVDCSKAGNNMLLVGVHG
                     PRTPCEEILVKHMGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRIMVP"
     exon            594..842
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            843..940
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1088
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1207
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1285
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1448
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1649
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1787
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1911
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2048
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2242
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2356
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2500
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2624
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2785
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2876
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3046
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3164
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3427
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..4025
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            4026..4199
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            4200..4362
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            4363..4523
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            4524..4694
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            4695..4818
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            4819..4975
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            4976..5165
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            5166..5189
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            5190..5437
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            5438..5533
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            5534..5636
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            5637..5777
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            5778..5906
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            5907..6080
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            6081..6242
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            6243..6446
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            6447..6599
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            6600..6722
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            6723..6989
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            6990..7127
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            7128..7243
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            7244..7376
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            7377..7553
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            7554..7772
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            7773..7976
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     exon            7977..8493
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8464..8469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /note="hexamer: AATAAA"
     polyA_site      8493
                     /gene="Flna"
                     /gene_synonym="ABP-280; Dilp2; F730004A14Rik; filamin-1;
                     Fln1; GENA 379"
                     /note="major polyA site"
ORIGIN      
        1 attcgcgtgg aggcgcgcag cgcgcagcgg acgccagtgg agctctgagg cttccggcgc
       61 gggcgcgaag agctgggcgc cacccggcgg ttagagggac agcagtgcaa cctctgttct
      121 gtgcctcgtc gttcatgctc ggaggtgcct actgctttaa ttaaagggcc gtcccatcgg
      181 cgaagctgca gcaccgcccc tccgttcctc gcgcctcaaa atgagtagct ctcactcccg
      241 ctgtggccag agtgcggcgg ttgcgtctcc gggaggcagt atcgattcac gggacgcgga
      301 gatgccggct accgaaaaag acctagcaga agatgcaccg tggaagaaaa ttcagcagaa
      361 cacattcacc cgctggtgca atgagcacct taagtgcgta agcaagcgca tcgccaatct
      421 gcagacggac ctgagcgatg ggttgcggct catcgcgctg ctcgaggtac tcagccagaa
      481 gaaaatgcac cgcaagcaca accaaagacc cactttccgc cagatgcagc tcgaaaatgt
      541 gtcggtggcg cttgaattcc tggaccgtga gagcatcaag ctcgtgtcca tagacagcaa
      601 ggctattgtg gatggaaatc tgaagctgat cttaggcctc atctggaccc tgatcctgca
      661 ctattccatc tcaatgccca tgtgggatga ggaagaggat gaggaggcca agaagcaaac
      721 acccaagcag aggcttctag gctggattca gaacaagcta ccacagcttc ccattaccaa
      781 cttcagtcga gactggcaga gtggccgggc cctgggtgct cttgttgata gctgtgcccc
      841 aggcctatgt cctgactggg actcctggga tgctagtaag cctgtgaaca atgcacggga
      901 agccatgcag caggctgatg actggctagg cattcctcag gtgattaccc cagaagaaat
      961 tgtggacccc aatgtagatg agcattctgt tatgacctac ctgtctcagt ttcccaaggc
     1021 caagctgaag ccaggggctc ctcttcggcc caaactgaac ccgaagaaag cccgagccta
     1081 tgggccaggc atcgagccta caggcaatat ggtgaagaag agagcagaat tcactgtgga
     1141 gacccgaagt gctggacagg gagaagtgct tgtatatgtg gaggacccag ctggacacca
     1201 ggaagaggca aaagtgactg ccaataatga caagaaccgt actttctctg tctggtatgt
     1261 ccctgaagtg acagggactc ataaggtgac tgtgctcttt gctggccaac atattgccaa
     1321 gagccccttt gaggtgtatg tggacaagtc acagggtgat gccagcaaag tgactgccca
     1381 gggccctggt ctggagccca gtggcaatat tgccaacaag actacctact ttgagatctt
     1441 cactgcagga gctggcatgg gtgaggtgga agttgtcatc caggacccta caggacagaa
     1501 aggcacagtg gaacctcagc tggaggccag gggtgacagc acctatcgct gtagctatca
     1561 gcccaccatg gagggtgtcc atacagtaca tgtcaccttc gccggtgttc ccatccctcg
     1621 tagcccctac actgtcactg ttggccaagc ctgtaaccca gctgcctgcc gggctattgg
     1681 tagaggcctt cagcccaagg gtgttcgagt gaaggaaaca gccgacttca aggtgtacac
     1741 aaagggcgct ggcagtgggg agctaaaggt cactgtaaag ggtcccaagg gtgaggagcg
     1801 tgtaaagcag aaggacttag gggatggtgt gtatggcttt gaatattacc ctacaatccc
     1861 tggcacatac actgtcacca tcacatgggg tggccagaac attggtcgaa gtccgtttga
     1921 ggtgaaggta ggcactgagt gtggcaatca gaaagttcgg gcatggggtc ctggcctgga
     1981 aggaggcatt gttggcaagt cagcagactt cgtagtagag gccattggtg atgatgtggg
     2041 caccttgggt ttctctgtgg aaggtccatc acaggcaaag attgaatgtg acgacaaggg
     2101 tgatggctcc tgtgatgtgc gctattggcc ccaggaggct ggcgagtatg ctgttcatgt
     2161 gctgtgtaac agtgaggata tccgtctcag tcctttcatg gctgacatcc gtgaggcacc
     2221 ccaggatttt cacccagaca gggtgaaggc acgtgggcct ggattggaga agactggtgt
     2281 ggctgtcaac aagccagcag agttcacagt tgatgccaag catgctggga aggctcctct
     2341 tcgagttcaa gttcaggaca atgagggctg ctctgtggaa gcgacagtca aggacaatgg
     2401 caatggtact tacagctgtt cttatgtgcc cagaaagcca gtgaagcaca cagccatggt
     2461 ttcttgggga ggtgtcagca tccccaacag tcctttccgg gtgaatgtgg gagctggcag
     2521 ccatccaaac aaagtcaagg tgtatggtcc aggagtggcc aagactgggc tcaaggccca
     2581 tgaacctacc tactttactg tggattgtac tgaagctggc cagggagatg tcagcattgg
     2641 tatcaagtgt gcccctggag tagtgggccc cactgaggct gatattgact ttgatatcat
     2701 ccgcaatgac aatgacacct tcactgtaaa atacacaccc tgtggggctg gcagctatac
     2761 catcatggtc ctttttgctg accaggccac acccaccagc cccatcagag tcaaagtgga
     2821 gccttctcat gatgccagca aggtgaaggc tgagggtcct ggcctaaatc gcactggtgt
     2881 tgaacttggc aaacccaccc atttcacagt caatgctaaa actgctggga aaggcaagct
     2941 ggatgtccaa ttctcaggac tggctaaggg agatgcagta cgggatgtgg acatcattga
     3001 ccaccatgat aatacctaca cagtcaagta cattcctgtg cagcagggcc cagtaggtgt
     3061 caatgtcact tatggaggag atcacatccc caagagtcca ttttcagtgg gagtatctcc
     3121 aagcctggat ctcagcaaaa tcaaggtgtc tggccttggt gacaaagtgg acgttggcaa
     3181 agatcaagag ttcacagtaa agtcaaaggg tgcaggtggt caaggcaaag tagcatccaa
     3241 gattgtgagt ccctcaggtg cagcggtacc ctgcaaggta gagccaggcc tgggagctga
     3301 caacagcgtg gtacgttttg tgccccgtga agaggggccc tatgaggtgg aagtgaccta
     3361 tgatggtgtg cctgtacctg gcagtccctt tccactagaa gctgtggccc ccaccaaacc
     3421 cagcaaggtg aaggcgtttg gaccagggct acaggggggc aatgcaggct cccctgcccg
     3481 cttcaccatt gatacaaagg gtgctggcac tggtggcctg ggcctgacag tggaaggccc
     3541 ctgtgaagca cagcttgagt gcctagacaa cggggatggt acatgctctg tgtcttatgt
     3601 acccactgag cctggggact acaacatcaa catccttttt gctgacaccc acattcctgg
     3661 atccccattc aaggcccatg tggctccttg ttttgatgca tccaaggtga agtgctcagg
     3721 ccctgggctg gagcgggcta ctgctggtga ggtagggcag ttccaagtgg actgttcaag
     3781 tgctggcagt gctgagttga cgattgagat ctgctctgag gcaggactgc cagctgaagt
     3841 atacattcaa gaccatggtg atggcacaca caccattacc tatattcctc tctgtcctgg
     3901 ggcttacact gttaccatca agtatggcgg ccagcctgtg cccaacttcc ccagcaagct
     3961 acaggtggaa cctgctgtag atacctcagg tgtacagtgc tatgggcctg ggattgaagg
     4021 tcaaggtgtc ttccgagagg caaccactga gttcagtgtg gatgcccggg ctcttacaca
     4081 gactggaggg ccacatgtca aggctcgagt ggccaacccc tcaggcaatc tgacagatac
     4141 ctatgtgcaa gactgtgggg atggcacata caaagtggaa tacactccat atgaggaagg
     4201 agtacactct gtggatgtga cttatgatgg cagccctgtg cccagcagcc ccttccaggt
     4261 gcctgtaaca gagggctgtg acccctcccg ggtgcgtgtc catggaccag gcatccaaag
     4321 tggtaccacc aacaaaccca acaagttcac agtagaaacc aggggagctg gcacaggtgg
     4381 cctgggcttg gctgttgagg gtccctcaga ggccaagatg tcttgtatgg ataataaaga
     4441 tggcagctgc tcagtagaat acatccccta tgaagctgga acctatagcc ttaatgtcac
     4501 ttatggtggt caccaagtgc caggtagtcc cttcaaggtc cctgtacatg atgtgacaga
     4561 tgcatctaaa gtcaagtgtt ctggacctgg cctaagccca ggcatggtcc gtgccaacct
     4621 ccctcagtcc tttcaggtgg acacaagcaa agctggagtt gccccactgc aggtcaaagt
     4681 gcaggggccc aaaggcctgg tggagccagt ggatgtagtg gacaatgctg atggtactca
     4741 gactgtcaac tatgtgccca gccgagaagg gtcctatagc atttctgtgc tgtatggtga
     4801 agaagaagtg ccacggagcc ccttcaaggt caaggtgctg cctacacatg atgccagtaa
     4861 ggtgaaggcc agtggacctg gactcaacac cactggtgta cctgctagcc tgcctgtgga
     4921 gttcaccatt gatgccaagg atgctgggga gggtctgttg gctgtccaga ttacggatcc
     4981 tgaaggcaag cccaagaaga cacacattca agataatcat gatggcacat acacggtggc
     5041 ttatgtgcca gatgtgccag gccggtacac aatcctcatc aagtatggtg gtgatgagat
     5101 tcccttttcc ccgtaccgtg tccgggctgt gcccactggg gatgccagca agtgcacagt
     5161 cacagtgtca atcggaggtc acgggctagg tgctggcatt ggccccacca tccagattgg
     5221 ggaggagacg gtgattactg tggacacaaa agcagcaggc aaaggcaaag tgacttgtac
     5281 tgtgtgcaca cctgatggct cagaggtaga cgtggacgtg gtggagaatg aggatggcac
     5341 ctttgacatc ttctacacag ctccccaacc gggcaaatat gtcatctgtg tgcgcttcgg
     5401 tggcgagcat gtgcccaaca gccccttcca agttacagct ttggctgggg accaaccaac
     5461 agtgcagacc ccattaaggt ctcagcagct ggctccacag tataactatc ctcagggtag
     5521 ccagcaaacc tggattccag agaggcccat ggtgggcgtt aatgggctgg atgtgaccag
     5581 cctgaggccc tttgatcttg tcatcccctt cactatcaag aagggggaga tcactgggga
     5641 agttcgaatg ccctcaggca aggtggccca gccttccatt actgataaca aagatggcac
     5701 tgttactgta cgttactcac ccagtgaagc tggcctgcat gaaatggaca ttcgctatga
     5761 caatatgcat atcccaggaa gccctctgca gttctatgtt gattatgtca actgtggcca
     5821 catcactgct tatggtcctg gccttaccca tggagtggtc aacaaacctg ccaccttcac
     5881 tgtcaacacc aaggatgcag gagagggggg cttgtctctg gccattgagg gtccatctaa
     5941 agcagaaatc agttgcactg acaaccagga tggaacatgc agtgtctctt acctgcctgt
     6001 actgcctggt gactatagca tcctagttaa gtacaatgat caacacatcc caggcagtcc
     6061 ctttactgcc agagtaacag gtgacgattc catgcgtatg tcccacctaa aggtgggttc
     6121 tgctgctgat atccccatca atatctcaga aacagacctt agcctactca cagccactgt
     6181 ggtgccacct tcgggtcgag aggaaccctg tctgctgaaa cgtttgcgaa atggccacgt
     6241 ggggatttcc ttcgtgccca aggagacagg ggagcacctg gtacatgtga agaagaatgg
     6301 ccagcatgtg gcaagcagtc ccatcccagt agtgatcagc cagtcggaga taggtgatgc
     6361 cagccgtgtg agggtctctg gtcaaggtct tcatgaaggt catacctttg agcctgcaga
     6421 gtttattatt gacaccagag atgcaggcta cggtgggctt agtctgtcca ttgagggccc
     6481 tagcaaagta gacatcaaca cagaggatct ggaggatggc acatgcaggg tcacctactg
     6541 tcccacagag cctggaaact acattataaa catcaaattt gctgaccagc atgtgcctgg
     6601 cagtcccttt tctgtgaagg tgacaggtga gggccgggtg aaagagagta tcacacgcag
     6661 gcgacgtgcc ccttctgtgg ccaatattgg cagtcattgt gacctcagcc tgaagattcc
     6721 tgaaattagc atccaagata tgacagccca ggtgaccagc ccatcaggca agacccatga
     6781 ggcagagatc gtagaaggag agaaccatac ttactgtatc cgatttgtgc ctgctgagat
     6841 gggaatgcat acagtcagtg tcaagtacaa gggccagcat gtacctggga gccccttcca
     6901 gttcactgtg gggcctctgg gggaaggggg tgctcacaag gtccgtgctg gaggccctgg
     6961 cctagagagg gctgaagttg gagtgccagc ggagttcggc atttggacta gggaagctgg
     7021 cgctggaggc ctggccattg ctgttgaagg ccccagcaag gctgagatct ctttcgagga
     7081 ccgaaaggat ggctcctgtg gtgtggccta cgtagttcag gagccaggtg actatgaggt
     7141 ctcagtcaag ttcaacgagg agcacatacc tgatagcccc ttcgtggtgc ctgtggcttc
     7201 tccgtctggt gacgcccgcc gccttactgt ttctagtctt caggagtcag ggttaaaggt
     7261 caaccagcca gcatcttttg cagtcagtct gaatggagcc aagggggcaa ttgatgccaa
     7321 ggtgcacagc ccctcaggag ctctggagga gtgctatgtc acagagattg accaagataa
     7381 gtatgctgtg cgtttcatcc cacgagagaa tggcatctac ttgattgatg tcaagttcaa
     7441 tggtactcac attcctggaa gtcccttcaa gatccgagtt ggggagcctg ggcatggagg
     7501 ggacccaggc ttagtgtccg cctatggagc aggcctggaa ggtggtgtca cagggagccc
     7561 agcagagttt attgtgaaca caagcaatgc aggagctggt gccctttcgg ttaccattga
     7621 tggcccctcc aaggtgaaga tggattgcca ggagtgcccc gagggctatc gtgtcaccta
     7681 tacccccatg gcacctggca gctacctcat ctccatcaag tatggtggcc cctatcacat
     7741 tggtggaagt ccctttaaag ccaaggtcac aggtcctcgt cttgtaagca accacagcct
     7801 ccatgagaca tcatctgtgt ttgtggactc tttgactaaa gttgccacgg ttccccagca
     7861 tgcaacctca ggcccaggtc ctgctgatgt cagcaaggta gtagccaaag gcctggggct
     7921 aagcaaggct tatgtaggcc agaagagcaa cttcacagta gattgcagca aagcaggtaa
     7981 caacatgctg ctggtgggcg tgcatggccc aaggacaccc tgtgaagaga tcctggtgaa
     8041 acacatgggc agccgcctct atagtgtctc ttacctgctc aaggacaaag gggagtacac
     8101 actggtggtc aagtggggtg atgagcatat cccaggcagc ccataccgca ttatggtacc
     8161 ctgagcctgc cacctaagtt ggcacctgtg ccagctagaa gctcccatgg caatgagcat
     8221 ccccacacct gtcctattcc caagaagccc cattttcctt tcctgagccc tggaccctcc
     8281 cttccctgga tcactctggc cgctcttcac tgcattcgcc cttgccctgc actgtgttca
     8341 cctgtctctg ggctttcact tgggcagagg gagccatttg gtggcagagc atgtcttctt
     8401 tggttctggg aggtggaagt cctatgtaca accaccttct agttctcttt cccagccaag
     8461 aggaataaaa ttttgcttcc gttgtcctgt gaa
//
