LOCUS       NM_008026               3117 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus Friend leukemia integration 1 (Fli1), transcript
            variant 1, mRNA.
ACCESSION   NM_008026
VERSION     NM_008026.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3117)
  AUTHORS   Huang,S., Reed,C., Ilsley,M., Magor,G., Tallack,M., Landsberg,M.,
            Mitchell,H., Gillinder,K. and Perkins,A.
  TITLE     Mutations in linker-2 of KLF1 impair expression of membrane
            transporters and cytoskeletal proteins causing hemolysis
  JOURNAL   Nat Commun 15 (1), 7019 (2024)
   PUBMED   39147774
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3117)
  AUTHORS   Wang,X., Richard,M.L., Caldwell,T.S., Sundararaj,K., Sato,S.,
            Nowling,T.K. and Zhang,X.K.
  TITLE     Role of the transcription factor Fli-1 on the CXCL10/CXCR3 Axis
  JOURNAL   Front Immunol 14, 1219279 (2023)
   PUBMED   37790939
  REMARK    GeneRIF: Role of the transcription factor Fli-1 on the CXCL10/CXCR3
            Axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3117)
  AUTHORS   Sato,S., Zhang,X.K., Matsuoka,N., Sumichika,Y., Saito,K.,
            Yoshida,S., Matsumoto,H., Temmoku,J., Fujita,Y., Asano,T. and
            Migita,K.
  TITLE     Transcription factor Fli-1 impacts the expression of CXCL13 and
            regulates immune cell infiltration into the kidney in MRL/lpr mouse
  JOURNAL   Lupus Sci Med 10 (1) (2023)
   PUBMED   37094946
  REMARK    GeneRIF: Transcription factor Fli-1 impacts the expression of
            CXCL13 and regulates immune cell infiltration into the kidney in
            MRL/lpr mouse.
REFERENCE   4  (bases 1 to 3117)
  AUTHORS   Shintani,A., Fukai,S., Nobusawa,R., Taniguchi,K., Hatatani,T.,
            Nagai,H., Sakai,T., Yoshimura,T., Miyasaka,M. and Hayasaka,H.
  TITLE     Dach1 transcription factor regulates the expression of peripheral
            node addressin and lymphocyte trafficking in lymph nodes
  JOURNAL   Curr Res Immunol 3, 175-185 (2022)
   PUBMED   36045707
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3117)
  AUTHORS   Sarrazin,S., Starck,J., Gonnet,C., Doubeikovski,A., Melet,F. and
            Morle,F.
  TITLE     Negative and translation termination-dependent positive control of
            FLI-1 protein synthesis by conserved overlapping 5' upstream open
            reading frames in Fli-1 mRNA
  JOURNAL   Mol Cell Biol 20 (9), 2959-2969 (2000)
   PUBMED   10757781
REFERENCE   6  (bases 1 to 3117)
  AUTHORS   Barbeau,B., Bergeron,D., Beaulieu,M., Nadjem,Z. and Rassart,E.
  TITLE     Characterization of the human and mouse Fli-1 promoter regions
  JOURNAL   Biochim Biophys Acta 1307 (2), 220-232 (1996)
   PUBMED   8679708
REFERENCE   7  (bases 1 to 3117)
  AUTHORS   Watson,D.K., Smyth,F.E., Thompson,D.M., Cheng,J.Q., Testa,J.R.,
            Papas,T.S. and Seth,A.
  TITLE     The ERGB/Fli-1 gene: isolation and characterization of a new member
            of the family of human ETS transcription factors
  JOURNAL   Cell Growth Differ 3 (10), 705-713 (1992)
   PUBMED   1445800
REFERENCE   8  (bases 1 to 3117)
  AUTHORS   Delattre,O., Zucman,J., Plougastel,B., Desmaze,C., Melot,T.,
            Peter,M., Kovar,H., Joubert,I., de Jong,P., Rouleau,G. et al.
  TITLE     Gene fusion with an ETS DNA-binding domain caused by chromosome
            translocation in human tumours
  JOURNAL   Nature 359 (6391), 162-165 (1992)
   PUBMED   1522903
REFERENCE   9  (bases 1 to 3117)
  AUTHORS   Moore,S.K., Appella,E., Villar,C.J. and Kozak,C.A.
  TITLE     Mapping of the mouse 86-kDa heat-shock protein expressed gene
            (Hsp86-1) on chromosome 12 and related genes on chromosomes 3, 4,
            9, and 11
  JOURNAL   Genomics 10 (4), 1019-1029 (1991)
   PUBMED   1916807
REFERENCE   10 (bases 1 to 3117)
  AUTHORS   Bergeron,D., Poliquin,L., Kozak,C.A. and Rassart,E.
  TITLE     Identification of a common viral integration region in Cas-Br-E
            murine leukemia virus-induced non-T-, non-B-cell lymphomas
  JOURNAL   J Virol 65 (1), 7-15 (1991)
   PUBMED   1845910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127581.4 and AC141646.4.
            
            On Aug 1, 2022 this sequence version replaced NM_008026.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036655.1, AK154714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 10757781
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               AC127581.4         150885-151091
            208-419             AC141646.4         169696-169907       c
            420-574             AC141646.4         158819-158973       c
            575-778             AC141646.4         154385-154588       c
            779-844             AC141646.4         145267-145332       c
            845-910             AC141646.4         123042-123107       c
            911-970             AC141646.4         121140-121199       c
            971-1018            AC141646.4         119186-119233       c
            1019-3117           AC141646.4         115341-117439       c
FEATURES             Location/Qualifiers
     source          1..3117
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 17.74 cM"
     gene            1..3117
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /note="Friend leukemia integration 1"
                     /db_xref="GeneID:14247"
                     /db_xref="MGI:MGI:95554"
     exon            1..207
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      149..226
                     /regulatory_class="uORF"
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:10757781]"
                     /note="this uORF is predicted to encode a 25 aa peptide
                     (PMID:10757781)"
     regulatory      153..206
                     /regulatory_class="uORF"
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:10757781]"
                     /note="this uORF is initiated by a GTG start codon and is
                     predicted to encode a 17 aa peptide (PMID:10757781)"
     CDS             190..1548
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     friend leukemia integration 1 transcription factor;
                     retroviral integration site protein Fli-1"
                     /codon_start=1
                     /product="Friend leukemia integration 1 transcription
                     factor isoform 1"
                     /protein_id="NP_032052.1"
                     /db_xref="CCDS:CCDS40571.1"
                     /db_xref="GeneID:14247"
                     /db_xref="MGI:MGI:95554"
                     /translation="MDGTIKEALSVVSDDQSLFDSAYGAAAHLPKADMTASGSPDYGQ
                     PHKINPLPPQQEWINQPVRVNVKREYDHMNGSRESPVDCSVSKCNKLVGGGEANPMNY
                     NSYMDEKNGPPPPNMTTNERRVIVPADPTLWTQEHVRQWLEWAIKEYGLMEIDTSFFQ
                     NMDGKELCKMNKEDFLRATSAYNTEVLLSHLSYLRESSLLAYNTTSHTDQSSRLNVKE
                     DPSYDSVRRGAWNNNMNSGLNKSPLLGGSQTMGKNTEQRPQPDPYQILGPTSSRLANP
                     GSGQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDK
                     LSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPTETSMYKYPSDISYMPSYH
                     AHQQKVNFVPSHPSSMPVTSSSFFGAASQYWTSPTAGIYPNPSVPRHPNTHVPSHLGS
                     YY"
     exon            208..419
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..574
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..778
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..844
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..910
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..970
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1018
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..3117
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3082..3087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /note="hexamer: AATAAA"
     polyA_site      3117
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /note="major polyA site"
ORIGIN      
        1 ctctttttcg atccgctaca acaacaaacg tgcacagggg agcgagggca gggcgctcgc
       61 agggggcact cagagagggc ccagggcgcc aaagaggccg cgccgggcta atctgaaggg
      121 gctacgaggt caggctgtaa ccgggtcaat gtgtggaata ttggggggct cggctgcaga
      181 cttggccaaa tggacgggac tattaaggag gctctgtctg tggtgagtga cgatcagtcc
      241 ctttttgatt cagcatacgg agcggcagcc catctcccca aggcagatat gactgcttcg
      301 gggagtcctg actacgggca gccccacaaa atcaaccccc tgccaccgca gcaggagtgg
      361 atcaaccagc cagtgagagt caatgtcaag cgggagtatg accacatgaa tggatccagg
      421 gagtctccgg tggactgcag tgtcagcaaa tgtaacaagc tggtgggcgg aggcgaagcc
      481 aaccccatga actataatag ctacatggat gagaagaacg gcccccctcc tcccaacatg
      541 accaccaacg aacggagagt cattgtgcct gcagacccca cactgtggac acaggagcac
      601 gttcgacagt ggctggagtg ggctataaag gaatacggat tgatggagat tgacacttcc
      661 ttcttccaga acatggatgg caaggaattg tgtaaaatga acaaggagga cttcctccga
      721 gccacctccg cctacaacac agaagtgctg ttgtcgcacc tcagttacct cagggaaagt
      781 tcactgctgg cctataacac aacctcccat acagaccagt cctcacgact gaatgtcaag
      841 gaagaccctt cttatgactc tgtcaggaga ggagcatgga acaataatat gaactctggc
      901 ctcaacaaaa gtcctctcct tggaggatca cagaccatgg gcaagaacac tgagcagcgg
      961 ccccagccag atccttatca gatcctgggg ccaaccagca gccgcctagc aaaccctggg
     1021 agtgggcaga tccagctgtg gcagtttctc ctggaactac tgtccgacag cgccaacgcc
     1081 agctgtatca cctgggaggg gaccaacggg gagttcaaaa tgacggaccc tgatgaggtg
     1141 gccaggcgct ggggagagcg gaagagcaag cccaacatga attatgacaa gctgagccgg
     1201 gccctccgat actactatga caaaaacatt atgaccaaag tgcatggcaa aaggtatgcc
     1261 tacaagtttg acttccatgg cattgcccag gccctgcagc cacatccaac agagacatcc
     1321 atgtacaagt atccctctga tatctcctac atgccttcct accatgccca tcaacagaag
     1381 gtgaactttg tcccgtctca cccatcctcc atgcctgtca cctcctccag cttctttgga
     1441 gcagcatcac aatactggac ctcccccact gctgggatct atccaaaccc cagtgtcccc
     1501 cgccatccta acacccacgt gccttcacac ttaggcagct actactagaa ctaacaccag
     1561 ttggccttct ggctgaagtt ccagctctca ctttactgga tactctggac tctaaaaggc
     1621 acagtagcct tgaagagata agaaaactgg atgttctttc ttttggatag aacctttgta
     1681 tttgttcttc taaaaaaatt attattttta tgttaaaaac ttttgtttcc tctacctgaa
     1741 aaaaaaaaaa gatcattcca tgagccagtc caccagtttg gattctcaac ctcctatcat
     1801 cgaatgagtt aaatatttag gttactggaa cggtttatac catgattctg agaaaggagt
     1861 acgcattttc tttactcttt ttttttatga ccaaagcagt ttcttatcag cacacgggtc
     1921 tcatcattgt aggattccct acgatcatga atcatggact tgaccagggt tggtctggtt
     1981 tgagacttag taaaagtcaa ggcaggatgt ttataatctt atcttcggag gactcaattc
     2041 agtggatggc aactggaaca ctggctctga ggccagtgaa gttttttgcc caactggaat
     2101 ttaaaagatg tgtgtctatg tgtgtattta agaagccatt attattacaa aattcctcac
     2161 aatgggcagt atgtgtttgg gtgactcttc tccccagaaa tagtcagaat atgaacaaag
     2221 aaagtttaac acaaactcag acactcctga cgggcagagg attaaataac atttttttgg
     2281 agggtttaat aacatttttg gaggggtttt tttgtttgtt tttgtttttg ggggtttttt
     2341 ttgtttgttt tttgtttttt ggtttttggt ttttttttgt tttttttttt tttttggttt
     2401 tgatttttaa tgacagtgag tcccagaact ttgaaaagtc atggggattt ctaaactcag
     2461 attcgcaaac gctgtgcgtt tgtcagacca ccagaccaag gtcaaacaat cagaaggcaa
     2521 ctaactgtat aaattatgca gagttatttt cctatatctc acagtattaa aaaaataaat
     2581 aattaaaaat taaagaataa gtaaacgagt tgacctcggt cacaaatgca gttttactat
     2641 caaatcaatc attgttattt ttttaaaata taatttgtac atctttgtca atctgtacat
     2701 ttgggctatt tgtacgtttt tgtaactgtt tttttttaat aagcataatg tgactattga
     2761 aaacgaggag ttaaaagtca ctgagttttt aggaagaaaa acctaaaaat acagttattt
     2821 aacacgcatg cccaaacaag atctgtttag acctacaacg ctttagaaat gtttgtaaat
     2881 aacagagttg caataacctg aaaaggacaa acaaactttt ctctgtgcac acgaggcact
     2941 ctcctgctct atatatgcaa tatattttta gatgtgcaaa tatatatata atttttcagg
     3001 taatcgtgac tttttaaacg atattgttaa ggtgacaact cttagtccac tgaagactaa
     3061 gttgtaaaat aatttgacct taataaattg tgccttcttc tttttcttct tctctca
//
