LOCUS       NM_001271356            3420 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus folliculin (Flcn), transcript variant 1, mRNA.
ACCESSION   NM_001271356
VERSION     NM_001271356.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3420)
  AUTHORS   Raynor,J.L., Collins,N., Shi,H., Guy,C., Saravia,J., Ah Lim,S.,
            Chapman,N.M., Zhou,P., Wang,Y., Sun,Y., Risch,I., Hu,H., Kc,A.,
            Sun,R., Shrestha,S., Huang,H., Connelly,J.P., Pruett-Miller,S.M.,
            Reina-Campos,M., Goldrath,A.W., Belkaid,Y. and Chi,H.
  TITLE     CRISPR screens unveil nutrient-dependent lysosomal and
            mitochondrial nodes impacting intestinal tissue-resident memory
            CD8+ T cell formation
  JOURNAL   Immunity 57 (11), 2597-2614 (2024)
   PUBMED   39406246
REFERENCE   2  (bases 1 to 3420)
  AUTHORS   Guo,C., You,Z., Shi,H., Sun,Y., Du,X., Palacios,G., Guy,C.,
            Yuan,S., Chapman,N.M., Lim,S.A., Sun,X., Saravia,J., Rankin,S.,
            Dhungana,Y. and Chi,H.
  TITLE     SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour
            immunity
  JOURNAL   Nature 620 (7972), 200-208 (2023)
   PUBMED   37407815
REFERENCE   3  (bases 1 to 3420)
  AUTHORS   Zhang,X., Li,S., Malik,I., Do,M.H., Ji,L., Chou,C., Shi,W.,
            Capistrano,K.J., Zhang,J., Hsu,T.W., Nixon,B.G., Xu,K., Wang,X.,
            Ballabio,A., Schmidt,L.S., Linehan,W.M. and Li,M.O.
  TITLE     Reprogramming tumour-associated macrophages to outcompete cancer
            cells
  JOURNAL   Nature 619 (7970), 616-623 (2023)
   PUBMED   37380769
REFERENCE   4  (bases 1 to 3420)
  AUTHORS   Di Malta,C., Zampelli,A., Granieri,L., Vilardo,C., De Cegli,R.,
            Cinque,L., Nusco,E., Pece,S., Tosoni,D., Sanguedolce,F.,
            Sorrentino,N.C., Merino,M.J., Nielsen,D., Srinivasan,R., Ball,M.W.,
            Ricketts,C.J., Vocke,C.D., Lang,M., Karim,B., Lanfrancone,L.,
            Schmidt,L.S., Linehan,W.M. and Ballabio,A.
  TITLE     TFEB and TFE3 drive kidney cystogenesis and tumorigenesis
  JOURNAL   EMBO Mol Med 15 (5), e16877 (2023)
   PUBMED   36987696
REFERENCE   5  (bases 1 to 3420)
  AUTHORS   Shillingford,J.M. and Shayman,J.A.
  TITLE     Functional TFEB activation characterizes multiple models of renal
            cystic disease and loss of polycystin-1
  JOURNAL   Am J Physiol Renal Physiol 324 (4), F404-F422 (2023)
   PUBMED   36794754
REFERENCE   6  (bases 1 to 3420)
  AUTHORS   Hudon,V., Sabourin,S., Dydensborg,A.B., Kottis,V., Ghazi,A.,
            Paquet,M., Crosby,K., Pomerleau,V., Uetani,N. and Pause,A.
  TITLE     Renal tumour suppressor function of the Birt-Hogg-Dube syndrome
            gene product folliculin
  JOURNAL   J Med Genet 47 (3), 182-189 (2010)
   PUBMED   19843504
  REMARK    GeneRIF: FLCN is shown as a general tumour suppressor in the
            kidney.
REFERENCE   7  (bases 1 to 3420)
  AUTHORS   Hartman,T.R., Nicolas,E., Klein-Szanto,A., Al-Saleem,T., Cash,T.P.,
            Simon,M.C. and Henske,E.P.
  TITLE     The role of the Birt-Hogg-Dube protein in mTOR activation and renal
            tumorigenesis
  JOURNAL   Oncogene 28 (13), 1594-1604 (2009)
   PUBMED   19234517
REFERENCE   8  (bases 1 to 3420)
  AUTHORS   Baba,M., Furihata,M., Hong,S.B., Tessarollo,L., Haines,D.C.,
            Southon,E., Patel,V., Igarashi,P., Alvord,W.G., Leighty,R., Yao,M.,
            Bernardo,M., Ileva,L., Choyke,P., Warren,M.B., Zbar,B.,
            Linehan,W.M. and Schmidt,L.S.
  TITLE     Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model:
            Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and
            polycystic kidneys
  JOURNAL   J Natl Cancer Inst 100 (2), 140-154 (2008)
   PUBMED   18182616
  REMARK    GeneRIF: Homozygous loss of BHD may initiate renal tumorigenesis in
            the mouse. The conditional BHD knockout mouse may be a useful
            research model for dissecting multistep kidney carcinogenesis, and
            rapamycin may be a potential treatment for Birt-Hogg-Dube syndrome
REFERENCE   9  (bases 1 to 3420)
  AUTHORS   Chen,J., Futami,K., Petillo,D., Peng,J., Wang,P., Knol,J., Li,Y.,
            Khoo,S.K., Huang,D., Qian,C.N., Zhao,P., Dykema,K., Zhang,R.,
            Cao,B., Yang,X.J., Furge,K., Williams,B.O. and Teh,B.T.
  TITLE     Deficiency of FLCN in mouse kidney led to development of polycystic
            kidneys and renal neoplasia
  JOURNAL   PLoS One 3 (10), e3581 (2008)
   PUBMED   18974783
  REMARK    GeneRIF: Deficiency of FLCN in mouse kidney led to development of
            polycystic kidneys and renal neoplasia.
            Erratum:[PLoS ONE. 2008;3(11). doi:
            10.1371/annotation/0f06471c-1993-4144-b785-d58924ac0b5c]
REFERENCE   10 (bases 1 to 3420)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596204.8.
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172245.1, SRR7345562.3792327.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               AL596204.8         3395-3734
            341-456             AL596204.8         5519-5634
            457-727             AL596204.8         8643-8913
            728-874             AL596204.8         9539-9685
            875-1096            AL596204.8         11084-11305
            1097-1257           AL596204.8         12231-12391
            1258-1349           AL596204.8         13989-14080
            1350-1540           AL596204.8         15189-15379
            1541-1654           AL596204.8         17571-17684
            1655-1778           AL596204.8         18170-18293
            1779-1910           AL596204.8         19030-19161
            1911-2016           AL596204.8         19243-19348
            2017-3420           AL596204.8         20623-22026
FEATURES             Location/Qualifiers
     source          1..3420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.79 cM"
     gene            1..3420
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /note="folliculin"
                     /db_xref="GeneID:216805"
                     /db_xref="MGI:MGI:2442184"
     exon            1..340
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /inference="alignment:Splign:2.1.0"
     exon            341..456
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /inference="alignment:Splign:2.1.0"
     exon            457..727
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /inference="alignment:Splign:2.1.0"
     CDS             479..2218
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /EC_number="2.7.1.21"
                     /note="birt-Hogg-Dube syndrome protein homolog"
                     /codon_start=1
                     /product="folliculin"
                     /protein_id="NP_001258285.1"
                     /db_xref="CCDS:CCDS24777.1"
                     /db_xref="GeneID:216805"
                     /db_xref="MGI:MGI:2442184"
                     /translation="MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGSGDSPDQVEQ
                     AEEEEGGIQMSSRVRAHSPAEGASSESSSPGPKKSDMCEGCRSLAVGHPGYISHDKET
                     SIKYVSHQHPNHPQLFSIVRQACVRSLSCEVCPGREGPIFFGDEQHGFVFSHTFFIKD
                     SLARGFQRWYSIIAIMMDRIYLINSWPFLLGRIRGIISELQAKAFKVFEAEQFGCPQR
                     AQRMNTAFTPFLHQRNGNAARSLTSLTSDDNLWACLHTSFAWLLKACGSRLTEKLLEG
                     APTEDTLVQMEKLADLEEESESWDNSEAEEEEKAPVTPEGAEGRELTSCPTESSFLSA
                     CGSWQPPKLTGFKSLRHMRQVLGAPSFRMLAWHVLMGNQVIWKSRDVNLVHSAFEVLR
                     TMLPVGCVRIIPYSSQYEEAYRCNFLGLSPPVPIPAHVLASEFVVVVEVHTATRSNLH
                     PAGCEDDQSLSKYEFVVTSGSPVAADRVGPTILNKIEAALTNQNLSVDVVDQCLICLK
                     EEWMNKVKVLFKFTKVDSRPKEDTQKLLSVLGASEEDNVKLLKFWMTGLSKTYKSHLM
                     STVRSPTATESRS"
     exon            728..874
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1096
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1257
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1349
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1540
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1654
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1778
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1910
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2016
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..3420
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3057..3062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /note="hexamer: AATAAA"
     polyA_site      3078
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /note="major polyA site"
     regulatory      3353..3358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
                     /note="hexamer: ATTAAA"
     polyA_site      3375
                     /gene="Flcn"
                     /gene_synonym="B430214A04Rik; Bhd; FLCL"
ORIGIN      
        1 gcttttccgc ggggcgactt gccgcgccga ggggcgcgcg tggccgaggg gcttggattc
       61 cttgcctgga ggagcattac gtgacacagc aaggctccgc acatcctagt cgcctgcggg
      121 ggacgcaacg ctgctcgctc cggctagtca ctggcgttgc ctgccctctg ccggcctgcg
      181 gatggttcgg tccggctggg tcacgcgcta aggctcagtg caagggcctg cggaacgggc
      241 tagcacttgc cgaggggcag aacagtggcg acagccccag gacagttgcg agcgggttcc
      301 ggcccagcat ccgggagacg gcggcaagcg ccccagctgg acaacctcaa gtctttgaat
      361 tcgaatagtg cagcttgctt acctgactct tccggcgggc ctcgtacatg ttctgctcta
      421 ggcgggatgg tgcagttgtg atgtgctaag cataaggcct cggccattct ccagcaccat
      481 gaacgccata gtcgccctct gccacttctg cgagctccat ggcccccgca cgctcttctg
      541 cacggaagtt ctacacgctc ccctgcccca gggggccgga agtggggaca gtcctgacca
      601 ggttgagcag gctgaggagg aggagggtgg cattcagatg agcagccggg tccgtgccca
      661 cagcccagcc gagggtgcca gcagtgagtc cagcagcccg gggcccaaga agtcggacat
      721 gtgtgagggc tgccggtcac ttgccgtagg gcacccaggc tatatcagtc atgataaaga
      781 gacctctatt aagtacgtca gtcaccagca ccccaaccac ccgcagctct tcagcatcgt
      841 ccgccaggcc tgtgtccgga gcctgagctg tgaggtatgc cctggtcgtg aaggccccat
      901 cttctttggt gatgagcagc acggctttgt gttcagccac accttcttca tcaaagacag
      961 cctggccaga ggcttccagc gctggtacag catcatcgcc atcatgatgg atcggatcta
     1021 cctcatcaac tcctggccct tcctgctggg gaggatccgc ggcatcatca gtgagctcca
     1081 ggccaaggcc ttcaaggtgt ttgaggcaga gcagtttgga tgtccacagc gtgcccagag
     1141 gatgaacact gccttcacgc ccttcctgca ccagaggaac ggcaacgctg cccgctctct
     1201 gacctccttg accagtgatg acaacttgtg ggcgtgtctg cacacttcct ttgcctggct
     1261 cctgaaggca tgcggtagca ggctgacaga aaagctctta gagggcgctc ccacagagga
     1321 caccctggtc cagatggaga agcttgctga cttggaggaa gaatcagaaa gttgggacaa
     1381 ttctgaggct gaggaggagg agaaagctcc tgttacacca gagggtgctg aagggcgaga
     1441 gctgaccagt tgcccaacag agtcatcctt tctctcagcc tgtgggagct ggcagccccc
     1501 aaagcttacc ggcttcaagt ctcttcgaca catgagacag gtcttgggtg ctccatcctt
     1561 ccgtatgttg gcttggcatg tcctcatggg gaatcaggtg atctggaaaa gcagagatgt
     1621 gaacctggtc cattcagcgt ttgaagtcct ccggaccatg ctgcctgtgg gctgtgtccg
     1681 catcatccct tacagcagcc agtatgagga ggcctatcgc tgcaacttcc tggggctcag
     1741 ccctcccgtg cctatccctg cccatgttct ggcctcagag ttcgtagttg tcgtggaggt
     1801 ccacacggcc actcgctcaa acctccaccc tgctgggtgc gaggatgacc agtccctcag
     1861 caagtatgag tttgtggtga ccagtggtag ccctgtggct gcagacagag ttgggcccac
     1921 tatcctgaat aagattgaag cagctctgac caaccagaac ctgtctgtgg atgtggtgga
     1981 ccaatgtctc atctgcctca aggaggaatg gatgaacaaa gtgaaagtcc tgtttaaatt
     2041 caccaaggta gacagtcgcc ccaaggagga cacacagaag ctcctaagcg tcctaggcgc
     2101 atcagaggag gacaacgtca aactgctgaa gttctggatg acgggactga gcaaaaccta
     2161 caagtcccat ctcatgtcca ccgtccgaag ccccacagct acagagtcac ggagctgact
     2221 ccgagaactc cttctggaag gtggtgtaca gaccagctct gtgggaaaaa ctgcccttgg
     2281 gtttctgact tctggggtga ggccctgttt atggcctagg gttcaccctc cttgtaagac
     2341 tctatcagcc catgttgaaa tgtaggggac acagagacag tggtcccttt gcatcaaact
     2401 gcgctgtcag gacctggcga gatgtgttct gtgccccgtg aggacaaagg ctgggaactg
     2461 agaggagtcc atcagtctgc ctctgaggtt ttgttgttgg agcgtgtcct catggggtta
     2521 ggacaacgcc ttcccaccat ggaagacagc aagcatcgtg gatcatttgt ctttcggttg
     2581 gtgacttctc aggtcacgtg cacagccgtg gcctctgcac atcttgccgg cctgtggata
     2641 catcaaaacc atggctgttt tgtttgcttt tgtttttttt taattttggt ttttgagtca
     2701 gggtcttatt ctgtatccta tcccagttta gaactcatgg tgtggcctct gctacttcca
     2761 gacttgtagc aatcctcctg cctcagcctc ccaagtgctg ggattaccga actgagccat
     2821 cagaacatta cattgctttc ttctctgttg ctgccgtagc gctaaccagc cactgtagac
     2881 tatgacggtg ttacgacaga tcgcctctca ccattgcagt ttaataagga cgtagcttgg
     2941 aaagatttcc tgaaagcttt cccaatttgt ttttataata ttcttggtgt ttgtttatat
     3001 ttaacatgaa gactgtgtat ctcagtctct gtacagttgc aagaatgttg aaacacaata
     3061 aatctgtatt tttgtaaact gccgactaca tgtttttatg ttaaatactg tggtggtttg
     3121 tatgtgctct gcccagggag tggcactatt aggaggtgca gccctgttgg agtaggtgtg
     3181 tcactgtggg tgtggcttta agaccctcct cttagctgcc tggaagtcag tatcctacta
     3241 gcagccttca gatgaagatg gagaactctt agctcctcct gctccatgcc tgcctggaag
     3301 ctgccatgtt cccaccttga tgataatgga ctgaaactat aagacagccc caattaaatg
     3361 ttgtccttat gagaattgcc ttggtcatgg tgtctgttca tatcaataaa actgctaacc
//
