LOCUS       NM_019873               1713 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus FK506 binding protein-like (Fkbpl), mRNA.
ACCESSION   NM_019873 NM_001368190
VERSION     NM_019873.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1713)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1713)
  AUTHORS   Yakkundi,A., Bennett,R., Hernandez-Negrete,I., Delalande,J.M.,
            Hanna,M., Lyubomska,O., Arthur,K., Short,A., McKeen,H., Nelson,L.,
            McCrudden,C.M., McNally,R., McClements,L., McCarthy,H.O.,
            Burns,A.J., Bicknell,R., Kissenpfennig,A. and Robson,T.
  TITLE     FKBPL is a critical antiangiogenic regulator of developmental and
            pathological angiogenesis
  JOURNAL   Arterioscler Thromb Vasc Biol 35 (4), 845-854 (2015)
   PUBMED   25767277
  REMARK    GeneRIF: FKBPL is an important regulator of developmental and
            pathological angiogenesis.
REFERENCE   3  (bases 1 to 1713)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1713)
  AUTHORS   Jascur,T., Brickner,H., Salles-Passador,I., Barbier,V., El
            Khissiin,A., Smith,B., Fotedar,R. and Fotedar,A.
  TITLE     Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding
            TPR protein
  JOURNAL   Mol Cell 17 (2), 237-249 (2005)
   PUBMED   15664193
  REMARK    GeneRIF: Results demonstrate the importance of posttranslational
            stabilization of p21 protein by WISp39 in regulating cellular p21
            activity.
REFERENCE   5  (bases 1 to 1713)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   6  (bases 1 to 1713)
  AUTHORS   Yung Yu,C., Yang,Z., Blanchong,C.A. and Miller,W.
  TITLE     The human and mouse MHC class III region: a parade of 21 genes at
            the centromeric segment
  JOURNAL   Immunol Today 21 (7), 320-328 (2000)
   PUBMED   10871871
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146018.1, CD776267.1 and CT009767.6.
            
            On or before Jan 29, 2019 this sequence version replaced
            NM_001368190.1, NM_019873.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146018.1, BC046338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-713               AK146018.1         2-714
            714-1220            CD776267.1         19-525              c
            1221-1713           CT009767.6         203752-204244
FEATURES             Location/Qualifiers
     source          1..1713
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.22 cM"
     gene            1..1713
                     /gene="Fkbpl"
                     /gene_synonym="DIR1; NG7; Ppiase-X; Wisp39"
                     /note="FK506 binding protein-like"
                     /db_xref="GeneID:56299"
                     /db_xref="MGI:MGI:1932127"
     exon            1..140
                     /gene="Fkbpl"
                     /gene_synonym="DIR1; NG7; Ppiase-X; Wisp39"
                     /inference="alignment:Splign:2.1.0"
     exon            141..1713
                     /gene="Fkbpl"
                     /gene_synonym="DIR1; NG7; Ppiase-X; Wisp39"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1199
                     /gene="Fkbpl"
                     /gene_synonym="DIR1; NG7; Ppiase-X; Wisp39"
                     /EC_number="5.2.1.8"
                     /note="immunophilin-like protein NG7; WAF-1/CIP1
                     stabilizing protein 39"
                     /codon_start=1
                     /product="FK506-binding protein-like"
                     /protein_id="NP_063926.1"
                     /db_xref="CCDS:CCDS28654.1"
                     /db_xref="GeneID:56299"
                     /db_xref="MGI:MGI:1932127"
                     /translation="METSPISPMNEKNTAQPQQREENAQQILNTAIPFRQRSPGLLPE
                     ALKVGVRPDPANQIVETQEIEHPVAGFEGDSDQFQVSTNEMAEHLQASDLWYCPDGSF
                     VKKIIVPGHGLDKPKLGSKCQVLALGFPFGSGMPEGWTELTIGIGQWREKMWGELMEK
                     CLESMRQGEEAKIHLPGSSAPLAKLRLDSFTNGRDSWEMEAMEKEALAKEEHRRGTEL
                     FRAGNPQGAARCYGRALRLLLTLPPPGPPERTTLYANLAACQLLLGHPQLAAQSCDRV
                     LEREPGHLKALYRRGVARAALGDLEKATADFKKVLAVDPKNRAAKEELGKVVIQGRKQ
                     DAGLARGLRKMFS"
     regulatory      1199..1204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fkbpl"
                     /gene_synonym="DIR1; NG7; Ppiase-X; Wisp39"
                     /note="hexamer: ATTAAA"
     polyA_site      1223
                     /gene="Fkbpl"
                     /gene_synonym="DIR1; NG7; Ppiase-X; Wisp39"
                     /note="major polyA site"
ORIGIN      
        1 gactagcttc tccgtctctg agggctcgag agctgataga gactctcagc tgctcccagg
       61 ctgcccttcc aggcctcaac atcatacaca atgcaacaac tgtgacttag gccgtcctgc
      121 tatgctcctt ggtctctcag ggatcaggag atccaatgga gacctcacct atcagcccaa
      181 tgaacgagaa gaacaccgct cagccgcagc agcgggaaga gaacgcccag caaatcttaa
      241 atacagccat tccgtttagg cagcggtccc caggtcttct ccctgaagcc ctgaaggtgg
      301 gagtgagacc ggatccagcc aatcaaattg tagagactca agagattgaa catcccgtgg
      361 ctggatttga aggtgactct gatcaatttc aagtctcaac caatgagatg gcagagcacc
      421 tccaagcttc tgatctttgg tactgtcctg atgggagttt tgtaaagaag atcatagtcc
      481 ctggccatgg cttagacaaa cccaagctag gctccaaatg ccaagtgttg gctttgggat
      541 ttccttttgg atctgggatg ccagagggct ggacagaact aaccataggc ataggacaat
      601 ggagggaaaa aatgtggggg gaactcatgg aaaaatgcct ggagtctatg cgtcaaggtg
      661 aggaggcaaa gattcacctt cctggatcct ctgcacctct tgctaaactc agactggatt
      721 ccttcaccaa tggccgggac tcctgggaga tggaggctat ggagaaggag gctctggcca
      781 aagaagaaca cagaaggggt acagaactgt ttcgagctgg gaaccctcaa ggggctgccc
      841 gatgctatgg acgggctctc cgactgctgc tgacgttgcc cccacccggc cctcccgaac
      901 gaactaccct ttatgccaat ctggctgcct gccagttgct gctaggacac ccccagttgg
      961 cagcccagag ctgtgaccga gtgctggagc gggagccggg ccatttaaag gccttatacc
     1021 gaaggggggt tgctcgggct gccctcgggg acttggaaaa agccactgct gatttcaaga
     1081 aagtgctagc agtagatccc aaaaaccgtg cagcgaaaga ggagctgggg aaggtggtca
     1141 ttcagggaag gaaacaggat gcagggctgg ctcggggact gcgcaagatg tttagctgat
     1201 taaaggagac aggaacccgc gaactgtggt ctgtgttgtg gaattttcaa gggccccgaa
     1261 ggaagttgtt tgaactcgta tctcgttctg acctacaggg agttagcgac ggtgtcagtg
     1321 agccacttgg tggagggagt cccgggaagc gtatccacct ccgaggatag gagaggttgt
     1381 ctatttggga ctggctgtgg caaacgccag aacttccgga tgtcagggag ttgcatccca
     1441 gggaggtgga gttacaagtg gttgcgtgtc gccaggtgtg ggtgctgaga atgtaatcca
     1501 gacccttata agagcaacaa gcactttcct tttgggtggg agggtttgag acagggcttc
     1561 tctgtgtaac aaccctggcc gtcctggagc acactttgta gaccaggctg agatccgcct
     1621 gcctctgcct cctgagtgct gggattaaag gcgtgcacca ctaccgccta gtcgcaataa
     1681 gcaatattaa actgctgagc catctcttat cct
//
