LOCUS       NM_001111066            1730 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Mus musculus FK506 binding protein 8 (Fkbp8), transcript variant 1,
            mRNA.
ACCESSION   NM_001111066
VERSION     NM_001111066.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1730)
  AUTHORS   Wang,S., Xiao,G., Tang,M., Bi,X., Xing,C., Liu,A., Zhao,A.Z. and
            Li,F.
  TITLE     FKBP38 deletion exacerbates ConA-induced hepatitis by promoting the
            immune response through the MCP-1/p38 pathway
  JOURNAL   Int Immunopharmacol 138, 112659 (2024)
   PUBMED   38996665
  REMARK    GeneRIF: FKBP38 deletion exacerbates ConA-induced hepatitis by
            promoting the immune response through the MCP-1/p38 pathway.
REFERENCE   2  (bases 1 to 1730)
  AUTHORS   Zuo,L., Kuo,W.T., Cao,F., Chanez-Paredes,S.D., Zeve,D., Mannam,P.,
            Jean-Francois,L., Day,A., Vallen Graham,W., Sweat,Y.Y.,
            Shashikanth,N., Breault,D.T. and Turner,J.R.
  TITLE     Tacrolimus-binding protein FKBP8 directs myosin light chain
            kinase-dependent barrier regulation and is a potential therapeutic
            target in Crohn's disease
  JOURNAL   Gut 72 (5), 870-881 (2023)
   PUBMED   35537812
  REMARK    GeneRIF: Tacrolimus-binding protein FKBP8 directs myosin light
            chain kinase-dependent barrier regulation and is a potential
            therapeutic target in Crohn's disease.
REFERENCE   3  (bases 1 to 1730)
  AUTHORS   Zhou,Y., Zhao,H., Shuai,L., She,J., Diao,R. and Wang,L.
  TITLE     [Fkbp38 deletion induces premature ovarian insufficiency in mice by
            activating mTOR signaling and inducing granulosa cell apoptosis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (11), 1611-1617 (2022)
   PUBMED   36504053
  REMARK    GeneRIF: [Fkbp38 deletion induces premature ovarian insufficiency
            in mice by activating mTOR signaling and inducing granulosa cell
            apoptosis].
REFERENCE   4  (bases 1 to 1730)
  AUTHORS   Tian,T., Cao,X., Kim,S.E., Lin,Y.L., Steele,J.W., Cabrera,R.M.,
            Karki,M., Yang,W., Marini,N.J., Hoffman,E.N., Han,X., Hu,C.,
            Wang,L., Wlodarczyk,B.J., Shaw,G.M., Ren,A., Finnell,R.H. and
            Lei,Y.
  TITLE     FKBP8 variants are risk factors for spina bifida
  JOURNAL   Hum Mol Genet 29 (18), 3132-3144 (2020)
   PUBMED   32969478
  REMARK    GeneRIF: FKBP8 variants are risk factors for spina bifida.
REFERENCE   5  (bases 1 to 1730)
  AUTHORS   Yoo,S.M., Yamashita,S.I., Kim,H., Na,D., Lee,H., Kim,S.J.,
            Cho,D.H., Kanki,T. and Jung,Y.K.
  TITLE     FKBP8 LIRL-dependent mitochondrial fragmentation facilitates
            mitophagy under stress conditions
  JOURNAL   FASEB J 34 (2), 2944-2957 (2020)
   PUBMED   31908024
  REMARK    GeneRIF: FKBP8 LIRL-dependent mitochondrial fragmentation
            facilitates mitophagy under stress conditions.
REFERENCE   6  (bases 1 to 1730)
  AUTHORS   Nielsen,J.V., Mitchelmore,C., Pedersen,K.M., Kjaerulff,K.M.,
            Finsen,B. and Jensen,N.A.
  TITLE     Fkbp8: novel isoforms, genomic organization, and characterization
            of a forebrain promoter in transgenic mice
  JOURNAL   Genomics 83 (1), 181-192 (2004)
   PUBMED   14667822
REFERENCE   7  (bases 1 to 1730)
  AUTHORS   Fong,S., Mounkes,L., Liu,Y., Maibaum,M., Alonzo,E., Desprez,P.Y.,
            Thor,A.D., Kashani-Sabet,M. and Debs,R.J.
  TITLE     Functional identification of distinct sets of antitumor activities
            mediated by the FKBP gene family
  JOURNAL   Proc Natl Acad Sci U S A 100 (24), 14253-14258 (2003)
   PUBMED   14612567
  REMARK    GeneRIF: used systemic gene transfer in tumor-bearing mice to
            identify novel antiinvasive and antimetastatic functions for Fkbp8,
            and subsequently for Fkbp1a.
REFERENCE   8  (bases 1 to 1730)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1730)
  AUTHORS   Shirane,M. and Nakayama,K.I.
  TITLE     Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria
            and inhibits apoptosis
  JOURNAL   Nat Cell Biol 5 (1), 28-37 (2003)
   PUBMED   12510191
REFERENCE   10 (bases 1 to 1730)
  AUTHORS   Pedersen,K.M., Finsen,B., Celis,J.E. and Jensen,N.A.
  TITLE     muFKBP38: a novel murine immunophilin homolog differentially
            expressed in Schwannoma cells and central nervous system neurons in
            vivo
  JOURNAL   Electrophoresis 20 (2), 249-255 (1999)
   PUBMED   10197430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB842097.1, AK165281.1 and DV644627.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform a). Variants 1 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027808.1, AK146122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BB842097.1         1-8
            9-1694              AK165281.1         2-1687
            1695-1730           DV644627.1         89-124
FEATURES             Location/Qualifiers
     source          1..1730
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..1730
                     /gene="Fkbp8"
                     /gene_synonym="38kDa; FKBP-38; FKBP-8; Fkbp38; FKBPR38;
                     mFKBP38"
                     /note="FK506 binding protein 8"
                     /db_xref="GeneID:14232"
                     /db_xref="MGI:MGI:1341070"
     exon            1..94
                     /gene="Fkbp8"
                     /gene_synonym="38kDa; FKBP-38; FKBP-8; Fkbp38; FKBPR38;
                     mFKBP38"
                     /inference="alignment:Splign:2.1.0"
     exon            95..379
                     /gene="Fkbp8"
                     /gene_synonym="38kDa; FKBP-38; FKBP-8; Fkbp38; FKBPR38;
                     mFKBP38"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1329
                     /gene="Fkbp8"
                     /gene_synonym="38kDa; FKBP-38; FKBP-8; Fkbp38; FKBPR38;
                     mFKBP38"
                     /EC_number="5.2.1.8"
                     /note="isoform a is encoded by transcript variant 1;
                     FK506-binding protein 38; peptidyl-prolyl cis-trans
                     isomerase FKBP8; rotamase; 38 kDa FK506-binding protein;
                     38 kDa FKBP; PPIase FKBP8"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP8
                     isoform a"
                     /protein_id="NP_001104536.1"
                     /db_xref="CCDS:CCDS52575.1"
                     /db_xref="GeneID:14232"
                     /db_xref="MGI:MGI:1341070"
                     /translation="MASWAEPSEPAALRLPGAPLLEGFEVLDGVDDAEEEDDLSGLPP
                     LEDMGQPTVEEAEQPGALAREFLAATEPEPAPAPAPEEWLDILGNGLLRMKTLVPGPK
                     GSSRPLKGQVVTVHLQMSLENGTRVQEEPELAFTLGDCDVIQALDLSVPLMDVGETAM
                     VTADSKYCYGPQGSRSPYIPPHAALCLEVTLKTAEDGPDLEMLSGQERVALANRKREC
                     GNAHYQRADFVLAANSYDLAIKAITSNTKVDMTCEEEEELLQLKVKCLNNLAASQLKL
                     DHYRAALRSCSQVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIH
                     AELSKLVKKRAAQRSTETALYRKMLGNPSRLPAKCPGKGAWSIPWKWLFGATAVALGG
                     VALSVVIAARN"
     exon            380..549
                     /gene="Fkbp8"
                     /gene_synonym="38kDa; FKBP-38; FKBP-8; Fkbp38; FKBPR38;
                     mFKBP38"
                     /inference="alignment:Splign:2.1.0"
     exon            550..638
                     /gene="Fkbp8"
                     /gene_synonym="38kDa; FKBP-38; FKBP-8; Fkbp38; FKBPR38;
                     mFKBP38"
                     /inference="alignment:Splign:2.1.0"
     exon            639..859
                     /gene="Fkbp8"
                     /gene_synonym="38kDa; FKBP-38; FKBP-8; Fkbp38; FKBPR38;
                     mFKBP38"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1032
                     /gene="Fkbp8"
                     /gene_synonym="38kDa; FKBP-38; FKBP-8; Fkbp38; FKBPR38;
                     mFKBP38"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1110
                     /gene="Fkbp8"
                     /gene_synonym="38kDa; FKBP-38; FKBP-8; Fkbp38; FKBPR38;
                     mFKBP38"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1242
                     /gene="Fkbp8"
                     /gene_synonym="38kDa; FKBP-38; FKBP-8; Fkbp38; FKBPR38;
                     mFKBP38"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1704
                     /gene="Fkbp8"
                     /gene_synonym="38kDa; FKBP-38; FKBP-8; Fkbp38; FKBPR38;
                     mFKBP38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1681..1686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fkbp8"
                     /gene_synonym="38kDa; FKBP-38; FKBP-8; Fkbp38; FKBPR38;
                     mFKBP38"
                     /note="hexamer: AATAAA"
     polyA_site      1704
                     /gene="Fkbp8"
                     /gene_synonym="38kDa; FKBP-38; FKBP-8; Fkbp38; FKBPR38;
                     mFKBP38"
                     /note="major polyA site"
ORIGIN      
        1 ggctgcgtat ctgaagctgt ttcccgaggc gcggcggccg cggctggggg cggggagggg
       61 gcacaggacc ccgagcgggg tccccgagcc gcagggccag ttcctgatcc cagcagcatg
      121 gcgtcttggg ctgagccctc tgagcctgct gccctgcgac ttcctggggc cccactgctg
      181 gagggctttg aggtgctcga tggggttgat gatgcagagg aggaagatga cctaagtggg
      241 ctgccaccac tagaggacat gggacagcct acagtggagg aggctgagca gcctggagcc
      301 ctggctcggg agttcctggc agccacagag cctgagccag ccccagcccc agccccggaa
      361 gagtggctgg acattctggg gaacggattg ctgcggatga agacactggt cccaggcccg
      421 aaaggctcta gccgcccact caagggccag gtggtgaccg ttcacctgca gatgtccctg
      481 gagaatggca cccgtgtaca ggaagagcct gaactggcct tcacgctggg agactgcgat
      541 gttatccagg ccctggacct cagtgtcccg ctcatggatg tgggcgagac agccatggtt
      601 accgctgact ccaagtactg ctacggcccc cagggcagca ggagcccata catccccccc
      661 cacgcagccc tgtgcctgga agtcaccctg aagacggcag aggatggacc cgacctggag
      721 atgctgagtg ggcaggagcg cgtggccctg gccaaccgca agcgggagtg tggcaatgcc
      781 cactaccagc gtgccgactt tgtgctggcc gccaattcct atgacctggc catcaaggct
      841 atcacctcca acaccaaagt ggacatgact tgtgaggagg aagaggagct gctacagctg
      901 aaggtcaagt gtctgaacaa ccttgcggcc tcacagctga agctggacca ctaccgagca
      961 gctctgcgct cctgtagcca ggtgctggag caccagccgg acaacatcaa ggcactgttc
     1021 cgcaagggca aggtgctggc tcagcaaggt gaatatagtg aggccatccc aatcctgagg
     1081 gctgccctga agctggaacc ttccaacaag acgatccacg cagagctctc aaagctggta
     1141 aagaagcgtg ctgcacagcg gagcacagag accgccctgt accgaaagat gctaggcaac
     1201 cccagccggc tgcctgccaa gtgtccggga aagggggcct ggtccatccc gtggaaatgg
     1261 ctgtttgggg cgactgccgt ggccctgggg ggcgtggctc tctctgtggt cattgctgcc
     1321 aggaactgac tgtccccctg ctcacctgga ccccaacctg tgctccctaa ctcccccagg
     1381 ctccctgtcc attgccctcc ctggctgaga tgcctcctat gggtttgggg agcaaggatt
     1441 gagggtcaaa taacccaaga agcaggaagg actgagaccc tgagggggga catggggtgc
     1501 agcccagagg gagggaccct gttcttctag acccagttgt ttctatccca caaccctgtc
     1561 ctctggggtc aggcctcggc tgtgacagcc tcagttttcc ctctcagtag gcctggggca
     1621 gcactaccat tccttcctgc ccgtctgcac cctctgtcca ggcttcccca cagtgaatta
     1681 aataaagcct caccccacac cctaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
