LOCUS       NP_001104536             403 aa            linear   ROD 06-AUG-2024
DEFINITION  peptidyl-prolyl cis-trans isomerase FKBP8 isoform a [Mus musculus].
ACCESSION   NP_001104536
VERSION     NP_001104536.1
DBSOURCE    REFSEQ: accession NM_001111066.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 403)
  AUTHORS   Wang,S., Xiao,G., Tang,M., Bi,X., Xing,C., Liu,A., Zhao,A.Z. and
            Li,F.
  TITLE     FKBP38 deletion exacerbates ConA-induced hepatitis by promoting the
            immune response through the MCP-1/p38 pathway
  JOURNAL   Int Immunopharmacol 138, 112659 (2024)
   PUBMED   38996665
  REMARK    GeneRIF: FKBP38 deletion exacerbates ConA-induced hepatitis by
            promoting the immune response through the MCP-1/p38 pathway.
REFERENCE   2  (residues 1 to 403)
  AUTHORS   Zuo,L., Kuo,W.T., Cao,F., Chanez-Paredes,S.D., Zeve,D., Mannam,P.,
            Jean-Francois,L., Day,A., Vallen Graham,W., Sweat,Y.Y.,
            Shashikanth,N., Breault,D.T. and Turner,J.R.
  TITLE     Tacrolimus-binding protein FKBP8 directs myosin light chain
            kinase-dependent barrier regulation and is a potential therapeutic
            target in Crohn's disease
  JOURNAL   Gut 72 (5), 870-881 (2023)
   PUBMED   35537812
  REMARK    GeneRIF: Tacrolimus-binding protein FKBP8 directs myosin light
            chain kinase-dependent barrier regulation and is a potential
            therapeutic target in Crohn's disease.
REFERENCE   3  (residues 1 to 403)
  AUTHORS   Zhou,Y., Zhao,H., Shuai,L., She,J., Diao,R. and Wang,L.
  TITLE     [Fkbp38 deletion induces premature ovarian insufficiency in mice by
            activating mTOR signaling and inducing granulosa cell apoptosis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (11), 1611-1617 (2022)
   PUBMED   36504053
  REMARK    GeneRIF: [Fkbp38 deletion induces premature ovarian insufficiency
            in mice by activating mTOR signaling and inducing granulosa cell
            apoptosis].
REFERENCE   4  (residues 1 to 403)
  AUTHORS   Tian,T., Cao,X., Kim,S.E., Lin,Y.L., Steele,J.W., Cabrera,R.M.,
            Karki,M., Yang,W., Marini,N.J., Hoffman,E.N., Han,X., Hu,C.,
            Wang,L., Wlodarczyk,B.J., Shaw,G.M., Ren,A., Finnell,R.H. and
            Lei,Y.
  TITLE     FKBP8 variants are risk factors for spina bifida
  JOURNAL   Hum Mol Genet 29 (18), 3132-3144 (2020)
   PUBMED   32969478
  REMARK    GeneRIF: FKBP8 variants are risk factors for spina bifida.
REFERENCE   5  (residues 1 to 403)
  AUTHORS   Yoo,S.M., Yamashita,S.I., Kim,H., Na,D., Lee,H., Kim,S.J.,
            Cho,D.H., Kanki,T. and Jung,Y.K.
  TITLE     FKBP8 LIRL-dependent mitochondrial fragmentation facilitates
            mitophagy under stress conditions
  JOURNAL   FASEB J 34 (2), 2944-2957 (2020)
   PUBMED   31908024
  REMARK    GeneRIF: FKBP8 LIRL-dependent mitochondrial fragmentation
            facilitates mitophagy under stress conditions.
REFERENCE   6  (residues 1 to 403)
  AUTHORS   Nielsen,J.V., Mitchelmore,C., Pedersen,K.M., Kjaerulff,K.M.,
            Finsen,B. and Jensen,N.A.
  TITLE     Fkbp8: novel isoforms, genomic organization, and characterization
            of a forebrain promoter in transgenic mice
  JOURNAL   Genomics 83 (1), 181-192 (2004)
   PUBMED   14667822
REFERENCE   7  (residues 1 to 403)
  AUTHORS   Fong,S., Mounkes,L., Liu,Y., Maibaum,M., Alonzo,E., Desprez,P.Y.,
            Thor,A.D., Kashani-Sabet,M. and Debs,R.J.
  TITLE     Functional identification of distinct sets of antitumor activities
            mediated by the FKBP gene family
  JOURNAL   Proc Natl Acad Sci U S A 100 (24), 14253-14258 (2003)
   PUBMED   14612567
  REMARK    GeneRIF: used systemic gene transfer in tumor-bearing mice to
            identify novel antiinvasive and antimetastatic functions for Fkbp8,
            and subsequently for Fkbp1a.
REFERENCE   8  (residues 1 to 403)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (residues 1 to 403)
  AUTHORS   Shirane,M. and Nakayama,K.I.
  TITLE     Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria
            and inhibits apoptosis
  JOURNAL   Nat Cell Biol 5 (1), 28-37 (2003)
   PUBMED   12510191
REFERENCE   10 (residues 1 to 403)
  AUTHORS   Pedersen,K.M., Finsen,B., Celis,J.E. and Jensen,N.A.
  TITLE     muFKBP38: a novel murine immunophilin homolog differentially
            expressed in Schwannoma cells and central nervous system neurons in
            vivo
  JOURNAL   Electrophoresis 20 (2), 249-255 (1999)
   PUBMED   10197430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB842097.1, AK165281.1 and DV644627.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform a). Variants 1 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027808.1, AK146122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     Protein         1..403
                     /product="peptidyl-prolyl cis-trans isomerase FKBP8
                     isoform a"
                     /EC_number="5.2.1.8"
                     /note="FK506-binding protein 38; peptidyl-prolyl cis-trans
                     isomerase FKBP8; rotamase; 38 kDa FK506-binding protein;
                     38 kDa FKBP; PPIase FKBP8"
                     /calculated_mol_wt=43485
     Region          28..54
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O35465.2)"
     Region          103..192
                     /region_name="FKBP_C"
                     /note="FKBP-type peptidyl-prolyl cis-trans isomerase;
                     pfam00254"
                     /db_xref="CDD:459735"
     Region          210..>337
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          212..245
                     /region_name="TPR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35465.2)"
     Site            order(220..221,223,264,267..268,271..272,274..275,298,
                     301..302,305..306,309)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          245..292
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          263..296
                     /region_name="TPR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (O35465.2)"
     Site            287
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14318; propagated from
                     UniProtKB/Swiss-Prot (O35465.2)"
     Region          297..330
                     /region_name="TPR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (O35465.2)"
     Region          297..325
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            381..401
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35465.2)"
     CDS             1..403
                     /gene="Fkbp8"
                     /gene_synonym="38kDa; FKBP-38; FKBP-8; Fkbp38; FKBPR38;
                     mFKBP38"
                     /coded_by="NM_001111066.1:118..1329"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS52575.1"
                     /db_xref="GeneID:14232"
                     /db_xref="MGI:MGI:1341070"
ORIGIN      
        1 maswaepsep aalrlpgapl legfevldgv ddaeeeddls glppledmgq ptveeaeqpg
       61 alareflaat epepapapap eewldilgng llrmktlvpg pkgssrplkg qvvtvhlqms
      121 lengtrvqee pelaftlgdc dviqaldlsv plmdvgetam vtadskycyg pqgsrspyip
      181 phaalclevt lktaedgpdl emlsgqerva lanrkrecgn ahyqradfvl aansydlaik
      241 aitsntkvdm tceeeeellq lkvkclnnla asqlkldhyr aalrscsqvl ehqpdnikal
      301 frkgkvlaqq geyseaipil raalklepsn ktihaelskl vkkraaqrst etalyrkmlg
      361 npsrlpakcp gkgawsipwk wlfgataval ggvalsvvia arn
//
