LOCUS       NM_010222                898 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus FK506 binding protein 7 (Fkbp7), transcript variant 1,
            mRNA.
ACCESSION   NM_010222
VERSION     NM_010222.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 898)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 898)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 898)
  AUTHORS   Feng,M., Gu,C., Ma,S., Wang,Y., Liu,H., Han,R., Gao,J., Long,Y. and
            Mi,H.
  TITLE     Mouse FKBP23 mediates conformer-specific functions of BiP by
            catalyzing Pro117 cis/trans isomerization
  JOURNAL   Biochem Biophys Res Commun 408 (4), 537-540 (2011)
   PUBMED   21527244
  REMARK    GeneRIF: FKBP23 is demonstrated to mediate functions of BiP by
            catalyzing the Pro(117)cis/trans conformational interconversion in
            the ATPase domain of BiP.
REFERENCE   4  (bases 1 to 898)
  AUTHORS   Wang,Y., Han,R., Wu,D., Li,J., Chen,C., Ma,H. and Mi,H.
  TITLE     The binding of FKBP23 to BiP modulates BiP's ATPase activity with
            its PPIase activity
  JOURNAL   Biochem Biophys Res Commun 354 (1), 315-320 (2007)
   PUBMED   17223077
  REMARK    GeneRIF: In this study, we demonstrate the ability of mFKBP23 to
            modulate the ATPase activity of BiP, and that the bound mFKBP23,
            but not the free mFKBP23, can suppress the ATPase activity of mBiP
            through its PPIase activity.
REFERENCE   5  (bases 1 to 898)
  AUTHORS   Chen,C., Ma,H., Wang,Y. and Mi,H.
  TITLE     Binding of FKBP23 to BiP in ER shown by gel filtration
            chromatography
  JOURNAL   Z Naturforsch C J Biosci 62 (1-2), 133-137 (2007)
   PUBMED   17425118
  REMARK    GeneRIF: binds to Grp78 (Bip) in endoplasmic reticulum.
REFERENCE   6  (bases 1 to 898)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   7  (bases 1 to 898)
  AUTHORS   Zhang,X., Wang,Y., Li,H., Zhang,W., Wu,D. and Mi,H.
  TITLE     The mouse FKBP23 binds to BiP in ER and the binding of C-terminal
            domain is interrelated with Ca2+ concentration
  JOURNAL   FEBS Lett 559 (1-3), 57-60 (2004)
   PUBMED   14960307
  REMARK    GeneRIF: mFKBP23 binds to immunoglobulin binding protein
            (mBiP,Hsp70); the binding of the C-terminus is Ca(2+)-dependent and
            the switch point is between 2 and 3 mM, no binding being detected
            at high concentration of calcium
REFERENCE   8  (bases 1 to 898)
  AUTHORS   Thach,D.C., Kleeberger,S.R., Tucker,P.C. and Griffin,D.E.
  TITLE     Genetic control of neuroadapted sindbis virus replication in female
            mice maps to chromosome 2 and associates with paralysis and
            mortality
  JOURNAL   J Virol 75 (18), 8674-8680 (2001)
   PUBMED   11507212
REFERENCE   9  (bases 1 to 898)
  AUTHORS   Nakamura,T., Yabe,D., Kanazawa,N., Tashiro,K., Sasayama,S. and
            Honjo,T.
  TITLE     Molecular cloning, characterization, and chromosomal localization
            of FKBP23, a novel FK506-binding protein with Ca2+-binding ability
  JOURNAL   Genomics 54 (1), 89-98 (1998)
   PUBMED   9806833
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928867.9.
            
            On Jun 27, 2009 this sequence version replaced NM_010222.1.
            
            Transcript Variant: This variant (1) represents the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032961.1, AF040252.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               AL928867.9         94227-94519         c
            294-445             AL928867.9         93118-93269         c
            446-579             AL928867.9         87098-87231         c
            580-898             AL928867.9         84455-84773         c
FEATURES             Location/Qualifiers
     source          1..898
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 45.09 cM"
     gene            1..898
                     /gene="Fkbp7"
                     /gene_synonym="23kDa; FKBP-7; FKBP23"
                     /note="FK506 binding protein 7"
                     /db_xref="GeneID:14231"
                     /db_xref="MGI:MGI:1336879"
     exon            1..293
                     /gene="Fkbp7"
                     /gene_synonym="23kDa; FKBP-7; FKBP23"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..741
                     /gene="Fkbp7"
                     /gene_synonym="23kDa; FKBP-7; FKBP23"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; peptidyl-prolyl cis-trans isomerase FKBP7;
                     FKBP-23; rotamase; 23 kDa FKBP; PPIase FKBP7; 23 kDa
                     FK506-binding protein"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP7
                     isoform 1 precursor"
                     /protein_id="NP_034352.1"
                     /db_xref="CCDS:CCDS16161.1"
                     /db_xref="GeneID:14231"
                     /db_xref="MGI:MGI:1336879"
                     /translation="MNLLFRLAVFLSLWCCSDAQGQTKEESTEEVKIEVLHRPENCSK
                     TSRKGDLLNAHYDGYLAKDGSKFYCSRTQDEGHPKWFVLGVGHVIKGLDIAMMDMCPG
                     EKRKVIIPPSFAYGKEGYAEGKIPPNATLMFEIELYAVTKGPRSIETFKQIDTDNDRQ
                     LSKAEIELYLQKDFEKDANPRDKSYQKAVLEDIFKKNDHNGDGFISPKEYNVHQHDEL
                     "
     exon            294..445
                     /gene="Fkbp7"
                     /gene_synonym="23kDa; FKBP-7; FKBP23"
                     /inference="alignment:Splign:2.1.0"
     exon            446..579
                     /gene="Fkbp7"
                     /gene_synonym="23kDa; FKBP-7; FKBP23"
                     /inference="alignment:Splign:2.1.0"
     exon            580..898
                     /gene="Fkbp7"
                     /gene_synonym="23kDa; FKBP-7; FKBP23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      858..863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fkbp7"
                     /gene_synonym="23kDa; FKBP-7; FKBP23"
                     /note="hexamer: AATAAA"
     polyA_site      888
                     /gene="Fkbp7"
                     /gene_synonym="23kDa; FKBP-7; FKBP23"
                     /note="major polyA site"
ORIGIN      
        1 tgccacgcgt cccaattcag tctgatcagc ctgctgacac tctgtggggc ttacactggg
       61 cctgggagtg ctgctttggg aaacatgaat ctcctattca gactagcagt tttccttagc
      121 ctgtggtgtt gttccgatgc tcagggacaa acaaaagaag aaagcactga ggaagtgaaa
      181 atagaagttt tgcaccgtcc agaaaactgc tccaaaacaa gcaggaaagg agacttgcta
      241 aatgcccatt acgatggcta cttggctaaa gacggctcca aattctactg cagccggaca
      301 caagatgaag gccaccccaa atggtttgtt cttggtgtcg gacatgtcat aaaggggctg
      361 gacattgcta tgatggacat gtgccctggg gaaaagagaa aggtgattat accgccttcg
      421 tttgcatatg gaaaagaagg ctacgcagaa ggcaagattc cacccaatgc aactctgatg
      481 tttgagattg aactttatgc tgtgaccaaa ggaccaagga gcattgaaac atttaagcaa
      541 atagacacgg ataatgaccg gcaactctcc aaagctgaga tagagcttta cttacagaag
      601 gactttgaaa aagatgcaaa cccccgtgac aagtcatatc agaaggcagt tttggaagat
      661 atctttaaga aaaatgacca caatggagac ggcttcattt ctcctaagga atacaatgtg
      721 caccaacatg atgagctata aatataatta cttctctatt tgttagtaac tcacatactt
      781 tgctttaaaa aaaataccac cgttctctat gttgtggtta tacctgtttt cccttgtgag
      841 aagatatttg ttccttcaat aaacataatt ttggtgtatt aatgtaaacc tgttttgc
//
