LOCUS       NM_001277891            1289 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus FK506 binding protein 6 (Fkbp6), transcript variant 2,
            mRNA.
ACCESSION   NM_001277891
VERSION     NM_001277891.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1289)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1289)
  AUTHORS   Papanikos,F., Daniel,K., Goercharn-Ramlal,A., Fei,J.F., Kurth,T.,
            Wojtasz,L., Dereli,I., Fu,J., Penninger,J., Habermann,B.,
            Surani,A., Stewart,A.F. and Toth,A.
  TITLE     The enigmatic meiotic dense body and its newly discovered
            component, SCML1, are dispensable for fertility and gametogenesis
            in mice
  JOURNAL   Chromosoma 126 (3), 399-415 (2017)
   PUBMED   27165042
REFERENCE   3  (bases 1 to 1289)
  AUTHORS   Strogantsev,R., Krueger,F., Yamazawa,K., Shi,H., Gould,P.,
            Goldman-Roberts,M., McEwen,K., Sun,B., Pedersen,R. and
            Ferguson-Smith,A.C.
  TITLE     Allele-specific binding of ZFP57 in the epigenetic regulation of
            imprinted and non-imprinted monoallelic expression
  JOURNAL   Genome Biol 16 (1), 112 (2015)
   PUBMED   26025256
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1289)
  AUTHORS   Segura-Puimedon,M., Sahun,I., Velot,E., Dubus,P., Borralleras,C.,
            Rodrigues,A.J., Valero,M.C., Valverde,O., Sousa,N., Herault,Y.,
            Dierssen,M., Perez-Jurado,L.A. and Campuzano,V.
  TITLE     Heterozygous deletion of the Williams-Beuren syndrome critical
            interval in mice recapitulates most features of the human disorder
  JOURNAL   Hum Mol Genet 23 (24), 6481-6494 (2014)
   PUBMED   25027326
REFERENCE   5  (bases 1 to 1289)
  AUTHORS   Finn,E.H., Smith,C.L., Rodriguez,J., Sidow,A. and Baker,J.C.
  TITLE     Maternal bias and escape from X chromosome imprinting in the
            midgestation mouse placenta
  JOURNAL   Dev Biol 390 (1), 80-92 (2014)
   PUBMED   24594094
REFERENCE   6  (bases 1 to 1289)
  AUTHORS   Kan,R., Sun,X., Kolas,N.K., Avdievich,E., Kneitz,B., Edelmann,W.
            and Cohen,P.E.
  TITLE     Comparative analysis of meiotic progression in female mice bearing
            mutations in genes of the DNA mismatch repair pathway
  JOURNAL   Biol Reprod 78 (3), 462-471 (2008)
   PUBMED   18057311
REFERENCE   7  (bases 1 to 1289)
  AUTHORS   Crackower,M.A., Kolas,N.K., Noguchi,J., Sarao,R., Kikuchi,K.,
            Kaneko,H., Kobayashi,E., Kawai,Y., Kozieradzki,I., Landers,R.,
            Mo,R., Hui,C.C., Nieves,E., Cohen,P.E., Osborne,L.R., Wada,T.,
            Kunieda,T., Moens,P.B. and Penninger,J.M.
  TITLE     Essential role of Fkbp6 in male fertility and homologous chromosome
            pairing in meiosis
  JOURNAL   Science 300 (5623), 1291-1295 (2003)
   PUBMED   12764197
  REMARK    GeneRIF: Fkbp6 is a component of the synaptonemal complex essential
            for sex-specific fertility and for the fidelity of homologous
            chromosome pairing in meiosis
REFERENCE   8  (bases 1 to 1289)
  AUTHORS   DeSilva,U., Elnitski,L., Idol,J.R., Doyle,J.L., Gan,W.,
            Thomas,J.W., Schwartz,S., Dietrich,N.L., Beckstrom-Sternberg,S.M.,
            McDowell,J.C., Blakesley,R.W., Bouffard,G.G., Thomas,P.J.,
            Touchman,J.W., Miller,W. and Green,E.D.
  TITLE     Generation and comparative analysis of approximately 3.3 Mb of
            mouse genomic sequence orthologous to the region of human
            chromosome 7q11.23 implicated in Williams syndrome
  JOURNAL   Genome Res 12 (1), 3-15 (2002)
   PUBMED   11779826
REFERENCE   9  (bases 1 to 1289)
  AUTHORS   Valero,M.C., de Luis,O., Cruces,J. and Perez Jurado,L.A.
  TITLE     Fine-scale comparative mapping of the human 7q11.23 region and the
            orthologous region on mouse chromosome 5G: the low-copy repeats
            that flank the Williams-Beuren syndrome deletion arose at
            breakpoint sites of an evolutionary inversion(s)
  JOURNAL   Genomics 69 (1), 1-13 (2000)
   PUBMED   11013070
REFERENCE   10 (bases 1 to 1289)
  AUTHORS   Coss,M.C., Winterstein,D., Sowder,R.C. 2nd and Simek,S.L.
  TITLE     Molecular cloning, DNA sequence analysis, and biochemical
            characterization of a novel 65-kDa FK506-binding protein (FKBP65)
  JOURNAL   J Biol Chem 270 (49), 29336-29341 (1995)
   PUBMED   7493967
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC074359.2 and AF367709.1.
            
            Summary: This gene is a member of the FK506-binding protein (Fkbp)
            family. The encoded protein plays a role in male-specific fertility
            and homologous pairing of chromosomes during meiosis. The protein
            may also be involved in LINE1 transposon silencing and binding to
            Hsp90 as a co-chaperone. Alternative splicing of this gene results
            in multiple transcript variants encoding different isoforms.
            [provided by RefSeq, Apr 2013].
            
            Transcript Variant: This variant (2) transcribes past a splice site
            that is used in variant 1. This results in a novel 3' UTR, compared
            to variant 1. Variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090036.1, AF367709.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC074359.2         81179-81197         c
            20-1285             AF367709.1         1-1266
            1286-1289           AC074359.2         68518-68521         c
FEATURES             Location/Qualifiers
     source          1..1289
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.11 cM"
     gene            1..1289
                     /gene="Fkbp6"
                     /gene_synonym="1700008G22Rik; 36kDa; D5Ertd724e; FKBP-36;
                     FKBP-6"
                     /note="FK506 binding protein 6"
                     /db_xref="GeneID:94244"
                     /db_xref="MGI:MGI:2137612"
     exon            1..110
                     /gene="Fkbp6"
                     /gene_synonym="1700008G22Rik; 36kDa; D5Ertd724e; FKBP-36;
                     FKBP-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1037
                     /gene="Fkbp6"
                     /gene_synonym="1700008G22Rik; 36kDa; D5Ertd724e; FKBP-36;
                     FKBP-6"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 2;
                     peptidyl-prolyl cis-trans isomerase FKBP6; rotamase;
                     immunophilin FKBP36; 36 kDa FK506-binding protein; 36 kDa
                     FKBP; PPIase FKBP6; inactive PPIase FKBP6; inactive
                     peptidyl-prolyl cis-trans isomerase FKBP6"
                     /codon_start=1
                     /product="inactive peptidyl-prolyl cis-trans isomerase
                     FKBP6 isoform 1"
                     /protein_id="NP_001264820.1"
                     /db_xref="CCDS:CCDS19738.1"
                     /db_xref="GeneID:94244"
                     /db_xref="MGI:MGI:2137612"
                     /translation="MSVFSRLRNGIPPSRDDCQSPYERLSQRMLDISGDRGVLKDIIR
                     EGTGDTVTPDASVLVKYSGYLEHMDKPFDSNCFRKTPRLMKLGEDITLWGMELGLLSM
                     RKGELARFLFKPAYAYGTLGCPPLIPPNATVLFEIELIDFLDSAESDKFCALSAEQQE
                     QFPLQKVLKVAATEREFGNYLFRQNRFCDAKVRYKRALLLLHRRLATCEEQHLVEPAV
                     LLVLLNLSFVYLKLDRPAMALRYGEQALLIDKRNAKALFRCGQACLLLTEYERARDFL
                     VRAQKEQPCNHDINNELKKLSSHYRDYVDREREMCHRMFAPCGSRSSVGGN"
     exon            111..228
                     /gene="Fkbp6"
                     /gene_synonym="1700008G22Rik; 36kDa; D5Ertd724e; FKBP-36;
                     FKBP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            229..318
                     /gene="Fkbp6"
                     /gene_synonym="1700008G22Rik; 36kDa; D5Ertd724e; FKBP-36;
                     FKBP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            319..521
                     /gene="Fkbp6"
                     /gene_synonym="1700008G22Rik; 36kDa; D5Ertd724e; FKBP-36;
                     FKBP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            522..641
                     /gene="Fkbp6"
                     /gene_synonym="1700008G22Rik; 36kDa; D5Ertd724e; FKBP-36;
                     FKBP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            642..836
                     /gene="Fkbp6"
                     /gene_synonym="1700008G22Rik; 36kDa; D5Ertd724e; FKBP-36;
                     FKBP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            837..946
                     /gene="Fkbp6"
                     /gene_synonym="1700008G22Rik; 36kDa; D5Ertd724e; FKBP-36;
                     FKBP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1289
                     /gene="Fkbp6"
                     /gene_synonym="1700008G22Rik; 36kDa; D5Ertd724e; FKBP-36;
                     FKBP-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1260..1265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fkbp6"
                     /gene_synonym="1700008G22Rik; 36kDa; D5Ertd724e; FKBP-36;
                     FKBP-6"
                     /note="hexamer: ATTAAA"
     polyA_site      1285
                     /gene="Fkbp6"
                     /gene_synonym="1700008G22Rik; 36kDa; D5Ertd724e; FKBP-36;
                     FKBP-6"
                     /note="major polyA site"
ORIGIN      
        1 ctgacttccg gggtcgtttc cggcaaggcc tttggagaca gttgtgcggc aagatgagcg
       61 tcttctcgcg cctcaggaac ggaatcccac cgtcgcgaga cgactgccag tctccctatg
      121 agcgactaag tcaacgcatg ttggacatct ccggggaccg aggtgtgctg aaggacatca
      181 tccgagaggg cactggcgat accgtgacac ctgacgcttc tgtgctggtg aaatattctg
      241 gatacctgga gcacatggac aagcctttcg attctaattg ctttaggaaa acacctcggc
      301 tgatgaaact tggagaagat attacactct ggggcatgga gctgggcctt ctgagcatgc
      361 gcaaagggga actggccagg ttcctgttca agccagccta tgcttacggc accctggggt
      421 gccctcccct catcccgcca aatgccaccg tcctgtttga gatcgagctg attgacttcc
      481 tggattctgc tgagtcagac aagttctgtg cactctcagc tgagcagcaa gaacagtttc
      541 cactccagaa agtcctcaaa gtagcagcaa ctgagaggga gtttggcaac taccttttcc
      601 gccagaatcg cttctgtgat gccaaagtga gatacaagcg ggctttgctg ctgctccacc
      661 gacgattggc cacctgtgag gagcagcact tggtagaacc tgccgtgctt ctagtcctcc
      721 ttaacctgtc ctttgtgtac ctgaagctag accgacctgc catggccctg cgctatgggg
      781 agcaggctct gctcattgac aaaaggaacg ccaaggccct cttcaggtgt ggacaggctt
      841 gcctcctcct aactgagtat gagcgggccc gggattttct agtgcgagct cagaaagagc
      901 agccctgcaa ccatgacatc aataatgagc tgaaaaagct gtccagccac tacagggact
      961 atgtggacag agagagagag atgtgtcacc gcatgtttgc tccctgtgga agcagatctt
     1021 cagtgggagg aaactgaagg tactcagccg gctgggcctt catccaaaga ttcaggctct
     1081 gtccattggg gagatgctcc ttctcacggc tctcgctcgc cactgagaac agcataggac
     1141 agaatccact gtgggggctc cccacagagt ggtcactgaa ggaggagcac ttggagctta
     1201 cattcatgtt tgggaggtcc tgagctctcc cattcaacaa ctttttcata ctttgtgaaa
     1261 ttaaactctt cctcaaagtt tcttagaac
//
