LOCUS       NM_010220               3884 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus FK506 binding protein 5 (Fkbp5), mRNA.
ACCESSION   NM_010220
VERSION     NM_010220.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3884)
  AUTHORS   Gebru,N.T., Guergues,J., Verdina,L.A., Wohlfahrt,J., Wang,S.,
            Armendariz,D.S., Gray,M., Beaulieu-Abdelahad,D., Stevens,S.M. Jr.,
            Gulick,D. and Blair,L.J.
  TITLE     Fkbp5 gene deletion: Circadian rhythm profile and brain proteomics
            in aged mice
  JOURNAL   Aging Cell 23 (12), e14314 (2024)
   PUBMED   39225086
REFERENCE   2  (bases 1 to 3884)
  AUTHORS   Gan,Y.L., Lin,W.J., Fang,Y.C., Tang,C.Y., Lee,Y.H. and Jeng,C.J.
  TITLE     FKBP51 is involved in LPS-induced microglial activation via
            NF-kappaB signaling to mediate neuroinflammation
  JOURNAL   Life Sci 351, 122867 (2024)
   PUBMED   38914303
  REMARK    GeneRIF: FKBP51 is involved in LPS-induced microglial activation
            via NF-kappaB signaling to mediate neuroinflammation.
REFERENCE   3  (bases 1 to 3884)
  AUTHORS   Cattane,N., Di Benedetto,M.G., D'Aprile,I., Riva,M.A. and
            Cattaneo,A.
  TITLE     Dissecting the Long-Term Effect of Stress Early in Life on FKBP5:
            The Role of miR-20b-5p and miR-29c-3p
  JOURNAL   Biomolecules 14 (3), 371 (2024)
   PUBMED   38540789
  REMARK    GeneRIF: Dissecting the Long-Term Effect of Stress Early in Life on
            FKBP5: The Role of miR-20b-5p and miR-29c-3p.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3884)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3884)
  AUTHORS   Williams,K.E., Zou,Y., Qiu,B., Kono,T., Guo,C., Garcia,D., Chen,H.,
            Graves,T., Lai,Z., Evans-Molina,C., Ma,Y.Y., Liangpunsakul,S.,
            Yong,W. and Liang,T.
  TITLE     Sex-Specific Impact of Fkbp5 on Hippocampal Response to Acute
            Alcohol Injection: Involvement in Alterations of Metabolism-Related
            Pathways
  JOURNAL   Cells 13 (1), 89 (2023)
   PUBMED   38201293
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3884)
  AUTHORS   Wang,H.Y., Arden,K.C., Bermingham,J.R. Jr., Viars,C.S., Lin,W.,
            Boyer,A.D. and Fu,X.D.
  TITLE     Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2),
            specific for the SR family of splicing factors in mouse and human
            chromosomes
  JOURNAL   Genomics 57 (2), 310-315 (1999)
   PUBMED   10198174
REFERENCE   7  (bases 1 to 3884)
  AUTHORS   Nair,S.C., Rimerman,R.A., Toran,E.J., Chen,S., Prapapanich,V.,
            Butts,R.N. and Smith,D.F.
  TITLE     Molecular cloning of human FKBP51 and comparisons of immunophilin
            interactions with Hsp90 and progesterone receptor
  JOURNAL   Mol Cell Biol 17 (2), 594-603 (1997)
   PUBMED   9001212
REFERENCE   8  (bases 1 to 3884)
  AUTHORS   Yeh,W.C., Li,T.K., Bierer,B.E. and McKnight,S.L.
  TITLE     Identification and characterization of an immunophilin expressed
            during the clonal expansion phase of adipocyte differentiation
  JOURNAL   Proc Natl Acad Sci U S A 92 (24), 11081-11085 (1995)
   PUBMED   7479941
REFERENCE   9  (bases 1 to 3884)
  AUTHORS   Baughman,G., Wiederrecht,G.J., Campbell,N.F., Martin,M.M. and
            Bourgeois,S.
  TITLE     FKBP51, a novel T-cell-specific immunophilin capable of calcineurin
            inhibition
  JOURNAL   Mol Cell Biol 15 (8), 4395-4402 (1995)
   PUBMED   7542743
REFERENCE   10 (bases 1 to 3884)
  AUTHORS   Baughman,G., Harrigan,M.T., Campbell,N.F., Nurrish,S.J. and
            Bourgeois,S.
  TITLE     Genes newly identified as regulated by glucocorticoids in murine
            thymocytes
  JOURNAL   Mol Endocrinol 5 (5), 637-644 (1991)
   PUBMED   2072923
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY740772.1, BU613862.1, CF949740.1 and AC154912.3.
            
            On Mar 5, 2013 this sequence version replaced NM_010220.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U16959.1, SRR7974084.6335.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-438               BY740772.1         1-438
            439-1003            BU613862.1         106-670
            1004-1537           CF949740.1         33-566
            1538-3884           AC154912.3         147125-149471
FEATURES             Location/Qualifiers
     source          1..3884
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.66 cM"
     gene            1..3884
                     /gene="Fkbp5"
                     /gene_synonym="D17Ertd592e; Dit1; FKBP-5; FKBP51"
                     /note="FK506 binding protein 5"
                     /db_xref="GeneID:14229"
                     /db_xref="MGI:MGI:104670"
     exon            1..198
                     /gene="Fkbp5"
                     /gene_synonym="D17Ertd592e; Dit1; FKBP-5; FKBP51"
                     /inference="alignment:Splign:2.1.0"
     exon            199..324
                     /gene="Fkbp5"
                     /gene_synonym="D17Ertd592e; Dit1; FKBP-5; FKBP51"
                     /inference="alignment:Splign:2.1.0"
     exon            325..469
                     /gene="Fkbp5"
                     /gene_synonym="D17Ertd592e; Dit1; FKBP-5; FKBP51"
                     /inference="alignment:Splign:2.1.0"
     exon            470..612
                     /gene="Fkbp5"
                     /gene_synonym="D17Ertd592e; Dit1; FKBP-5; FKBP51"
                     /inference="alignment:Splign:2.1.0"
     exon            613..727
                     /gene="Fkbp5"
                     /gene_synonym="D17Ertd592e; Dit1; FKBP-5; FKBP51"
                     /inference="alignment:Splign:2.1.0"
     exon            728..884
                     /gene="Fkbp5"
                     /gene_synonym="D17Ertd592e; Dit1; FKBP-5; FKBP51"
                     /inference="alignment:Splign:2.1.0"
     exon            885..975
                     /gene="Fkbp5"
                     /gene_synonym="D17Ertd592e; Dit1; FKBP-5; FKBP51"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1059
                     /gene="Fkbp5"
                     /gene_synonym="D17Ertd592e; Dit1; FKBP-5; FKBP51"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1245
                     /gene="Fkbp5"
                     /gene_synonym="D17Ertd592e; Dit1; FKBP-5; FKBP51"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1485
                     /gene="Fkbp5"
                     /gene_synonym="D17Ertd592e; Dit1; FKBP-5; FKBP51"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..3884
                     /gene="Fkbp5"
                     /gene_synonym="D17Ertd592e; Dit1; FKBP-5; FKBP51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3521..3526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fkbp5"
                     /gene_synonym="D17Ertd592e; Dit1; FKBP-5; FKBP51"
                     /note="hexamer: AATAAA"
     polyA_site      3540
                     /gene="Fkbp5"
                     /gene_synonym="D17Ertd592e; Dit1; FKBP-5; FKBP51"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgggac gacggcgggc gctgcccggc gcactagccg gcttgcgggc gctgccagtc
       61 tccggcggcg gtgtccggcg cgcggctgag cgaccgagcg tgcggacgga gcggcggcct
      121 gctgggcggg ctgagcggcg cgcgcggcgg cggagagacg cggagcgagg gacgcggcgg
      181 cggcggacgc ggcgacaggt cttctactta caaaggacaa tgactactga tgagggcacc
      241 agtaacaatg gagagaaccc agcagccacc atgactgagc agggtgaaga tatcactacg
      301 aagaaagaca gaggagtatt aaagattgtc aaaagagtgg ggactagtga cgaggcccca
      361 atgtttggtg acaaagttta tgtccactac aaagggatgt tgtcagatgg aaagaagttt
      421 gattccagtc atgacagaaa gaagccattt gcctttagcc ttggccaagg ccaggttatc
      481 aaagcctggg acattggggt gtctactatg aagaaaggcg agatctgcca tttattatgt
      541 aaaccagaat atgcttatgg ctcggctggc cacctccaaa aaattccatc aaatgcaact
      601 ctcttttttg agattgagct ccttgatttc aaaggtgagg atttatttga agattcaggc
      661 gttatccgta gaatcaaacg gaaaggcgag ggatactcaa acccaaacga aggagcaacg
      721 gtaaaagtcc acctggaagg ctgctgtggt ggaaggacat ttgattgccg agatgtggtg
      781 ttcgttgttg gggaaggaga agaccacgac attccgattg ggatcgacaa agccctggtg
      841 aagatgcaga gagaagaaca gtgtattcta tatcttggac cacgctatgg ttttggagaa
      901 gccgggaagc ctaagtttgg cattgacccc aatgctgagc ttatgtacga ggtcaccctt
      961 aagagcttcg agaaggccaa agaatcttgg gagatggaca ccaaagaaaa gctgacgcag
     1021 gctgccatcg tgaaagagaa gggaactgtg tacttcaagg gaggcaagta cacgcaggcc
     1081 gtgattcagt acaggaagat agtgtcctgg ctggagatgg aatacggcct gtcagagaag
     1141 gagtccaaag cctcagagtc gttcctcctc gcagccttcc tgaacctggc catgtgctac
     1201 ctgaagctcc gagagtacaa caaagccgtg gagtgctgcg acaaggccct tggactggac
     1261 agtgccaatg agaaaggctt gtacagaagg ggcgaggccc agctgctcat gaatgacttt
     1321 gagtcggcca agggcgactt cgagaaggtg ttggcagtca atcctcagaa cagggccgct
     1381 cgcctgcaga tctccatgtg ccagaggaag gcgaaggagc acaacgagcg ggaccgcagg
     1441 gtgtacgcca acatgttcaa gaagttcgca gagcgggacg caaaggagga agccagcaaa
     1501 gctgggagca agaaggctgt agaaggagcc gctggcaaac aacacgagag tcaggccatg
     1561 gaagaaggaa aggccaaagg ccatgtatga cgctgcgcca cggagggaag agagtcctaa
     1621 tgaactcggc cctcctcgct gggctcgcct ccaactcagg actgaacagt gtttagtgta
     1681 aggtttgtta cagtctctgt gattctggaa gcaaatggca taccagtagc ttcccaaatg
     1741 accacctgct gctgcggggg ggtgggggtg ggggacatgc caggaaacag cagagaaggc
     1801 cgctggtgtg aagagaccag gccagcagct cagtccagcc catttcagtt tgtcaccttt
     1861 cagtgtccag cacagcatcc ctgtgaacct agggcccagc tgctgtgggt tctacatcgg
     1921 cactagggtc acactgcaga aaccgttgat aaaacaaact cagtgatctc tgctttccta
     1981 ttggtgggca tggcaggggc gggtgatgag atttgcttag cactgactga ctggcctgct
     2041 aagaacacaa gcccacagcc aggggctccc tggtccacag ctgggtctca ggccccttac
     2101 ctgccttcca agtcctttcg cagactcttg agtgtggctt tctgtcctag ccagcatgtc
     2161 ccacagactc tgttgttcct ccaacgcccg tcattagtga cagctttctc tctgagtttc
     2221 tgtggtgtgg agagtgggta gaagtaggtt tatctttccc gctgtctgcc ccactcaagg
     2281 acgatgttag cgctcagcca tccctgccca gcacagctgc tcagcctcat gctcccaccc
     2341 gcacccttgc tgtgcagaac ctaaggcttg ctcccgtccc agactcgagt ggacggacat
     2401 ccatgtccac ccaggattga cgaaggaagg aacttcacac tcctctatca tgcaaaaata
     2461 gttttcaatt tttacttttt agcttgggtt ttgaaaggca aactctagga ggcttaaaac
     2521 gggcagttac tcttaaggcg aggtagatac ctcatcctgc accgcagcct ctgtattctg
     2581 gtgggagctg taagggttgc gggcttccgg tgtccatgca tcaagccaaa gtctccaaaa
     2641 cttgggcatt gaattagggc aaatcttaaa tagttttggg gttggatttt agtcctacag
     2701 gtgatgattg aacgtggctg gcttctccac agcctaagga acccccatgg ggacacaccc
     2761 accacccaat gacccatgca cctctgcctg gacagctcac ttccagccct aaggaccact
     2821 gtgctcaaga tgtgtggctg tagtaagaca gtctcatgtc aggcattaag tcaaggcctt
     2881 ccttcacacc tgcgggacag cgcttctgag gctccagttc tgctctgctc gaagcaggag
     2941 ggatgggttg tgaaggagtc tgggatgtga ctgggaccct cgcatctcac actcggcact
     3001 ctgcctcttt ccatccatgt ttgagagccc tggtctcacc aggaagtgca gagcaggagc
     3061 cgactgtgtg tgtaatgctc tagtgtttgt agttctcttc actagccttg cagcgccagg
     3121 gaggccgggc tggaatttga gcctaacatg ttaggttttt acgggaaagc tctttttcca
     3181 gctgtctccc aagtgcgtat tgtgggccaa ggagactggt atgggaaggg gggatggtca
     3241 aggttccaag ccagaaatgg aaggtgccca gcacccctgg attttacatg ttcttgtatt
     3301 cagtaatctc agacgattta cacggaaatc agaagatgtc ttcaaatacc cttagactgg
     3361 atagagtgat ggggaagcag atgatgcatt gaaattttgg tttttaaaaa atcacttaga
     3421 tgctgggagt aatggtgaca cacacccttg gtcccgtgac ctgggaggcc ctgtctcaaa
     3481 acaaaacaaa aaatcattta gatgcatttt gtgttcctta aataaatttt ttaaaaagtg
     3541 gtttttcatt gttcatggct ttttgttttt gttgtttgtt tgatttttga agtttacttt
     3601 tatctttgtc tgctagagtt ttgtgtccag ctgcccttgg ggaccagaaa gggactttga
     3661 atctccttga aatgaagata cagttgttag ccagatgtgg gtgttgagaa ctgaacccaa
     3721 gtcctctgaa aagcaggaag tgctcttaac tgctgggctg cccctctccc acccctccat
     3781 tgtttgggtt tgacttaaac acttgatttt ttttatgatt tttttaaaca gatttattta
     3841 ttgtatgtat gtgaatacgc tgttgttgtc ttcaggcaca gcag
//
