LOCUS       NP_034350                456 aa            linear   ROD 03-JUN-2025
DEFINITION  peptidyl-prolyl cis-trans isomerase FKBP5 [Mus musculus].
ACCESSION   NP_034350
VERSION     NP_034350.1
DBSOURCE    REFSEQ: accession NM_010220.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 456)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (residues 1 to 456)
  AUTHORS   Sato,A., Omichi,R., Maeda,Y. and Ando,M.
  TITLE     A glucocorticoid-regulating molecule, Fkbp5, may interact with
            mitogen-activated protein kinase signaling in the organ of Corti of
            mice cochleae
  JOURNAL   Sci Rep 15 (1), 7506 (2025)
   PUBMED   40033010
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 456)
  AUTHORS   Gebru,N.T., Guergues,J., Verdina,L.A., Wohlfahrt,J., Wang,S.,
            Armendariz,D.S., Gray,M., Beaulieu-Abdelahad,D., Stevens,S.M. Jr.,
            Gulick,D. and Blair,L.J.
  TITLE     Fkbp5 gene deletion: Circadian rhythm profile and brain proteomics
            in aged mice
  JOURNAL   Aging Cell 23 (12), e14314 (2024)
   PUBMED   39225086
REFERENCE   4  (residues 1 to 456)
  AUTHORS   Gan,Y.L., Lin,W.J., Fang,Y.C., Tang,C.Y., Lee,Y.H. and Jeng,C.J.
  TITLE     FKBP51 is involved in LPS-induced microglial activation via
            NF-kappaB signaling to mediate neuroinflammation
  JOURNAL   Life Sci 351, 122867 (2024)
   PUBMED   38914303
  REMARK    GeneRIF: FKBP51 is involved in LPS-induced microglial activation
            via NF-kappaB signaling to mediate neuroinflammation.
REFERENCE   5  (residues 1 to 456)
  AUTHORS   Cattane,N., Di Benedetto,M.G., D'Aprile,I., Riva,M.A. and
            Cattaneo,A.
  TITLE     Dissecting the Long-Term Effect of Stress Early in Life on FKBP5:
            The Role of miR-20b-5p and miR-29c-3p
  JOURNAL   Biomolecules 14 (3), 371 (2024)
   PUBMED   38540789
  REMARK    GeneRIF: Dissecting the Long-Term Effect of Stress Early in Life on
            FKBP5: The Role of miR-20b-5p and miR-29c-3p.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 456)
  AUTHORS   Wang,H.Y., Arden,K.C., Bermingham,J.R. Jr., Viars,C.S., Lin,W.,
            Boyer,A.D. and Fu,X.D.
  TITLE     Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2),
            specific for the SR family of splicing factors in mouse and human
            chromosomes
  JOURNAL   Genomics 57 (2), 310-315 (1999)
   PUBMED   10198174
REFERENCE   7  (residues 1 to 456)
  AUTHORS   Nair,S.C., Rimerman,R.A., Toran,E.J., Chen,S., Prapapanich,V.,
            Butts,R.N. and Smith,D.F.
  TITLE     Molecular cloning of human FKBP51 and comparisons of immunophilin
            interactions with Hsp90 and progesterone receptor
  JOURNAL   Mol Cell Biol 17 (2), 594-603 (1997)
   PUBMED   9001212
REFERENCE   8  (residues 1 to 456)
  AUTHORS   Yeh,W.C., Li,T.K., Bierer,B.E. and McKnight,S.L.
  TITLE     Identification and characterization of an immunophilin expressed
            during the clonal expansion phase of adipocyte differentiation
  JOURNAL   Proc Natl Acad Sci U S A 92 (24), 11081-11085 (1995)
   PUBMED   7479941
REFERENCE   9  (residues 1 to 456)
  AUTHORS   Baughman,G., Wiederrecht,G.J., Campbell,N.F., Martin,M.M. and
            Bourgeois,S.
  TITLE     FKBP51, a novel T-cell-specific immunophilin capable of calcineurin
            inhibition
  JOURNAL   Mol Cell Biol 15 (8), 4395-4402 (1995)
   PUBMED   7542743
REFERENCE   10 (residues 1 to 456)
  AUTHORS   Baughman,G., Harrigan,M.T., Campbell,N.F., Nurrish,S.J. and
            Bourgeois,S.
  TITLE     Genes newly identified as regulated by glucocorticoids in murine
            thymocytes
  JOURNAL   Mol Endocrinol 5 (5), 637-644 (1991)
   PUBMED   2072923
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY740772.1, BU613862.1, CF949740.1 and AC154912.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U16959.1, SRR7974084.6335.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.66 cM"
     Protein         1..456
                     /product="peptidyl-prolyl cis-trans isomerase FKBP5"
                     /EC_number="5.2.1.8"
                     /note="rotamase; 51 kDa FK506-binding protein; 51 kDa
                     FKBP; PPIase FKBP5"
                     /calculated_mol_wt=50835
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64378.1)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q13451; propagated from
                     UniProtKB/Swiss-Prot (Q64378.1)"
     Site            28
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q13451; propagated from
                     UniProtKB/Swiss-Prot (Q64378.1)"
     Region          44..135
                     /region_name="FKBP_C"
                     /note="FKBP-type peptidyl-prolyl cis-trans isomerase;
                     pfam00254"
                     /db_xref="CDD:459735"
     Site            155
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q13451; propagated from
                     UniProtKB/Swiss-Prot (Q64378.1)"
     Region          268..301
                     /region_name="TPR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64378.1)"
     Region          268..296
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          274..>403
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          317..350
                     /region_name="TPR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64378.1)"
     Region          319..345
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(321..322,325..326,328,352,355..356,359..360,
                     362..363,386,389..390,393..394,397)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          350..380
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          351..384
                     /region_name="TPR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64378.1)"
     Region          421..456
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64378.1)"
     Site            444
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13451; propagated from
                     UniProtKB/Swiss-Prot (Q64378.1)"
     CDS             1..456
                     /gene="Fkbp5"
                     /gene_synonym="D17Ertd592e; Dit1; FKBP-5; FKBP51"
                     /coded_by="NM_010220.4:220..1590"
                     /db_xref="CCDS:CCDS37528.1"
                     /db_xref="GeneID:14229"
                     /db_xref="MGI:MGI:104670"
ORIGIN      
        1 mttdegtsnn genpaatmte qgedittkkd rgvlkivkrv gtsdeapmfg dkvyvhykgm
       61 lsdgkkfdss hdrkkpfafs lgqgqvikaw digvstmkkg eichllckpe yaygsaghlq
      121 kipsnatlff eielldfkge dlfedsgvir rikrkgegys npnegatvkv hlegccggrt
      181 fdcrdvvfvv gegedhdipi gidkalvkmq reeqcilylg prygfgeagk pkfgidpnae
      241 lmyevtlksf ekakeswemd tkekltqaai vkekgtvyfk ggkytqaviq yrkivswlem
      301 eyglsekesk asesfllaaf lnlamcylkl reynkavecc dkalgldsan ekglyrrgea
      361 qllmndfesa kgdfekvlav npqnraarlq ismcqrkake hnerdrrvya nmfkkfaerd
      421 akeeaskags kkavegaagk qhesqameeg kakghv
//
