LOCUS       NM_010219               2212 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus FK506 binding protein 4 (Fkbp4), mRNA.
ACCESSION   NM_010219
VERSION     NM_010219.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2212)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2212)
  AUTHORS   Meduri,G., Guillemeau,K., Daguinot,C., Dounane,O., Genet,M.,
            Ferrara,L., Chambraud,B., Baulieu,E.E. and Giustiniani,J.
  TITLE     Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is an Early
            Feature of Different Human and Experimental Tauopathies
  JOURNAL   J Alzheimers Dis 94 (1), 313-331 (2023)
   PUBMED   37248902
  REMARK    GeneRIF: Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is
            an Early Feature of Different Human and Experimental Tauopathies.
REFERENCE   3  (bases 1 to 2212)
  AUTHORS   Kageyama,K., Iwasaki,Y., Watanuki,Y., Niioka,K. and Daimon,M.
  TITLE     Differential Effects of Fkbp4 and Fkbp5 on Regulation of the
            Proopiomelanocortin Gene in Murine AtT-20 Corticotroph Cells
  JOURNAL   Int J Mol Sci 22 (11), 5724 (2021)
   PUBMED   34072036
  REMARK    GeneRIF: Differential Effects of Fkbp4 and Fkbp5 on Regulation of
            the Proopiomelanocortin Gene in Murine AtT-20 Corticotroph Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2212)
  AUTHORS   Ruiz-Estevez,M., Staats,J., Paatela,E., Munson,D., Katoku-Kikyo,N.,
            Yuan,C., Asakura,Y., Hostager,R., Kobayashi,H., Asakura,A. and
            Kikyo,N.
  TITLE     Promotion of Myoblast Differentiation by Fkbp5 via Cdk4
            Isomerization
  JOURNAL   Cell Rep 25 (9), 2537-2551 (2018)
   PUBMED   30485818
REFERENCE   5  (bases 1 to 2212)
  AUTHORS   Young,M.J., Geiszler,P.C. and Pardon,M.C.
  TITLE     A novel role for the immunophilin FKBP52 in motor coordination
  JOURNAL   Behav Brain Res 313, 97-110 (2016)
   PUBMED   27418439
  REMARK    GeneRIF: Study demonstrates that FKBP52 by itself does not directly
            affect cognition and may play an indirect, modulatory role in the
            functional pathology of Alzheimer's disease, whereas it directly
            affects motor coordination, an early sign of neurodegenerative
            damages to the brain.
REFERENCE   6  (bases 1 to 2212)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   7  (bases 1 to 2212)
  AUTHORS   Coss,M.C., Winterstein,D., Sowder,R.C. 2nd and Simek,S.L.
  TITLE     Molecular cloning, DNA sequence analysis, and biochemical
            characterization of a novel 65-kDa FK506-binding protein (FKBP65)
  JOURNAL   J Biol Chem 270 (49), 29336-29341 (1995)
   PUBMED   7493967
REFERENCE   8  (bases 1 to 2212)
  AUTHORS   Schmitt,J., Pohl,J. and Stunnenberg,H.G.
  TITLE     Cloning and expression of a mouse cDNA encoding p59, an
            immunophilin that associates with the glucocorticoid receptor
  JOURNAL   Gene 132 (2), 267-271 (1993)
   PUBMED   7693550
REFERENCE   9  (bases 1 to 2212)
  AUTHORS   Alnemri,E.S., Fernandes-Alnemri,T., Nelki,D.S., Dudley,K.,
            DuBois,G.C. and Litwack,G.
  TITLE     Overexpression, characterization, and purification of a recombinant
            mouse immunophilin FKBP-52 and identification of an associated
            phosphoprotein
  JOURNAL   Proc Natl Acad Sci U S A 90 (14), 6839-6843 (1993)
   PUBMED   8341706
REFERENCE   10 (bases 1 to 2212)
  AUTHORS   Kuhner,M.K. and Goodenow,R.S.
  TITLE     DNA sequences of mouse H-2 and Qa genes
  JOURNAL   Immunogenetics 30 (6), 458-464 (1989)
   PUBMED   2592022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY280598.1, AK083912.1 and X17069.2.
            
            On Feb 23, 2018 this sequence version replaced NM_010219.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X17069.2, AK089972.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BY280598.1         6-30
            26-2190             AK083912.1         1-2165
            2191-2212           X17069.2           2030-2051
FEATURES             Location/Qualifiers
     source          1..2212
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.0 cM"
     gene            1..2212
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; FKBP52; FKPB52; p59"
                     /note="FK506 binding protein 4"
                     /db_xref="GeneID:14228"
                     /db_xref="MGI:MGI:95543"
     exon            1..251
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; FKBP52; FKPB52; p59"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1523
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; FKBP52; FKPB52; p59"
                     /EC_number="5.2.1.8"
                     /note="HBI; FKBP59; rotamase; HSP-binding immunophilin; 52
                     kDa FK506-binding protein; 52 kDa FKBP; PPIase FKBP4; 59
                     kDa immunophilin; immunophilin FKBP52"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP4"
                     /protein_id="NP_034349.1"
                     /db_xref="CCDS:CCDS20573.1"
                     /db_xref="GeneID:14228"
                     /db_xref="MGI:MGI:95543"
                     /translation="MTAEEMKAAENGAQSAPLPLEGVDISPKQDEGVLKVIKREGTGT
                     ETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEV
                     CHITCKPEYAYGAAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIRTRGEG
                     YARPNDGAMVEVALEGYHKDRLFDQRELCFEVGEGESLDLPCGLEEAIQRMEKGEHSI
                     VYLKPSYAFGSVGKERFQIPPHAELRYEVRLKSFEKAKESWEMSSAEKLEQSNIVKER
                     GTAYFKEGKYKQALLQYKKIVSWLEYESSFSGEEMQKVHALRLASHLNLAMCHLKLQA
                     FSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQ
                     LAVCQQRTRRQLAREKKLYANMFERLAEEEHKVKAEVAAGDHPTDAEMKGERNNVAEN
                     QSRVETEA"
     exon            252..396
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; FKBP52; FKPB52; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            397..539
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; FKBP52; FKPB52; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            540..660
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; FKBP52; FKPB52; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            661..817
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; FKBP52; FKPB52; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            818..908
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; FKBP52; FKPB52; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            909..992
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; FKBP52; FKPB52; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1178
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; FKBP52; FKPB52; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1418
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; FKBP52; FKPB52; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..2196
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; FKBP52; FKPB52; p59"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1636
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; FKBP52; FKPB52; p59"
     regulatory      2176..2181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; FKBP52; FKPB52; p59"
                     /note="hexamer: AATAAA"
     polyA_site      2196
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; FKBP52; FKPB52; p59"
                     /note="major polyA site"
ORIGIN      
        1 agccgggtgc gcgagcctgg agcgcggttc gaggtgggca gcgccgcctt ccgccgcacg
       61 ccgccccgtc gctcactccg gtcggcggcc agagtgccgt gctcgcgctt gccacactct
      121 cgcagccaac ggtgcgccca gcggccatga ccgccgagga gatgaaggcg gcggagaacg
      181 gggcgcagtc ggcgcccctg cctctcgaag gagtggacat cagccccaaa caggacgagg
      241 gcgtgctcaa ggtcatcaag agagagggta caggcacaga gacacccatg atcggggacc
      301 gagtctttgt ccactacact ggctggctgc tagatggcac aaagtttgac tccagtctgg
      361 accgcaagga caaattctcc tttgacctgg gaaaagggga ggtcatcaag gcttgggata
      421 ttgctgtggc aaccatgaaa gtgggggaag tgtgccacat cacctgcaag ccagaatatg
      481 cctatggcgc agcaggcagc cctccgaaga tcccccccaa cgccacactt gtatttgagg
      541 tggagctgtt tgagttcaaa ggagaagatc ttacagaaga agaagatggc gggatcatcc
      601 gcagaatacg gactcggggt gaaggctatg ccaggcccaa tgatggtgct atggtggaag
      661 tggccctgga aggctaccac aaggaccgcc tctttgacca gcgggagctc tgctttgaag
      721 tcggggaagg ggaaagtcta gatctgccct gtgggctgga ggaggccatt cagcgcatgg
      781 agaaaggaga gcattccatc gtgtacctca aacctagcta tgcttttggc agtgtgggga
      841 aggagaggtt ccagatccca ccgcacgctg agctgaggta tgaagtgcgg ctgaagagct
      901 ttgagaaggc caaggagtct tgggagatga gctccgcgga gaagctggag cagagcaaca
      961 tagtgaaaga gaggggcacc gcgtacttca aggaaggcaa gtacaagcag gcgttactgc
     1021 agtacaagaa gatcgtgtct tggctagaat acgagtctag cttctccggt gaggaaatgc
     1081 aaaaggtcca tgcactccga ctggcctcac acctcaatct ggccatgtgt cacctgaaac
     1141 tgcaggcctt ctcagctgcc atcgaaagct gcaacaaggc cttggagctg gacagcaaca
     1201 acgagaaggg cctgtttcgc cggggagagg cccacctggc cgtgaatgac tttgacctgg
     1261 caagagctga cttccaaaag gtcctgcagc tctatcccag caacaaagcc gccaagaccc
     1321 agctggctgt gtgccagcag cggacccgta ggcagctcgc ccgggaaaag aagctctatg
     1381 ccaacatgtt tgagaggctg gctgaggagg agcacaaggt gaaggcagaa gtggcagcag
     1441 gagaccatcc cactgatgct gagatgaagg gtgagcggaa caatgtggcc gagaaccagt
     1501 ctcgggtgga gacagaagcg tagcctgcct cttccgctgc ccacctctgc agctgctccc
     1561 tgctcccttc ttactccacc ctgttagttt tgtaaaaact gaagaatttt gagtgaatta
     1621 gacctttatt tttctatctg tttggatgat ggctttgggg gagaagggag aagagaaggc
     1681 tgagggtgaa atggggggta gttttagatg gtgtcaaccc tacttttctt cccccgttac
     1741 acacaagtgt atatcctttc acacgtacat cagaatgtta atttattttg ctccctctgt
     1801 tagctccatt ttcacgtggt agaagggggg acgtgatagg gatggggtct gataagccag
     1861 ggtggagaag aaaactcctg gacagccatt ttcccatctc ttccctctgt ggttttccaa
     1921 gcctgtgtct ccgtgcaggt gctaggggca tgggtacacc gctgttgcat ccattgcctc
     1981 tcttaccttg ctctcctgag ttggtattcc tgataacgcc ctctggtatc acagtgatca
     2041 cctctagaca gcccctacca gtacctccgc tcctctcagt ttcctcatcc aggttgtccc
     2101 tgtcctgtcc ctatcccctc agcctcttta atgcacgctg aaggtccagg cacacctcaa
     2161 gtcctgtgct tgagcaataa agtggaaaca acaaaaaaaa aaaaaaaaaa aa
//
