LOCUS       NM_013902                945 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus FK506 binding protein 3 (Fkbp3), mRNA.
ACCESSION   NM_013902
VERSION     NM_013902.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 945)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 945)
  AUTHORS   Cree,T., Gomez,T.R., Timpani,C.A., Rybalka,E., Price,J.T. and
            Goodman,C.A.
  TITLE     FKBP25 regulates myoblast viability and migration and is
            differentially expressed in in vivo models of muscle adaptation
  JOURNAL   FEBS J 290 (19), 4660-4678 (2023)
   PUBMED   37345229
  REMARK    GeneRIF: FKBP25 regulates myoblast viability and migration and is
            differentially expressed in in vivo models of muscle adaptation.
REFERENCE   3  (bases 1 to 945)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 945)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 945)
  AUTHORS   Jiang,Q., Wu,G., Yang,L., Lu,Y.P., Liu,X.X., Han,F., Deng,Y.P.,
            Fu,X.C., Liu,Q.B. and Lu,Y.M.
  TITLE     Elucidation of the FKBP25-60S Ribosomal Protein L7a Stress Response
            Signaling During Ischemic Injury
  JOURNAL   Cell Physiol Biochem 47 (5), 2018-2030 (2018)
   PUBMED   29969783
  REMARK    GeneRIF: findings reveal that the nuclear import of FKBP25 and
            binding with 60S ribosomal protein L7a are protective stress
            responses to ischemia/nitrosaive stress injury.
REFERENCE   6  (bases 1 to 945)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 945)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   8  (bases 1 to 945)
  AUTHORS   Ahn,J., Murphy,M., Kratowicz,S., Wang,A., Levine,A.J. and
            George,D.L.
  TITLE     Down-regulation of the stathmin/Op18 and FKBP25 genes following p53
            induction
  JOURNAL   Oncogene 18 (43), 5954-5958 (1999)
   PUBMED   10557083
REFERENCE   9  (bases 1 to 945)
  AUTHORS   Zambrowicz,B.P., Friedrich,G.A., Buxton,E.C., Lilleberg,S.L.,
            Person,C. and Sands,A.T.
  TITLE     Disruption and sequence identification of 2,000 genes in mouse
            embryonic stem cells
  JOURNAL   Nature 392 (6676), 608-611 (1998)
   PUBMED   9560157
REFERENCE   10 (bases 1 to 945)
  AUTHORS   Murphy,M., Hinman,A. and Levine,A.J.
  TITLE     Wild-type p53 negatively regulates the expression of a
            microtubule-associated protein
  JOURNAL   Genes Dev 10 (23), 2971-2980 (1996)
   PUBMED   8956998
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC159621.2.
            
            On Apr 28, 2007 this sequence version replaced NM_013902.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002122.2, AK145648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AC159621.2         89267-89390
            125-226             AC159621.2         93153-93254
            227-334             AC159621.2         94096-94203
            335-470             AC159621.2         96428-96563
            471-538             AC159621.2         97401-97468
            539-636             AC159621.2         99430-99527
            637-945             AC159621.2         100465-100773
FEATURES             Location/Qualifiers
     source          1..945
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 27.21 cM"
     gene            1..945
                     /gene="Fkbp3"
                     /gene_synonym="25kDa; FKBP-3; FKBP25"
                     /note="FK506 binding protein 3"
                     /db_xref="GeneID:30795"
                     /db_xref="MGI:MGI:1353460"
     exon            1..124
                     /gene="Fkbp3"
                     /gene_synonym="25kDa; FKBP-3; FKBP25"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..691
                     /gene="Fkbp3"
                     /gene_synonym="25kDa; FKBP-3; FKBP25"
                     /EC_number="5.2.1.8"
                     /note="FKBP-25; rotamase; 25 kDa FKBP; rapamycin-selective
                     25 kDa immunophilin; PPIase FKBP3; immunophilin FKBP25; 25
                     kDa FK506-binding protein"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP3"
                     /protein_id="NP_038930.1"
                     /db_xref="CCDS:CCDS25940.1"
                     /db_xref="GeneID:30795"
                     /db_xref="MGI:MGI:1353460"
                     /translation="MAAAVPQRAWTVEQLRSEQLPKKDIIKFLQDHGSDSFLAEHKLL
                     GNIKNVAKTANKDHLVNAYNHLFESKRFKGTETISKVSEQVKNVKLSDDKPKDSKSEE
                     TLDEGPPKYTKSILKKGDKTNFPKKGDVVHCWYTGTLPDGTVFDTNIQTSSKKKKNAK
                     PLSFKVGVGKVIRGWDEALLTMSKGEKARLEIEPEWAYGKKGQPDAKIPPNTKLIFEV
                     ELVDID"
     exon            125..226
                     /gene="Fkbp3"
                     /gene_synonym="25kDa; FKBP-3; FKBP25"
                     /inference="alignment:Splign:2.1.0"
     exon            227..334
                     /gene="Fkbp3"
                     /gene_synonym="25kDa; FKBP-3; FKBP25"
                     /inference="alignment:Splign:2.1.0"
     exon            335..470
                     /gene="Fkbp3"
                     /gene_synonym="25kDa; FKBP-3; FKBP25"
                     /inference="alignment:Splign:2.1.0"
     exon            471..538
                     /gene="Fkbp3"
                     /gene_synonym="25kDa; FKBP-3; FKBP25"
                     /inference="alignment:Splign:2.1.0"
     exon            539..636
                     /gene="Fkbp3"
                     /gene_synonym="25kDa; FKBP-3; FKBP25"
                     /inference="alignment:Splign:2.1.0"
     exon            637..945
                     /gene="Fkbp3"
                     /gene_synonym="25kDa; FKBP-3; FKBP25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      920..925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fkbp3"
                     /gene_synonym="25kDa; FKBP-3; FKBP25"
                     /note="hexamer: AATAAA"
     polyA_site      941
                     /gene="Fkbp3"
                     /gene_synonym="25kDa; FKBP-3; FKBP25"
                     /note="major polyA site"
ORIGIN      
        1 gcagcagcag gggaagatgg cggcggctgt tccgcagcgt gcatggaccg tggagcagct
       61 gcgcagcgag cagctgccca agaaggacat tatcaagttt ctgcaggatc acggttcaga
      121 ttcgtttctt gcagagcata aattactggg aaacatcaaa aatgttgcca agactgctaa
      181 taaggaccat ttggttaatg cctataacca tctttttgaa agtaagcgtt tcaagggtac
      241 tgaaactata agtaaagtgt ctgaacaggt gaaaaatgtg aagcttagtg acgacaaacc
      301 caaagactcc aagtctgaag agactcttga tgagggtcca ccaaaataca caaaatctat
      361 tctaaaaaag ggagataaaa ccaactttcc taaaaagggg gatgttgttc actgctggta
      421 tacagggaca ctcccagatg ggactgtttt tgatactaat attcaaacaa gttcaaagaa
      481 gaagaaaaat gccaaacctt taagttttaa ggtcggagta ggcaaggtta tcagaggatg
      541 ggatgaagcg ctcttgacta tgagtaaagg agaaaaggct cgactggaga tcgaaccaga
      601 atgggcctac ggaaagaaag gacagcccga tgccaaaatt ccaccaaaca ccaagctcat
      661 ttttgaagtg gaattagtag acattgactg aaaccagtac ttcagatcgg acatcagcaa
      721 acataaaaat gagctgtggc taattagagc ttgtaaggga agagtcaact ggaaaattta
      781 gagttaaagc ttgtttactt gatctcacat tttgagaaac ataatcctgt tactcccttt
      841 aagtctcaga tattttccta cagctatgta aagtattcca gagagctgct ttccttttac
      901 cttgtaaact agaagactca ataaaagtgt catggattgt cttga
//
