LOCUS       NM_016863                956 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus FK506 binding protein 1b (Fkbp1b), transcript variant
            1, mRNA.
ACCESSION   NM_016863
VERSION     NM_016863.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 956)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 956)
  AUTHORS   Mei,L., Zheng,Y.M., Song,T., Yadav,V.R., Joseph,L.C., Truong,L.,
            Kandhi,S., Barroso,M.M., Takeshima,H., Judson,M.A. and Wang,Y.X.
  TITLE     Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling
            and subsequent pulmonary hypertension through NF-kappaB/cyclin D1
            pathway
  JOURNAL   Nat Commun 11 (1), 3527 (2020)
   PUBMED   32669538
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 956)
  AUTHORS   Han,R.W., Liu,Z.P., Lin,H.R., Tian,A.W., Xiao,Y.F., Wei,J.,
            Deng,K.Y., Pan,B.X. and Xin,H.B.
  TITLE     Role of lateral amygdala calstabin2 in regulation of fear memory
  JOURNAL   Mol Brain 13 (1), 35 (2020)
   PUBMED   32151269
  REMARK    GeneRIF: Role of lateral amygdala calstabin2 in regulation of fear
            memory.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 956)
  AUTHORS   Xiao,Y.F., Zeng,Z.X., Guan,X.H., Wang,L.F., Wang,C.J., Shi,H.,
            Shou,W., Deng,K.Y. and Xin,H.B.
  TITLE     FKBP12.6 protects heart from AngII-induced hypertrophy through
            inhibiting Ca2+ /calmodulin-mediated signalling pathways in vivo
            and in vitro
  JOURNAL   J Cell Mol Med 22 (7), 3638-3651 (2018)
   PUBMED   29682889
  REMARK    GeneRIF: FKBP12.6 plays protective role in cardiac hypertrophy
            through inhibiting Ca(2+) /calmodulin-mediated signalling pathways.
REFERENCE   5  (bases 1 to 956)
  AUTHORS   Zhao,Y.T., Guo,Y.B., Gu,L., Fan,X.X., Yang,H.Q., Chen,Z., Zhou,P.,
            Yuan,Q., Ji,G.J. and Wang,S.Q.
  TITLE     Sensitized signalling between L-type Ca2+ channels and ryanodine
            receptors in the absence or inhibition of FKBP12.6 in
            cardiomyocytes
  JOURNAL   Cardiovasc Res 113 (3), 332-342 (2017)
   PUBMED   28077437
  REMARK    GeneRIF: The heart contraction is controlled by the Ca2+-induced
            Ca2+ release between L-type Ca2+ channels and ryanodine receptors.
            RyRs became more sensitive to Ca2+ triggers without FKBP12.6,
            leading to ventricular arrthymias.
REFERENCE   6  (bases 1 to 956)
  AUTHORS   Wehrens,X.H., Lehnart,S.E., Huang,F., Vest,J.A., Reiken,S.R.,
            Mohler,P.J., Sun,J., Guatimosim,S., Song,L.S., Rosemblit,N.,
            D'Armiento,J.M., Napolitano,C., Memmi,M., Priori,S.G., Lederer,W.J.
            and Marks,A.R.
  TITLE     FKBP12.6 deficiency and defective calcium release channel
            (ryanodine receptor) function linked to exercise-induced sudden
            cardiac death
  JOURNAL   Cell 113 (7), 829-840 (2003)
   PUBMED   12837242
  REMARK    GeneRIF: During exercise, RyR2 phosphorylation by protein kinase A
            dissociates FKBP12.6 from the channel, increasing Ca(2+) release
            and cardiac contractility. FKBP12.6(-/-) mice showed
            exercise-induced arrhythmias.
REFERENCE   7  (bases 1 to 956)
  AUTHORS   Xu,X., Su,B., Barndt,R.J., Chen,H., Xin,H., Yan,G., Chen,L.,
            Cheng,D., Heitman,J., Zhuang,Y., Fleischer,S. and Shou,W.
  TITLE     FKBP12 is the only FK506 binding protein mediating T-cell
            inhibition by the immunosuppressant FK506
  JOURNAL   Transplantation 73 (11), 1835-1838 (2002)
   PUBMED   12085010
REFERENCE   8  (bases 1 to 956)
  AUTHORS   Xin,H.B., Senbonmatsu,T., Cheng,D.S., Wang,Y.X., Copello,J.A.,
            Ji,G.J., Collier,M.L., Deng,K.Y., Jeyakumar,L.H., Magnuson,M.A.,
            Inagami,T., Kotlikoff,M.I. and Fleischer,S.
  TITLE     Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy
  JOURNAL   Nature 416 (6878), 334-338 (2002)
   PUBMED   11907581
  REMARK    GeneRIF: modulates cardiac excitation-contraction coupling
REFERENCE   9  (bases 1 to 956)
  AUTHORS   Datta,P.K., Chytil,A., Gorska,A.E. and Moses,H.L.
  TITLE     Identification of STRAP, a novel WD domain protein in transforming
            growth factor-beta signaling
  JOURNAL   J Biol Chem 273 (52), 34671-34674 (1998)
   PUBMED   9856985
REFERENCE   10 (bases 1 to 956)
  AUTHORS   Bennett,J.A., Clancy,Y.C. and McNeish,J.D.
  TITLE     Identification and characterization of the murine FK506 binding
            protein (FKBP) 12.6 gene
  JOURNAL   Mamm Genome 9 (12), 1069-1071 (1998)
   PUBMED   9880681
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CU468259.2 and CT025683.13.
            
            On Mar 11, 2020 this sequence version replaced NM_016863.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061121.1, AF060872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               CU468259.2         10087-10261         c
            176-223             CU468259.2         6857-6904           c
            224-336             CU468259.2         3427-3539           c
            337-819             CU468259.2         2001-2483           c
            820-956             CT025683.13        181999-182135       c
FEATURES             Location/Qualifiers
     source          1..956
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 2.09 cM"
     gene            1..956
                     /gene="Fkbp1b"
                     /gene_synonym="12.6kDa; calstabin2; FKBP12.6"
                     /note="FK506 binding protein 1b"
                     /db_xref="GeneID:14226"
                     /db_xref="MGI:MGI:1336205"
     exon            1..175
                     /gene="Fkbp1b"
                     /gene_synonym="12.6kDa; calstabin2; FKBP12.6"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..465
                     /gene="Fkbp1b"
                     /gene_synonym="12.6kDa; calstabin2; FKBP12.6"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peptidyl-prolyl cis-trans isomerase FKBP1B; FK506-binding
                     protein 12.6; FKBP-1B; rotamase; FKBP-12.6; 12.6 kDa FKBP;
                     PPIase FKBP1B; immunophilin FKBP12.6; FK506-binding
                     protein 1B; 12.6 kDa FK506-binding protein"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP1B
                     isoform 1"
                     /protein_id="NP_058559.3"
                     /db_xref="CCDS:CCDS25792.1"
                     /db_xref="GeneID:14226"
                     /db_xref="MGI:MGI:1336205"
                     /translation="MGVEIETISPGDGRTFPKKGQICVVHYTGMLQNGKKFDSSRDRN
                     KPFKFRIGKQEVIKGFEEGTAQMSLGQRAKLTCTPDVAYGATGHPGVIPPNATLIFDV
                     ELLSLE"
     exon            176..223
                     /gene="Fkbp1b"
                     /gene_synonym="12.6kDa; calstabin2; FKBP12.6"
                     /inference="alignment:Splign:2.1.0"
     exon            224..336
                     /gene="Fkbp1b"
                     /gene_synonym="12.6kDa; calstabin2; FKBP12.6"
                     /inference="alignment:Splign:2.1.0"
     exon            337..956
                     /gene="Fkbp1b"
                     /gene_synonym="12.6kDa; calstabin2; FKBP12.6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      925..930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fkbp1b"
                     /gene_synonym="12.6kDa; calstabin2; FKBP12.6"
                     /note="hexamer: AATAAA"
     polyA_site      956
                     /gene="Fkbp1b"
                     /gene_synonym="12.6kDa; calstabin2; FKBP12.6"
                     /note="major polyA site"
ORIGIN      
        1 gactccagcc gcacctcctc cggctctgca gtggcggcaa gaaggcgagc gggagtgcct
       61 gcggggtccg cgccagagcg gagccggggt cggggcagcc gcgaggaccc ccttggaggc
      121 ggggcctgtg ggaccgtgat gggcgtggag atcgagacca tctccccagg agacggaagg
      181 acattcccta agaagggtca gatatgtgtg gtgcactaca caggaatgct tcaaaatggc
      241 aagaaatttg attcatccag agacagaaac aaacctttca agttcagaat tggcaaacag
      301 gaagtcatca aaggctttga agaaggcact gcccagatga gcttggggca gagggcgaag
      361 ctgacctgca cccctgatgt ggcctatgga gctaccggcc accccggtgt catccctccc
      421 aatgccaccc tcatctttga cgtggagctg ctcagcttag agtgaaggca ggaaggaaat
      481 cgaggtggct ggagatggcc cctgctctgt cctagcctgc tctctctgcc actgggacgg
      541 ctcctcctat gtagggctct tgatcagtgt gctgacccca ccgcccctcc acattatctg
      601 tcctctctac ccatcgtgct ctctctgtgt cagccattta atcatcccca cacacctctg
      661 cttgagaaaa ccttagttca gatccagaca tttcagactg cacattttgt gtgatgcatg
      721 tagtagccat tcctgatcat aggacacaga tcttgtttgc acaatctata ttgccttacc
      781 tgcacttaag ccagacatac aaggtgctca gacatgtgct gtacatggtt acatggaggg
      841 acttgagcca gttacctttg ctgtcatttc ttatcttctg ttggctgctc actttaagca
      901 ctgccctctg gaaataatat gtaaaataaa ggctctgtac ttggcgtctt cctgtt
//
