LOCUS       NM_001378818             953 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus FK506 binding protein 1b (Fkbp1b), transcript variant
            4, mRNA.
ACCESSION   NM_001378818
VERSION     NM_001378818.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 953)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 953)
  AUTHORS   Mei,L., Zheng,Y.M., Song,T., Yadav,V.R., Joseph,L.C., Truong,L.,
            Kandhi,S., Barroso,M.M., Takeshima,H., Judson,M.A. and Wang,Y.X.
  TITLE     Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling
            and subsequent pulmonary hypertension through NF-kappaB/cyclin D1
            pathway
  JOURNAL   Nat Commun 11 (1), 3527 (2020)
   PUBMED   32669538
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 953)
  AUTHORS   Han,R.W., Liu,Z.P., Lin,H.R., Tian,A.W., Xiao,Y.F., Wei,J.,
            Deng,K.Y., Pan,B.X. and Xin,H.B.
  TITLE     Role of lateral amygdala calstabin2 in regulation of fear memory
  JOURNAL   Mol Brain 13 (1), 35 (2020)
   PUBMED   32151269
  REMARK    GeneRIF: Role of lateral amygdala calstabin2 in regulation of fear
            memory.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 953)
  AUTHORS   Xiao,Y.F., Zeng,Z.X., Guan,X.H., Wang,L.F., Wang,C.J., Shi,H.,
            Shou,W., Deng,K.Y. and Xin,H.B.
  TITLE     FKBP12.6 protects heart from AngII-induced hypertrophy through
            inhibiting Ca2+ /calmodulin-mediated signalling pathways in vivo
            and in vitro
  JOURNAL   J Cell Mol Med 22 (7), 3638-3651 (2018)
   PUBMED   29682889
  REMARK    GeneRIF: FKBP12.6 plays protective role in cardiac hypertrophy
            through inhibiting Ca(2+) /calmodulin-mediated signalling pathways.
REFERENCE   5  (bases 1 to 953)
  AUTHORS   Zhao,Y.T., Guo,Y.B., Gu,L., Fan,X.X., Yang,H.Q., Chen,Z., Zhou,P.,
            Yuan,Q., Ji,G.J. and Wang,S.Q.
  TITLE     Sensitized signalling between L-type Ca2+ channels and ryanodine
            receptors in the absence or inhibition of FKBP12.6 in
            cardiomyocytes
  JOURNAL   Cardiovasc Res 113 (3), 332-342 (2017)
   PUBMED   28077437
  REMARK    GeneRIF: The heart contraction is controlled by the Ca2+-induced
            Ca2+ release between L-type Ca2+ channels and ryanodine receptors.
            RyRs became more sensitive to Ca2+ triggers without FKBP12.6,
            leading to ventricular arrthymias.
REFERENCE   6  (bases 1 to 953)
  AUTHORS   Wehrens,X.H., Lehnart,S.E., Huang,F., Vest,J.A., Reiken,S.R.,
            Mohler,P.J., Sun,J., Guatimosim,S., Song,L.S., Rosemblit,N.,
            D'Armiento,J.M., Napolitano,C., Memmi,M., Priori,S.G., Lederer,W.J.
            and Marks,A.R.
  TITLE     FKBP12.6 deficiency and defective calcium release channel
            (ryanodine receptor) function linked to exercise-induced sudden
            cardiac death
  JOURNAL   Cell 113 (7), 829-840 (2003)
   PUBMED   12837242
  REMARK    GeneRIF: During exercise, RyR2 phosphorylation by protein kinase A
            dissociates FKBP12.6 from the channel, increasing Ca(2+) release
            and cardiac contractility. FKBP12.6(-/-) mice showed
            exercise-induced arrhythmias.
REFERENCE   7  (bases 1 to 953)
  AUTHORS   Xu,X., Su,B., Barndt,R.J., Chen,H., Xin,H., Yan,G., Chen,L.,
            Cheng,D., Heitman,J., Zhuang,Y., Fleischer,S. and Shou,W.
  TITLE     FKBP12 is the only FK506 binding protein mediating T-cell
            inhibition by the immunosuppressant FK506
  JOURNAL   Transplantation 73 (11), 1835-1838 (2002)
   PUBMED   12085010
REFERENCE   8  (bases 1 to 953)
  AUTHORS   Xin,H.B., Senbonmatsu,T., Cheng,D.S., Wang,Y.X., Copello,J.A.,
            Ji,G.J., Collier,M.L., Deng,K.Y., Jeyakumar,L.H., Magnuson,M.A.,
            Inagami,T., Kotlikoff,M.I. and Fleischer,S.
  TITLE     Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy
  JOURNAL   Nature 416 (6878), 334-338 (2002)
   PUBMED   11907581
  REMARK    GeneRIF: modulates cardiac excitation-contraction coupling
REFERENCE   9  (bases 1 to 953)
  AUTHORS   Datta,P.K., Chytil,A., Gorska,A.E. and Moses,H.L.
  TITLE     Identification of STRAP, a novel WD domain protein in transforming
            growth factor-beta signaling
  JOURNAL   J Biol Chem 273 (52), 34671-34674 (1998)
   PUBMED   9856985
REFERENCE   10 (bases 1 to 953)
  AUTHORS   Bennett,J.A., Clancy,Y.C. and McNeish,J.D.
  TITLE     Identification and characterization of the murine FK506 binding
            protein (FKBP) 12.6 gene
  JOURNAL   Mamm Genome 9 (12), 1069-1071 (1998)
   PUBMED   9880681
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CU468259.2 and CT025683.13.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3596473.1,
                                           ERR3363658.4102438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               CU468259.2         10087-10261         c
            176-288             CU468259.2         3427-3539           c
            289-816             CU468259.2         2001-2528           c
            817-953             CT025683.13        181999-182135       c
FEATURES             Location/Qualifiers
     source          1..953
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 2.09 cM"
     gene            1..953
                     /gene="Fkbp1b"
                     /gene_synonym="12.6kDa; calstabin2; FKBP12.6"
                     /note="FK506 binding protein 1b"
                     /db_xref="GeneID:14226"
                     /db_xref="MGI:MGI:1336205"
     exon            1..175
                     /gene="Fkbp1b"
                     /gene_synonym="12.6kDa; calstabin2; FKBP12.6"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..333
                     /gene="Fkbp1b"
                     /gene_synonym="12.6kDa; calstabin2; FKBP12.6"
                     /EC_number="5.2.1.8"
                     /note="isoform 4 is encoded by transcript variant 4;
                     peptidyl-prolyl cis-trans isomerase FKBP1B; FK506-binding
                     protein 12.6; FKBP-1B; rotamase; FKBP-12.6; 12.6 kDa FKBP;
                     PPIase FKBP1B; immunophilin FKBP12.6; FK506-binding
                     protein 1B; 12.6 kDa FK506-binding protein"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP1B
                     isoform 4"
                     /protein_id="NP_001365747.1"
                     /db_xref="GeneID:14226"
                     /db_xref="MGI:MGI:1336205"
                     /translation="MGVEIETISPGDGMLQNGKKFDSSRDRNKPFKFRIGKQEVIKGF
                     EEGTAQLGPLSPLPICPHPC"
     exon            176..288
                     /gene="Fkbp1b"
                     /gene_synonym="12.6kDa; calstabin2; FKBP12.6"
                     /inference="alignment:Splign:2.1.0"
     exon            289..953
                     /gene="Fkbp1b"
                     /gene_synonym="12.6kDa; calstabin2; FKBP12.6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      922..927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fkbp1b"
                     /gene_synonym="12.6kDa; calstabin2; FKBP12.6"
                     /note="hexamer: AATAAA"
     polyA_site      953
                     /gene="Fkbp1b"
                     /gene_synonym="12.6kDa; calstabin2; FKBP12.6"
                     /note="major polyA site"
ORIGIN      
        1 gactccagcc gcacctcctc cggctctgca gtggcggcaa gaaggcgagc gggagtgcct
       61 gcggggtccg cgccagagcg gagccggggt cggggcagcc gcgaggaccc ccttggaggc
      121 ggggcctgtg ggaccgtgat gggcgtggag atcgagacca tctccccagg agacggaatg
      181 cttcaaaatg gcaagaaatt tgattcatcc agagacagaa acaaaccttt caagttcaga
      241 attggcaaac aggaagtcat caaaggcttt gaagaaggca ctgcccagct gggtcctctt
      301 tctcctctcc ccatctgccc ccatccctgc tagatgagct tggggcagag ggcgaagctg
      361 acctgcaccc ctgatgtggc ctatggagct accggccacc ccggtgtcat ccctcccaat
      421 gccaccctca tctttgacgt ggagctgctc agcttagagt gaaggcagga aggaaatcga
      481 ggtggctgga gatggcccct gctctgtcct agcctgctct ctctgccact gggacggctc
      541 ctcctatgta gggctcttga tcagtgtgct gaccccaccg cccctccaca ttatctgtcc
      601 tctctaccca tcgtgctctc tctgtgtcag ccatttaatc atccccacac acctctgctt
      661 gagaaaacct tagttcagat ccagacattt cagactgcac attttgtgtg atgcatgtag
      721 tagccattcc tgatcatagg acacagatct tgtttgcaca atctatattg ccttacctgc
      781 acttaagcca gacatacaag gtgctcagac atgtgctgta catggttaca tggagggact
      841 tgagccagtt acctttgctg tcatttctta tcttctgttg gctgctcact ttaagcactg
      901 ccctctggaa ataatatgta aaataaaggc tctgtacttg gcgtcttcct gtt
//
