LOCUS       NM_008019               1667 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus FK506 binding protein 1a (Fkbp1a), transcript variant
            1, mRNA.
ACCESSION   NM_008019
VERSION     NM_008019.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1667)
  AUTHORS   Lee,C.S., Jung,S.Y., Yee,R.S.Z., Agha,N.H., Hong,J., Chang,T.,
            Babcock,L.W., Fleischman,J.D., Clayton,B., Hanna,A.D., Ward,C.S.,
            Lanza,D., Hurley,A.E., Zhang,P., Wehrens,X.H.T., Lagor,W.R.,
            Rodney,G.G. and Hamilton,S.L.
  TITLE     Speg interactions that regulate the stability of
            excitation-contraction coupling protein complexes in triads and
            dyads
  JOURNAL   Commun Biol 6 (1), 942 (2023)
   PUBMED   37709832
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1667)
  AUTHORS   Pettinato,M., Dulja,A., Colucci,S., Furiosi,V., Fette,F.,
            Steinbicker,A.U., Muckenthaler,M.U., Nai,A., Pagani,A. and
            Silvestri,L.
  TITLE     FKBP12 inhibits hepcidin expression by modulating BMP receptors
            interaction and ligand responsiveness in hepatocytes
  JOURNAL   Am J Hematol 98 (8), 1223-1235 (2023)
   PUBMED   37199280
  REMARK    GeneRIF: FKBP12 inhibits hepcidin expression by modulating BMP
            receptors interaction and ligand responsiveness in hepatocytes.
REFERENCE   3  (bases 1 to 1667)
  AUTHORS   Battaglino,R.A., Jha,P., Sultana,F., Liu,W. and Morse,L.R.
  TITLE     FKBP12: A partner of Snx10 required for vesicular trafficking in
            osteoclasts
  JOURNAL   J Cell Biochem 120 (8), 13321-13329 (2019)
   PUBMED   30887568
  REMARK    GeneRIF: FKBP12: A partner of Snx10 required for vesicular
            trafficking in osteoclasts.
REFERENCE   4  (bases 1 to 1667)
  AUTHORS   Pan,Z., Ai,T., Chang,P.C., Liu,Y., Liu,J., Maruyama,M., Homsi,M.,
            Fishbein,M.C., Rubart,M., Lin,S.F., Xiao,D., Chen,H., Chen,P.S.,
            Shou,W. and Li,B.Y.
  TITLE     Atrial fibrillation and electrophysiology in transgenic mice with
            cardiac-restricted overexpression of FKBP12
  JOURNAL   Am J Physiol Heart Circ Physiol 316 (2), H371-H379 (2019)
   PUBMED   30499712
  REMARK    GeneRIF: cardiomyocyte-restricted overexpression of FKBP12 reduces
            the atrial Nav1.5 expression level and mean peak INa, which is
            associated with increased peak L-type Ca(2+) current and
            interstitial fibrosis in atria. The combined electrophysiological
            and structural changes facilitated the development of local
            conduction block and altered action potential duration and
            spontaneous AF.
            Erratum:[Am J Physiol Heart Circ Physiol. 2019 Apr 1;316(4):H938.
            doi: 10.1152/ajpheart.zh4-2716-corr.2019.. PMID: 30946606]
REFERENCE   5  (bases 1 to 1667)
  AUTHORS   Colucci,S., Pagani,A., Pettinato,M., Artuso,I., Nai,A.,
            Camaschella,C. and Silvestri,L.
  TITLE     The immunophilin FKBP12 inhibits hepcidin expression by binding the
            BMP type I receptor ALK2 in hepatocytes
  JOURNAL   Blood 130 (19), 2111-2120 (2017)
   PUBMED   28864813
  REMARK    GeneRIF: Acute tacrolimus treatment transiently increases hepcidin
            in wild-type mice. FKBP12 preferentially targets the BMP receptor
            ALK2. ALK2 mutants defective in binding FKBP12 increase hepcidin
            expression in a ligand-independent manner, through BMP-SMAD
            signaling.
REFERENCE   6  (bases 1 to 1667)
  AUTHORS   Poon,M., Marx,S.O., Gallo,R., Badimon,J.J., Taubman,M.B. and
            Marks,A.R.
  TITLE     Rapamycin inhibits vascular smooth muscle cell migration
  JOURNAL   J Clin Invest 98 (10), 2277-2283 (1996)
   PUBMED   8941644
REFERENCE   7  (bases 1 to 1667)
  AUTHORS   Marks,A.R.
  TITLE     Cellular functions of immunophilins
  JOURNAL   Physiol Rev 76 (3), 631-649 (1996)
   PUBMED   8757784
  REMARK    Review article
REFERENCE   8  (bases 1 to 1667)
  AUTHORS   Paterson,J.M., Smith,S.M., Harmar,A.J. and Antoni,F.A.
  TITLE     Control of a novel adenylyl cyclase by calcineurin
  JOURNAL   Biochem Biophys Res Commun 214 (3), 1000-1008 (1995)
   PUBMED   7575502
REFERENCE   9  (bases 1 to 1667)
  AUTHORS   Hendrickson,B.A., Zhang,W., Craig,R.J., Jin,Y.J., Bierer,B.E.,
            Burakoff,S. and DiLella,A.G.
  TITLE     Structural organization of the genes encoding human and murine
            FK506-binding protein (FKBP) 13 and comparison to FKBP1
  JOURNAL   Gene 134 (2), 271-275 (1993)
   PUBMED   7505249
REFERENCE   10 (bases 1 to 1667)
  AUTHORS   Nelson,P.A., Lippke,J.A., Murcko,M.A., Rosborough,S.L. and
            Peattie,D.A.
  TITLE     cDNA encoding murine FK506-binding protein (FKBP): nucleotide and
            deduced amino acid sequence
  JOURNAL   Gene 109 (2), 255-258 (1991)
   PUBMED   1722474
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ081656.1, BY108774.1,
            BY065108.1, AK169242.1 and BE945323.1.
            
            On Sep 26, 2014 this sequence version replaced NM_008019.2.
            
            Summary: This gene is a member of the immunophilin family. The
            encoded protein is a cis-trans prolyl isomerase that binds the
            immunosuppressants FK506 and rapamycin, and is associated with
            immunoregulation, protein folding, receptor signaling, protein
            trafficking and T-cell activation. It may modulate the calcium
            release activity of the ryanodine receptor Ryr1. It also interacts
            with the type I TGF-beta receptor. Disruption of this gene in mouse
            causes severe ventricular defects. Pseudogenes of this gene have
            been defined on chromosomes 4, 10, 14, and 16. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Sep
            2014].
            
            Transcript Variant: This variant (1) encodes isoform 1. Variants 1
            and 2 both encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X60203.1, SRR1660811.86494.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 CJ081656.1         1-4
            5-60                BY108774.1         1-56
            61-61               BY065108.1         45-45
            62-104              BY108774.1         58-100
            105-1656            AK169242.1         2-1553
            1657-1667           BE945323.1         7-17                c
FEATURES             Location/Qualifiers
     source          1..1667
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.83 cM"
     gene            1..1667
                     /gene="Fkbp1a"
                     /gene_synonym="Fkbp; Fkbp1; FKBP12"
                     /note="FK506 binding protein 1a"
                     /db_xref="GeneID:14225"
                     /db_xref="MGI:MGI:95541"
     exon            1..262
                     /gene="Fkbp1a"
                     /gene_synonym="Fkbp; Fkbp1; FKBP12"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..552
                     /gene="Fkbp1a"
                     /gene_synonym="Fkbp; Fkbp1; FKBP12"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A;
                     FK506 binding protein 12; immunophilin FKBP12;
                     calstabin-1"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP1A
                     isoform 1"
                     /protein_id="NP_032045.1"
                     /db_xref="CCDS:CCDS16869.1"
                     /db_xref="GeneID:14225"
                     /db_xref="MGI:MGI:95541"
                     /translation="MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRN
                     KPFKFTLGKQEVIRGWEEGVAQMSVGQRAKLIISSDYAYGATGHPGIIPPHATLVFDV
                     ELLKLE"
     exon            263..310
                     /gene="Fkbp1a"
                     /gene_synonym="Fkbp; Fkbp1; FKBP12"
                     /inference="alignment:Splign:2.1.0"
     exon            311..423
                     /gene="Fkbp1a"
                     /gene_synonym="Fkbp; Fkbp1; FKBP12"
                     /inference="alignment:Splign:2.1.0"
     exon            424..586
                     /gene="Fkbp1a"
                     /gene_synonym="Fkbp; Fkbp1; FKBP12"
                     /inference="alignment:Splign:2.1.0"
     exon            587..1657
                     /gene="Fkbp1a"
                     /gene_synonym="Fkbp; Fkbp1; FKBP12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      774..779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fkbp1a"
                     /gene_synonym="Fkbp; Fkbp1; FKBP12"
                     /note="hexamer: CATAAA"
     polyA_site      794
                     /gene="Fkbp1a"
                     /gene_synonym="Fkbp; Fkbp1; FKBP12"
     regulatory      1628..1633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fkbp1a"
                     /gene_synonym="Fkbp; Fkbp1; FKBP12"
                     /note="hexamer: AATAAA"
     polyA_site      1657
                     /gene="Fkbp1a"
                     /gene_synonym="Fkbp; Fkbp1; FKBP12"
                     /note="major polyA site"
ORIGIN      
        1 ttccggtccc tccgcctagc tgccccgctt cagggatgtg agcgcctcgc gcaaataggg
       61 cggggcgtgc cgtgcggtgc ggtgcgcgtg cgcaggagcc acgagaggga cgaagccgaa
      121 cctctgaacc gccgccaggt ccgctccggc tccacgccgc ccgtcgcgcc gccacccgcg
      181 tccttttcct cctcctccgc caacgccgcc gccgccgccg ccgccatggg agtgcaggtg
      241 gagaccatct ctcctggaga cgggcgcacc ttcccaaagc gcggccagac ctgcgtggtg
      301 cactacacgg ggatgcttga agatggaaag aaatttgatt cctctcggga cagaaacaag
      361 ccttttaagt ttacactagg caagcaggag gtgatccgag gctgggagga aggggtagcc
      421 cagatgagtg tgggtcagag agccaaactg ataatctcct cagactatgc ctatggagcc
      481 accgggcacc caggcatcat cccaccacat gccactcttg tttttgatgt ggagcttcta
      541 aaactggaat gacagaagtg gcctcctccc ttagctctgc acgtggatct gccatggagg
      601 aatctggtac ctccagatgg gtgcacatga atccatgggg agctcttcct gacgtcccac
      661 caccctttgt atagacacct acccgactga atgtgttccg tcactcagct ttgcttcgga
      721 cacctccatg tcctcttccc ccctctgtat gtgtgttgac ctaaactata tgccataaac
      781 ctcaagttac tttattttgg ggtgaagact cagtttctgt ttcagatcta agtttccaat
      841 gaagtatatt gtcaagtgtt aacagcacaa gcgatgggtt aacttagaat agaaattggt
      901 gttggggggg gatttgcaag aatttttatt ttattttatt ttaatttttt ggatgaaaat
      961 tttatctatt atatattaag acattctgct gctgtgctgc aaagccatag cagattcgag
     1021 atgctgttga gggctggatt tttctctagt gagggaggtc ctgttaaact gaaagcccta
     1081 cccaaactga ggtgggaagg aagcggggga gagagccttg gcttctgaca gtccttccac
     1141 cttctgaaac tagctgcctt ttaaagcaga tcccttcact gctatgttgg acactacagt
     1201 atctgtccct gggttggcag agacttgaaa gcctttgtga cctggcttaa tttgtttttc
     1261 atcctatggt ttttctaatg gattttctgg acttttgtaa tcttgtaact attcaagctc
     1321 cactttctaa attttaagaa cttcagtgga aagtttaaat tgaaggtgct gtttgtagac
     1381 tcaccaccca acggacgccc agccaccacg gcaaatcctt gagtgttctc taagaatacg
     1441 atgctggtca tcacagcttc agcatctcct gggttttgat gcttggctct ttgctgatct
     1501 tggcttcctg gcttttcctc cttcagttcc ttctcaccct ctgctgtcct tgtgtagtga
     1561 tttggtgaga gaaagctttt gtcccctgcc ctctgcacta catatgcggt tcaagtttta
     1621 ttattgcaat aaaagtgctt tatgctggct tttctcaaaa aaaaaaa
//
