LOCUS       NM_001045528            4411 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus FK506 binding protein 15 (Fkbp15), transcript variant
            1, mRNA.
ACCESSION   NM_001045528 XM_485391 XM_982256
VERSION     NM_001045528.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4411)
  AUTHORS   Tyrrell BJ, Woodham EF, Spence HJ, Strathdee D, Insall RH and
            Machesky LM.
  TITLE     Loss of strumpellin in the melanocytic lineage impairs the WASH
            Complex but does not affect coat colour
  JOURNAL   Pigment Cell Melanoma Res 29 (5), 559-571 (2016)
   PUBMED   27390154
REFERENCE   2  (bases 1 to 4411)
  AUTHORS   Nakajima O, Nakamura F, Yamashita N, Tomita Y, Suto F, Okada T,
            Iwamatsu A, Kondo E, Fujisawa H, Takei K and Goshima Y.
  TITLE     FKBP133: a novel mouse FK506-binding protein homolog alters growth
            cone morphology
  JOURNAL   Biochem Biophys Res Commun 346 (1), 140-149 (2006)
   PUBMED   16756961
  REMARK    GeneRIF: FKBP133 contains a domain similar to Wiskott-Aldrich
            syndrome protein homology region 1 (WH1) and a domain homologous to
            FK506-binding protein motif.
REFERENCE   3  (bases 1 to 4411)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S,
            Nakajima D, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   4  (bases 1 to 4411)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ044507.1, AK049509.1 and BC060651.1.
            
            [WARNING] On Jan 19, 2024 this sequence was replaced by
            NM_001045528.3.
            
            On Sep 15, 2017 this sequence version replaced NM_001045528.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060651.1, SRR9219380.69058.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                CJ044507.1         2-49
            49-134              AK049509.1         2-87
            135-4411            BC060651.1         1-4277
FEATURES             Location/Qualifiers
     source          1..4411
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.08 cM"
     gene            1..4411
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /note="FK506 binding protein 15"
                     /db_xref="GeneID:338355"
                     /db_xref="MGI:MGI:2444782"
     exon            1..227
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..3825
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 1; WAFL;
                     FK506-binding protein 133; 133 kDa FKBP; 133 kDa
                     FK506-binding protein"
                     /codon_start=1
                     /product="FK506-binding protein 15 isoform 1"
                     /protein_id="NP_001038993.1"
                     /db_xref="CCDS:CCDS51201.1"
                     /db_xref="GeneID:338355"
                     /db_xref="MGI:MGI:2444782"
                     /translation="MFGAGDEDDTDFLSPSGGAKLASLFGLDQATMGHGNEFFQYTAP
                     KQPKKGQGTAAGNQTAPKPAPATTGTSSVLFATAVHAYRYINGQYAKQGKFGAAVLGN
                     HTSREYRILLYISQQQPVTVATIHLNFELMVRPNNYSTFYDDQRQNWSIMFESEKAAV
                     SFNKQVCVAKCNSISSLDAVLCQDLVAAEGPAVETGDSLEVAYTGWLLQNHVLGQVFD
                     STANKDKPLRLKLGSGKVVKGLEDGLLGMKKGGKRLIITPSACAAGSEGVIGWTQPTD
                     SILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPASDSLSADPVVTPLPLPLKPG
                     EPGLRSKSNSLSEQLTVNSNPDTVKAKLISRMAKMGQPMLPILPPQLDSNDSETEDAT
                     VLRGAGQSLVTPSIQPSLQPAHPVLPQMASQAPQPSGSGLQTPSAALMQAVSLDSHSA
                     VSGNAQNFQPYAGVQAYAYPQTPSVTSQLQPVRPLYPAPLSQAPHFQGSGDMMSFLMT
                     EARQHNTEIRMAVNKVADKMDHLMTKVEELQKHSSGNSMLLPSMSVTMETSMIMSNIQ
                     RIIQENERLKQELLEKSSRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQTATEN
                     TQARILHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLR
                     GHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKN
                     LSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTLAQAE
                     LQSQWEAKCEQLLASARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQIAAFTEQ
                     KEHMQRLEKTKSQAPAGRAAADPSEKVKKIMNQVFQSLRGEFELEESYDGGTILRTIM
                     HTIKMVTLQLLNHQEEEEEEEEEEEEEKKPLRPSLEQPGPATPGMPPAPPSGETQEAP
                     EVLPEQVVGETTPLPLQALPTPENGAQTRKGEPAEAEVPSEIKDSSLPPQPAGIPAHR
                     VLGPPTSIPPKPPGPVTMDSESEEMLAADQRTVQPNGLLGEEHVREVATDGLLQGNSR
                     RLSLTPDPEKGEPPALDPESQGGEAQPPECKQAEDVSSSGPRETLLDTELASAAAGTS
                     LRHNQDSQHCSLSGDEEDELFKGATLKVPRPTAQPEEEDEDEVSMKGRPPPTPLFGDD
                     DDDDDDDIGWLG"
     exon            228..340
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            341..425
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            426..495
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            496..570
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            571..669
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            670..819
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            820..888
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1035
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1175
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1233
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1341
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1444
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1551
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1666
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1776
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1884
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1979
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2082
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2254
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2391
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2547
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2700
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2820
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2928
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3644
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            3645..3741
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
     exon            3742..4390
                     /gene="Fkbp15"
                     /gene_synonym="C430014M02Rik; FKBO133; FKBP-133; FKBP-15;
                     FKBP133; mKIAA0674"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttgccttt gctccacctc ctccaccgct gggtctcctc tgggcctcac taccctgaga
       61 gagtttgtcc tgccggaaag cagctcgccg ccacggcgtt ttacgttacc ggcggtgaca
      121 ggccctggga acatccaact tcctcctccc ttcagctggg cgaaagccga cgtgatgttc
      181 ggtgccggag acgaggatga caccgacttc ctctcgccaa gcggcggagc taagctggct
      241 tctctttttg gactggatca agcaactatg ggccatggaa atgaattctt ccagtacaca
      301 gccccaaagc aacctaagaa aggccaggga acagcagcag gaaatcagac agcaccaaag
      361 ccagccccag ctaccacagg cacgtcctca gtgctgtttg ccactgcagt gcatgcatac
      421 cgctacataa atggtcaata tgcaaagcag ggcaaatttg gagcggctgt cctggggaac
      481 cacacaagca gagagtatag gattcttctt tacatcagtc agcagcagcc agtgactgtt
      541 gctacaattc atctgaactt tgagctaatg gttcggccca ataactacag caccttttat
      601 gatgaccaga gacaaaactg gtctatcatg tttgagtcag agaaggccgc tgtgtcattc
      661 aataaacagg tgtgtgtggc caagtgcaat agcatctctt ccttggatgc agtgctgtgt
      721 caggacctgg ttgcagcaga gggccctgct gtggaaactg gagattcttt agaagtagcc
      781 tatacgggct ggctccttca gaatcatgtg ctgggccagg tttttgattc tactgctaac
      841 aaagataagc cgcttcgcct aaaattagga tcaggaaaag ttgtcaaggg cttagaggac
      901 gggctactgg gcatgaagaa aggaggaaag cgcttaatta tcactccttc agcctgcgct
      961 gctggctctg aaggagtaat aggctggact cagccaacag actccatcct ggtgtttgag
     1021 gtagaagtta ggcgggtgaa gtttgccaga gattctggct ctgatggcca cagtgtgagc
     1081 tcccgggatt ctgcagcccc ttcccccatc cctgcttctg acagcctctc tgctgatcct
     1141 gttgtgacac ccctgccatt gcctctcaaa cctggggaac cgggtcttcg ttccaaatct
     1201 aactctctca gcgaacagct aactgtaaat tcaaatcctg atacggtcaa ggccaagctg
     1261 atctcgagga tggctaaaat gggccagccc atgctaccca tccttccgcc acagctggac
     1321 tccaatgact cagaaaccga agatgcaact gttctgcgag gagctgggca gtcccttgtg
     1381 acaccatcta tccagccttc tcttcagcca gctcatccgg tattaccaca gatggcctca
     1441 caggcacctc agccatctgg ttctgggctc cagacaccct ctgctgcctt gatgcaagct
     1501 gtgtcccttg attctcactc ggctgtatct ggaaatgcac agaacttcca gccctatgca
     1561 ggtgtgcaag cctatgcata tccccagaca ccctcagtta cttcccagct gcagcctgtt
     1621 cggcccttgt acccagcacc actgtcccag gctccccact ttcaaggatc aggagacatg
     1681 atgtcctttc tcatgactga agcccggcaa cacaacactg aaattcgaat ggcagtcaac
     1741 aaagtggctg ataaaatgga tcacctcatg actaaggtgg aggagttaca gaagcatagc
     1801 tctggcaact ccatgcttct tcctagcatg tcggtcacaa tggaaacaag catgattatg
     1861 agcaacatcc agcgcatcat ccaggaaaat gagagactga agcaggagct ccttgagaaa
     1921 agcagtcgga tagaagagca gaatgacaag attagtgacc tcattgaacg caaccagaga
     1981 tatgttgagc agagtaacct gatgatggag aagaggaaca actcgcttca aacagccaca
     2041 gaaaacacac aggcaagaat attgcatgct gaacaagaga aggccaaggt aacagaagag
     2101 ttagcagcag ctactgcaca ggtgtctcac ctgcagctga aaatgacggc tcaccagaag
     2161 aaggagacag aattgcagtt gcagctgaca gacaacttga aggagacaga tcttctcagg
     2221 ggccacgtca ccaggctcca ggctgacctc tcggagctcc gagaagcctc tgagcaaaca
     2281 cagaccaaat tcaaaagtga aaagcagagc cggcggcagc tggagctcaa ggtaacatcc
     2341 ctggaggaag agctgactga cctccgagct gagaagacct cccttgaaaa gaacctctca
     2401 gagaggaaaa agaagtcagc tcaggagcgc tgccaggcgg aggcagagat ggacgagatt
     2461 cgcaagtcac accaggagga actggacaga cttcggcagc tcttgaaaaa ggctcgggtg
     2521 tccacagacc aagcagctgc agagcagctg actcttgcac aggctgagct gcagagccag
     2581 tgggaggcta agtgtgagca gcttttggcc tctgcaagag atgaacacct gcagcaatac
     2641 cgagaagtgt gcgcgcagag ggatgcccat caacagaagc tggctctcct tcaggatgag
     2701 tgcttagctc tccaggccca gatcgcagcc ttcactgaac agaaggaaca catgcagcga
     2761 ctggagaaga ctaagtccca ggcacctgca ggcagagctg ctgctgaccc ctcagagaag
     2821 gtcaagaaga tcatgaacca ggtgttccag tcactgaggg gagagtttga gctggaggaa
     2881 tcttatgatg gagggaccat tctgaggacc atcatgcata caattaagat ggtgacgctg
     2941 cagctgttga accatcagga ggaagaggag gaagaggaag aggaggagga agaggagaag
     3001 aagcccctga gaccttccct ggagcagcca ggccctgcca ccccggggat gcctccagca
     3061 cccccaagtg gggagacgca ggaggctccc gaggtgctgc cagaacaggt agtaggggag
     3121 accaccccac tgcctctaca ggctctcccc acgccagaga atggtgcaca gacaaggaaa
     3181 ggggagcccg cagaagcgga ggtaccttca gaaatcaaag acagttctct cccacctcag
     3241 ccagctggca tcccagctca cagagtcctg gggcccccga cttcaatccc acctaaacct
     3301 ccaggacctg taactatgga ctctgagtct gaggagatgc ttgctgctga ccagagaaca
     3361 gtgcagccca atggcttgtt gggagaagaa catgtcaggg aagtagccac agatggtcta
     3421 ctgcaaggca actccaggag attgtcactg actccagacc ctgagaaggg agagccacca
     3481 gccttagacc ctgaaagcca aggaggagaa gctcagcctc ctgagtgcaa acaagctgag
     3541 gatgttagta gctctggtcc ccgtgagacg ctgttagaca cagagcttgc ttcagcagct
     3601 gcagggacat ccctcaggca caaccaggac tcccagcact gcagtctctc tggagatgaa
     3661 gaggacgagc tgtttaaagg agcgactctg aaagttccga ggcccacagc ccagcctgag
     3721 gaggaggatg aagatgaggt gagcatgaag ggacgcccgc ctccaacccc cctttttgga
     3781 gacgatgatg atgatgatga cgatgacatt ggctggctgg ggtgaagacc taggaagcag
     3841 gcatgcaggc ttcccgccca gcccttccct aagcatgggt ttgcacagct gtctaggtga
     3901 gcctcagggt gcagtcctgg tgaacattct gagatagtgg ttcagggctc tgagttagct
     3961 gccatctgag cccccacctg acctgctgaa gaggatcatg aggctgtctg cagaactgct
     4021 gttgtaacag ccctcagtga gtaactctac catggaggaa gggctgggag ggtcacctgc
     4081 agccagtcac aagcatcctg ccatctctcc caaggttttc ttatcattca ttctcaagtt
     4141 gacctggaag ccctcctgct ctcccagggc tcatcagaac tgctgcgaca gggtcaggac
     4201 ccttagggga gtcctcaaca gagaactaag agaccaatca tggtggccta gcctgtggtt
     4261 ctgggacatg tatcttctct ctctgcctta aatcttctaa aagaggtcaa tgggtatttg
     4321 aaactaacaa gactaaaata ataaaacttg actcaggccc ttgaggggaa actgagtttg
     4381 gtttccagga aaaaaaaaaa aaaaaaaaaa a
//
