LOCUS       NM_024169                736 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus FK506 binding protein 11 (Fkbp11), transcript variant
            1, mRNA.
ACCESSION   NM_024169
VERSION     NM_024169.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 736)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 736)
  AUTHORS   Karin,M.
  TITLE     Diabesity? No worries, FKBP11 to the rescue
  JOURNAL   Cell Metab 34 (7), 942-944 (2022)
   PUBMED   35793657
  REMARK    GeneRIF: Diabesity? No worries, FKBP11 to the rescue.
REFERENCE   3  (bases 1 to 736)
  AUTHORS   Herrema,H., Guan,D., Choi,J.W., Feng,X., Salazar Hernandez,M.A.,
            Faruk,F., Auen,T., Boudett,E., Tao,R., Chun,H. and Ozcan,U.
  TITLE     FKBP11 rewires UPR signaling to promote glucose homeostasis in type
            2 diabetes and obesity
  JOURNAL   Cell Metab 34 (7), 1004-1022 (2022)
   PUBMED   35793654
  REMARK    GeneRIF: FKBP11 rewires UPR signaling to promote glucose
            homeostasis in type 2 diabetes and obesity.
REFERENCE   4  (bases 1 to 736)
  AUTHORS   Wang,X., Cui,X., Zhu,C., Li,M., Zhao,J., Shen,Z., Shan,X., Wang,L.,
            Wu,H., Shen,Y., Ni,Y., Zhang,D. and Zhou,G.
  TITLE     FKBP11 protects intestinal epithelial cells against
            inflammation-induced apoptosis via the JNK-caspase pathway in
            Crohn's disease
  JOURNAL   Mol Med Rep 18 (5), 4428-4438 (2018)
   PUBMED   30221722
  REMARK    GeneRIF: these results suggest that the UPR protein FKBP11 may
            protect IECs against IFNg/TNFa induced apoptosis by inhibiting the
            ER stressassociated JNK/caspase apoptotic pathway in Crohn's
            disease
            Erratum:[Mol Med Rep. 2024 Mar;29(3):50. doi:
            10.3892/mmr.2024.13172.. PMID: 38299256]
REFERENCE   5  (bases 1 to 736)
  AUTHORS   Tsukamoto,T., Li,X., Morita,H., Minowa,T., Aizawa,T., Hanagata,N.
            and Demura,M.
  TITLE     Role of S-palmitoylation on IFITM5 for the interaction with FKBP11
            in osteoblast cells
  JOURNAL   PLoS One 8 (9), e75831 (2013)
   PUBMED   24058703
  REMARK    GeneRIF: These results indicate that the S-palmitoylation on IFITM5
            promotes the interaction with FKBP11.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 736)
  AUTHORS   Song,B., Scheuner,D., Ron,D., Pennathur,S. and Kaufman,R.J.
  TITLE     Chop deletion reduces oxidative stress, improves beta cell
            function, and promotes cell survival in multiple mouse models of
            diabetes
  JOURNAL   J Clin Invest 118 (10), 3378-3389 (2008)
   PUBMED   18776938
REFERENCE   7  (bases 1 to 736)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK003331.1 and AC156543.10.
            
            On Jan 27, 2018 this sequence version replaced NM_024169.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY703591.1, AK003331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-732               AK003331.1         2-733
            733-736             AC156543.10        123638-123641       c
FEATURES             Location/Qualifiers
     source          1..736
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 54.65 cM"
     gene            1..736
                     /gene="Fkbp11"
                     /gene_synonym="1110002O23Rik; FKBP-11"
                     /note="FK506 binding protein 11"
                     /db_xref="GeneID:66120"
                     /db_xref="MGI:MGI:1913370"
     exon            1..242
                     /gene="Fkbp11"
                     /gene_synonym="1110002O23Rik; FKBP-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..719
                     /gene="Fkbp11"
                     /gene_synonym="1110002O23Rik; FKBP-11"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; peptidyl-prolyl cis-trans isomerase FKBP11;
                     FKBP-19; rotamase; 19 kDa FK506-binding protein; 19 kDa
                     FKBP; PPIase FKBP11"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP11
                     isoform 1 precursor"
                     /protein_id="NP_077131.2"
                     /db_xref="CCDS:CCDS27803.1"
                     /db_xref="GeneID:66120"
                     /db_xref="MGI:MGI:1913370"
                     /translation="MTLSPLLLPLQLLLLLLFSGAVCRAEAGPETESPVRTLQVETLV
                     QPPESCTESAAIGDTLHIHYTGSLVDGRIIDTSLTRDPLVIELGQKQVIPGLEQSLLD
                     MCVGEKRRAVIPSHLAYGKRGYPPSIPADAVVQYDVELIALIRANYWQKLLKSILPLV
                     GIAMVPALLGLIGYHLYRKASRPKVSKKKLKEEKRNKSKKK"
     exon            243..308
                     /gene="Fkbp11"
                     /gene_synonym="1110002O23Rik; FKBP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            309..396
                     /gene="Fkbp11"
                     /gene_synonym="1110002O23Rik; FKBP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            397..430
                     /gene="Fkbp11"
                     /gene_synonym="1110002O23Rik; FKBP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            431..501
                     /gene="Fkbp11"
                     /gene_synonym="1110002O23Rik; FKBP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            502..736
                     /gene="Fkbp11"
                     /gene_synonym="1110002O23Rik; FKBP-11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      715..720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fkbp11"
                     /gene_synonym="1110002O23Rik; FKBP-11"
                     /note="hexamer: AATAAA"
     polyA_site      736
                     /gene="Fkbp11"
                     /gene_synonym="1110002O23Rik; FKBP-11"
                     /note="major polyA site"
ORIGIN      
        1 agcgccttga aaacccgccc ataccagtct ggcctggagt gagggaaccc gtcctggtcg
       61 cgtgcacccg aacagcctgc cctggtatcc tggtgctctg acccggtcca atcatgaccc
      121 tgagcccttt gctcctacca ctccagctgt tactgctgct actgttcagt ggggcggtgt
      181 gccgggctga ggctgggcca gaaaccgaaa gtcctgtccg gaccctccaa gtggagaccc
      241 tggtgcagcc ccctgaatcg tgcacggaat ctgctgccat tggagacacg ctccacatac
      301 actacacggg cagtttggta gatggacgca ttattgacac ttctctgacc agagatcctc
      361 tggtcataga actcggccaa aagcaggtga ttccaggtct ggagcagagc cttttggaca
      421 tgtgtgtggg agagaagcga agagcagtca ttccttctca cctggcttat ggaaagcgag
      481 ggtacccgcc atctatccca gccgatgcag tggtgcagta cgatgtggag ctgatcgctt
      541 tgattcgagc caactactgg cagaagctgc taaagagcat tttgcctctg gtaggcatcg
      601 ccatggtgcc ggcgctcctg gggctgatcg ggtatcacct gtacagaaag gccagcagac
      661 ccaaagtctc caaaaagaag ctaaaagagg agaaacgaaa caagagtaag aagaaataaa
      721 tagtggtttt taacaa
//
