LOCUS       NM_010221               2619 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus FK506 binding protein 10 (Fkbp10), transcript variant
            1, mRNA.
ACCESSION   NM_010221
VERSION     NM_010221.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2619)
  AUTHORS   Kot,A., Chun,C., Martin,J.H., Wachtell,D., Hudson,D., Weis,M.,
            Marks,H., Srivastava,S., Eyre,D.R., Duran,I., Zieba,J. and
            Krakow,D.
  TITLE     Loss of the long form of Plod2 phenocopies contractures of Bruck
            syndrome-osteogenesis imperfecta
  JOURNAL   J Bone Miner Res 39 (9), 1240-1252 (2024)
   PUBMED   39088537
REFERENCE   2  (bases 1 to 2619)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2619)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2619)
  AUTHORS   Lim,J., Lietman,C., Grol,M.W., Castellon,A., Dawson,B., Adeyeye,M.,
            Rai,J., Weis,M., Keene,D.R., Schweitzer,R., Park,D., Eyre,D.R.,
            Krakow,D. and Lee,B.H.
  TITLE     Localized chondro-ossification underlies joint dysfunction and
            motor deficits in the Fkbp10 mouse model of osteogenesis imperfecta
  JOURNAL   Proc Natl Acad Sci U S A 118 (25) (2021)
   PUBMED   34161280
  REMARK    GeneRIF: Localized chondro-ossification underlies joint dysfunction
            and motor deficits in the Fkbp10 mouse model of osteogenesis
            imperfecta.
REFERENCE   5  (bases 1 to 2619)
  AUTHORS   Hoffmann,S., Schmitteckert,S., Raedecke,K., Rheinert,D.,
            Diebold,S., Roeth,R., Weiss,B., Granzow,M., Niesler,B.,
            Griesbeck,A., Eckstein,V., Zimmermann,W.H., Just,S. and
            Rappold,G.A.
  TITLE     Network-driven discovery yields new insight into Shox2-dependent
            cardiac rhythm control
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (4-5), 194702 (2021)
   PUBMED   33706013
REFERENCE   6  (bases 1 to 2619)
  AUTHORS   Patterson,C.E., Gao,J., Rooney,A.P. and Davis,E.C.
  TITLE     Genomic organization of mouse and human 65 kDa FK506-binding
            protein genes and evolution of the FKBP multigene family
  JOURNAL   Genomics 79 (6), 881-889 (2002)
   PUBMED   12036304
REFERENCE   7  (bases 1 to 2619)
  AUTHORS   Patterson,C.E., Schaub,T., Coleman,E.J. and Davis,E.C.
  TITLE     Developmental regulation of FKBP65. An ER-localized extracellular
            matrix binding-protein
  JOURNAL   Mol Biol Cell 11 (11), 3925-3935 (2000)
   PUBMED   11071917
REFERENCE   8  (bases 1 to 2619)
  AUTHORS   Coss,M.C., Winterstein,D., Sowder,R.C. 2nd and Simek,S.L.
  TITLE     Molecular cloning, DNA sequence analysis, and biochemical
            characterization of a novel 65-kDa FK506-binding protein (FKBP65)
  JOURNAL   J Biol Chem 270 (49), 29336-29341 (1995)
   PUBMED   7493967
REFERENCE   9  (bases 1 to 2619)
  AUTHORS   Kozak,C.A., Danciger,M., Bowes,C., Adamson,M.C., Palczewski,K.,
            Polans,A.S. and Farber,D.B.
  TITLE     Localization of three genes expressed in retina on mouse chromosome
            11
  JOURNAL   Mamm Genome 6 (2), 142-144 (1995)
   PUBMED   7767000
REFERENCE   10 (bases 1 to 2619)
  AUTHORS   Simek,S.L., Kozak,C.A., Winterstein,D., Hegamyer,G. and
            Colburn,N.H.
  TITLE     Sequence and localization of a novel FK506-binding protein to mouse
            chromosome 11
  JOURNAL   Genomics 18 (2), 407-409 (1993)
   PUBMED   7507077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY311176.1, AL590968.8, AK019446.2 and AI846779.1.
            
            On Jul 31, 2009 this sequence version replaced NM_010221.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029546.1, L07063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                BY311176.1         1-51
            52-52               AL590968.8         132721-132721
            53-63               BY311176.1         53-63
            64-920              AK019446.2         2-858
            921-2585            AK019446.2         860-2524
            2586-2619           AI846779.1         1-34                c
FEATURES             Location/Qualifiers
     source          1..2619
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.47 cM"
     gene            1..2619
                     /gene="Fkbp10"
                     /gene_synonym="FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs;
                     Fkbp6; FKBP65; Fkbprp"
                     /note="FK506 binding protein 10"
                     /db_xref="GeneID:14230"
                     /db_xref="MGI:MGI:104769"
     exon            1..332
                     /gene="Fkbp10"
                     /gene_synonym="FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs;
                     Fkbp6; FKBP65; Fkbprp"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1836
                     /gene="Fkbp10"
                     /gene_synonym="FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs;
                     Fkbp6; FKBP65; Fkbprp"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; FK506 binding protein 6 (65 kDa); rotamase;
                     immunophilin FKBP65; peptidyl-prolyl cis-trans isomerase
                     FKBP10; 65 kDa FK506-binding protein; 65 kDa FKBP; PPIase
                     FKBP10"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP10
                     isoform 1 precursor"
                     /protein_id="NP_034351.2"
                     /db_xref="CCDS:CCDS25422.1"
                     /db_xref="GeneID:14230"
                     /db_xref="MGI:MGI:104769"
                     /translation="MFLVGSSSHTLHRLRILPLLLLLQTLERGLGRASPAGAPLEDVV
                     IERYHIPRACPREVQMGDFVRYHYNGTFEDGKKFDSSYDRSTLVAIVVGVGRLITGMD
                     RGLMGMCVNERRRLIVPPHLGYGSIGVAGLIPPDATLYFDVVLLDVWNKADTVQSTIL
                     LRPPYCPRMVQNSDFVRYHYNGTLLDGTAFDNSYSRGGTYDTYIGSGWLIKGMDQGLL
                     GMCPGEKRKIIIPPFLAYGEKGYGTVIPPQASLVFYVLLLDVHNPKDTVQLETLELPQ
                     GCVRRAVAGDFMRYHYNGSLMDGTLFDSSYSRNHTYNTYVGQGYIIPGMDQGLQGACI
                     GERRRITVPPHLAYGENGTGDKIPGSAVLIFDVHVIDFHNPSDPVEIKTLSRPPENCN
                     ETSKIGDFIRYHYNCSLLDGTRLFSSHDYEAPQEITLGANKVIEGLDRGLQGMCVGER
                     RQLIVPPHLAHGENGARGVPGSAVLLFEVELVSREDGLPTGYLFVWYQDPSTSLFEDM
                     DLNKDGEVPPEEFSSFIKAQVNEGKGRLMPGQDPDKTISDMFQNQDRNQDGKITAEEL
                     KLKSDEDQERVHEEL"
     exon            333..478
                     /gene="Fkbp10"
                     /gene_synonym="FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs;
                     Fkbp6; FKBP65; Fkbprp"
                     /inference="alignment:Splign:2.1.0"
     exon            479..668
                     /gene="Fkbp10"
                     /gene_synonym="FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs;
                     Fkbp6; FKBP65; Fkbprp"
                     /inference="alignment:Splign:2.1.0"
     exon            669..814
                     /gene="Fkbp10"
                     /gene_synonym="FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs;
                     Fkbp6; FKBP65; Fkbprp"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1004
                     /gene="Fkbp10"
                     /gene_synonym="FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs;
                     Fkbp6; FKBP65; Fkbprp"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1150
                     /gene="Fkbp10"
                     /gene_synonym="FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs;
                     Fkbp6; FKBP65; Fkbprp"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1343
                     /gene="Fkbp10"
                     /gene_synonym="FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs;
                     Fkbp6; FKBP65; Fkbprp"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1486
                     /gene="Fkbp10"
                     /gene_synonym="FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs;
                     Fkbp6; FKBP65; Fkbprp"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1650
                     /gene="Fkbp10"
                     /gene_synonym="FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs;
                     Fkbp6; FKBP65; Fkbprp"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..2603
                     /gene="Fkbp10"
                     /gene_synonym="FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs;
                     Fkbp6; FKBP65; Fkbprp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2569..2574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fkbp10"
                     /gene_synonym="FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs;
                     Fkbp6; FKBP65; Fkbprp"
                     /note="hexamer: AATAAA"
     polyA_site      2595
                     /gene="Fkbp10"
                     /gene_synonym="FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs;
                     Fkbp6; FKBP65; Fkbprp"
                     /note="major polyA site"
ORIGIN      
        1 aggaaggggg ggagtcagct ctgagaggag ggggaaggag gctagcggct ggcgtccgct
       61 ctcactgccg gcgtccctgg tctgggcacc atgttccttg tggggtcctc cagccacacc
      121 ctccatcggc tccgcatact gccgttgctg ttgcttctac agaccttgga gaggggactg
      181 ggccgtgcca gcccggccgg agcccccttg gaagatgtgg tcatcgagag ataccacatc
      241 cctcgggcct gtccccgaga agtgcagatg ggggattttg tgcgttacca ctacaatggc
      301 actttcgaag acgggaaaaa gtttgactcc agctatgacc gtagcaccct ggtggccatc
      361 gttgtgggcg taggccgcct catcaccggc atggaccggg gtctcatggg catgtgtgtc
      421 aacgagcgcc gccgcctcat tgtgcctccc cacctgggct acggcagcat cggtgtggcg
      481 ggcctcatcc cccctgatgc caccctctat tttgacgtgg tcctgctgga cgtgtggaac
      541 aaagcagaca cggtgcagtc aactatcctc ctgcgccctc cctactgccc ccgaatggtg
      601 cagaacagtg actttgtgcg ctatcactac aatggcactc tgctggatgg cactgccttt
      661 gacaacagct acagtagggg aggcacttat gacacctaca tcggctctgg ttggctgatc
      721 aaaggcatgg accaggggct gctgggcatg tgccctggag agaaaaggaa gatcattatc
      781 cctcccttcc tggcttatgg ggagaaaggc tatgggactg tgataccccc gcaggcctcc
      841 ctggtcttct atgtcctgct gctggatgtc cacaacccga aggacacggt ccagctggag
      901 acgctggagc tgccccaggg ctgtgtccgg cgagctgtgg cgggggactt catgcgttac
      961 cactacaatg gctctttgat ggatggtacc ctctttgatt ccagctactc ccgaaaccac
     1021 acctacaata cctatgtcgg gcagggttac atcatccctg ggatggacca ggggctgcaa
     1081 ggcgcatgca taggggagcg aaggaggatt actgtgcccc ctcaccttgc ctacggggag
     1141 aatgggacag gagacaagat ccctggctcg gctgtgctca tcttcgatgt gcacgtcatc
     1201 gacttccaca acccttcgga ccctgtggaa atcaagacgc tgtcccggcc tcctgagaac
     1261 tgcaatgaga catccaaaat cggggacttc attcgctacc actacaactg ttctctgctg
     1321 gacggcacca ggctcttctc gtcccacgac tatgaggccc ctcaagagat caccctcgga
     1381 gccaacaaag tgatcgaagg tctggacagg ggcctgcagg gcatgtgtgt aggagagagg
     1441 aggcagctca ttgtgccccc acacctggcc cacggggaga atggagcccg gggtgtccct
     1501 ggcagtgctg tgctgctatt tgaggtggag ctggtatccc gagaggatgg cctgcccaca
     1561 ggctacctgt ttgtgtggta ccaggatcct tccactagcc tttttgaaga catggatctc
     1621 aataaagatg gagaggtgcc cccagaagag ttctcttcct tcatcaaggc tcaagtgaat
     1681 gaaggcaaag gacgcctcat gcctgggcaa gacccagaca aaaccatcag tgacatgttt
     1741 cagaaccagg accggaacca ggatggcaag atcacagctg aggagctcaa gctgaagtca
     1801 gatgaggacc aggagcgggt ccatgaggag ctctgagggc cagagtgtca ggcctgacct
     1861 cagacacaaa ggcccctcgg ctggggggca gtgggcatgg agctggcctg ctaacagccc
     1921 cccgatccgt cagggggaat aactctggga gtcactggat atcagtggag actactgtgg
     1981 tcttcccacg catgggccgt ggctttcagt tctcagcaca gacatctgtg tttttctcgt
     2041 ccaaccctaa gcctcttcct taaggttctt gtgacagatc cagttcaggg aggaggcact
     2101 gagatttggt tagggccatc gcgaacccca cacacccatc ctcccatctc acgtcactag
     2161 gcacggcaag ggtgagcttc ttggtccttc actttcccag acgtgccctt tatttgtact
     2221 gtcctgtccc atctccctgt ccccgcctgt ccccgtcccc tctgtcatgg cagctctgca
     2281 ggggcatgaa tctgagtgac gagagcctgc gttcttctgc ctcagctctg ctcctcagga
     2341 aggggtggct ccagctgccc accattctca ctcttctcct cccaagccac cggggtcagg
     2401 tctctcatct taagaagttc cctctaaaat gaaaggttgt gtaagaggaa agcctgctca
     2461 ggcccaaggg tttcgagaac ctgcacttgg tgctaatctg aggggaggaa ggtgggcagg
     2521 gtcttggact caaaggctaa actgatccag tcctttctcc tttgtgtcaa taaaaggcta
     2581 aactgaagac ctccagaagt ggaaaaaaaa aaaaaaaaa
//
