LOCUS       NP_034351                581 aa            linear   ROD 28-APR-2025
DEFINITION  peptidyl-prolyl cis-trans isomerase FKBP10 isoform 1 precursor [Mus
            musculus].
ACCESSION   NP_034351
VERSION     NP_034351.2
DBSOURCE    REFSEQ: accession NM_010221.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 581)
  AUTHORS   Kot,A., Chun,C., Martin,J.H., Wachtell,D., Hudson,D., Weis,M.,
            Marks,H., Srivastava,S., Eyre,D.R., Duran,I., Zieba,J. and
            Krakow,D.
  TITLE     Loss of the long form of Plod2 phenocopies contractures of Bruck
            syndrome-osteogenesis imperfecta
  JOURNAL   J Bone Miner Res 39 (9), 1240-1252 (2024)
   PUBMED   39088537
REFERENCE   2  (residues 1 to 581)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 581)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 581)
  AUTHORS   Lim,J., Lietman,C., Grol,M.W., Castellon,A., Dawson,B., Adeyeye,M.,
            Rai,J., Weis,M., Keene,D.R., Schweitzer,R., Park,D., Eyre,D.R.,
            Krakow,D. and Lee,B.H.
  TITLE     Localized chondro-ossification underlies joint dysfunction and
            motor deficits in the Fkbp10 mouse model of osteogenesis imperfecta
  JOURNAL   Proc Natl Acad Sci U S A 118 (25) (2021)
   PUBMED   34161280
  REMARK    GeneRIF: Localized chondro-ossification underlies joint dysfunction
            and motor deficits in the Fkbp10 mouse model of osteogenesis
            imperfecta.
REFERENCE   5  (residues 1 to 581)
  AUTHORS   Hoffmann,S., Schmitteckert,S., Raedecke,K., Rheinert,D.,
            Diebold,S., Roeth,R., Weiss,B., Granzow,M., Niesler,B.,
            Griesbeck,A., Eckstein,V., Zimmermann,W.H., Just,S. and
            Rappold,G.A.
  TITLE     Network-driven discovery yields new insight into Shox2-dependent
            cardiac rhythm control
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (4-5), 194702 (2021)
   PUBMED   33706013
REFERENCE   6  (residues 1 to 581)
  AUTHORS   Patterson,C.E., Gao,J., Rooney,A.P. and Davis,E.C.
  TITLE     Genomic organization of mouse and human 65 kDa FK506-binding
            protein genes and evolution of the FKBP multigene family
  JOURNAL   Genomics 79 (6), 881-889 (2002)
   PUBMED   12036304
REFERENCE   7  (residues 1 to 581)
  AUTHORS   Patterson,C.E., Schaub,T., Coleman,E.J. and Davis,E.C.
  TITLE     Developmental regulation of FKBP65. An ER-localized extracellular
            matrix binding-protein
  JOURNAL   Mol Biol Cell 11 (11), 3925-3935 (2000)
   PUBMED   11071917
REFERENCE   8  (residues 1 to 581)
  AUTHORS   Coss,M.C., Winterstein,D., Sowder,R.C. 2nd and Simek,S.L.
  TITLE     Molecular cloning, DNA sequence analysis, and biochemical
            characterization of a novel 65-kDa FK506-binding protein (FKBP65)
  JOURNAL   J Biol Chem 270 (49), 29336-29341 (1995)
   PUBMED   7493967
REFERENCE   9  (residues 1 to 581)
  AUTHORS   Kozak,C.A., Danciger,M., Bowes,C., Adamson,M.C., Palczewski,K.,
            Polans,A.S. and Farber,D.B.
  TITLE     Localization of three genes expressed in retina on mouse chromosome
            11
  JOURNAL   Mamm Genome 6 (2), 142-144 (1995)
   PUBMED   7767000
REFERENCE   10 (residues 1 to 581)
  AUTHORS   Simek,S.L., Kozak,C.A., Winterstein,D., Hegamyer,G. and
            Colburn,N.H.
  TITLE     Sequence and localization of a novel FK506-binding protein to mouse
            chromosome 11
  JOURNAL   Genomics 18 (2), 407-409 (1993)
   PUBMED   7507077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY311176.1, AL590968.8, AK019446.2 and AI846779.1.
            
            On Jul 31, 2009 this sequence version replaced NP_034351.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029546.1, L07063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..581
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.47 cM"
     Protein         1..581
                     /product="peptidyl-prolyl cis-trans isomerase FKBP10
                     isoform 1 precursor"
                     /EC_number="5.2.1.8"
                     /note="FK506 binding protein 6 (65 kDa); rotamase;
                     immunophilin FKBP65; peptidyl-prolyl cis-trans isomerase
                     FKBP10; 65 kDa FK506-binding protein; 65 kDa FKBP; PPIase
                     FKBP10"
                     /calculated_mol_wt=61003
     sig_peptide     1..33
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61576.2)"
                     /calculated_mol_wt=3713
     mat_peptide     34..581
                     /product="Peptidyl-prolyl cis-trans isomerase FKBP10.
                     /id=PRO_0000025518"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61576.2)"
                     /calculated_mol_wt=61003
     Region          54..146
                     /region_name="FKBP_C"
                     /note="FKBP-type peptidyl-prolyl cis-trans isomerase;
                     pfam00254"
                     /db_xref="CDD:459735"
     Site            69
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61576.2)"
     Region          166..258
                     /region_name="FKBP_C"
                     /note="FKBP-type peptidyl-prolyl cis-trans isomerase;
                     pfam00254"
                     /db_xref="CDD:459735"
     Site            181
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61576.2)"
     Region          278..370
                     /region_name="FKBP_C"
                     /note="FKBP-type peptidyl-prolyl cis-trans isomerase;
                     pfam00254"
                     /db_xref="CDD:459735"
     Site            293
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61576.2)"
     Site            309
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61576.2)"
     Site            351
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61576.2)"
     Region          391..482
                     /region_name="FKBP_C"
                     /note="FKBP-type peptidyl-prolyl cis-trans isomerase;
                     pfam00254"
                     /db_xref="CDD:459735"
     Site            392
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61576.2)"
     Site            406
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61576.2)"
     Region          482..>567
                     /region_name="FRQ1"
                     /note="Ca2+-binding protein, EF-hand superfamily [Signal
                     transduction mechanisms]; COG5126"
                     /db_xref="CDD:444056"
     Region          533..581
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61576.2)"
     Region          578..581
                     /region_name="Prevents secretion from ER.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU10138"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61576.2)"
     CDS             1..581
                     /gene="Fkbp10"
                     /gene_synonym="FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs;
                     Fkbp6; FKBP65; Fkbprp"
                     /coded_by="NM_010221.2:91..1836"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS25422.1"
                     /db_xref="GeneID:14230"
                     /db_xref="MGI:MGI:104769"
ORIGIN      
        1 mflvgsssht lhrlrilpll lllqtlergl graspagapl edvvieryhi pracprevqm
       61 gdfvryhyng tfedgkkfds sydrstlvai vvgvgrlitg mdrglmgmcv nerrrlivpp
      121 hlgygsigva glippdatly fdvvlldvwn kadtvqstil lrppycprmv qnsdfvryhy
      181 ngtlldgtaf dnsysrggty dtyigsgwli kgmdqgllgm cpgekrkiii ppflaygekg
      241 ygtvippqas lvfyvllldv hnpkdtvqle tlelpqgcvr ravagdfmry hyngslmdgt
      301 lfdssysrnh tyntyvgqgy iipgmdqglq gacigerrri tvpphlayge ngtgdkipgs
      361 avlifdvhvi dfhnpsdpve iktlsrppen cnetskigdf iryhyncsll dgtrlfsshd
      421 yeapqeitlg ankviegldr glqgmcvger rqlivpphla hgengargvp gsavllfeve
      481 lvsredglpt gylfvwyqdp stslfedmdl nkdgevppee fssfikaqvn egkgrlmpgq
      541 dpdktisdmf qnqdrnqdgk itaeelklks dedqervhee l
//
