LOCUS       NM_010218               2446 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus four jointed box 1 (Fjx1), mRNA.
ACCESSION   NM_010218
VERSION     NM_010218.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2446)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2446)
  AUTHORS   Zhang,H., Zhang,Z., Wang,Q., Wang,L., Yang,Z., Geng,Z., Wang,Y.,
            Li,J. and Zuo,L.
  TITLE     [FJX1 overexpression is associated with poor prognosis and promotes
            gastric cancer proliferation via the PI3K/AKT signaling pathway]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (6), 975-984 (2023)
   PUBMED   37439170
  REMARK    GeneRIF: [FJX1 overexpression is associated with poor prognosis and
            promotes gastric cancer proliferation via the PI3K/AKT signaling
            pathway].
REFERENCE   3  (bases 1 to 2446)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2446)
  AUTHORS   Formica,C., Happe,H., Veraar,K.A., Vortkamp,A., Scharpfenecker,M.,
            McNeill,H. and Peters,D.J.
  TITLE     Four-jointed knock-out delays renal failure in an ADPKD model with
            kidney injury
  JOURNAL   J Pathol 249 (1), 114-125 (2019)
   PUBMED   31038742
  REMARK    GeneRIF: Fjx1 disruption protects the cystic kidneys against kidney
            failure by reducing inflammation and fibrosis.
REFERENCE   5  (bases 1 to 2446)
  AUTHORS   Zhang,H., Bagherie-Lachidan,M., Badouel,C., Enderle,L., Peidis,P.,
            Bremner,R., Kuure,S., Jain,S. and McNeill,H.
  TITLE     FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling
  JOURNAL   Dev Cell 48 (6), 780-792 (2019)
   PUBMED   30853441
REFERENCE   6  (bases 1 to 2446)
  AUTHORS   Rock,R., Schrauth,S. and Gessler,M.
  TITLE     Expression of mouse dchs1, fjx1, and fat-j suggests conservation of
            the planar cell polarity pathway identified in Drosophila
  JOURNAL   Dev Dyn 234 (3), 747-755 (2005)
   PUBMED   16059920
  REMARK    GeneRIF: data are compatible with conservation and
            sub-functionalization of dachsous 1, Fj, and Fat signaling in
            higher vertebrates
REFERENCE   7  (bases 1 to 2446)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 2446)
  AUTHORS   Gawin,B., Niederfuhr,A., Schumacher,N., Hummerich,H., Little,P.F.
            and Gessler,M.
  TITLE     A 7.5 Mb sequence-ready PAC contig and gene expression map of human
            chromosome 11p13-p14.1
  JOURNAL   Genome Res 9 (11), 1074-1086 (1999)
   PUBMED   10568747
REFERENCE   9  (bases 1 to 2446)
  AUTHORS   Ashery-Padan,R., Alvarez-Bolado,G., Klamt,B., Gessler,M. and
            Gruss,P.
  TITLE     Fjx1, the murine homologue of the Drosophila four-jointed gene,
            codes for a putative secreted protein expressed in restricted
            domains of the developing and adult brain
  JOURNAL   Mech Dev 80 (2), 213-217 (1999)
   PUBMED   10072791
REFERENCE   10 (bases 1 to 2446)
  AUTHORS   Thate,C., Pongratz,J., Konig,A., Klamt,B., Tsaoussidou,S.,
            Higgins,M., Shows,T., Jones,C. and Gessler,M.
  TITLE     CpG island clones for chromosome 11p--a resource for mapping and
            gene identification
  JOURNAL   Mamm Genome 6 (6), 421-425 (1995)
   PUBMED   7647465
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC051990.1.
            
            On May 6, 2004 this sequence version replaced NM_010218.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC051990.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2446
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.13 cM"
     gene            1..2446
                     /gene="Fjx1"
                     /note="four jointed box 1"
                     /db_xref="GeneID:14221"
                     /db_xref="MGI:MGI:1341907"
     exon            1..2427
                     /gene="Fjx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1557
                     /gene="Fjx1"
                     /note="four-jointed box protein 1; four-jointed protein
                     x1; four-jointed protein homolog"
                     /codon_start=1
                     /product="four-jointed box protein 1 precursor"
                     /protein_id="NP_034348.2"
                     /db_xref="CCDS:CCDS16467.1"
                     /db_xref="GeneID:14221"
                     /db_xref="MGI:MGI:1341907"
                     /translation="MGRKMRGAAAAAGLWLLALSSLLTLWGGLLPPRTELPASRPPED
                     RLPPHPIQSGGPAPEPRFPLPPPLVWDARGGSLKTFRALLTLAAGADNPPRRHQDDRG
                     RHEPSGLSWPEERRAVHGGVFWSRGLEEQVPRGFSEAQAAAWLEVARGARVVALDRGG
                     CGRSSNRLARFADGTRACVRYGINPEQIQGEALSYYLARLLGLQRHVPPLALARVEAR
                     GAQWVQVQEELRTAHWTEGSVVSLTRWLPNLTDVVVPEPWRSEDGRLRPLRDAGGELT
                     NLSQAELVDLVQWTDLILFDYLTANFDRLVSNLFSLQWDPRVMHRATSNLHRGPGGAL
                     VFLDNEAGLVHGYRVAGMWDKYNEPLLQSVCVFRERTARRVLELHRGQDAAARLLRLY
                     SRHEPRFPELAELSEPHAQLLQRRLDFLAKHILHCKAKYGRRPGDLITLRGREGLGYE
                     "
     regulatory      2397..2402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fjx1"
                     /note="hexamer: AATAAA"
     polyA_site      2419
                     /gene="Fjx1"
                     /note="major polyA site"
ORIGIN      
        1 gctgctggga agccacgggg aggcgagttc ccagcgccgg ggcagagcgc tggccagagc
       61 cccgcagcgc tccgcggccg cgatggggct ccggcacccg aagccccgga gccagctagc
      121 agccgggccc gcctcgccgc ccgcacccgg gcgcccgggc ttggcttgaa gcggcggcgg
      181 tggcaccggc gcgccggcag gagcatgggg aggaagatgc ggggcgccgc cgccgccgcg
      241 gggctctggc tgctggcttt gagctcgctg ctgacgctgt ggggaggact cctgccaccg
      301 cggaccgagc tgccagcctc ccggccgccc gaagatcgac tccctccgca tccgatccag
      361 agtggcggcc ccgcgcccga gccgcgattc cctctgcccc cgcccctagt atgggacgcc
      421 cgcggcggct ccctgaaaac tttccgggcg ctgctcaccc tggcggccgg cgcggataac
      481 ccgcctagga ggcaccagga cgaccgcggg cggcacgagc cctccgggct gtcctggcca
      541 gaggagcgca gggcggtgca cgggggcgtc ttctggagcc gcggcctgga ggagcaggtt
      601 ccccggggct tttccgaagc ccaagcagca gcgtggctgg aggtggcacg gggtgctcgg
      661 gtggtggctc tggatcgcgg gggctgcgga cgcagttcca accgcctagc ccgctttgcc
      721 gacggcaccc gtgcctgtgt acgctacggc atcaacccag agcagataca gggcgaggcc
      781 ctgtcctact accttgcgcg cctgctgggc ctccagcgcc acgtgccgcc gctggcactg
      841 gctcgggtgg aggctcgggg cgcgcagtgg gtgcaggtgc aggaggagct gcgcaccgcg
      901 cactggaccg agggcagcgt ggtgagcctg acgcgctggc tgcctaacct caccgacgtg
      961 gtggtgcccg agccctggcg atcagaggac ggccgtctgc ggcccctgcg cgacgccggg
     1021 ggcgagctga ccaacctcag ccaggcggag ctggtggact tggtacaatg gaccgatctg
     1081 atcctcttcg attacctgac ggccaacttt gaccggcttg tgagcaacct cttcagctta
     1141 cagtgggacc cacgcgttat gcaccgcgct acgagcaacc tgcaccgagg accaggaggg
     1201 gcgttggtct ttctggacaa tgaggcgggc ttggtgcacg gctaccgggt agccggcatg
     1261 tgggacaagt ataacgaacc gctgctacag tcggtgtgtg tattccgaga gcggactgct
     1321 aggcgcgtct tggagctgca ccggggtcag gacgcggcgg cccggttgct gcgcctctac
     1381 agtcgccacg aaccgcgttt cccagagctg gcggagctct cagaacccca cgctcagctg
     1441 ctacagcgcc gccttgactt cctcgccaaa cacattttgc actgcaaggc caagtacggc
     1501 cgccggcccg gggacttaat aacactccga ggaagagagg gactggggta tgaatgatgg
     1561 gggttagggc tgtcttctct gccacgggca acgaccaacc agccaacgcc cacccaatgg
     1621 tctgatcgcc aagctgtcta aaaaaaaaaa ttgtgtgtta cccacttgcc cctttctttt
     1681 catgccaggc tgtttccttt ccaagttctg gaagggcaaa ctcaccgagg cgagaagtgt
     1741 aacattccct ccacctagct tataaaaaga gttctgtgct tgtgtggaga ttggatccga
     1801 agaaactggc tgctggggtt tggcccggga atggcagtct ctttgggaga tgcagtccat
     1861 ttttgtcgcc ccctccaccc cttcccaaaa aggaaaactt ccgtttgagc taattcctct
     1921 atttcctact aaacacagcg ctggtggccc cagagcaggc tgtgacaagg gctggtgaaa
     1981 cccccttcct gtgttcgccc tttgttccgg cgcgcgatgg tgagataact gttccaagct
     2041 gagggacagc tctggatagg acaaagagag caagacttcc ccgcccctgg gagccctcca
     2101 gaccctgaca gtttgtctca cccattcctg aactcctatc attttggcct gaaggctatg
     2161 aattcaggac tagttataag cagagtcaat aatgaatttc ttcctgcgtc tcccaattga
     2221 ccaaaattga caatgatgat gttcaccaga gggggaaaaa aatcagtttc atgcacttta
     2281 ctttttttaa ttttaatttt ttagtaagaa aactttttta tttgacagaa tttgccttct
     2341 gtgtgtatat atgtgcataa attgtgctgt aaatagacta aacaaactta tatttcaata
     2401 aaagggagtt taaaatttag aacttaaaaa aaaaaaaaaa aaaaaa
//
