LOCUS       NM_001110329            2615 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus Flt3 interacting zinc finger protein 1 (Fiz1),
            transcript variant 3, mRNA.
ACCESSION   NM_001110329
VERSION     NM_001110329.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2615)
  AUTHORS   Tsuruyama,T., Imai,Y., Takeuchi,H., Hiratsuka,T., Maruyama,Y.,
            Kanaya,K., Kaszynski,R., Jin,G., Okuno,T., Ozeki,M., Nakamura,T.,
            Takakuwa,T., Manabe,T., Tamaki,K. and Hiai,H.
  TITLE     Dual retrovirus integration tagging: identification of new
            signaling molecules Fiz1 and Hipk2 that are involved in the IL-7
            signaling pathway in B lymphoblastic lymphomas
  JOURNAL   J Leukoc Biol 88 (1), 107-116 (2010)
   PUBMED   20360400
  REMARK    GeneRIF: FLT3 and CD43 signaling pathways involve STAT5A via Fiz1
            and Hipk2 in B lymphoblastic lymphomas.
REFERENCE   2  (bases 1 to 2615)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   3  (bases 1 to 2615)
  AUTHORS   Mali,R.S., Peng,G.H., Zhang,X., Dang,L., Chen,S. and Mitton,K.P.
  TITLE     FIZ1 is part of the regulatory protein complex on active
            photoreceptor-specific gene promoters in vivo
  JOURNAL   BMC Mol Biol 9, 87 (2008)
   PUBMED   18854042
  REMARK    GeneRIF: Fiz1 is part of the regulatory protein complex on active
            photoreceptor-specific gene promoters in vivo.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2615)
  AUTHORS   Yee,K.W., Schittenhelm,M., O'Farrell,A.M., Town,A.R., McGreevey,L.,
            Bainbridge,T., Cherrington,J.M. and Heinrich,M.C.
  TITLE     Synergistic effect of SU11248 with cytarabine or daunorubicin on
            FLT3 ITD-positive leukemic cells
  JOURNAL   Blood 104 (13), 4202-4209 (2004)
   PUBMED   15304385
  REMARK    GeneRIF: Addition of potent FLT3 inhibitors such as SU11248 to
            acute myeloid leukemia chemotherapy regimens could result in
            improved treatment results.
REFERENCE   5  (bases 1 to 2615)
  AUTHORS   Garcia-Frigola,C., Burgaya,F., Calbet,M., Lopez-Domenech,G., de
            Lecea,L. and Soriano,E.
  TITLE     A collection of cDNAs enriched in upper cortical layers of the
            embryonic mouse brain
  JOURNAL   Brain Res Mol Brain Res 122 (2), 133-150 (2004)
   PUBMED   15010206
REFERENCE   6  (bases 1 to 2615)
  AUTHORS   Mitton,K.P., Swain,P.K., Khanna,H., Dowd,M., Apel,I.J. and
            Swaroop,A.
  TITLE     Interaction of retinal bZIP transcription factor NRL with
            Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as
            a transcriptional repressor
  JOURNAL   Hum Mol Genet 12 (4), 365-373 (2003)
   PUBMED   12566383
REFERENCE   7  (bases 1 to 2615)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2615)
  AUTHORS   Masuhara,M., Nagao,K., Nishikawa,M., Sasaki,M., Yoshimura,A. and
            Osawa,M.
  TITLE     Molecular cloning of murine STAP-1, the stem-cell-specific adaptor
            protein containing PH and SH2 domains
  JOURNAL   Biochem Biophys Res Commun 268 (3), 697-703 (2000)
   PUBMED   10679268
REFERENCE   9  (bases 1 to 2615)
  AUTHORS   Wolf,I. and Rohrschneider,L.R.
  TITLE     Fiz1, a novel zinc finger protein interacting with the receptor
            tyrosine kinase Flt3
  JOURNAL   J Biol Chem 274 (30), 21478-21484 (1999)
   PUBMED   10409713
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ131593.1, AK142205.1 and AW045450.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 5. All seven variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142205.1, BC106113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                CJ131593.1         1-50
            51-2595             AK142205.1         1-2545
            2596-2615           AW045450.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..2615
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.9 cM"
     gene            1..2615
                     /gene="Fiz1"
                     /gene_synonym="mFLJ00416"
                     /note="Flt3 interacting zinc finger protein 1"
                     /db_xref="GeneID:23877"
                     /db_xref="MGI:MGI:1344336"
     exon            1..104
                     /gene="Fiz1"
                     /gene_synonym="mFLJ00416"
                     /inference="alignment:Splign:2.1.0"
     exon            105..449
                     /gene="Fiz1"
                     /gene_synonym="mFLJ00416"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1640
                     /gene="Fiz1"
                     /gene_synonym="mFLJ00416"
                     /codon_start=1
                     /product="flt3-interacting zinc finger protein 1"
                     /protein_id="NP_001103799.1"
                     /db_xref="CCDS:CCDS20751.1"
                     /db_xref="GeneID:23877"
                     /db_xref="MGI:MGI:1344336"
                     /translation="MEDSSLPVVPAPIAAPGPAPSATAPRVPFHCSECGKSFRYRSDL
                     RRHFARHTALKPHACPRCGKGFKHSFNLANHLRSHTGERPYRCSACPKGFRDSTGLLH
                     HQVVHTGEKPYCCLVCELRFSSRSSLGRHLKRQHRGTLPSPLQPSPGLPPLSSPCSVC
                     CNVGPCSVCGGGGSSGGEGLEGAGATSWGLAEAAAAAAASLPPFACGACARRFDHGRE
                     LAAHWAAHTDVKPFKCPRCERDFNAPALLERHKLTHDLQGSNAPPTQVWASGGGPEVA
                     GEGDASEVGAAPQTWDAGLLLSPTGAGVPKLEALLPGDEGSGNDQAPAAAAEASSEDT
                     LYQCDCGTFFASAPALASHLEAHSGPATYGCGHCGALYAALAALEEHRRASHGEGSGE
                     AAPDGEGNQAAGGPGPGSSSRSKKIFGCSECEKLFRSPRDLERHVLVHTGEKPFPCLE
                     CGKFFRHECYLKRHRLLHGTERPFPCHICGKGFITLSNLSRHLKLHRGMD"
     exon            450..2599
                     /gene="Fiz1"
                     /gene_synonym="mFLJ00416"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2578..2583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fiz1"
                     /gene_synonym="mFLJ00416"
                     /note="hexamer: AATAAA"
     polyA_site      2596
                     /gene="Fiz1"
                     /gene_synonym="mFLJ00416"
                     /note="major polyA site"
ORIGIN      
        1 gggttggggg ggcgtagaag agagctgagg cggaagtcga gaggcccctc aggtggaagt
       61 gacgctgacc ccgctaccca aaatgtcggc gcccagaggg aggtagaaag ccccaagcca
      121 cctccggacc ttccgtcatg gaagactcct cgctgcctgt ggttcctgcc cccatcgctg
      181 ctccaggacc agcaccatct gccactgcgc ctcgggtccc ctttcactgt agcgaatgtg
      241 gcaagagttt ccgttaccga tcagacctga ggcgccactt tgctcgacac acggctctca
      301 agccccacgc atgtcctcga tgcggtaagg gcttcaagca tagcttcaac ttggctaacc
      361 acctgcgctc acacactggt gaacgaccct accgatgctc tgcctgccct aagggattcc
      421 gagactccac tggcctgctg caccaccagg tggtccacac tggtgaaaag ccctactgct
      481 gtttggtctg tgagctccgc ttctcctctc gctccagcct gggccgccat ctcaagcggc
      541 agcaccgggg cacacttccc tctcccctgc agcctagccc cggcctgcct cccctgagct
      601 ccccctgctc agtatgttgc aacgtgggtc cctgttcggt ttgtggaggt ggagggtcca
      661 gtggaggaga gggcctggag ggagcaggag caaccagctg gggactggca gaggctgcag
      721 cagccgcggc agcctcgctg cccccatttg catgcggtgc ctgtgccagg cgttttgacc
      781 atggccggga gcttgcagcc cactgggccg cacacaccga tgtgaagcca ttcaagtgcc
      841 ctcgctgtga gcgcgacttc aacgcacctg cgctgctgga acgccacaag ctcactcatg
      901 acctgcaggg gagcaatgca cctccaacgc aggtttgggc ctcgggtggg ggtccggagg
      961 tggcaggaga gggagatgcc tcagaggtgg gggccgcccc ccagacttgg gacgccgggc
     1021 tgctcctgag ccctaccggg gcaggcgtgc ccaagctgga ggcattgctc ccgggggacg
     1081 agggctctgg gaatgaccag gctccggctg cagcagccga agcatcttcg gaagacacac
     1141 tgtaccagtg cgactgcggg accttcttcg catctgcccc ggctttggcc agccatttag
     1201 aggctcactc aggcccagcc acttatggct gtggccactg cggggcgctg tacgcagcgc
     1261 tggctgccct ggaggagcat cggcgtgcaa gccatggtga gggtagcggg gaggcagccc
     1321 ccgatggtga gggcaatcag gcggctggcg ggccgggacc cggctcctcc agccgtagca
     1381 agaagatctt tggctgttcc gaatgtgaga agctgttccg ttcacctcga gacctggaaa
     1441 ggcatgtgtt ggtccatacc ggggaaaagc cgttcccgtg cctggagtgt ggcaagttct
     1501 tccgccacga gtgctacctc aagcgtcacc ggctgctgca tggcacagag cggcccttcc
     1561 cctgccacat ctgtggcaag ggcttcatca cgcttagcaa cctctccagg catctgaagc
     1621 tacacagggg catggactga ataaccagga cacccctgcc cactgagtcc agagccagac
     1681 cgtaagacaa gccaggcccc tgcctggaaa aatggtgcca cccagaaccc acagtgaaac
     1741 atccttcagc aaagggggtc caagaacata attgttgggg aatttctctc tgaaacctac
     1801 agagactatt cactttgaga cccctggaat gtggcatgtt caaatcaact ggcctccaag
     1861 actgggtaca tagtaatgaa aaacgggtct ccactaacat ctctctgaag ataacatgta
     1921 ggcaccccca tgattttaac caccctgtga gccagcattc cagatccttc atctagagaa
     1981 tgggggtggg gcaatatctt agactcctcc aggaacccct caaatgacac ctgccagcca
     2041 ctggtgaccc cagaaaatga gtataaccga aatctgcctt ccgccaattt tgcttcctgt
     2101 actgaaagaa gatcagggta gatgcccccc accttcagtt aacccactct cagattaggt
     2161 ctcccttact gcagaatggt ctgaccctac tgatcttccc ccatcctgaa cactagatta
     2221 gactggccct ttaggttgga ctaacccaga tgcacatact cctatccact tggaatgggc
     2281 tggtgtctgg aatggttgtg gcctaatccc actctcctta gagtaatagg gcagacattc
     2341 ccttatgctg tagagcacag tcctttgacc acgatttccc aatcctgtga cctggtggag
     2401 gtggtagaca ttgaggcttt ccctacccct tgacttgtag tactttggtc tttccatcac
     2461 tacaacttga ctctttgttc caatgtccca aggggatatg ggaacttggc caggggtttc
     2521 tctcctgtga gcctcaacct gacccctgac ccctctcccc aatgtctctg ggactccaat
     2581 aaacctcatt cagtcattaa aaaaaaaaaa aaaaa
//
