LOCUS       NM_026808                912 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus fat storage-inducing transmembrane protein 1 (Fitm1),
            mRNA.
ACCESSION   NM_026808
VERSION     NM_026808.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 912)
  AUTHORS   Nishihama,N., Nagayama,T., Makino,S. and Koishi,R.
  TITLE     Mice lacking fat storage-inducing transmembrane protein 2 show
            improved profiles upon pressure overload-induced heart failure
  JOURNAL   Heliyon 5 (3), e01292 (2019)
   PUBMED   30923760
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 912)
  AUTHORS   Gross,D.A., Zhan,C. and Silver,D.L.
  TITLE     Direct binding of triglyceride to fat storage-inducing
            transmembrane proteins 1 and 2 is important for lipid droplet
            formation
  JOURNAL   Proc Natl Acad Sci U S A 108 (49), 19581-19586 (2011)
   PUBMED   22106267
  REMARK    GeneRIF: Findings indicate that lipid droplet (LD)produced by
            storage-inducing transmembrane proteins 2 (FIT2) were approximately
            80% larger than storage-inducing transmembrane proteins 1 (FIT1).
REFERENCE   3  (bases 1 to 912)
  AUTHORS   Gross,D.A., Snapp,E.L. and Silver,D.L.
  TITLE     Structural insights into triglyceride storage mediated by fat
            storage-inducing transmembrane (FIT) protein 2
  JOURNAL   PLoS One 5 (5), e10796 (2010)
   PUBMED   20520733
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 912)
  AUTHORS   Kadereit,B., Kumar,P., Wang,W.J., Miranda,D., Snapp,E.L.,
            Severina,N., Torregroza,I., Evans,T. and Silver,D.L.
  TITLE     Evolutionarily conserved gene family important for fat storage
  JOURNAL   Proc Natl Acad Sci U S A 105 (1), 94-99 (2008)
   PUBMED   18160536
  REMARK    GeneRIF: FIT1 and FIT2 are endoplasmic reticulum resident membrane
            proteins that induce lipid droplet accumulation in cell culture and
            when expressed in mouse liver.
REFERENCE   5  (bases 1 to 912)
  AUTHORS   Yawata,M., Murata,S., Tanaka,K., Ishigatsubo,Y. and Kasahara,M.
  TITLE     Nucleotide sequence analysis of the approximately 35-kb segment
            containing interferon-gamma-inducible mouse proteasome activator
            genes
  JOURNAL   Immunogenetics 53 (2), 119-129 (2001)
   PUBMED   11345588
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB054000.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104408.1, AB054000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..912
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BFM/2Msf"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..912
                     /gene="Fitm1"
                     /gene_synonym="1110028A07Rik; Cg10671; Fit1"
                     /note="fat storage-inducing transmembrane protein 1"
                     /db_xref="GeneID:68680"
                     /db_xref="MGI:MGI:1915930"
     exon            1..274
                     /gene="Fitm1"
                     /gene_synonym="1110028A07Rik; Cg10671; Fit1"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..887
                     /gene="Fitm1"
                     /gene_synonym="1110028A07Rik; Cg10671; Fit1"
                     /note="fat-inducing transcript 1; fat-inducing protein 1"
                     /codon_start=1
                     /product="fat storage-inducing transmembrane protein 1"
                     /protein_id="NP_081084.1"
                     /db_xref="CCDS:CCDS27116.1"
                     /db_xref="GeneID:68680"
                     /db_xref="MGI:MGI:1915930"
                     /translation="MERGPTVGAGLGAGTRVRALLGCLVKVLLWVASALLYFGSEQAA
                     RLLGSPCLRRLYHAWLAAVVIFGPLLQFHVNSRTIFASHGNFFNIKFVNSAWGWTCTF
                     LGGFVLLVVFLATRRVAVTARHLSRLVVGAAVWRGAGRAFLLIEDLTGSCFEPLPQGL
                     LLHELPDRKSCLAAGHQWRGYTVSSHTFLLTFCCLLMAEEAAVFAKYLAHGLPAGAPL
                     RLVFLLNVLLLGLWNFLLLCTVIYFHQYTHKVVGAAVGTFAWYLTYGSWYHQPWSPGI
                     PGHGLFPRSRSMRKHN"
     exon            275..912
                     /gene="Fitm1"
                     /gene_synonym="1110028A07Rik; Cg10671; Fit1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      892..897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fitm1"
                     /gene_synonym="1110028A07Rik; Cg10671; Fit1"
                     /note="hexamer: AATAAA"
     polyA_site      912
                     /gene="Fitm1"
                     /gene_synonym="1110028A07Rik; Cg10671; Fit1"
                     /note="major polyA site"
ORIGIN      
        1 gagggaacat ggaacggggg ccgacggtgg gggcagggct gggggccggg acccgagtcc
       61 gagcactgct gggatgcctg gtcaaggtgc tgctctgggt ggcctctgcc ttactgtact
      121 ttggaagtga acaagccgcc cgcctcctgg gcagcccttg cttacggcgc ctctaccatg
      181 cttggttggc agcagtggtc atctttgggc cccttctgca gtttcacgtt aactctcgga
      241 cgatcttcgc tagccacggc aacttcttca acataaagtt tgtgaattca gcatggggct
      301 ggacatgcac cttcctgggg ggctttgtgc tgctggtggt gttcctggct acacgacgtg
      361 tagcagtgac tgccaggcac ctgagccgac tggtggtggg ggcagctgta tggcgggggg
      421 ccggacgtgc cttcctactc atcgaggacc tgacgggttc ctgcttcgag cctctgcccc
      481 agggcctatt gctgcatgag ctgcccgacc gcaagagttg cctggcagcc ggccaccagt
      541 ggaggggcta cactgtctcc tcccacacct tcctcctcac cttctgctgc ctcctcatgg
      601 ctgaggaagc cgctgtgttt gccaagtacc tggcccatgg gctaccagct ggcgccccac
      661 tgcgtcttgt tttcctactc aatgtgctgc tgctgggcct ctggaacttc ctgctgctct
      721 gcacggtcat ctatttccat caatataccc acaaggtggt gggtgcggca gtaggcacgt
      781 ttgcctggta ccttacctat ggcagctggt accatcaacc ctggtcccct gggatcccag
      841 gccacgggct cttccctcga tcccgctcaa tgcgcaaaca taactgaaag aaataaaagc
      901 ataccaggcc tg
//
