LOCUS       NM_025562                802 bp    mRNA    linear   ROD 14-MAY-2024
DEFINITION  Mus musculus fission, mitochondrial 1 (Fis1), transcript variant 1,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_025562
VERSION     NM_025562.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 802)
  AUTHORS   Shen,T., Wang,S., Huang,C., Zhu,S., Zhu,X., Li,N., Wang,H.,
            Huang,L., Ren,M., Han,Z., Ge,J., Chen,Z. and Ouyang,K.
  TITLE     Cardiac-specific deletion of heat shock protein 60 induces
            mitochondrial stress and disrupts heart development in mice
  JOURNAL   Biochem Biophys Res Commun 710, 149883 (2024)
   PUBMED   38588611
REFERENCE   2  (bases 1 to 802)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 802)
  AUTHORS   Rios,L., Pokhrel,S., Li,S.J., Heo,G., Haileselassie,B. and
            Mochly-Rosen,D.
  TITLE     Targeting an allosteric site in dynamin-related protein 1 to
            inhibit Fis1-mediated mitochondrial dysfunction
  JOURNAL   Nat Commun 14 (1), 4356 (2023)
   PUBMED   37468472
  REMARK    GeneRIF: Targeting an allosteric site in dynamin-related protein 1
            to inhibit Fis1-mediated mitochondrial dysfunction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 802)
  AUTHORS   Suh,J., Kim,N.K., Shim,W., Lee,S.H., Kim,H.J., Moon,E., Sesaki,H.,
            Jang,J.H., Kim,J.E. and Lee,Y.S.
  TITLE     Mitochondrial fragmentation and donut formation enhance
            mitochondrial secretion to promote osteogenesis
  JOURNAL   Cell Metab 35 (2), 345-360 (2023)
   PUBMED   36754021
REFERENCE   5  (bases 1 to 802)
  AUTHORS   Salazar-Petres,E., Pereira-Carvalho,D., Lopez-Tello,J. and
            Sferruzzi-Perri,A.N.
  TITLE     Placental structure, function, and mitochondrial phenotype relate
            to fetal size in each fetal sex in micedagger
  JOURNAL   Biol Reprod 106 (6), 1292-1311 (2022)
   PUBMED   35293971
REFERENCE   6  (bases 1 to 802)
  AUTHORS   Karbowski,M., Norris,K.L., Cleland,M.M., Jeong,S.Y. and Youle,R.J.
  TITLE     Role of Bax and Bak in mitochondrial morphogenesis
  JOURNAL   Nature 443 (7112), 658-662 (2006)
   PUBMED   17035996
REFERENCE   7  (bases 1 to 802)
  AUTHORS   Stojanovski,D., Koutsopoulos,O.S., Okamoto,K. and Ryan,M.T.
  TITLE     Levels of human Fis1 at the mitochondrial outer membrane regulate
            mitochondrial morphology
  JOURNAL   J Cell Sci 117 (Pt 7), 1201-1210 (2004)
   PUBMED   14996942
REFERENCE   8  (bases 1 to 802)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   9  (bases 1 to 802)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 802)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW988976.1, AK008078.1 and CD774298.1.
            
            On Jul 11, 2009 this sequence version replaced NM_025562.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010783.1, AK008078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AW988976.1         1-26
            27-784              AK008078.1         19-776
            785-802             CD774298.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..802
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.06 cM"
     gene            1..802
                     /gene="Fis1"
                     /gene_synonym="2010003O14Rik; Ttc11"
                     /note="fission, mitochondrial 1"
                     /db_xref="GeneID:66437"
                     /db_xref="MGI:MGI:1913687"
     exon            1..152
                     /gene="Fis1"
                     /gene_synonym="2010003O14Rik; Ttc11"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..566
                     /gene="Fis1"
                     /gene_synonym="2010003O14Rik; Ttc11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tetratricopeptide repeat domain 11; mitochondrial fission
                     1 protein; FIS1 homolog; TPR repeat protein 11;
                     tetratricopeptide repeat protein 11; fission 1
                     (mitochondrial outer membrane) homolog"
                     /codon_start=1
                     /product="mitochondrial fission 1 protein isoform 1"
                     /protein_id="NP_079838.1"
                     /db_xref="CCDS:CCDS19757.1"
                     /db_xref="GeneID:66437"
                     /db_xref="MGI:MGI:1913687"
                     /translation="MEAVLNELVSVEDLKNFERKFQSEQAAGSVSKSTQFEYAWCLVR
                     SKYNEDIRRGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEP
                     QNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS"
     exon            153..285
                     /gene="Fis1"
                     /gene_synonym="2010003O14Rik; Ttc11"
                     /inference="alignment:Splign:2.1.0"
     exon            286..362
                     /gene="Fis1"
                     /gene_synonym="2010003O14Rik; Ttc11"
                     /inference="alignment:Splign:2.1.0"
     exon            363..468
                     /gene="Fis1"
                     /gene_synonym="2010003O14Rik; Ttc11"
                     /inference="alignment:Splign:2.1.0"
     exon            469..786
                     /gene="Fis1"
                     /gene_synonym="2010003O14Rik; Ttc11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      761..766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fis1"
                     /gene_synonym="2010003O14Rik; Ttc11"
                     /note="hexamer: AATAAA"
     polyA_site      786
                     /gene="Fis1"
                     /gene_synonym="2010003O14Rik; Ttc11"
                     /note="major polyA site"
ORIGIN      
        1 gggcctccac aggtcgatgc cggaagtgcc tctccgcccc tgctactgga ccatggagac
       61 tgtggcccag tagagacctt agtgtgaggc tttcaggggc ggcggccatg gaggccgtgc
      121 tgaacgagct ggtgtctgtg gaggatctga agaattttga aaggaaattt cagtctgagc
      181 aggcagctgg ttctgtgtcc aagagcacgc aatttgaata tgcctggtgc ctggttcgaa
      241 gcaaatacaa tgaggacatc cgcagaggca tcgtgctgct ggaggagctg ttgcccaaag
      301 ggagcaaaga ggaacagcgg gactatgtct tctacctggc cgtgggcaac taccggctca
      361 aggaatatga aaaggctcta aagtatgtgc gagggctgtt gcagactgag ccccagaaca
      421 accaggccaa ggagctggaa cgcctgattg ataaggccat gaagaaagat ggactggtag
      481 gcatggccat cgttggtggc atggccctgg gcgtggcagg cctggctgga ctcattggac
      541 tggctgtctc caagtccaaa tcctgaaggc agcctcacct gctctctgcc ccgggacgcc
      601 taggagcctg ggggacactg gaagaggggc ctgtccatcc tcaccatcgc cttccctttt
      661 ctcctgcacc cctgtagtct acctctacag tctccatgac ccccagcctc ttagcccctg
      721 cacctgtcgt ttaaccctgt catgctttgc aatgagtgta aataaaattg ggccgtggct
      781 cgggaaaaaa aaaaaaaaaa aa
//
