LOCUS       NM_201364               2945 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus FIGNL1 interacting regulator of recombination and
            mitosis (Firrm), transcript variant 1, mRNA.
ACCESSION   NM_201364 XM_355253
VERSION     NM_201364.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2945)
  AUTHORS   Zainu,A., Dupaigne,P., Bouchouika,S., Cau,J., Clement,J.A.J.,
            Auffret,P., Ropars,V., Charbonnier,J.B., de Massy,B., Mercier,R.,
            Kumar,R. and Baudat,F.
  TITLE     FIGNL1-FIRRM is essential for meiotic recombination and prevents
            DNA damage-independent RAD51 and DMC1 loading
  JOURNAL   Nat Commun 15 (1), 7015 (2024)
   PUBMED   39147779
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2945)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2945)
  AUTHORS   Zhang,Q., Fan,J., Xu,W., Cao,H., Qiu,C., Xiong,Y., Zhao,H.,
            Wang,Y., Huang,J. and Yu,C.
  TITLE     The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in
            homologous recombination and replication fork restart
  JOURNAL   Nucleic Acids Res 51 (16), 8606-8622 (2023)
   PUBMED   37439366
  REMARK    GeneRIF: The FLIP-FIGNL1 complex regulates the dissociation of
            RAD51/DMC1 in homologous recombination and replication fork
            restart.
REFERENCE   4  (bases 1 to 2945)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2945)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2945)
  AUTHORS   van Dam,S., Cordeiro,R., Craig,T., van Dam,J., Wood,S.H. and de
            Magalhaes,J.P.
  TITLE     GeneFriends: an online co-expression analysis tool to identify
            novel gene targets for aging and complex diseases
  JOURNAL   BMC Genomics 13, 535 (2012)
   PUBMED   23039964
  REMARK    GeneRIF: BC055324 gene is strongly co-expressed with known
            cancer-associated genes and with genes involved in the cell cycle.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2945)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110499.19, BC055324.1 and AC158964.4.
            
            On Oct 18, 2017 this sequence version replaced NM_201364.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055324.1, AK031594.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC110499.19        170946-170960
            16-2604             BC055324.1         1-2589
            2605-2605           AC158964.4         170586-170586       c
            2606-2945           BC055324.1         2591-2930
FEATURES             Location/Qualifiers
     source          1..2945
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 71.25 cM"
     gene            1..2945
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /note="FIGNL1 interacting regulator of recombination and
                     mitosis"
                     /db_xref="GeneID:381306"
                     /db_xref="MGI:MGI:3590554"
     exon            1..187
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..2788
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C1orf112 homolog;
                     POLO1-associating protein; FIDGETIN-like-1 interacting
                     protein"
                     /codon_start=1
                     /product="FIGNL1-interacting regulator of recombination
                     and mitosis isoform 1"
                     /protein_id="NP_958752.1"
                     /db_xref="CCDS:CCDS35752.1"
                     /db_xref="GeneID:381306"
                     /db_xref="MGI:MGI:3590554"
                     /translation="MSQDDAEVASGVVLEELSSWSEEMCRRELPSVLPRLLSMYQCSE
                     SWIEHIRILKIIVEMFLPHMNHLTLEETLFSQVLPKSIKLFDGMICELTSEARELSSQ
                     NLEIQVTIRNILQAMVQVIGGFTGCVRHVCATQKSVFLGSIQSLPSFILHIIKSAFVH
                     CKNSECVYSGRLHLVSDLLQVLFKEAYSLQKQLMGLLDTVCLDPSVDENNALIMVGVI
                     HSLLDICSVISGMDQAFHANTWKFIIKQSLKHHSVIKSQLRHKEIISSLCEDILFSFH
                     SCLQLAEQITQPAAQGNADYRLFQKTLKLCRFFANSLLHYTKECLPFLSDSCCTLHQL
                     YLQIHSKFLSLCAAKTSKAQQEEIASTFLVLLDPLISQLLKSQPFVQAVLASKLALPC
                     ELQLPQVLLLVVAMDKLPSQPQDVQTLWSTEDMTRMSILKGIFYNFGQCSGELSLPTH
                     LQGTKGKGQAEVPVTLYQHVCVHLCAFVASFHSSLFPRLDAALLNAVLSTNMSTSLLA
                     MDVWCFLARYGTAKLGAHHVTLVAHLVKSCPGKCVQLTNLSILLKRLLFFMAAPHQVQ
                     FIQKFSPKEADNLHLWQYISLQAFDADLRKPVACELVRVCRAQCRKWLSSTRTLAELD
                     SLNTALSVVLTVCNSAGEALDSRQLTAVTEVLGELWTFINVEQIISQPYVQQAFSLLL
                     QLLAFFIQTVDLQLISQVVNVLTSVIKLEPPDHVSLAVLDFISSLGKLYISQTIRDKV
                     LPSLSCILTSLIVNKNWLLEQHTLEAFTQFAEGTKHEEIVPQCLGSEEIKNKVVSFLE
                     KTESVDEAEVATVDNVKQEKGTFWEPAAKVTVEEVKTSAFQPHTKRARRVLPFEEEYR
                     SVFKAAARALETTEFLLKHSLAPAWLLPELEALQGRIEKLKRCVLTG"
     exon            188..227
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            228..316
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            317..421
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            422..562
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            563..725
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            726..810
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            811..949
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1030
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1095
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1241
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1356
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1543
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1626
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1678
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1768
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1954
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2077
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2173
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2287
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2392
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2473
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2593
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2927
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2900..2905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /note="hexamer: CATAAA"
     polyA_site      2927
                     /gene="Firrm"
                     /gene_synonym="FLIP"
                     /note="major polyA site"
ORIGIN      
        1 aaagcctgct gggacggcgt tccaagctgt ggcgggagtc gtgcggattc gttcgtctct
       61 cgggggtggc gaaagaatgt cgcaggacga tgcggaggtg gcgagcgggg tcgtgctgga
      121 ggaactcagc agctggtcgg aggagatgtg ccgtcgggag ctgccttcgg tgctgccccg
      181 gctcctctct atgtatcaat gttctgaaag ttggattgaa catatccgaa ttttaaaaat
      241 cattgttgaa atgtttttgc ctcatatgaa ccacctgaca ctggaagaaa ctttgttttc
      301 ccaagtttta ccaaagagta taaaattgtt tgatggcatg atatgtgaat taaccagtga
      361 agccagagaa ctctccagcc aaaatttaga aatccaggtc accataagga acattttaca
      421 agcaatggtg caggtcatag gaggttttac aggatgtgtc cgtcatgtct gtgccacaca
      481 gaaatctgtc tttctaggaa gtattcagag tcttccctca ttcatcctgc atataattaa
      541 aagtgcattt gtgcactgta agaacagcga atgtgtgtat tctgggcgct tacacctagt
      601 gtcagacctt ctccaggttc tgttcaagga ggcctattct ctccagaagc agctgatggg
      661 actgctggac acggtttgcc tggacccttc agtagatgag aataacgctt tgataatggt
      721 aggagttatt cattcattat tggatatctg ctctgttatc tctggtatgg accaagcatt
      781 tcatgccaat acttggaagt ttattattaa gcagagcctc aaacaccact cggttataaa
      841 gagccagttg agacacaaag agatcatttc tagcttgtgt gaagacattc ttttctcctt
      901 tcattcttgt ttacagttag ctgagcagat aacacagcca gctgcacagg gtaatgctga
      961 ctacaggtta tttcaaaaaa cactgaaatt gtgtcgtttc tttgctaact cccttttgca
     1021 ctacactaag gaatgtcttc ctttcctgtc tgattcttgc tgtactctgc accagcttta
     1081 tctgcagata cacagcaagt ttctaagcct ctgtgctgcc aagacttcca aagcccagca
     1141 ggaggaaata gcaagcactt tccttgtgct actggaccca ctcatcagtc agctgctcaa
     1201 atcccagcct tttgtgcagg cagttttggc gagtaaactt gccctgccct gtgagctgca
     1261 gctcccacaa gtcctactcc tggttgtcgc catggataaa ctgccctctc agccacagga
     1321 cgtgcagacc ctgtggagca cagaggatat gactaggatg tccatactga aaggaatttt
     1381 ctacaatttt ggccagtgtt ctggtgaact ctctctgcct actcatttac aaggaacgaa
     1441 gggtaaagga caagctgagg tgcctgtcac gttgtatcag catgtttgtg ttcatctgtg
     1501 tgcatttgtg gcttcttttc attcttcatt gtttcctcgg ctggatgctg ctctattgaa
     1561 tgctgtgctt agtaccaata tgagtacctc tttgttagcg atggatgtgt ggtgcttcct
     1621 tgctcggtat gggactgcta aacttggtgc acaccatgtc accctagtgg ctcatctggt
     1681 taaatcttgc cctggaaaat gtgttcagct taccaacctc tccatactgt tgaagcgcct
     1741 ccttttcttc atggctgcac cccatcaggt gcaattcatc cagaaatttt ctccaaaaga
     1801 agcagacaac ttgcatttgt ggcagtatat ttccctccag gcgttcgatg ctgatctcag
     1861 gaagccggtt gcatgtgaat tggtcagagt gtgcagagca cagtgcagga agtggttgag
     1921 cagcactcgg actctggcag agcttgactc tctgaacaca gcactttctg ttgtacttac
     1981 tgtctgcaat tctgctggag aagctttgga tagtagacag ctaactgcag ttactgaagt
     2041 tttgggtgag ctttggactt tcataaacgt tgaacaaatt atcagtcagc cctatgttca
     2101 acaggcattt agccttttac ttcaactgct ggcgtttttc atccaaactg tagatctgca
     2161 gctgataagt caggttgtaa atgtcctgac ttcggtgatt aaactagagc ctcctgacca
     2221 cgtctctttg gcagtgctgg attttatatc gtctctgggc aaactttata tatctcaaac
     2281 tatccgggac aaggtgctgc ccagcttgtc ttgtattctt acttcactga tcgtcaacaa
     2341 gaattggttg ctagagcaac atactttgga ggcatttact cagtttgctg agggaacaaa
     2401 gcatgaagag atagttccac agtgtctcgg ttctgaagaa atcaagaaca aagttgtatc
     2461 ctttttggag aagacagaat ctgtagatga agctgaggtt gccacagtgg acaatgtgaa
     2521 gcaggagaaa ggcactttct gggaacctgc tgctaaggtg actgtagaag aagtgaagac
     2581 gtcagcgttt cagcctcaca caaagagagc ccgtcgggtg ttgccctttg aagaagaata
     2641 cagatcagta tttaaagctg cagcaagggc tttggagaca actgagtttt tactcaaaca
     2701 ctctcttgct ccagcatggc tgctgccaga actggaggcg ctgcaaggaa ggatcgagaa
     2761 gctaaaacgc tgtgtgctta cagggtaaaa tatgaatggc ctgtgtatcg acagaactgg
     2821 gctgactctt cagatgcctg cctgggtgtt ttgtaaatga aattgtgaat gtaaattatg
     2881 tttgtatatt ttcatagcac ataaaagagc ttttgtaaat gtgaaaaaaa aaaaaaaaaa
     2941 aaaaa
//
