LOCUS       NM_001159573            4739 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus factor interacting with PAPOLA and CPSF1 (Fip1l1),
            transcript variant 1, mRNA.
ACCESSION   NM_001159573
VERSION     NM_001159573.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4739)
  AUTHORS   Cai,Y., Yoneda,M., Tomita,T., Kurotani,R., Okamoto,M., Kido,T.,
            Abe,H., Mitzner,W., Guha,A. and Kimura,S.
  TITLE     Transgenically-expressed secretoglobin 3A2 accelerates resolution
            of bleomycin-induced pulmonary fibrosis in mice
  JOURNAL   BMC Pulm Med 15, 72 (2015)
   PUBMED   26178733
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4739)
  AUTHORS   Lackford,B., Yao,C., Charles,G.M., Weng,L., Zheng,X., Choi,E.A.,
            Xie,X., Wan,J., Xing,Y., Freudenberg,J.M., Yang,P., Jothi,R., Hu,G.
            and Shi,Y.
  TITLE     Fip1 regulates mRNA alternative polyadenylation to promote stem
            cell self-renewal
  JOURNAL   EMBO J 33 (8), 878-889 (2014)
   PUBMED   24596251
REFERENCE   3  (bases 1 to 4739)
  AUTHORS   Kiefer,H., Mizutani,A., Iemura,S., Natsume,T., Ando,H., Kuroda,Y.
            and Mikoshiba,K.
  TITLE     Inositol 1,4,5-triphosphate receptor-binding protein released with
            inositol 1,4,5-triphosphate (IRBIT) associates with components of
            the mRNA 3' processing machinery in a phosphorylation-dependent
            manner and inhibits polyadenylation
  JOURNAL   J Biol Chem 284 (16), 10694-10705 (2009)
   PUBMED   19224921
REFERENCE   4  (bases 1 to 4739)
  AUTHORS   Stover,E.H., Chen,J., Folens,C., Lee,B.H., Mentens,N., Marynen,P.,
            Williams,I.R., Gilliland,D.G. and Cools,J.
  TITLE     Activation of FIP1L1-PDGFRalpha requires disruption of the
            juxtamembrane domain of PDGFRalpha and is FIP1L1-independent
  JOURNAL   Proc Natl Acad Sci U S A 103 (21), 8078-8083 (2006)
   PUBMED   16690743
  REMARK    GeneRIF: FIP1L1-PDGFRalpha activation requires disruption of the
            juxtamembrane domain of PDGFRalpha and is FIP1L1-independent
REFERENCE   5  (bases 1 to 4739)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113300.7 and AC164523.4.
            
            On Dec 5, 2019 this sequence version replaced NM_001159573.1.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219383.27961.1, AK008561.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               AC113300.7         16505-16775         c
            272-316             AC113300.7         15421-15465         c
            317-356             AC113300.7         15285-15324         c
            357-414             AC113300.7         11277-11334         c
            415-518             AC113300.7         10154-10257         c
            519-583             AC113300.7         6790-6854           c
            584-691             AC113300.7         6106-6213           c
            692-822             AC113300.7         5441-5571           c
            823-932             AC164523.4         19100-19209
            933-1040            AC164523.4         26579-26686
            1041-1134           AC164523.4         33159-33252
            1135-1291           AC164523.4         34489-34645
            1292-1318           AC164523.4         47106-47132
            1319-1373           AC164523.4         49063-49117
            1374-1429           AC164523.4         50205-50260
            1430-1649           AC164523.4         53834-54053
            1650-1787           AC164523.4         57134-57271
            1788-4739           AC164523.4         57899-60850
FEATURES             Location/Qualifiers
     source          1..4739
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 39.51 cM"
     gene            1..4739
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /note="factor interacting with PAPOLA and CPSF1"
                     /db_xref="GeneID:66899"
                     /db_xref="MGI:MGI:1914149"
     exon            1..271
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..1935
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pre-mRNA 3'-end-processing factor FIP1; FIP1-like 1
                     protein; FIP1 like 1"
                     /codon_start=1
                     /product="pre-mRNA 3'-end-processing factor FIP1 isoform
                     1"
                     /protein_id="NP_001153045.1"
                     /db_xref="CCDS:CCDS51520.1"
                     /db_xref="GeneID:66899"
                     /db_xref="MGI:MGI:1914149"
                     /translation="MSAGEVERLVELSGGTGGDEEEEWLYGGPWDVHVHSDLAKDLDE
                     NEVERPEEENASANPPSGIEEEAAENGVAKPKVTETEDDSDSDSDDDEDDVHVTIGDI
                     KTGAPQYGSYGTAPVNLNIKAGGRVYGNTGTKVKGVDLDAPGSINGVPLLEVDLDSFE
                     DKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITVQQGRTG
                     NSEKEAALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKASSSVGKWQDRYG
                     RAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSDRSATEVDNNFSKPPP
                     FFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGIPITVPPPGFPPPPGAPPPSLIPT
                     IESGHSSGYDSRSARAFPYGNVAFPHLTSSAPSWPSLVDTTKQWDYYARREKDRDRDR
                     ERDRDRERERDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRAS
                     REKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGS
                     EPVPEQESTEAAPAE"
     exon            272..316
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     exon            317..356
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     exon            357..414
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     exon            415..518
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     exon            519..583
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     exon            584..691
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     exon            692..822
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     exon            823..932
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1040
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1134
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1291
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1318
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1373
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1429
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1649
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1787
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..4739
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2067..2072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /note="hexamer: AATAAA"
     polyA_site      2102
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /note="major polyA site"
     regulatory      2126..2131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /note="hexamer: AATAAA"
     polyA_site      2148
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
     regulatory      4713..4718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
                     /note="hexamer: AATAAA"
     polyA_site      4739
                     /gene="Fip1l1"
                     /gene_synonym="1300019H17Rik; Rje"
ORIGIN      
        1 gcagacggat cggtcgctga ctcttcaggg tcgccgcctc caccgaggtt ggccccagat
       61 ttgagtctcg cgctcttcgt tcgcttaccg gcggcttccc tcccattctc gcgccctggg
      121 acggcgaggc tggaaaaagg ggttgagaga gctgttggcc gccgccttta acttgtgcgt
      181 ggggcggcca tgtcggccgg cgaggtggag cgcctggtgg agctgagcgg cgggaccgga
      241 ggggatgagg aggaagagtg gctgtatggc ggcccgtggg acgtgcatgt gcacagtgac
      301 ttggcaaagg atctagatga gaatgaagtt gaaaggccag aagaagaaaa tgccagtgct
      361 aatcctccat ctggaattga agaagaagct gctgaaaatg gcgtggcaaa accgaaagtg
      421 acagagactg aagacgacag tgatagtgac agtgacgatg atgaagatga tgttcacgtc
      481 actataggag acatcaaaac aggagcacca cagtatggga gttatggaac agcaccagta
      541 aatcttaata tcaaggcagg gggaagagtt tatggaaata caggaaccaa agtcaaagga
      601 gtggacctcg atgcacctgg cagcattaat ggagttccac tcttggaagt agatctggat
      661 tcttttgaag ataaaccatg gcggaaacct ggtgctgatc tttctgatta ttttaactat
      721 ggctttaatg aagatacttg gaaagcttac tgtgaaaaac aaaagaggat acgaatggga
      781 ctggaagtta tacctgttac ttcaaccaca aacaagatta cggtacagca agggagaact
      841 ggaaattcag agaaagaagc agcacttcca tctacaaaag ctgagtttac ttctccgcca
      901 tcattgttca agactggtct gccaccaagc agaaacagca cctcttctca gtctcagaca
      961 agtactgcct ccagaaaagc cagttcaagc gttgggaagt ggcaggatcg atatgggagg
     1021 gccgagtcac ctgatctaag gagattacct ggagcaattg atgtcattgg tcaaacaata
     1081 accatcagcc gagtggaagg aagacggcgt gcaaatgaga acagcaatat acaggtcctt
     1141 tctgacagat ctgccactga agtagacaac aatttcagca aaccacctcc atttttccct
     1201 ccaggggctc ctcctactca ccttcctcct cctccatttc tcccaccacc tccaactgtc
     1261 agcaccgccc cacctctcat tccaccacca ggtattccaa taactgtacc acctccaggt
     1321 ttcccccctc caccaggcgc cccacctcca tctcttatac caacaataga aagtggccat
     1381 tcctccgggt atgacagccg ttctgcacga gcgtttccct atggcaatgt cgcctttccc
     1441 caccttacca gttctgctcc ctcatggccg agccttgtgg acaccaccaa gcagtgggac
     1501 tattatgcaa ggagagaaaa agaccgagac cgagaccggg agagagaccg agacagagag
     1561 cgagagcggg accgggacag agaaagggag cgcacccggg agcgggagcg agagcgcgac
     1621 cacagcccca ccccaagtgt tttcaacagt gacgaagagc gatacagata cagggagtat
     1681 gcagagagag gctatgagcg ccatagagct agtcgggaga aagaagagcg gcacagagaa
     1741 cgacgtcaca gagagaagga ggaaacaaga cacaagtcct ctcgcagtaa tagtagacgt
     1801 cgccatgaaa gtgaagaagg ggacagtcac agaagacaca agcacaaaaa gtctaaaaga
     1861 agcaaagaag gaaaagaggc tggcagcgag ccggtcccag aacaggagag caccgaagcc
     1921 gcccctgccg agtaggctcc acctcttctg tacgtcagtc ccagaaatag atgctataaa
     1981 tctccttatt tttctggata atgtttaaga aatatacctt taatcttgtt ctgttagaat
     2041 gaaacgttaa cttttttctt ttccaaaata aaagtgtgca tttttttgtg ttaagttaaa
     2101 aagctttgtc ttgtaatatt taaagaataa aagacagaag tgactttata tctaagaaag
     2161 taatgtgaat taagtcatca ggggatttag agctaaggtt gaccatgtga tcacgggatg
     2221 gtgaaggcca aggcctcatc ctggctagct ttctggttag tgggatagtg ttgcagaaga
     2281 ggtgctgccc tgcagactcc ctcttgacat gaagtcaggc ttcatcttac tgctgggaca
     2341 ctcctgcatc ttcaagaact tggacccagt cttgatatca cagtttttga tagcaggttt
     2401 tcagtgttct gaatttgagt ccatagtaac taagtggact atttgtatat ctaaattcat
     2461 aaatggtatg aggcacttgg gtacccctgt gatgaaactt gtgtgcttcc tagcaggcac
     2521 atgaacctga ctggcagagc atcagaccag tccatggcca tctgagcaag gatcaaggtg
     2581 ctctggctgc tgttagtatg ttttccaagg atcaacggta gcgtaggacg tgggggattt
     2641 ttttttttat atcgtttcca tattaagaat aaaaataaaa atagactcag cgacagtagt
     2701 gttagatcag tcatttctta ttaaaaccag agcacaggtt aaactctgga ctaaccccaa
     2761 gaggcattct agagcagcga tggggctagg agcctagtgt gtgaaagatg gggcagttag
     2821 agccaccagt aagaggactg ctctcactta gaagatactc atttctcatt gaaatcctcc
     2881 gccatttagc ttaaatgccc ataatatact ctgtcttcaa ctctaccaca tttggaactg
     2941 acttgaatta agtgtggcat acaaaccatg taaatcttca tgggcttttt tattgaatta
     3001 aaaatatata aacttaaaag acttggagta ataagaaatc ctctacacca aataaaaatt
     3061 atcactagtt tttatttttg agaacagtct ctgaggtgta acttttcata atatcatact
     3121 tttctggcat tttttacaat atattcttta aatataaaaa ttgacaagat aaatacaatt
     3181 ttacctagcc tatctgtggt ttttctaaga tccatcattg attttataaa aaagtaccag
     3241 gccaagaagc aatggtcaga gtaattctcc ctttaagttc cttgagcatc ctggccaggc
     3301 aagcgtgtat catacccgat gtacttctac cgttgacagc gagaagaatg tcaccacatc
     3361 taaaaagaac acagcactga gatcagaacc acttcatggt tgaagctcct caaagggact
     3421 tgagtggtcc tagggtttgc catattggtc cattttaatt ctgatctgat cttccctctt
     3481 cacgtaaatt cttcaagctc tactcggctt gcattagaag gtatagtagt atataggaac
     3541 ttgagaggta ggaccaaggc cggttataat tttgggtttc ttactaccta actagtacac
     3601 tcatgttttc atttctcact cttcaggaaa gtataatcta tgctttttct ttcaagtggg
     3661 gccaagtttt tacatgtaga aaacaaaaat acttgaatat tattttttgc taagtaatca
     3721 ttacctgatt cttccgtcat tgtatgcagg tgttccttca acaatggact tgataaaaaa
     3781 aggtttgttc ccactgtatt cttcataacc tcccacaatg cagaagccca ggcttccagc
     3841 tgtgttcctt cgcagtatca catctttaca gttacataag tacctgaaat agaatgtaat
     3901 taatgtctat ttaaatgagt ttttagctgt gacttctctc attcattttt tggggacact
     3961 tttaaaatga aaaaatactg cgtcagcttt tgtattttga tctctttttt ccatagctga
     4021 ataccctttc aacaaaagga cttagtatta ttttctattt gtgtctctgc tgagaaagat
     4081 ggccacattt ttttggctaa ggacaaaata atgcatgagc cagaagtagg atatgtctcg
     4141 atacttctaa tgataaccca cagtggaaca tattgagggg gtataatttt atatacttgg
     4201 gggctcatat aatttgtaaa gaagacaaac attctcagaa ttagcgatta attgcaagga
     4261 caataatttt aacttatgct aatgaacttc actaagttgt aagctttcta ttgacccttg
     4321 gaaaatacta gtttatactc acacaaactg aagactgtag acaaagtgaa tggaaacttg
     4381 gccaaaaata gtggagtggt tgttgtagga aaataacatg gcatagctgc agcaaagagt
     4441 acagagggga gggaggagca cagctggcct gagaaccaat accaccttca actaggagag
     4501 tcgcggctgt cagacctaag tgcaaacagc tgcattagag tagacagtgt gtcggaagat
     4561 gggggtggct ctaggatcaa gggatctacc acatgtgtat ctatggtcta ggaactgctt
     4621 ttgactggaa gatagtgttt ttatgttggt agaaatgaag atgttttgtt tatagactgt
     4681 accttaaaat aatcagttgc tttttgataa tcaataaaaa tgatcttgtg aaatattaa
//
