LOCUS       NM_001040397            3946 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus filamin A interacting protein 1-like (Filip1l),
            transcript variant 1, mRNA.
ACCESSION   NM_001040397 NM_030163 XR_002318 XR_004520 XR_005141
VERSION     NM_001040397.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3946)
  AUTHORS   Kwon M, Rubio G, Wang H, Riedlinger G, Adem A, Zhong H, Slegowski
            D, Post-Zwicker L, Chidananda A, Schrump DS, Pine SR and Libutti
            SK.
  TITLE     Smoking-associated Downregulation of FILIP1L Enhances Lung
            Adenocarcinoma Progression Through Mucin Production, Inflammation,
            and Fibrosis
  JOURNAL   Cancer Res Commun 2 (10), 1197-1213 (2022)
   PUBMED   36860703
  REMARK    GeneRIF: Smoking-associated Downregulation of FILIP1L Enhances Lung
            Adenocarcinoma Progression Through Mucin Production, Inflammation,
            and Fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3946)
  AUTHORS   Kwon M, Rubio G, Nolan N, Auteri P, Volmar JA, Adem A, Javidian P,
            Zhou Z, Verzi MP, Pine SR and Libutti SK.
  TITLE     FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal
            Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1
  JOURNAL   Cancer Res 81 (21), 5523-5539 (2021)
   PUBMED   34417201
  REMARK    GeneRIF: FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal
            Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1.
REFERENCE   3  (bases 1 to 3946)
  AUTHORS   Revert-Ros F, Lopez-Pascual E, Granero-Molto F, Macias J, Breyer R,
            Zent R, Hudson BG, Saadeddin A, Revert F, Blasco R, Navarro C,
            Burks D and Saus J.
  TITLE     Goodpasture antigen-binding protein (GPBP) directs myofibril
            formation: identification of intracellular downstream effector
            130-kDa GPBP-interacting protein (GIP130)
  JOURNAL   J Biol Chem 286 (40), 35030-35043 (2011)
   PUBMED   21832087
  REMARK    GeneRIF: GPBP directs myofibril formation through interaction with
            intracellular downstream effector 130-kDa GPBP-interacting protein
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY739488.1, CT030226.8 and AC144776.2.
            
            [WARNING] On Jan 16, 2024 this sequence was replaced by
            NM_001040397.5.
            
            On or before Apr 30, 2010 this sequence version replaced
            NM_030163.1, NM_001040397.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU704258.1, SRR9219383.82025.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-462               BY739488.1         2-463
            463-612             CT030226.8         5589-5738           c
            613-657             CT030226.8         1-45                c
            658-791             AC144776.2         73919-74052         c
            792-3946            AC144776.2         14559-17713         c
FEATURES             Location/Qualifiers
     source          1..3946
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 34.22 cM"
     gene            1..3946
                     /gene="Filip1l"
                     /gene_synonym="4631422O05Rik; Doc1"
                     /note="filamin A interacting protein 1-like"
                     /db_xref="GeneID:78749"
                     /db_xref="MGI:MGI:1925999"
     exon            1..182
                     /gene="Filip1l"
                     /gene_synonym="4631422O05Rik; Doc1"
                     /inference="alignment:Splign:2.1.0"
     exon            183..438
                     /gene="Filip1l"
                     /gene_synonym="4631422O05Rik; Doc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..3588
                     /gene="Filip1l"
                     /gene_synonym="4631422O05Rik; Doc1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     downregulated in ovarian cancer 1-like; protein
                     down-regulated in ovarian cancer 1 homolog"
                     /codon_start=1
                     /product="filamin A-interacting protein 1-like isoform 1"
                     /protein_id="NP_001035487.2"
                     /db_xref="CCDS:CCDS37366.2"
                     /db_xref="GeneID:78749"
                     /db_xref="MGI:MGI:1925999"
                     /translation="MRSRSSNAEGSAPKQIPRHSKFQDSIQDMKHRTHKKDPSCESEG
                     VLPRPVSEKSHTGKGHHTEDLSRDDLLFLLSILEGELQARDEVIGILRAEKIDLALLE
                     AQYGFVTPKKVLEALQRDAFQAKSAPWQEDIYEKPMNELDKVVEKHKESHRRILEQLL
                     MVERSHRQTIMEMEEEKRKHKEYMKKSDEFINLLEQECERLKKLIDQETASQEKKEQE
                     KEKRIKTLKEELTKLKSFALMVVDEQQRLTAQLALQRQKIQALTTSAKETQGKLALAE
                     ARAQEEEQKATRLEKELQTQTTEFHQNQDKIMAKLTNEDSQNRQLRQKLAALSRQIDE
                     LEETNRSLRKAEEELQDIKDKINKGEYGNSGIMDEVDELRKRVLDMEGKDEELIKMEE
                     QCRDLNKRLEKETVQSKDFKLEVDKLSVRITALEKLEDALDKSKQECYSLKCNLEKEK
                     MTTKQLSEELESLNARIKELEAIESRLEKTEITLKDDLTKLKTLTVMLVDERKTMSEK
                     LKQTEDKLQSTTSQLQAEQNKVTTVTEKLIEETKRALKSKTDAEEKMYSVTKERDDLR
                     NKLKAEEEKGHDLLSKVTILKNRLQSLEAIEKDFVKNKLNQDSSKSTAALHQENNKIK
                     ELSQEVENLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSQELEHAKMEL
                     AKYKLAEKTESSHEQWLFRRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGD
                     HSLLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNERRISDPQVFSKEV
                     QTEAADSEPPDYKSLIPLERAVINGQFYEENEDQDDDPNEEESVLSFRCSQSSSLPMN
                     RKLWIPWMKSKEGHPQNGKIQTKSNGNFVQPGDLVLSHTPGQPLHIKVTPDHIQNTAT
                     LEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPIKSKSSTESLMNLEQSMS
                     PVTMATFARAQTPESCGSVTPERTMSPIQVLAMTGSPSSPEQGCSPEPIEISAKHAIF
                     RVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVAGPMRPASPSAPLQDN
                     RTQGLTNGALNKTTNKVTSSITITPTATPLPRQSQITVSNIYN"
     exon            439..612
                     /gene="Filip1l"
                     /gene_synonym="4631422O05Rik; Doc1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..791
                     /gene="Filip1l"
                     /gene_synonym="4631422O05Rik; Doc1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..3946
                     /gene="Filip1l"
                     /gene_synonym="4631422O05Rik; Doc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagaaccgt ccctggtccc tggttacata ctctccgtga ctttgagacc cacaaggcaa
       61 atagcgagag ggtgcccaaa aagaaaagaa aacgcttttg ggtgctcagg ctccactgct
      121 ggatttcgac aggcatcaga agagagaacg gccaggcgtg atgaagccca ggtacctgca
      181 tgtccttgaa gaatgcgttc cagaagcagc aatgctgagg gctcagcccc aaagcaaatc
      241 ccaagacata gcaaattcca ggacagtatc caggacatga agcacagaac acacaaaaaa
      301 gacccctcgt gtgagtcaga aggggtcctt ccacgtcccg tgtcagagaa gtcacacact
      361 ggcaaaggcc accacacaga agacctctca agagatgact tactatttct gctcagcatt
      421 ctggagggag aactgcaggc tcgagatgaa gtcattggca ttttaagggc tgaaaaaata
      481 gacctggctt tgctggaggc tcagtatggg tttgtcactc cgaaaaaggt gttggaggct
      541 ctccagagag atgcttttca agcaaaatct gccccgtggc aggaggacat ctatgagaaa
      601 ccaatgaatg agttggataa agtcgtagaa aagcataaag aatctcacag gcggatcttg
      661 gaacaactct taatggtaga aagatcccac cggcaaacca taatggagat ggaggaagaa
      721 aagagaaaac acaaagaata tatgaagaag agtgatgaat tcataaactt attggagcag
      781 gaatgtgaga gattaaagaa actaattgat caagaaactg cgtcccagga aaagaaggag
      841 caagaaaagg agaagaggat caagaccctg aaggaggagc tgaccaagct gaagtccttt
      901 gctttgatgg tggtggatga acaacaacgg cttacagctc aactcgccct tcaaagacag
      961 aaaatccaag ctctgaccac aagtgcaaag gaaacacagg gtaaactagc ccttgctgag
     1021 gccagagctc aggaagaaga gcagaaggca accagactag aaaaagaact gcagacacag
     1081 accacagagt ttcaccaaaa ccaagacaaa attatggcga agctcaccaa tgaggacagt
     1141 caaaatcgcc agctccgaca gaagctggca gcactcagtc ggcaaattga tgagttagaa
     1201 gagaccaaca ggtctttaag aaaagccgag gaagagctgc aggatataaa agacaaaata
     1261 aacaagggag aatatggaaa ctctggcatc atggatgaag tggatgagct caggaagcgc
     1321 gtgctggaca tggaagggaa agatgaagag ctcataaaaa tggaggagca gtgcagagac
     1381 ctcaataaga ggctagagaa agagacagta cagagtaaag acttcaaact agaggttgac
     1441 aaacttagtg taaggatcac agctctggaa aaattagaag atgctttaga caaaagcaaa
     1501 caagaatgct actctctgaa atgcaattta gaaaaagaaa agatgaccac aaagcaattg
     1561 tctgaagagc tggagagttt aaatgccaga atcaaagagc tagaagccat tgaaagtcgg
     1621 ctagaaaaga cagaaatcac actaaaggat gatttaacta aactgaaaac tttaactgtg
     1681 atgcttgtag atgaacgcaa aacaatgagt gaaaaattaa agcaaacaga agataagtta
     1741 caaagcacca cctctcagct ccaagcagag caaaataaag taacaacagt gactgagaag
     1801 ttaattgagg aaaccaagag ggcactcaag tccaaaactg atgcagaaga gaagatgtac
     1861 agtgtaacca aggagagaga tgacctcaga aataaactga aagcagaaga agagaaagga
     1921 catgatctct tgtcaaaagt tactatattg aaaaacaggc ttcagtcact ggaagcaatt
     1981 gagaaagatt ttgtaaaaaa caaattaaac caagactcca gtaagtccac agcagcatta
     2041 caccaagaaa acaataagat taaagagctc tctcaagaag tggaaaatct gaaactgaag
     2101 ctaaaggata tgaaagccat tgaggatgac ctcatgaaaa cagaggatga gtacgagacc
     2161 ttagaacgga ggtatgctaa cgagagagac aaggctcagt ttctgtctca ggagctggaa
     2221 catgccaaga tggagcttgc caagtacaag ttggccgaga agacagagtc cagccacgag
     2281 cagtggctct ttaggaggct ccaggaagaa gaagcaaaat cagggcacct gtccagagaa
     2341 gtggatgcat taaaagagaa aattcatgag tacatggcca cagaggacct aatatgtcac
     2401 ctccaaggag accactccct tctgcaaaag aaactaaacc aacaagaaaa caggaacaga
     2461 gatttgggaa gagagattga aaacctcact aaagagttag aaaggtatag gcactttagt
     2521 aagagcctcc ggcctagtct caacgaaaga agaatctctg acccgcaagt attttctaaa
     2581 gaagttcaaa cggaagcagc agacagtgag ccaccagact acaagagcct cattcctctg
     2641 gaaagagcag tgatcaatgg tcagttctat gaggagaatg aggaccagga tgacgaccct
     2701 aatgaggagg agtctgtgct gtccttcaga tgcagccagt cttcttctct tcctatgaac
     2761 aggaaactat ggattccctg gatgaaatcc aaggagggcc atcctcagaa tggaaaaata
     2821 caaactaagt ccaatggcaa ctttgtacaa cctggagatc ttgttctaag tcacacacct
     2881 gggcagccac ttcacataaa ggttactcca gaccacattc aaaatacagc tactcttgaa
     2941 atcacaagtc caaccacaga gagtcctcac tcctacacca gcacagcggt gataccaaac
     3001 tgtggcaccc caaagcaaag gattaccatt ctccaaaatg cctctataac accaattaag
     3061 tccaaaagct ctacagaaag ccttatgaac ttagagcaaa gcatgtcccc agttaccatg
     3121 gcaacctttg ccagagcaca gaccccagag tcctgtggtt ctgtgactcc agaacggaca
     3181 atgtcaccta ttcaggtttt ggctatgact ggttcaccta gttctcctga gcaaggctgc
     3241 tccccagagc cgatagaaat cagcgccaag catgcaattt tcagagtctc cccagaccgg
     3301 cagtcatcat ggcagtttca acgttcaaac agtaacagct caagtgtgat aactactgag
     3361 gataataaaa tccacattca cttaggaagt ccttacatgc aagctgtggc tggccccatg
     3421 agacctgcca gcccttcagc accactgcag gataacagaa ctcaaggctt aactaatggg
     3481 gcactaaaca aaacaaccaa taaagtcacc agcagtatta ctatcacacc aacagccaca
     3541 cctcttcctc gacaatcaca aattacagta agtaatatat ataactgacc accctcaccc
     3601 tcatccagtt catactgata ttcttgcaag gaactcagtc cctttttaat cacccctcca
     3661 aatcccttag aagaatgact aaacctgtac tttgggaaga tttgtgcatg gactgaacaa
     3721 gagtatctgg aactaactat gtgttgcctg catagtcaca tcaagtgtgc acttactgta
     3781 tatcttttta tttacatacc tgtatggaaa atatttagtc tgcacttgta taaatacatc
     3841 tttatgtatt tcattttcca taactcactt taatttgact gcaacttgtc ttggtgaatt
     3901 acttaacatt ataaaacagt aaatagtttg ttacttttgc cattgc
//
