LOCUS       NM_001357352            4502 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus filamin A interacting protein 1 (Filip1), transcript
            variant 1, mRNA.
ACCESSION   NM_001357352
VERSION     NM_001357352.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4502)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4502)
  AUTHORS   Savinko,T., Guenther,C., Uotila,L.M., Llort Asens,M., Yao,S.,
            Tojkander,S. and Fagerholm,S.C.
  TITLE     Filamin A Is Required for Optimal T Cell Integrin-Mediated Force
            Transmission, Flow Adhesion, and T Cell Trafficking
  JOURNAL   J Immunol 200 (9), 3109-3116 (2018)
   PUBMED   29581355
  REMARK    GeneRIF: Our results reveal a role of FlnA in integrin force
            transmission and T cell trafficking
REFERENCE   3  (bases 1 to 4502)
  AUTHORS   Militello,G., Hosen,M.R., Ponomareva,Y., Gellert,P., Weirick,T.,
            John,D., Hindi,S.M., Mamchaoui,K., Mouly,V., Doring,C., Zhang,L.,
            Nakamura,M., Kumar,A., Fukada,S.I., Dimmeler,S. and Uchida,S.
  TITLE     A novel long non-coding RNA Myolinc regulates myogenesis through
            TDP-43 and Filip1
  JOURNAL   J Mol Cell Biol 10 (2), 102-117 (2018)
   PUBMED   29618024
  REMARK    GeneRIF: Knockdown of a novel long non-coding RNA Myolinc impairs
            the expression of myogenic regulatory factors and formation of
            multi-nucleated myotubes in cultured myoblasts. Myolinc also
            regulates the expression of Filip1 in a cis-manner. Similar to
            Myolinc, knockdown of Filip1 inhibits myogenic differentiation.
REFERENCE   4  (bases 1 to 4502)
  AUTHORS   Yagi,H., Takabayashi,T., Xie,M.J., Kuroda,K. and Sato,M.
  TITLE     Subcellular distribution of non-muscle myosin IIb is controlled by
            FILIP through Hsc70
  JOURNAL   PLoS One 12 (2), e0172257 (2017)
   PUBMED   28234934
  REMARK    GeneRIF: Hsc70 interacts with FILIP to mediate its effects on
            non-muscle myosin IIb and to regulate spine morphology
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4502)
  AUTHORS   Yagi,H., Oka,Y., Komada,M., Xie,M.J., Noguchi,K. and Sato,M.
  TITLE     Filamin A interacting protein plays a role in proper positioning of
            callosal projection neurons in the cortex
  JOURNAL   Neurosci Lett 612, 18-24 (2016)
   PUBMED   26655467
  REMARK    GeneRIF: FILIP is a key molecule that links callosal projections to
            the pathogenesis of brain disorders.
REFERENCE   6  (bases 1 to 4502)
  AUTHORS   Yagi,H., Nagano,T., Xie,M.J., Ikeda,H., Kuroda,K., Komada,M.,
            Iguchi,T., Tariqur,R.M., Morikubo,S., Noguchi,K., Murase,K.,
            Okabe,M. and Sato,M.
  TITLE     Filamin A-interacting protein (FILIP) is a region-specific
            modulator of myosin 2b and controls spine morphology and NMDA
            receptor accumulation
  JOURNAL   Sci Rep 4, 6353 (2014)
   PUBMED   25220605
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4502)
  AUTHORS   Sato,M. and Nagano,T.
  TITLE     Involvement of filamin A and filamin A-interacting protein (FILIP)
            in controlling the start and cell shape of radially migrating
            cortical neurons
  JOURNAL   Anat Sci Int 80 (1), 19-29 (2005)
   PUBMED   15794127
  REMARK    Review article
REFERENCE   8  (bases 1 to 4502)
  AUTHORS   Nagano,T., Morikubo,S. and Sato,M.
  TITLE     Filamin A and FILIP (Filamin A-Interacting Protein) regulate cell
            polarity and motility in neocortical subventricular and
            intermediate zones during radial migration
  JOURNAL   J Neurosci 24 (43), 9648-9657 (2004)
   PUBMED   15509752
  REMARK    GeneRIF: Results suggest that the amount of Filamin A helps
            migrating neurons determine their mode of migration, multipolar or
            bipolar, before entering the cortical plate and that FILIP is
            responsible, at least in part, for Filamin A content.
REFERENCE   9  (bases 1 to 4502)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142111.3 and AC140247.3.
            
            On Jun 8, 2022 this sequence version replaced NM_001357352.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.79402.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AC142111.3         49891-50101         c
            212-493             AC140247.3         180204-180485       c
            494-667             AC140247.3         142089-142262       c
            668-846             AC140247.3         135631-135809       c
            847-3655            AC140247.3         99907-102715        c
            3656-4502           AC140247.3         97060-97906         c
FEATURES             Location/Qualifiers
     source          1..4502
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 43.83 cM"
     gene            1..4502
                     /gene="Filip1"
                     /gene_synonym="5730485H21Rik"
                     /note="filamin A interacting protein 1"
                     /db_xref="GeneID:70598"
                     /db_xref="MGI:MGI:1917848"
     exon            1..211
                     /gene="Filip1"
                     /gene_synonym="5730485H21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..3862
                     /gene="Filip1"
                     /gene_synonym="5730485H21Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     FILIP"
                     /codon_start=1
                     /product="filamin-A-interacting protein 1 isoform a"
                     /protein_id="NP_001344281.1"
                     /db_xref="GeneID:70598"
                     /db_xref="MGI:MGI:1917848"
                     /translation="MPRSFWKAVTVAVVGMRSRNQGGESSSNGHVSCPKPSIISSDGG
                     KGPSEDAKKNKANRKGEDDVMASGTVKRHLKPSGESEKKTKKPLELSKEDLIQLLSIM
                     EGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYE
                     KPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNL
                     LEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQL
                     GLQSQKVQDLTQKLREEEEKLKAITYKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNA
                     KLANQESHNRQLRLKLVGLSQRIEELEETNKSLQKAEEELQELRDKIAKGECGNSSLM
                     AEVESLRKRVLEMEGKDEEITKTEAQCRELKKKLQEEEHHSKELRLEVEKLQKRMSEL
                     EKLEEAFSRSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKVELS
                     LKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEES
                     KKLLKLKSEMEEKVYSLTKERDELMGKLRSEEERSCELSCSVDLLKKRLDGIEEVERE
                     INRGRLCKGSEFTCPEDNKIRELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKF
                     RTEQDKANFLSQQLEEIKHQMAKNKAIEKGEAVSQEAELRHRFRMEEAKSRDLQAEVQ
                     ALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEETKNKNMGREVLNLTKELELSKRYS
                     RALRPSGNGRRMVDVPVASTGVQTEAVCGDAAEEETPAVFIRKSFQEENHIMSNLRQV
                     GLKKPMERSSVLDRYPPAANELTMRKSWIPWMRKRENGPSAPQEKGPRPNQGTGHPGE
                     LVLAPKQGQPLHIRVTPDHENSTATLEITSPTSEEFFSSTTVIPTLGNQKPRITIIPS
                     PNVMSQKPKSADPTLGPERAMSPVTITTISREKSPEGGRGAFADRPASPIQIMTVSTS
                     AAPPEIAVSPDSQEVPMGRTILKVTPEKQTVPTPMRKYNANANIITTEDNKIHIHLGS
                     QFKRSPGPAAAEGVSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGANKVTSTIT
                     ITPVTTSSTRGTQSVSGQDGSSQRPTPTRIPMSKGMKAGKPVVAAPGAGNLTKFQPRA
                     ETQSMKIELKKSAASSTASLGGGKG"
     exon            212..493
                     /gene="Filip1"
                     /gene_synonym="5730485H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            494..667
                     /gene="Filip1"
                     /gene_synonym="5730485H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            668..846
                     /gene="Filip1"
                     /gene_synonym="5730485H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            847..3655
                     /gene="Filip1"
                     /gene_synonym="5730485H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3656..4502
                     /gene="Filip1"
                     /gene_synonym="5730485H21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4480..4485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Filip1"
                     /gene_synonym="5730485H21Rik"
                     /note="hexamer: AATGAA"
     polyA_site      4502
                     /gene="Filip1"
                     /gene_synonym="5730485H21Rik"
                     /note="major polyA site"
ORIGIN      
        1 aatgtataat gagacaccgc caatgtgagg gagatgtttg catacttccg ttttttattt
       61 tgcctctgag ctaaccaaag agaaacgttt gaaaacaatt ttcagccaca gacctgaaaa
      121 tagagaaaca acgtcttcaa ttttccgtct tcgaattctt tcgcaaacta caatgcccag
      181 aagcttctgg aaggcagtga cagtggctgt ggtgggaatg agatctcgaa atcaaggtgg
      241 agaaagttca tctaatgggc atgtctcctg ccccaagccc tccatcatca gcagtgatgg
      301 tggtaaggga ccctcagaag atgcaaaaaa gaacaaggca aatcggaagg gggaggatga
      361 tgtcatggct tccggaaccg tcaaacgcca cctcaagcca tcaggagaga gtgagaaaaa
      421 gactaagaag cctctggagt tatccaagga ggacctcatc cagctcctga gcatcatgga
      481 aggggagctg caggctcgag aagatgtcat ccacatgctg aagacggaga agaccaagcc
      541 cgaggttctg gaggcgcatt atggatctgc agaaccagag aaagtgcttc gagtcctgca
      601 ccgcgatgcc atccttgctc aggagaagtc cataggagaa gatgtctatg agaaacccat
      661 ctcagagctg gacagactgg aggaaaagca gaaggagaca taccgccgca tgctggagca
      721 gctgctgttg gctgagaagt gtcacaggcg caccgtgtac gagctggaaa acgagaagca
      781 caagcacacc gactacatga acaagagcga cgacttcacc aacctgctgg agcaggagcg
      841 agagaggttg aaaaagctcc ttgagcaaga aaaggcttac caagcccgca aagaaaagga
      901 aaacgccaag cggctcaaca aacttcggga tgagcttgtg aaactcaagt ccttcgcact
      961 catgctggtg gatgagaggc agatgcacat cgagcagctg ggcctgcaga gtcagaaagt
     1021 ccaggacctc actcagaaac tgagagagga ggaagaaaaa ctcaaagcca tcacttacaa
     1081 gtccaaggaa gaccgccaga aactgctcaa gttggaagtg gacttcgaac acaaggcctc
     1141 gaggttttcc caggagcacg aagagatgaa cgccaagttg gctaaccaag agtctcacaa
     1201 caggcagctt agactcaaac tggttggctt atcgcaaagg atcgaggaac tggaagagac
     1261 caataaaagt cttcagaagg ccgaggaaga gcttcaggag ctgagagata aaattgccaa
     1321 aggggaatgt ggaaactcca gtctcatggc ggaagtggaa agtctgcgca agcgcgtgct
     1381 tgagatggag ggcaaggatg aagagatcac taagaccgag gcccagtgcc gggagctgaa
     1441 gaagaagctc caagaggaag aacaccacag caaggaactt agactagaag tggagaagct
     1501 gcagaagagg atgtctgaac tggagaagct ggaggaggcc ttcagccgca gcaagtcgga
     1561 atgcacccag ctccatttga acctggagaa ggagaagaac ctaaccaaag acctgctgaa
     1621 cgagctggag gtggtcaaga gtcgggttaa agaactcgag tgctcggaga gcagactgga
     1681 gaaggttgag ttaagcctca aagacgacct cacgaagctg aagtccttca ctgtgatgct
     1741 ggtggacgag aggaaaaaca tgatggagaa aataaagcaa gaagagagga aggtggatgg
     1801 gttgaataaa aacttcaagg tggagcaggg gaaggtgatg gatgtgacgg agaagctaat
     1861 cgaggaaagc aagaagcttt taaaactcaa gtctgaaatg gaggaaaagg tgtatagtct
     1921 gaccaaggag agggatgagc tgatgggtaa actgagaagc gaagaagaaa ggtcctgtga
     1981 actgagctgc agcgttgact tgctaaagaa gcggcttgat ggcatagagg aggtggagag
     2041 ggaaatcaac cgaggcaggc tgtgcaaggg gtctgagttc acctgcccgg aagacaataa
     2101 aatcagggaa ctgacgcttg aaatcgagag actgaagaag cggctccagc agctggaggt
     2161 ggtggagggg gacttgatga agaccgagga cgaatacgac cagttggagc agaaattcag
     2221 aaccgagcag gataaggcaa atttcctctc ccagcagctc gaggaaatta agcaccaaat
     2281 ggccaagaac aaagccatag agaaagggga ggctgtgagc caggaagccg agctgcgaca
     2341 caggttccgg atggaggagg ctaaaagtcg tgacttacag gctgaggtgc aggctcttaa
     2401 agagaagatc cacgagctga tgaacaagga agatcagctc tctcagctcc aggtcgacta
     2461 ttcggtcctt cagcaaaggt ttatggaaga agaaactaag aacaagaaca tggggaggga
     2521 ggtcctcaac ctgaccaaag agctggagct ttccaagcgc tacagccgag ctctcaggcc
     2581 gagtggaaat ggccgaagga tggtggacgt acccgtggcc tccactgggg tgcagaccga
     2641 ggcggtgtgc ggggatgctg cggaggagga gaccccggct gtgttcatcc gcaaatcctt
     2701 ccaggaagaa aatcacatca tgagtaatct tcgacaggta ggcctgaaga aacccatgga
     2761 acggtcctcg gtcctcgaca ggtatccccc agccgccaat gaactcacca tgaggaagtc
     2821 ttggattcct tggatgagaa aaagagaaaa cggaccctca gctccccagg agaaagggcc
     2881 caggccaaac cagggtacag ggcaccctgg cgagctggtc ctagcaccca agcagggcca
     2941 gcccttgcac atccgtgtga cacctgatca cgagaacagc actgccaccc tggagatcac
     3001 aagccccaca tctgaagagt ttttctcgag taccaccgtc attcctacct taggcaacca
     3061 gaaaccacgg atcaccataa ttccatcacc caatgtcatg tcgcaaaagc ccaaaagtgc
     3121 agatcctact ctcggcccag aacgagccat gtcccctgtc acgattacta caatttccag
     3181 agagaagagc ccagaaggtg gaaggggcgc gtttgcagac aggcctgcat cccccatcca
     3241 gataatgacg gtgtcaacgt ctgcagcgcc ccctgaaatc gctgtctctc ctgactctca
     3301 ggaagtgcct atgggaagga ctatcctcaa agttaccccg gaaaaacaaa ctgttccaac
     3361 ccccatgcgg aagtacaatg ccaatgcgaa tatcatcacc acggaagaca ataaaattca
     3421 cattcacctg ggttctcagt ttaagcgatc tcccgggcct gcagcagcgg aaggcgtgag
     3481 tccagttatc acggtccggc ctgtcaacgt aacagccgag aaggaggttt ctacgggcac
     3541 agtccttcgc tctcccagga accacctctc ttcaagacct ggtgctaaca aagtgaccag
     3601 cactataacc ataaccccgg tcacaacgtc atccacacga ggaacccaat cagtgtcagg
     3661 acaagatggg tcatctcagc ggcctacacc cacccgcatc cccatgtcaa aaggtatgaa
     3721 agcaggaaag ccagtagtgg cagccccagg agcaggaaat ctgaccaaat tccagcctcg
     3781 agctgagact cagtctatga aaatagagct gaagaaatct gcagccagca gcactgcctc
     3841 tcttggaggg gggaagggct gagggcagtg gctaaggggg tatgttgtaa ggatgctact
     3901 gctgctgtgg aaacaaacct tcctctgttt gtgccaaccc tttacatgta ctactaattt
     3961 aagttttaaa taacttgttt ataaaataac catctaatag ccttgcggct ttcctctcta
     4021 ttttgtgcat ttgtttcaat gcagaggaat agaattaatt agcaaaattg ctgtttgctg
     4081 aaagttttgt tgaagatgtt ggtcctgaga caggttctgg cctccagttc agttttactt
     4141 ctagcatgtg gccccagcca atgtagctca cgagttatga agccctcagt atcttcatga
     4201 gagagatttg gggaccacgt tccatgcttc caaagactgg ctcccagttc ttctaattgt
     4261 aagccaagtt taatagactt agttctacga tttttttcca agaaaaaata ttttgaaata
     4321 agacagagtt taataattgt cattgtacac aatcaaatca tgagcttggt atatgtgata
     4381 taagaaaaaa tagttcaaag ctatcacaag gtcttttttg gaaagacaaa agcccctaat
     4441 atgacttcag gaaacaattt gaacatgcaa taaagtggaa atgaactgtg gaatctgaaa
     4501 aa
//
