LOCUS       NM_001214911            4403 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus fidgetin-like 2 (Fignl2), mRNA.
ACCESSION   NM_001214911 XM_001000159 XM_001479184 XM_006521282
VERSION     NM_001214911.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4403)
  AUTHORS   Baker,L., Tar,M., Kramer,A.H., Villegas,G.A., Charafeddine,R.A.,
            Vafaeva,O., Nacharaju,P., Friedman,J., Davies,K.P. and Sharp,D.J.
  TITLE     Fidgetin-like 2 negatively regulates axonal growth and can be
            targeted to promote functional nerve regeneration
  JOURNAL   JCI Insight 6 (9), 138484 (2021)
   PUBMED   33872220
  REMARK    GeneRIF: Fidgetin-like 2 negatively regulates axonal growth and can
            be targeted to promote functional nerve regeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4403)
  AUTHORS   Charafeddine,R.A., Makdisi,J., Schairer,D., O'Rourke,B.P.,
            Diaz-Valencia,J.D., Chouake,J., Kutner,A., Krausz,A., Adler,B.,
            Nacharaju,P., Liang,H., Mukherjee,S., Friedman,J.M., Friedman,A.,
            Nosanchuk,J.D. and Sharp,D.J.
  TITLE     Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing
  JOURNAL   J Invest Dermatol 135 (9), 2309-2318 (2015)
   PUBMED   25756798
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104834.4.
            
            On or before Mar 31, 2022 this sequence version replaced
            XM_006521282.1, NM_001214911.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were predicted based on mouse transcript
            alignments and on homologous protein alignment with human
            NP_001013712.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.152382.1,
                                           SRR14995047.836671.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AC104834.4         134622-134807       c
            187-4403            AC104834.4         106493-110709       c
FEATURES             Location/Qualifiers
     source          1..4403
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.39 cM"
     gene            1..4403
                     /gene="Fignl2"
                     /gene_synonym="EG668225"
                     /note="fidgetin-like 2"
                     /db_xref="GeneID:668225"
                     /db_xref="MGI:MGI:3646919"
     exon            1..186
                     /gene="Fignl2"
                     /gene_synonym="EG668225"
                     /inference="alignment:Splign:2.1.0"
     exon            187..4403
                     /gene="Fignl2"
                     /gene_synonym="EG668225"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..2132
                     /gene="Fignl2"
                     /gene_synonym="EG668225"
                     /codon_start=1
                     /product="fidgetin-like protein 2"
                     /protein_id="NP_001201840.1"
                     /db_xref="CCDS:CCDS57012.1"
                     /db_xref="GeneID:668225"
                     /db_xref="MGI:MGI:3646919"
                     /translation="MHWTPEHAQPLNQWPEQHLDVSSTTPSPAHKLELPPGGRQRCHY
                     AWAHDDISALTASNLLKRYAEKYSGVLDYERPGLGSYGDAAFLNGAKGDPEPWPGPEP
                     PYPLASLHEGLPGAKAAGAGGSAGLGGSPVVAGNLTEPLYTGNACGGPSAATEYAAGY
                     GGGYLASGYCAQTSAALAPPPPPALLQPAPPPGYGPSAPLYNYPAAGYAAQPGYGALP
                     PPAAPPAPYLPSGLAAPTPLPAPAPPRPAPYGFPAAAEGVSLKRKAVDEGAEARYRKY
                     AYEPAKAPAADGASYPAADDTECRGNGFRSKPPGATEDGTGKYGGGGPLKVLGSPAYA
                     PQLEPFDKFPERVPAAHGGFAEPSGEPAKGVDPGALELVSSKMVDCGPPVQWADVAGQ
                     GALKAALEEELLWPLLRPPACPGSALPPRTVLFFGPRGCGKALLGRCLATRLGATLLR
                     LRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDGASLRAPLLTC
                     LDGSCGARADGVLVVGTTSRPAALDEATRRRFALRFYVALPDGAARGQILQRALAQQG
                     CALNERELAALVQGTQGFSGGELGQLCQQAAAEAGISGLQRPLSYKDVEAALAKVGSR
                     APSKELDSLVEWDKMYGSGH"
     regulatory      4382..4387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fignl2"
                     /gene_synonym="EG668225"
                     /note="hexamer: ATTAAA"
     polyA_site      4403
                     /gene="Fignl2"
                     /gene_synonym="EG668225"
                     /note="major polyA site"
ORIGIN      
        1 actgcccagt cccgctcccg gccgcggcgg ccgcagcagc cgcagcagca gcggccccag
       61 gatggtgagc gccgctgacc cccagccctg gcccgtcgcc cccggcccgc gcttccgccc
      121 cggtccctgg gccggacgcc cccccaggcc gcgcacactc acctaggacc cggccgggat
      181 gccgagctct gttgaagatg cactggacac cggaacacgc ccagccccta aaccagtggc
      241 cagagcagca cctggacgtc tcctccacca ctccgtcgcc ggctcacaag ttggagttgc
      301 ctccaggggg tcgccagcgc tgccactacg cttgggcaca cgacgacatt tccgccctca
      361 cagcctccaa cctcctcaag cgctacgccg agaagtactc cggagtcctg gactacgagc
      421 gcccgggcct gggcagctac ggtgacgccg ccttcctcaa cggtgccaaa ggggacccgg
      481 agccctggcc cgggccagag ccaccttacc ctctagcctc gctccacgaa ggcctcccgg
      541 gagccaaggc ggctggcgcg ggtggctccg ccggcctcgg gggctccccg gtagtagctg
      601 gcaacctgac tgagccgctg tacacgggca acgcgtgcgg gggaccgtcg gcggccactg
      661 agtacgcggc gggctacgga ggcgggtacc tggcgtccgg ctactgcgcg caaacgagcg
      721 ccgcgctcgc cccgccgccc ccgcccgcgc tgctgcagcc agcgccgccg cccggctacg
      781 gcccctcggc gccgctctac aactacccgg cggccggcta cgcggcgcag cccggctacg
      841 gggcgctccc gccgcccgcc gcgccgcccg cgccctactt gccctccggg ctggcggcgc
      901 ccacgcccct gcccgcgccc gcgccacccc ggcccgcgcc ctacggcttc cccgcggccg
      961 ccgagggcgt gtcgctgaag cgcaaggcgg tggacgaggg cgcggaagcc cgctaccgca
     1021 agtacgctta cgagccggcc aaggcccccg cggccgacgg cgcctcctac cccgccgcgg
     1081 acgacaccga gtgtcggggc aacgggttcc gttcgaagcc acccggggcg acggaggatg
     1141 ggaccggcaa gtacggcggc ggcggccctc tcaaggtcct gggctccccc gcctacgcgc
     1201 cgcagctcga gccctttgac aagttcccgg agcgggtccc ggccgcccac ggaggcttcg
     1261 cggagccgtc gggggagccc gccaagggcg tggacccggg ggcgctggag ctggtgagca
     1321 gcaagatggt agactgcggg cccccagtgc agtgggcgga tgtggcgggc cagggcgcgc
     1381 tcaaggcggc cctagaggag gagctgcttt ggcccttgct gaggccgccc gcctgtcccg
     1441 gcagcgcgct cccgccgcgg accgtgctgt tcttcgggcc ccgcggctgc ggtaaggcgc
     1501 tgctggggcg ctgcctcgcc acccgactag gtgccacgct gctgcgcctg cgcggagccg
     1561 gcctggcggc ctcgggcgcc gtcgagggcg cgcgcctcct gcaggcggcc tttgctgctg
     1621 cgcgctgccg cccgcccgct gtgctgctca tcagcgagct ggacgcgctg ctgccggcga
     1681 gggacgacgg cgcgtccctg cgggcgcctc tactgacctg cctggacggc agctgcggcg
     1741 cgcgcgccga cggcgtgctg gtggtgggta ccacctcgcg gccggcggcc ctggacgaag
     1801 ctacccgccg gcggttcgcg ctgcgcttct acgtggcgct gcccgacggc gcggcgcgcg
     1861 ggcagatcct gcagagggcg ctggctcagc agggctgtgc gctgaacgag cgggagctgg
     1921 ccgccctggt gcagggaact cagggctttt ctgggggcga gctggggcag ttgtgccagc
     1981 aggcagcggc cgaggcgggc atctctggac tgcagaggcc cctctcctac aaagatgtgg
     2041 aggctgctct agccaaggtg ggctctcggg ctccctccaa ggagctggac tcgttagttg
     2101 agtgggacaa aatgtatggc tccggacact gagggtggca ggggaggcca actctgcctg
     2161 ggggtgcggg ggggtgatgt ctttggccaa aggagtgatg aatgtggggc ggggagaggg
     2221 cgggctctcc cggtggattt tttttttttt aaatgggaag gaaaatgctt ctgccaggca
     2281 gatcgatgcc atatgcaccg gtgtactcag gttttttttc ctatttattg tggacgggaa
     2341 gttcgccatc tccgctcggc agactggcca tacccgacat gagttggcac cagggcctaa
     2401 ggaactcctg ctctctctcc ccgcaacctt tgtctcttgt cctctgagcg acatcctcct
     2461 ttcccattct actttctcag tattggctta gtttttcttc tcatggttgt gtcactgacc
     2521 cctccccatg ctgtctctgt tccttttcag ctcttccttc tggtccccat ccatcacctt
     2581 ctgtgcttgt ctctgtctcc tggaccctgt gctttaaccc tccctctctc attgttctga
     2641 ttcacaccac agcgactctt ggcggaagtt cttttggccc agaggctgag aaggggggtg
     2701 ggggacaggg agccccaacc ccctccgtac tttacccacc tgaaatcttg gggccttagg
     2761 gggtgggaca aggattaaaa aaccacccaa agaaggcttc cccccccctt tttggtttgt
     2821 tcatttttga ggggaagtcc cagaaatgta ggttgcttaa tattttaggc ctcttatttt
     2881 tgtaagatgt gtaggatttg ctgtttttcg ttttattttg acaactcagg aagaaactga
     2941 cctcagaaag aatgttagag tttggctgct ctcctgttac ccccaacccc gtccctgggg
     3001 agcagattct cccagaccag agagatttgg ggctaatgag gaaagaccag acccgagccc
     3061 cagactgctg tccctgggat agacgcagaa tgtatctagg ggctttctcc ccaggcccag
     3121 cttgcaagca agaggatggg gcagaggctc cagggggtgc tgcttgctgc cttcttacca
     3181 ttcttccccg tgggccccag tcctcagctt ccggtggtct gtgaaccttg cagagagttg
     3241 gggtgctctt gtccattcag ctgggcagaa ggttctcagg ccatctgact ggaagcaggt
     3301 tctgtcagag gtgctcaata acaggctaag aggattgcct ctggcgtgaa cgtggtctag
     3361 ccacaagtct ggctggacac aacattgact actaggagcc aggcaccctg tgacgagaca
     3421 gagcactgcc ctggaaaggg ttctgtgtct ctgtgtgggg tgtctacttg tccccatgga
     3481 gctctgggtc taaactgagg gcctggaggg aactgggtgc tttcctgtga cgttagtcca
     3541 gacttctctg caaaccacat ccctcctgct ccttctcttg ataaggctct ttggtcccct
     3601 caggccattt cacactcttt ggtgcaaaga aggtacaccc cctatctttg tcccacctta
     3661 gcccccctac cccttgcccc tacagctcct agatcccttc atgttctaga tgctgagaat
     3721 accatgagag acatggcagg agcaggggca gggtgctgag ggcaggtgtg aggagtgtga
     3781 acaggagagc tactatgtct ccttcatcct tgttctctcc aagcctctct ctggagccag
     3841 ccgaccaagt acagggcttg atgcttcaga gcaagtggcc cagggtgata ctgcagatga
     3901 tcctcggtgg ggcctagagt aagggagttc tctcaggtct ggggtggggg tggggatacc
     3961 ggtgcaggaa agtggggggg gggtgggctg ggttaggagt acatggaccc accgctgggg
     4021 tccccacact tcctttgctg ggctctttct gttcccggtt tggaagcttt gcacaagaag
     4081 acagcccccg gctgcagcac ctacctcacg agcatggggc aggatggcag ggcgggtcta
     4141 gccctagcaa tgttgggggg cataccaaag aatccaggga tggagcgcag gggagggcac
     4201 accggccctc cactccctct gctaacattg ggttgggatc ctctctcggt tgtaacccat
     4261 ttctacctca ttttgctgtg tgttgtacat ggacatattt atctcctatc tgatgatgtt
     4321 ctgcagttgt ggcctgtcta cctcagaaga cactgtattt taaaagaaga tattacacag
     4381 tattaaagtt atgatgtgtg gca
//
