LOCUS       NM_001163360            2844 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus fidgetin-like 1 (Fignl1), transcript variant 3, mRNA.
ACCESSION   NM_001163360
VERSION     NM_001163360.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2844)
  AUTHORS   Zainu,A., Dupaigne,P., Bouchouika,S., Cau,J., Clement,J.A.J.,
            Auffret,P., Ropars,V., Charbonnier,J.B., de Massy,B., Mercier,R.,
            Kumar,R. and Baudat,F.
  TITLE     FIGNL1-FIRRM is essential for meiotic recombination and prevents
            DNA damage-independent RAD51 and DMC1 loading
  JOURNAL   Nat Commun 15 (1), 7015 (2024)
   PUBMED   39147779
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2844)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2844)
  AUTHORS   Ito,M., Furukohri,A., Matsuzaki,K., Fujita,Y., Toyoda,A. and
            Shinohara,A.
  TITLE     FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic
            DNA replication and meiotic recombination
  JOURNAL   Nat Commun 14 (1), 6857 (2023)
   PUBMED   37891173
  REMARK    GeneRIF: FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in
            pre-meiotic DNA replication and meiotic recombination.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2844)
  AUTHORS   Zhang,Q., Fan,J., Xu,W., Cao,H., Qiu,C., Xiong,Y., Zhao,H.,
            Wang,Y., Huang,J. and Yu,C.
  TITLE     The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in
            homologous recombination and replication fork restart
  JOURNAL   Nucleic Acids Res 51 (16), 8606-8622 (2023)
   PUBMED   37439366
  REMARK    GeneRIF: The FLIP-FIGNL1 complex regulates the dissociation of
            RAD51/DMC1 in homologous recombination and replication fork
            restart.
REFERENCE   5  (bases 1 to 2844)
  AUTHORS   Shou,H.F., Jin,Z., Yu,Y., Lai,Y.C., Wu,Q. and Gao,L.L.
  TITLE     Microtubule-severing protein Fidgetin-like 1 promotes spindle
            organization during meiosis of mouse oocytes
  JOURNAL   Zygote 30 (6), 872-881 (2022)
   PUBMED   36148793
  REMARK    GeneRIF: Microtubule-severing protein Fidgetin-like 1 promotes
            spindle organization during meiosis of mouse oocytes.
REFERENCE   6  (bases 1 to 2844)
  AUTHORS   Schraenen,A., de Faudeur,G., Thorrez,L., Lemaire,K., Van
            Wichelen,G., Granvik,M., Van Lommel,L., in't Veld,P. and Schuit,F.
  TITLE     mRNA expression analysis of cell cycle genes in islets of pregnant
            mice
  JOURNAL   Diabetologia 53 (12), 2579-2588 (2010)
   PUBMED   20886204
REFERENCE   7  (bases 1 to 2844)
  AUTHORS   Shiura,H., Nakamura,K., Hikichi,T., Hino,T., Oda,K.,
            Suzuki-Migishima,R., Kohda,T., Kaneko-ishino,T. and Ishino,F.
  TITLE     Paternal deletion of Meg1/Grb10 DMR causes maternalization of the
            Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to
            severe pre- and postnatal growth retardation
  JOURNAL   Hum Mol Genet 18 (8), 1424-1438 (2009)
   PUBMED   19174477
REFERENCE   8  (bases 1 to 2844)
  AUTHORS   Park,S.J., Kim,S.J., Rhee,Y., Byun,J.H., Kim,S.H., Kim,M.H.,
            Lee,E.J. and Lim,S.K.
  TITLE     Fidgetin-like 1 gene inhibited by basic fibroblast growth factor
            regulates the proliferation and differentiation of osteoblasts
  JOURNAL   J Bone Miner Res 22 (6), 889-896 (2007)
   PUBMED   17352653
  REMARK    GeneRIF: FIGNL1, a subfamily member of the AAA family of proteins,
            might play some regulatory role in osteoblast proliferation and
            differentiation.
REFERENCE   9  (bases 1 to 2844)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   10 (bases 1 to 2844)
  AUTHORS   Cox,G.A., Mahaffey,C.L., Nystuen,A., Letts,V.A. and Frankel,W.N.
  TITLE     The mouse fidgetin gene defines a new role for AAA family proteins
            in mammalian development
  JOURNAL   Nat Genet 26 (2), 198-202 (2000)
   PUBMED   11017077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN693395.1, BY231020.1, AK143850.1 and AK051874.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1-3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB864589.1, BY027904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                CN693395.1         124-157
            35-308              BY231020.1         1-274
            309-2345            AK143850.1         408-2444
            2346-2844           AK051874.1         2437-2935
FEATURES             Location/Qualifiers
     source          1..2844
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 7.08 cM"
     gene            1..2844
                     /gene="Fignl1"
                     /note="fidgetin-like 1"
                     /db_xref="GeneID:60530"
                     /db_xref="MGI:MGI:1890648"
     exon            1..68
                     /gene="Fignl1"
                     /inference="alignment:Splign:2.1.0"
     exon            69..2844
                     /gene="Fignl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..2130
                     /gene="Fignl1"
                     /codon_start=1
                     /product="fidgetin-like protein 1"
                     /protein_id="NP_001156832.1"
                     /db_xref="CCDS:CCDS24438.1"
                     /db_xref="GeneID:60530"
                     /db_xref="MGI:MGI:1890648"
                     /translation="METSSSMSVETTRSVQVDEWQKNYCVVTSSICTPKQKADAYRAL
                     LLHIQYAYANSEISQVFATNLFKRYTEKYSAIIDSDNVVTGLNNYAESIFALAGSRQA
                     DSNKWQSGLSIDNVFKMSCVQEMMQAGKKFEESLLEPADASVVLCKEPTAFEVPQLSV
                     CGGSEDADILSSSGHDTDKTQAIPGSSLRCSPFQSARLPKETNTTKTCLTSSTSLGES
                     ATAAFHMTPLFGNTEKDTQSFPKTSTGLNMFLSNLSCVPSGCENPQERKAFNDSDIID
                     ILSNPTLNKAPSKTEDRGRREDNSLPTFKTAKEQLWVDQKKKGHQSQHTSKSSNGVMK
                     KSLGAGRSRGIFGKFVPPVSNKQDGSEQHAKKHKSSRAGSAEPAHLTDDCLKNVEPRM
                     VELIMNEIMDHGPPVHWDDIAGVEFAKATIKEIVVWPMMRPDIFTGLRGPPKGILLFG
                     PPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFI
                     DEIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR
                     RLVKRLYIPLPEASARKQIVGNLMSKEQCCLSDEETDLVVQQSDGFSGADMTQLCREA
                     SLGPIRSLHAADIATISPDQVRPIAYIDFENAFKTVRPTVSPKDLELYENWNETFGCG
                     K"
     regulatory      2732..2737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fignl1"
                     /note="hexamer: AATAAA"
     polyA_site      2756
                     /gene="Fignl1"
                     /note="major polyA site"
     polyA_site      2842
                     /gene="Fignl1"
ORIGIN      
        1 gtcacttcgc gcaggcgcac ttcgaaaggc gcgcttttcg gtggctgcgg tcccggcagg
       61 gagcacagaa cctttgacat ggagacgtcc agctccatgt ctgtggagac gactaggtct
      121 gtgcaggtgg acgaatggca gaagaattac tgtgtggtta catccagcat atgtacacca
      181 aagcagaagg ccgatgcata ccgtgcacta ctactgcata ttcagtatgc atatgccaac
      241 tccgagatct ctcaggtctt tgctaccaac ctgttcaaaa ggtatacaga aaaatactct
      301 gcaattattg attctgacaa tgttgtaact ggcttgaata actatgcaga gagcattttt
      361 gctttggcag gatctcgaca ggctgacagt aacaagtggc agtctggatt gtcaatagat
      421 aatgttttca aaatgagttg tgtacaggag atgatgcagg ctggcaagaa atttgaagag
      481 tctctgttgg aacctgctga tgcatcagta gtcctgtgta aagagcccac cgcctttgag
      541 gttcctcagc ttagtgtttg tggaggttct gaagacgctg acatattatc cagttcaggt
      601 catgacacag ataagaccca agccattcca gggagcagtc tgagatgttc cccttttcag
      661 agtgctcggc tgcctaagga aactaatacc actaagacat gcctcacctc ctcaacatct
      721 ttaggtgagt cagccactgc agcatttcac atgacaccat tatttggaaa caccgaaaag
      781 gacactcaaa gctttcctaa aaccagcaca ggactaaata tgttcttatc taatctgtct
      841 tgtgttcctt ctggctgtga aaaccctcaa gaaaggaagg cttttaatga ctctgacatc
      901 attgacatac tttccaatcc aacactgaac aaggctccta gtaaaacaga agacagaggc
      961 cgaagggaag ataatagcct gcctaccttt aaaactgcaa aagaacaatt atgggtagat
     1021 caaaagaaaa agggccatca atcccagcat acatctaaat cttctaatgg tgttatgaaa
     1081 aagtctctgg gagctgggag gtcgagaggg atatttggca agtttgttcc tcctgtatct
     1141 aataagcaag acggaagtga gcagcatgcc aagaagcaca agtctagtag ggcagggtct
     1201 gcagaaccag cacacctcac tgatgattgt ctgaagaacg tggagccaag gatggttgaa
     1261 cttattatga atgaaattat ggaccatggg cctccagtac attgggacga tattgctgga
     1321 gtagaatttg ccaaagccac aataaaggaa atcgttgtgt ggcccatgat gaggccagat
     1381 atctttactg gattgcgagg gccccctaaa ggaattctgc tctttggccc tccagggact
     1441 ggtaaaactc tgattggcaa gtgcattgct agccagtctg gagcaacatt cttcagcatc
     1501 tctgcttcat cgttgacttc taagtgggta ggtgagggag aaaaaatggt ccgtgcactg
     1561 tttgctgttg ccaggtgtca gcagccagct gtcatattta ttgatgaaat tgattcttta
     1621 ttgtctcaac gaggagatgg tgaacatgaa tcttcaagaa ggataaaaac ggaattttta
     1681 gttcagttag atggagcaac cacatcttct gaagaccgga ttcttgtggt gggagctaca
     1741 aatcggcccc aagagattga tgaagctgcc cggagaagat tggtgaaaag actttatatt
     1801 cccctcccag aagcttcagc caggaaacag atagtaggta atctaatgtc taaggagcaa
     1861 tgttgtctca gtgatgaaga aactgatctg gtagtgcagc agtctgatgg gttttctggc
     1921 gcagatatga cacagctttg cagagaggct tctcttggtc ctattcgcag tttgcacgct
     1981 gctgacattg ctaccataag tccagatcaa gttcgaccaa tagcttatat tgattttgaa
     2041 aatgctttta aaactgtgcg acctactgta tctccaaaag acttggagct ttatgaaaac
     2101 tggaatgaaa catttggttg tggaaagtga atatagcgat tgaaaggaga agctgttatc
     2161 tagtagtcgt ctttaccttt agcctcggaa gcttgctgtg ctacttgtat tgttttggag
     2221 tatatcctga attctgtgcc tcagattaga atgataacag cttgactact gactgatata
     2281 ttagtatgtt gtatttgcct tccagttata taatatataa actcatttca tttaaataga
     2341 atgacctttt gtttctaagt gaattcaaat tagaacttta gtctggtaat aataaacttt
     2401 gttagtgtag tattattatt gcttacattt gaaacagcat tgcattcttg acttagagtt
     2461 aagatcttac caaaagctag agtgaaagca acagggagta aactaccgta acccgtgctg
     2521 gcttgtaact tgttttgtgg gctttttttc tattaaaatt aactaataaa aacatgttag
     2581 aaatagcaag atgtaatctt gtatcaggca tgtagcctgc ctcaaaagat aagtgtggct
     2641 tttttcaagg gatctggaaa gttttctatt attgttttgt ctgataattc ttaagagcct
     2701 atttcaaact aaatattttt aaattaaaga gaataaaagt tgttagtttg ttaccatttt
     2761 gacggagttg cttcattttg ctataacttc aaattatttg ttttaaacag tcctgtatac
     2821 aacatatatg tatatgattt tact
//
