LOCUS       NM_012013                759 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus folliculogenesis specific basic helix-loop-helix
            (Figla), mRNA.
ACCESSION   NM_012013
VERSION     NM_012013.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 759)
  AUTHORS   Hughes,C.H.K., Smith,O.E., Meinsohn,M.C., Brunelle,M., Gevry,N. and
            Murphy,B.D.
  TITLE     Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the
            ovarian reserve
  JOURNAL   Proc Natl Acad Sci U S A 120 (32), e2220849120 (2023)
   PUBMED   37494420
REFERENCE   2  (bases 1 to 759)
  AUTHORS   Okunomiya,A., Horie,A., Tani,H., Sato,Y., Takamatsu,S., Brown,J.B.,
            Sugimoto,M., Hamanishi,J., Kondoh,E., Matsumura,N. and Mandai,M.
  TITLE     Figla promotes secondary follicle growth in mature mice
  JOURNAL   Sci Rep 11 (1), 9842 (2021)
   PUBMED   33972571
  REMARK    GeneRIF: Figla promotes secondary follicle growth in mature mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 759)
  AUTHORS   Sorrenti,M., Klinger,F.G., Iona,S., Rossi,V., Marcozzi,S. and DE
            Felici,M.
  TITLE     Expression and possible roles of extracellular signal-related
            kinases 1-2 (ERK1-2) in mouse primordial germ cell development
  JOURNAL   J Reprod Dev 66 (5), 399-409 (2020)
   PUBMED   32418930
REFERENCE   4  (bases 1 to 759)
  AUTHORS   Wang,Z., Liu,C.Y., Zhao,Y. and Dean,J.
  TITLE     FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse
            oocyte growth and differentiation
  JOURNAL   Nucleic Acids Res 48 (7), 3525-3541 (2020)
   PUBMED   32086523
  REMARK    GeneRIF: findings substantiate a major role for FIGLA, LHX8 and
            SOHLH1 as multifunctional regulators of networks necessary for
            oocyte maintenance and differentiation during early
            folliculogenesis.
REFERENCE   5  (bases 1 to 759)
  AUTHORS   Kato,Y., Iwamori,T., Ninomiya,Y., Kohda,T., Miyashita,J., Sato,M.
            and Saga,Y.
  TITLE     ELAVL2-directed RNA regulatory network drives the formation of
            quiescent primordial follicles
  JOURNAL   EMBO Rep 20 (12), e48251 (2019)
   PUBMED   31657143
REFERENCE   6  (bases 1 to 759)
  AUTHORS   Nef,S., Verma-Kurvari,S., Merenmies,J., Vassalli,J.D.,
            Efstratiadis,A., Accili,D. and Parada,L.F.
  TITLE     Testis determination requires insulin receptor family function in
            mice
  JOURNAL   Nature 426 (6964), 291-295 (2003)
   PUBMED   14628051
REFERENCE   7  (bases 1 to 759)
  AUTHORS   Pitera,J.E., Milla,P.J., Scambler,P. and Adjaye,J.
  TITLE     Cloning of HOXD1 from unfertilised human oocytes and expression
            analyses during murine oogenesis and embryogenesis
  JOURNAL   Mech Dev 109 (2), 377-381 (2001)
   PUBMED   11731253
REFERENCE   8  (bases 1 to 759)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
REFERENCE   9  (bases 1 to 759)
  AUTHORS   Soyal,S.M., Amleh,A. and Dean,J.
  TITLE     FIGalpha, a germ cell-specific transcription factor required for
            ovarian follicle formation
  JOURNAL   Development 127 (21), 4645-4654 (2000)
   PUBMED   11023867
REFERENCE   10 (bases 1 to 759)
  AUTHORS   Liang,L., Soyal,S.M. and Dean,J.
  TITLE     FIGalpha, a germ cell specific transcription factor involved in the
            coordinate expression of the zona pellucida genes
  JOURNAL   Development 124 (24), 4939-4947 (1997)
   PUBMED   9362457
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158679.8 and DV657415.1.
            
            On Nov 21, 2015 this sequence version replaced NM_012013.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U91840.1, DV657415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC158679.8         22103-22165         c
            64-755              DV657415.1         1-692
            756-759             AC158679.8         18360-18363         c
FEATURES             Location/Qualifiers
     source          1..759
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.55 cM"
     gene            1..759
                     /gene="Figla"
                     /gene_synonym="bHLHc8; FIGalpha"
                     /note="folliculogenesis specific basic helix-loop-helix"
                     /db_xref="GeneID:26910"
                     /db_xref="MGI:MGI:1349421"
     exon            1..267
                     /gene="Figla"
                     /gene_synonym="bHLHc8; FIGalpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..639
                     /gene="Figla"
                     /gene_synonym="bHLHc8; FIGalpha"
                     /note="transcription factor FIGa; FIG alpha"
                     /codon_start=1
                     /product="factor in the germline alpha"
                     /protein_id="NP_036143.1"
                     /db_xref="CCDS:CCDS20307.1"
                     /db_xref="GeneID:26910"
                     /db_xref="MGI:MGI:1349421"
                     /translation="MDTAPASPEPFLVTPQAEVLEELIQAQMGPLPRLAAICRLKRLP
                     SGGYSTTDDLHLVLERRRVANAKERERIKNLNRGFAKLKALVPFLPQSRKPSKVDILK
                     GATEYIQILGCVLEEAKVSEKQSPEEQTHSGRPSDPHVSSTRELLGNATQPTSCASGL
                     KKEEEGPWAYAGHSEPLYSYHQSTVPETRSYFTH"
     exon            268..420
                     /gene="Figla"
                     /gene_synonym="bHLHc8; FIGalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            421..759
                     /gene="Figla"
                     /gene_synonym="bHLHc8; FIGalpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      733..738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Figla"
                     /gene_synonym="bHLHc8; FIGalpha"
                     /note="hexamer: ATTAAA"
     polyA_site      759
                     /gene="Figla"
                     /gene_synonym="bHLHc8; FIGalpha"
                     /note="major polyA site"
ORIGIN      
        1 gcttggaaca cctgaggcgc ccaggtgcct ctgctgcccg tggtcttgac caccatggat
       61 acagcacctg catccccaga gcccttcctg gtcactccgc aggctgaggt gctggaggag
      121 ctgattcagg cccagatggg gcccctgccc cggctcgccg ccatctgtag gctcaagcgc
      181 ctgccctcag gcggctactc caccacggat gacctgcatc tggtgttgga gcgcaggcgt
      241 gtggccaacg ccaaagagcg tgaacggata aaaaatctca accgtggctt tgccaagctg
      301 aaggctctgg tgccgtttct accacagagc aggaagccca gtaaagttga tatccttaaa
      361 ggtgccacag aatacataca gatactcggc tgtgttctgg aagaagcgaa ggtctcagag
      421 aaacaaagcc ctgaggagca gacccacagt ggcagaccct ctgaccctca tgtgtcctcg
      481 actagagagc tcttgggaaa tgctacccaa cctaccagct gtgcgagtgg cttgaagaaa
      541 gaagaggagg ggccttgggc gtatgctggc catagtgagc cattgtacag ctaccatcag
      601 agcacagtac ctgagactag gagttacttc actcattagg agtctgatga aagagtcctt
      661 ctaaaatagt catgtataag ttgaaaagtt caaaaagcat tgccaagatg agtatttttc
      721 atgtaaaata taattaaaat gagatgatat gggaaagga
//
