LOCUS       NM_001010825            3192 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus FIC domain containing (Ficd), mRNA.
ACCESSION   NM_001010825 XM_149654
VERSION     NM_001010825.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3192)
  AUTHORS   Casey,A.K., Stewart,N.M., Zaidi,N., Gray,H.F., Cox,A., Fields,H.A.
            and Orth,K.
  TITLE     FicD regulates adaptation to the unfolded protein response in the
            murine liver
  JOURNAL   Biochimie 225, 114-124 (2024)
   PUBMED   38740171
  REMARK    GeneRIF: FicD regulates adaptation to the unfolded protein response
            in the murine liver.
REFERENCE   2  (bases 1 to 3192)
  AUTHORS   Gulen,B., Blevins,A., Kinch,L.N., Servage,K.A., Stewart,N.M.,
            Gray,H.F., Casey,A.K. and Orth,K.
  TITLE     FicD sensitizes cellular response to glucose fluctuations in mouse
            embryonic fibroblasts
  JOURNAL   Proc Natl Acad Sci U S A 121 (38), e2400781121 (2024)
   PUBMED   39259589
  REMARK    GeneRIF: FicD sensitizes cellular response to glucose fluctuations
            in mouse embryonic fibroblasts.
REFERENCE   3  (bases 1 to 3192)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3192)
  AUTHORS   Casey,A.K., Gray,H.F., Chimalapati,S., Hernandez,G., Moehlman,A.T.,
            Stewart,N., Fields,H.A., Gulen,B., Servage,K.A., Stefanius,K.,
            Blevins,A., Evers,B.M., Kramer,H. and Orth,K.
  TITLE     Fic-mediated AMPylation tempers the unfolded protein response
            during physiological stress
  JOURNAL   Proc Natl Acad Sci U S A 119 (32), e2208317119 (2022)
   PUBMED   35914137
  REMARK    GeneRIF: Fic-mediated AMPylation tempers the unfolded protein
            response during physiological stress.
REFERENCE   5  (bases 1 to 3192)
  AUTHORS   McCaul,N., Porter,C.M., Becker,A., Tang,C.A., Wijne,C.,
            Chatterjee,B., Bousbaine,D., Bilate,A., Hu,C.A., Ploegh,H. and
            Truttmann,M.C.
  TITLE     Deletion of mFICD AMPylase alters cytokine secretion and affects
            visual short-term learning in vivo
  JOURNAL   J Biol Chem 297 (3), 100991 (2021)
   PUBMED   34419450
REFERENCE   6  (bases 1 to 3192)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 3192)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY271260.1, BC106090.1 and BP765693.1.
            
            On Mar 7, 2008 this sequence version replaced NM_001010825.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106090.1, AK087477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BY271260.1         2-30
            30-2855             BC106090.1         1-2826
            2856-3192           BP765693.1         1-337               c
FEATURES             Location/Qualifiers
     source          1..3192
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.55 cM"
     gene            1..3192
                     /gene="Ficd"
                     /gene_synonym="D5Ertd40e; Hype"
                     /note="FIC domain containing"
                     /db_xref="GeneID:231630"
                     /db_xref="MGI:MGI:1098550"
     exon            1..268
                     /gene="Ficd"
                     /gene_synonym="D5Ertd40e; Hype"
                     /inference="alignment:Splign:2.1.0"
     exon            269..620
                     /gene="Ficd"
                     /gene_synonym="D5Ertd40e; Hype"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..1696
                     /gene="Ficd"
                     /gene_synonym="D5Ertd40e; Hype"
                     /EC_number="2.7.7.108"
                     /note="huntingtin interacting protein E; huntingtin
                     interactor protein E; adenosine monophosphate-protein
                     transferase FICD; AMPylator FICD; FIC domain-containing
                     protein; de-AMPylase FICD"
                     /codon_start=1
                     /product="protein adenylyltransferase FICD"
                     /protein_id="NP_001010825.2"
                     /db_xref="CCDS:CCDS51620.1"
                     /db_xref="GeneID:231630"
                     /db_xref="MGI:MGI:1098550"
                     /translation="MILMPMASVVAVAEPKWVSVWGRFLWMALLSMALGSLLALLLPL
                     GVVEEHCLAVLRGFHLLRSKLDRAQPVVPKCTSLCTELSVSSRDAGLLTVKTTASPAG
                     KLEAKAALNQALEMKRQGKRGKAHKLFLHALKMDPGFVDALNEFGIFSEEDKDIIQAD
                     YLYTRALTISPFHEKALVNRDRTLPLVEEIDQRYFSVIDSKVKKVMSIPKGSSALRRV
                     MEETYYHHIYHTVAIEGNTLTLSEIRHILETRYAVPGKSLEEQNEVIGMHAAMKYINT
                     TLVSRIGSVTMDDMLEIHRRVLGYVDPVEAGRFRRTQVLVGHHIPPHPRDVEKQMQEF
                     TQWLNSEDAMNLHPVEFAALAHYKLVYIHPFIDGNGRTSRLLMNLILMQAGYPPITIR
                     KEQRSEYYHVLEVANEGDVRPFIRFIAKCTEVTLDTLLLATTEYSVALPEAQPNHSGF
                     KETLPVRP"
     exon            621..3161
                     /gene="Ficd"
                     /gene_synonym="D5Ertd40e; Hype"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2754..2759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ficd"
                     /gene_synonym="D5Ertd40e; Hype"
                     /note="hexamer: AATAAA"
     polyA_site      2775
                     /gene="Ficd"
                     /gene_synonym="D5Ertd40e; Hype"
                     /note="major polyA site"
     regulatory      3139..3144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ficd"
                     /gene_synonym="D5Ertd40e; Hype"
                     /note="hexamer: AATAAA"
     polyA_site      3161
                     /gene="Ficd"
                     /gene_synonym="D5Ertd40e; Hype"
                     /note="major polyA site"
ORIGIN      
        1 ggggcctgcg accgcggctg cggggaacgg ccgcgcgggt ttggatgctg gaggcgggca
       61 cgagccctgg gccggttcgt agcgggagct cgcggcagcc tcattccacc ccccacccca
      121 ccccccgctt cgggagtaag ccgaagtctg ctgggctcga gccgctgcac aggccgcgcg
      181 aagtgatgac gtggcgggtc aggccccgga gctccggcgc cgcctgtcag aacggcgtca
      241 tccctcatct gtaaaccggg agctacaggg tccagctttt cctctgtgtc gagtgctctg
      301 ggcccagccc tcagtccaga tgatactcat gccaatggcg tcggtggtgg cagtggccga
      361 acccaaatgg gtctccgtct ggggccgttt cctgtggatg gcgctgctga gcatggctct
      421 ggggtcgctg ctggctctgc tgctgccgct gggagttgtg gaagagcatt gcctggctgt
      481 gctcagaggt ttccacctgc tcaggagcaa actggacagg gcacagcctg tggtccccaa
      541 gtgcaccagc ctatgcacag agctcagtgt ctcctccagg gatgcagggc tgctgacagt
      601 caagactacg gcgtctccag cagggaagct ggaagccaag gccgccctaa accaagccct
      661 ggagatgaag cgtcaaggca agagagggaa agcccacaag ctcttcctgc acgccctcaa
      721 gatggacccc ggctttgtag acgcactgaa tgagttcggc atcttctccg aagaagacaa
      781 ggacatcatc caggctgact acttatacac cagggccctg accatctcgc ccttccacga
      841 gaaagccctg gtcaaccggg atcggacact gcccctcgtg gaggaaatcg accagaggta
      901 cttcagcgtc atcgacagca aagtgaagaa ggtcatgtcc atcccaaagg ggagctcagc
      961 gctgcgcagg gtcatggagg agacctacta ccaccacatc taccacacgg tggccatcga
     1021 gggcaacacc ctcaccctct cggagatcag gcacatcctg gagacccgct acgccgtgcc
     1081 agggaagagc ctggaagagc agaacgaggt gatcggcatg cacgcggcca tgaagtacat
     1141 caacaccacc ctggtctccc gcatcgggtc tgtcaccatg gacgacatgc tggagatcca
     1201 caggagggta ctggggtatg tggatccagt ggaggcgggc aggttccgga ggacccaggt
     1261 cctggtgggc caccacatcc caccccaccc ccgggatgtg gagaagcaga tgcaggagtt
     1321 cacacagtgg ctcaattcag aggacgccat gaacctgcac ccagtcgagt tcgcggccct
     1381 ggcccattac aaactggtgt acatccaccc tttcatcgac ggcaacggga ggacctcccg
     1441 tctgctgatg aacctgattt tgatgcaggc gggatacccg cccatcacca tccgcaagga
     1501 gcagaggtcc gagtactacc atgtactgga agtcgccaac gagggtgacg tgcggccttt
     1561 catccgcttc atagccaagt gtacggaggt cacactggac acgttgctcc ttgccaccac
     1621 cgagtactcg gtggcactgc cagaagccca gcccaaccat tctgggttca aggagacgct
     1681 ccctgtgagg ccctaaccgc cagccctccc ttggcatcca gagaaggcct ttctagaaac
     1741 agttctcccc tggtagcaaa aggaaaccct taaacattct ttacctccag atgtttttca
     1801 gttgagaaag aaaactaaat tattaagcct gtcttcagga taatttatag ttcagccaag
     1861 ttatttattt aatttttttt tcttactttt ttggtgagct agcagcgacc gagtggtgct
     1921 gcgaccacaa cacctgtggt gatcccggaa cccagtaggg cagcagtgct tttctaatgt
     1981 cctgagcctg ggtgtctaga cagactttgc acgaagggca gaggcagaga gatctgtgag
     2041 acggaactca gggccacggt gatcactcgg gtgccttgga ggtcctgaga cctcagaagg
     2101 ctgcaacctt gggcagaacc tgccctgtgc taaggtgggg ttttattcct gagaggctgt
     2161 ggcagcagct tctactggca gcccagccct ttgccagtag gaggttgcag atttccgaag
     2221 accctctgag ctattaactt gctaacctga gtggcagggg atagcgcttc cctgcccaga
     2281 ctgttctaag ggtggagggc aggcagaagg gctttccctt atctttgccc tatacttcac
     2341 ttgcatcaac tgaggctagc caagccaacc taccccctca ctccacagag caggtctgcc
     2401 ttcacctccc actcagtctt ctgaggacac gggaggtgac gcttggcggg agaatactac
     2461 ccagcatgca ccacacacaa ggcacctgcc ctaacattac aaaagggtgt atctgagaaa
     2521 ccgcatcaac cccaaataag cagttctgat aaaagactga aaacgggcaa acacctgtga
     2581 ccacgaccca gcctttcccc ctttgtctta tgctttgaaa ccctcttccc atctgatgcc
     2641 atcacagggt ccagtgtccc cactgccttg gagtggcctt cttctagtaa cttgtaaagt
     2701 gatggatggt gtcacatctg atagatacat ttccaagttg tcatcttagg aaaaataaac
     2761 tttttttcaa tcatatttat ggctaatgcc gatttgactg ctgctattta gagtcataat
     2821 ggctacgtca ctggattttg ttctgagaca gcctacagtg tcccagcgca ctgcactttt
     2881 tgtttgaatt ggaaactcat accagccacc aaacgatggt atccagcgtt tagaaagata
     2941 ctctgacagt tttctgacag actgagaaaa aaaacagatg tgtgcgtgca gcaccgtcaa
     3001 cagctctgca ggacgcggcc cccagctcct ggctcttctc tgcacaccaa gtctcatggg
     3061 aggctcactt tgtcctgtag tgagaacctg cactttagct acatgtggaa aatattattt
     3121 taacaaattc ctggttctaa taaagtattt tattacaaac aaaaaaaaaa aaaaaaaaaa
     3181 aaaaaaaaaa aa
//
