LOCUS       NM_021438               1219 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus fibroblast growth factor (acidic) intracellular
            binding protein (Fibp), transcript variant 2, mRNA.
ACCESSION   NM_021438
VERSION     NM_021438.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1219)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1219)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   3  (bases 1 to 1219)
  AUTHORS   Kolpakova,E., Frengen,E., Stokke,T. and Olsnes,S.
  TITLE     Organization, chromosomal localization and promoter analysis of the
            gene encoding human acidic fibroblast growth factor intracellular
            binding protein
  JOURNAL   Biochem J 352 Pt 3 (Pt 3), 629-635 (2000)
   PUBMED   11104667
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122861.4 and AK028029.1.
            
            On Dec 7, 2011 this sequence version replaced NM_021438.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028029.1, AK012629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC122861.4         195112-195120
            10-1218             AK028029.1         1-1209
            1219-1219           AC122861.4         199557-199557
FEATURES             Location/Qualifiers
     source          1..1219
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.33 cM"
     gene            1..1219
                     /gene="Fibp"
                     /gene_synonym="2010004G08Rik; 2010005N21Rik;
                     3010027N18Rik"
                     /note="fibroblast growth factor (acidic) intracellular
                     binding protein"
                     /db_xref="GeneID:58249"
                     /db_xref="MGI:MGI:1926233"
     exon            1..172
                     /gene="Fibp"
                     /gene_synonym="2010004G08Rik; 2010005N21Rik;
                     3010027N18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1161
                     /gene="Fibp"
                     /gene_synonym="2010004G08Rik; 2010005N21Rik;
                     3010027N18Rik"
                     /note="isoform 2 is encoded by transcript variant 2; aFGF
                     intracellular binding protein; acidic fibroblast growth
                     factor intracellular-binding protein; FGF-1
                     intracellular-binding protein"
                     /codon_start=1
                     /product="acidic fibroblast growth factor
                     intracellular-binding protein isoform 2"
                     /protein_id="NP_067413.1"
                     /db_xref="CCDS:CCDS89310.1"
                     /db_xref="GeneID:58249"
                     /db_xref="MGI:MGI:1926233"
                     /translation="MTSELDIFVGNTTLIDEDVYRLWLDGYSVNDAVALRVRSGILEQ
                     TGATTGVLQSDTMDHYRTFHMLERLLHAPPKLLHQLIFQIPPSRQTLLIERYYTFDEA
                     FVREVLGKKLSKGTKKDLDDISTKTGITLKSCRRQFDNFKRVFKVVEEMRGSLVDNIQ
                     QHFLLSDRLARDYAAIVFFANNRFETGKKKLQYLSFGDFAFCAELMIQNWTLGAVDSQ
                     VDDMDVDLDKEFLQDLKELKVLVADKDLLDLHKSLVCTALRGKLGVFSEMETNFKNLS
                     RGLVNVAAKLTHNKDVRDLFVDLVEKFVEPCRSDHWPLSDVRLFLSQYSASVHSLDGF
                     RHQALWDRYMGTLRGCLLRLYHD"
     exon            173..371
                     /gene="Fibp"
                     /gene_synonym="2010004G08Rik; 2010005N21Rik;
                     3010027N18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            372..498
                     /gene="Fibp"
                     /gene_synonym="2010004G08Rik; 2010005N21Rik;
                     3010027N18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            499..599
                     /gene="Fibp"
                     /gene_synonym="2010004G08Rik; 2010005N21Rik;
                     3010027N18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            600..733
                     /gene="Fibp"
                     /gene_synonym="2010004G08Rik; 2010005N21Rik;
                     3010027N18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            734..842
                     /gene="Fibp"
                     /gene_synonym="2010004G08Rik; 2010005N21Rik;
                     3010027N18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            843..906
                     /gene="Fibp"
                     /gene_synonym="2010004G08Rik; 2010005N21Rik;
                     3010027N18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            907..993
                     /gene="Fibp"
                     /gene_synonym="2010004G08Rik; 2010005N21Rik;
                     3010027N18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1091
                     /gene="Fibp"
                     /gene_synonym="2010004G08Rik; 2010005N21Rik;
                     3010027N18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1219
                     /gene="Fibp"
                     /gene_synonym="2010004G08Rik; 2010005N21Rik;
                     3010027N18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1197..1202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fibp"
                     /gene_synonym="2010004G08Rik; 2010005N21Rik;
                     3010027N18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1219
                     /gene="Fibp"
                     /gene_synonym="2010004G08Rik; 2010005N21Rik;
                     3010027N18Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaactcccgg aagtcgctct gcggctactc gcccggccgg ggcccgtaca agctccagct
       61 tcgggcgaac ccggcccggg catcgtcatg accagcgaac tagacatttt cgtggggaac
      121 acgaccctta tagatgaaga cgtgtatcgc ctctggctgg atggttactc agtgaacgat
      181 gcagtggctc tgcgagtacg ctccggaatc ttggagcaga cgggagccac cacaggagtg
      241 ctgcagagcg acaccatgga ccactaccgc acctttcaca tgcttgagcg tctgctgcac
      301 gcgccgccga agctgctgca ccagctcatc ttccagattc ctccctcccg acagacactc
      361 ctcatcgaga ggtactacac ctttgatgag gcctttgttc gggaggtctt gggcaagaag
      421 ctgtccaagg gtaccaagaa agacctggat gacatcagca ccaaaacagg aattactctc
      481 aagagctgcc ggaggcagtt tgacaacttt aaacgagtct tcaaggtggt ggaagaaatg
      541 cggggctccc tggtggacaa catccagcag cacttcctcc tctctgaccg gttagccagg
      601 gattacgcag ccatcgtctt ttttgccaac aaccgctttg aaacaggaaa gaaaaagctg
      661 cagtacctga gctttgggga ctttgccttc tgtgcagagc ttatgatcca gaactggacc
      721 cttggagccg tcgactctca ggtggacgac atggatgtgg acttagataa ggagtttctc
      781 caagacttga aggagctcaa ggttctcgtg gctgacaagg acctcctgga cctgcataag
      841 agcctggtgt gcactgccct ccggggaaag ctgggtgtct tctctgagat ggaaaccaac
      901 ttcaagaatc tgtctcgggg gctggtgaac gtggctgcca agctgaccca caataaggat
      961 gtcagagacc tatttgtgga cctcgtggag aagtttgtgg aaccctgccg ctctgaccac
     1021 tggccactga gtgatgtgcg gctcttcctc agccagtatt cagcgtcagt ccactccctg
     1081 gatggcttcc ggcaccaggc actctgggac cgctacatgg gcaccctccg tggctgcctt
     1141 ctgcgcctct atcatgatta aagccctttt ccttcctccc tccgacatac cctgagaata
     1201 aagttgccat aagtttgga
//
