LOCUS       NM_175276               6251 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus formin homology 2 domain containing 3 (Fhod3),
            transcript variant 1, mRNA.
ACCESSION   NM_175276 XM_981861
VERSION     NM_175276.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6251)
  AUTHORS   Boussaty,E.C., Ninoyu,Y., Andrade,L.R., Li,Q., Takeya,R.,
            Sumimoto,H., Ohyama,T., Wahlin,K.J., Manor,U. and Friedman,R.A.
  TITLE     Altered Fhod3 expression involved in progressive high-frequency
            hearing loss via dysregulation of actin polymerization
            stoichiometry in the cuticular plate
  JOURNAL   PLoS Genet 20 (3), e1011211 (2024)
   PUBMED   38498576
  REMARK    GeneRIF: Altered Fhod3 expression involved in progressive
            high-frequency hearing loss via dysregulation of actin
            polymerization stoichiometry in the cuticular plate.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6251)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6251)
  AUTHORS   Montanes-Agudo,P., Aufiero,S., Schepers,E.N., van der Made,I.,
            Cocera-Ortega,L., Ernault,A.C., Richard,S., Kuster,D.W.D.,
            Christoffels,V.M., Pinto,Y.M. and Creemers,E.E.
  TITLE     The RNA-binding protein QKI governs a muscle-specific alternative
            splicing program that shapes the contractile function of
            cardiomyocytes
  JOURNAL   Cardiovasc Res 119 (5), 1161-1174 (2023)
   PUBMED   36627242
REFERENCE   4  (bases 1 to 6251)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6251)
  AUTHORS   Sulistomo,H.W., Nemoto,T., Kage,Y., Fujii,H., Uchida,T.,
            Takamiya,K., Sumimoto,H., Kataoka,H., Bito,H. and Takeya,R.
  TITLE     Fhod3 Controls the Dendritic Spine Morphology of Specific
            Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex
  JOURNAL   Cereb Cortex 31 (4), 2205-2219 (2021)
   PUBMED   33251537
  REMARK    GeneRIF: Fhod3 Controls the Dendritic Spine Morphology of Specific
            Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex.
REFERENCE   6  (bases 1 to 6251)
  AUTHORS   Iskratsch,T., Reijntjes,S., Dwyer,J., Toselli,P., Degano,I.R.,
            Dominguez,I. and Ehler,E.
  TITLE     Two distinct phosphorylation events govern the function of muscle
            FHOD3
  JOURNAL   Cell Mol Life Sci 70 (5), 893-908 (2013)
   PUBMED   23052206
  REMARK    GeneRIF: Analysis of casein kinase 2 alpha knockout mice showed
            that phosphorylation by casein kinase 2 is also required for proper
            targeting of muscle Fhod3 to the myofibrils in embryonic
            cardiomyocytes in situ.
REFERENCE   7  (bases 1 to 6251)
  AUTHORS   Kan-o,M., Takeya,R., Taniguchi,K., Tanoue,Y., Tominaga,R. and
            Sumimoto,H.
  TITLE     Expression and subcellular localization of mammalian formin Fhod3
            in the embryonic and adult heart
  JOURNAL   PLoS One 7 (4), e34765 (2012)
   PUBMED   22509354
  REMARK    GeneRIF: embryonic heart of mice specifically expresses the Fhod3
            mRNA isoform harboring the three alternative exons
REFERENCE   8  (bases 1 to 6251)
  AUTHORS   Taniguchi,K., Takeya,R., Suetsugu,S., Kan-O,M., Narusawa,M.,
            Shiose,A., Tominaga,R. and Sumimoto,H.
  TITLE     Mammalian formin fhod3 regulates actin assembly and sarcomere
            organization in striated muscles
  JOURNAL   J Biol Chem 284 (43), 29873-29881 (2009)
   PUBMED   19706596
  REMARK    GeneRIF: actin dynamics regulated by Fhod3 are critical for
            sarcomere organization in striated muscle cells.
REFERENCE   9  (bases 1 to 6251)
  AUTHORS   Xu,X.Q., Soo,S.Y., Sun,W. and Zweigerdt,R.
  TITLE     Global expression profile of highly enriched cardiomyocytes derived
            from human embryonic stem cells
  JOURNAL   Stem Cells 27 (9), 2163-2174 (2009)
   PUBMED   19658189
REFERENCE   10 (bases 1 to 6251)
  AUTHORS   Kanaya,H., Takeya,R., Takeuchi,K., Watanabe,N., Jing,N. and
            Sumimoto,H.
  TITLE     Fhos2, a novel formin-related actin-organizing protein, probably
            associates with the nestin intermediate filament
  JOURNAL   Genes Cells 10 (7), 665-678 (2005)
   PUBMED   15966898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046161.1, AB078608.1 and BQ176384.1.
            
            On Jan 25, 2014 this sequence version replaced NM_175276.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB078608.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-822               AK046161.1         3-824
            823-6231            AB078608.1         1-5409
            6232-6251           BQ176384.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..6251
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.18 cM"
     gene            1..6251
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /note="formin homology 2 domain containing 3"
                     /db_xref="GeneID:225288"
                     /db_xref="MGI:MGI:1925847"
     exon            1..1151
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     CDS             987..5723
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /note="isoform 1 is encoded by transcript variant 1;
                     formin-family protein FHOS2; FH1/FH2 domain-containing
                     protein 3; formin homolog overexpressed in spleen 2"
                     /codon_start=1
                     /product="FH1/FH2 domain-containing protein 3 isoform 1"
                     /protein_id="NP_780485.2"
                     /db_xref="CCDS:CCDS29104.1"
                     /db_xref="GeneID:225288"
                     /db_xref="MGI:MGI:1925847"
                     /translation="MATLACRVQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLA
                     GVHRLLRAPHKLDDCTLQLSHNGAYLDLEATLAEQRDELEGFQDDTGRGKKNSIILRT
                     QLSVRVHACIEKLYNSSGRDLRRALFSLKQIFQDDKDLVHEFVIAEGLTCLIKVGAEA
                     DQNYQNYILRALGQIMLYVDGMNGVINHSETIQWLYTLVGSKFRLVVKTALKLLLVFV
                     EYSESNAPLLIQAVSAVDTKRGVKPWSNIMEILEEKDGVDTELLVYAMTLVNKTLAGL
                     PDQDTFYDVVDCLEELGIAAVSQRHLNKKGTDLDLLEQFNIYEVALRHEDGDETAEPP
                     PSGHRDRRRASMCSGGTVGEQQGLDRRRSRRHSIQNIKSPLSAPTSPCSPSVPAFKPS
                     QVRDLCEKDEEEEEEEEQPITEPNSEEEREDDAQCQGKDSKASSASGQSSPGKDAAPE
                     SSALHTTSSPTSQGRWLSASTAARSPVLGGTSGPEASRPAARLLPPSPGLATRPSTAP
                     KVSPTIDKLPYVPHSPFHLFSYDFEDSPLLTKDKGGDSQTENRYSNFSSNSFQSSRPS
                     PGPSGSPSYASSFSSPQDTRSSPSGLLTSSFRQHQESLAAERERRRQEREERLQRIER
                     EERNKFNREYLDKREEQRQARGERYKYLEQLAAETQEKEPRSQSVSRGRADLSLDLSL
                     PAAPAPPSPSSQSPSADSQEALPVPSSPPTLQCPQVSGKDHEPELEAEAGQGADEASQ
                     DIASAHRGAESQEEPVLELEPEERASLSEKERQNEEVNERDNCSASSISSSSSTLERE
                     EKEDKLSEDRATGLWSTSLQDVGVNGQCGDILTSKRFMLDMLYAHNRKSTEDEEKDDG
                     EPGRSAQEVEAVASLATRISTLQANSQAPEESIKRVDIGCLDNRGSVKAFAEKFNSGE
                     VGRGAISPDVESQDKVPDTPPAQLKTESDYIWDQLMANPRELRIQDMDFTDLGEEDDI
                     DVLDVDLGHREAPGPPPPPPPTFLGLPPPPPPPLLDSVPPPPVPGNLLASPVFNTPQG
                     LGWSQVPRGQPAFTKKKKTIRLFWNEVRPFEWPSKNNRRCREFLWSKLEPIKVDTSRL
                     EHLFESKSKELSVTKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNFD
                     EYALNKEGIEKILTMIPTEEEKQKIQEAQLANPEVPLGSAEQFLLTLSSISELSARLH
                     LWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKAFE
                     LSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDN
                     LCQMERRCKASWDHLKAIAKHEMKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHS
                     FLLFMGHPPYAIREVNINKFCRIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKM
                     ITDSGKFSGSSPAAPSQPQGLSYAEDAAEHENMKAVLKTSSPALEDATPVLGVRTRSR
                     ASRGSTSSWTMGTEESPSVTDDAADEIMDRIVKSATQVPSQRVVPRERKRSRANRKSL
                     RRTLKSGLTPEEARALGLVGTSELQL"
     exon            1152..1258
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1323
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1391
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1497
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1592
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1704
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1799
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1943
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2185
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2281
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2638
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2743
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2878
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..2929
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3138
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3417
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..4295
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            4296..4454
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            4455..4637
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            4638..4757
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            4758..4919
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            4920..5110
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            5111..5303
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            5304..5478
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            5479..5640
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     exon            5641..6237
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6211..6216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /note="hexamer: AATAAA"
     regulatory      6215..6220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /note="hexamer: AATAGA"
     polyA_site      6231
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
                     /note="major polyA site"
     polyA_site      6237
                     /gene="Fhod3"
                     /gene_synonym="A930009H06Rik; FHOS2; mKIAA1695"
ORIGIN      
        1 actccagcct ggaggaagaa ggcaggctgt caagctacat gctaagtccc tcttgtgagg
       61 gagaccccaa cctccacctc ggttcttctc agcatcttca ccattccggg atctgatcag
      121 aagcaccctt cttcctctgt cgcagaaggt caagttagaa cttccggaga cctagtactg
      181 aggagagggt tggtgatgat ggacaggttc aactgtaact ctcaggcagc tgtcccggtc
      241 cggtcttggg gtcgtggaga ctctccttgc agtctaccaa ttctcaatgc aggagccctt
      301 gggcgcaaga aatgctgctg ggattcctag gccccctatt ctcctactta gcttcttttc
      361 tcaccggcgc aaacctccct agagtccttg ccggggcttc ggatcgctat ctcccagtca
      421 caggcctgca gagagccttg ctccctggtc tgggtgccga gccgcaggga gaccagctct
      481 gtctctttca tctgggaagg gttgtgctgt tccctgtccc aggggtaacg tagtcagagg
      541 actgccttgt ccccagtcta gtgccagcgc tccaaggctg gtgcatctgg aacctgggca
      601 gcaggcacac gtgcagggag ctctgcgcag gggcgtttct gcgcgttgat tgctgccagg
      661 ctcagggcta ccgacgctgc gcaaacgact ctcgcattcc ctgtccctgc agcggtcgcg
      721 aaggtcgggg aagcccggtc cggtgcccag taaaccgagc aggggaggag ccggggcggg
      781 agcgggagga ggagggggcg agccccgccc ccgccccgcc ccccgtggcc ggagtccggg
      841 ctgcagccgg gcgcgccgtt gcctgcgagc ccgcgagcct gctagcggcg gcagtggcgg
      901 cagcttctcc tccgcacaga cccggagccc cggcctgcgc ggcccgctga ccctggggcc
      961 cgcgccccac ggggcaggga tgcatcatgg ccacgctggc ttgtcgcgtg cagttcttgg
     1021 acgacaccga tcctttcaac agcaccaact tcccagagcc aagccggcca ccgctgttca
     1081 cattccgcga ggacctggct ctgggcaccc agttggccgg ggtccatcgg ctgctgcggg
     1141 cgccgcacaa gctcgatgac tgtaccctgc agctgtccca caatggcgcc tacctggatc
     1201 tggaggccac gctggcggaa cagcgggatg agctagaagg cttccaggat gacacagggc
     1261 ggggcaagaa gaacagcatt attctgagga cacagctgtc tgtgagggtc catgcctgca
     1321 ttgaaaagct gtacaactcc agtggccgag atctaagaag ggcccttttc tcactgaagc
     1381 agatatttca ggatgacaag gatttggtgc atgaatttgt catagctgaa ggtctgacct
     1441 gtttgatcaa agtgggagcc gaggcggatc agaactatca gaactacatc ctgagggctc
     1501 tgggtcagat tatgttgtat gtggatggga tgaatggcgt catcaaccac agcgagacca
     1561 tccagtggct ttacacgctc gttgggtcga agttccgcct ggtagtgaag acagccctga
     1621 agcttcttct ggtctttgtg gagtattctg agtccaatgc accacttctc attcaggccg
     1681 tttctgctgt cgacaccaaa agaggtgtca aaccctggtc caacatcatg gaaatcttgg
     1741 aggaaaaaga tggagttgac acagagctat tggtttatgc aatgactcta gtgaacaaga
     1801 cactggcagg actgccagat caagacacct tctatgacgt agtagactgc ctggaagagc
     1861 tgggcatcgc cgctgtgtcc caaaggcact tgaacaagaa agggacagac ctggacttgc
     1921 tggagcagtt taatatctat gaggtggcac tcaggcatga agatggtgat gagacagctg
     1981 agccaccccc cagtgggcac cgggaccgga ggagggccag catgtgttct ggtggcactg
     2041 tgggtgagca acagggcctt gaccgcagaa ggagccgtag acactcaatc cagaatatca
     2101 agagcccact gtcagctccc accagcccct gctccccgtc tgttcctgcc ttcaaaccca
     2161 gccaagttcg agacctctgt gaaaaggatg aggaggagga ggaggaagaa gaacagccaa
     2221 tcacggagcc caattcagag gaggagagag aggacgatgc ccagtgtcag ggcaaggaca
     2281 gcaaggccag ctctgcctcc ggtcagagct cccctgggaa ggatgctgct cctgagagtt
     2341 ctgcactcca taccacctca agtcccacct cacagggaag gtggctttct gccagcacag
     2401 cagcacggag ccctgtgctt ggtgggacct ctgggcctga ggccagccgg cctgctgctc
     2461 gcttgctacc tcccagccct ggcttggcca ctcggccctc cacagcacca aaggtgtctc
     2521 caaccataga caagctgccc tacgtgcccc acagcccctt ccacctcttc tcctatgact
     2581 ttgaagattc acccctcctc accaaggaca agggaggaga ctctcagaca gaaaacagat
     2641 acagcaattt cagcagcaac tctttccaat cctccagacc ctctcctgga cctagtgggt
     2701 ccccatctta tgcatcatcc ttctcatccc cacaggatac caggtcatcg ccaagtggcc
     2761 ttctcacatc ctcgttcagg cagcaccaag agtcactggc agcagagaga gagcggaggc
     2821 ggcaagagag agaggaaaga ctgcagagga tagaacggga agaaaggaac aaattcaacc
     2881 gggaatatct agacaaaagg gaggagcaaa ggcaagcaag aggagaaaga tacaaatact
     2941 tggagcagtt ggcagccgag acgcaggaga aggagcctag aagccagagc gtgagccggg
     3001 gtagagctga cctctccttg gacctgagct tgcctgcagc ccctgctcca ccttcccctt
     3061 caagccagag tccctctgct gactcacaag aggctctccc tgtgccttca tccccaccca
     3121 ctctgcagtg cccccaagta agtggtaagg accacgagcc tgaactggag gcagaagctg
     3181 ggcaaggtgc tgatgaagcc agccaggata tagcatctgc ccacagggga gcagagagcc
     3241 aagaagagcc ggtgctggag ctagagccag aggaaagagc ttcactgagt gaaaaagaga
     3301 ggcaaaacga agaggtgaat gagagggaca actgttctgc ttccagcatc tcgtcctcca
     3361 gcagcacctt ggagagggaa gagaaggaag acaaactgtc tgaagacagg gcgaccggtt
     3421 tgtggtccac cagccttcag gatgtgggtg tgaatggaca gtgtggtgac atccttacca
     3481 gcaaaaggtt catgctggac atgctgtatg cccataacag aaaatccaca gaagatgagg
     3541 aaaaagatga cggcgagcct gggaggtctg cgcaggaggt ggaggcagtg gccagcctcg
     3601 ccaccaggat atccactctg caggccaact ctcaggcccc agaggagagc atcaagaggg
     3661 tggacattgg ctgtctagac aaccggggca gtgtgaaggc atttgctgag aaattcaaca
     3721 gtggagaagt agggaggggt gccatctctc ctgatgtgga gtctcaggac aaggtcccgg
     3781 atacaccccc agcacagctg aagactgagt ctgattacat ctgggaccag ctcatggcca
     3841 atccgaggga gctcagaatc caagacatgg atttcacaga cctaggggag gaggacgata
     3901 tcgatgtttt ggatgtggat cttggccacc gggaagcccc agggccaccc cctccacccc
     3961 ctcccacctt cctgggtttg ccacccccac cccctccacc cctgttggac agcgtgcctc
     4021 ccccaccagt ccccggtaat ttattggctt ctcctgtgtt caacactcct cagggcttag
     4081 ggtggtccca ggtacccagg ggtcagccag cgttcaccaa gaaaaagaag acgatccggc
     4141 tgttctggaa cgaagtccgg ccctttgagt ggccaagtaa gaacaatcgc cggtgcaggg
     4201 aattcctgtg gtcaaaactg gaacccatta aggtggacac ttccagactc gagcacctgt
     4261 ttgagtccaa gtctaaggag ctgtctgtca ccaagaaaac ggctgcagat ggtaaacggc
     4321 aggagatcat tgttctggat tccaagagga gcaatgccat caacatcggc ctgacggtgc
     4381 tgccccctcc aaggacaatt aagatagcca ttttgaactt tgatgagtat gccttaaaca
     4441 aagaagggat cgagaaaatt ctgaccatga ttccaactga agaggagaag cagaaaatcc
     4501 aggaggctca gctggctaac ccggaagtgc cgttgggcag tgcagagcag ttccttctca
     4561 cactctcttc catcagtgag ctctcggctc ggctccacct gtgggcattc aaaatggatt
     4621 atgaaaccac agaaaaggaa gtggccgaac cacttttgga cctgaaggaa ggaatagacc
     4681 agttggagaa caataagact ctgggcttca tcctgtctac tctccttgcc attgggaact
     4741 ttctaaatgg aactaatgcc aaagcatttg agttaagcta cctcgagaag gttccagaag
     4801 tcaaagatac agtgcacaag cagtctcttc tccaccacgt gtgcaccatg gtagtggaaa
     4861 actttccgga cagctcggat ctgtactcag agattggggc catcactagg tcagccaagg
     4921 ttgactttga tcaacttcag gataatttat gtcagatgga gagacgctgc aaagcttcat
     4981 gggaccacct caaggcgatt gcaaaacacg agatgaagcc tgttttgaaa cagcggatgt
     5041 cagagttcct aaaagactgt gcagagcgaa ttataatttt aaagatcgtc catcggagga
     5101 taattaacag atttcactca tttttactgt ttatgggcca tcccccttat gcaattcgag
     5161 aggtgaacat caacaagttc tgcaggatca tcagtgagtt tgccctggag tatcgcacga
     5221 ccagggaaag ggttctacag cagaaacaga agcgggccaa ccacagagag agaaacaaga
     5281 ccagagggaa gatgatcact gactctggca agttctctgg cagttctcca gcagcaccga
     5341 gccagccaca gggtctgagc tatgctgagg atgcagccga acatgagaac atgaaggccg
     5401 tgttgaaaac ctcctcccct gcgctggagg acgccacccc agtgcttggt gtccgcactc
     5461 gcagccgggc aagccgagga tccactagtt catggactat gggaactgag gagtcaccta
     5521 gtgtcactga tgatgcggct gatgagatca tggaccgcat tgtcaaatca gccacccaag
     5581 tgcccagtca gagagtggtg ccacgggaga gaaagcgttc cagggccaac cgcaaatctt
     5641 tgcgaaggac cttgaagagt ggcctgactc cagaagaagc cagagccctg ggcctggttg
     5701 gcacatctga actgcaactg tgacttttgt aggttctcag aagtgtgctg agcagaggac
     5761 cagatctggc tagacctgcc cctttcagta gaggcaggga gacttgacct gaacatctga
     5821 tggttagaac tgagtcctca tttctgagta acacactgct tgtcaccgtt gcgcattgac
     5881 atggatctcc agaaatctcc tgcatgtact ttatcaagtc agctgtgttt ctcttgtttc
     5941 cttgatacct ggtttattag ctccaagtgt gacacctttt ctaggaagca acagtccttg
     6001 taaggaacaa atcacttctg tcacagttgt taagataaca tggggcaatg tgattagact
     6061 cagagactgg gtctctacaa caaccaaatg tccagatata aatgccaatg ctgtacacac
     6121 atacaagcac agcttgttta ccagttgtgg attttagatg tactaaatgt ttatacaaac
     6181 tcataaatgt acactgtgtt tcaatgacta aataaataga ggttaatgtc accataaaaa
     6241 aaaaaaaaaa a
//
