LOCUS       NM_177699               3951 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus formin homology 2 domain containing 1 (Fhod1), mRNA.
ACCESSION   NM_177699
VERSION     NM_177699.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3951)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3951)
  AUTHORS   Zuidscherwoude,M., Haining,E.J., Simms,V.A., Watson,S.,
            Grygielska,B., Hardy,A.T., Bacon,A., Watson,S.P. and Thomas,S.G.
  TITLE     Loss of mDia1 and Fhod1 impacts platelet formation but not platelet
            function
  JOURNAL   Platelets 32 (8), 1051-1062 (2021)
   PUBMED   32981398
REFERENCE   3  (bases 1 to 3951)
  AUTHORS   Sanematsu,F., Kanai,A., Ushijima,T., Shiraishi,A., Abe,T., Kage,Y.,
            Sumimoto,H. and Takeya,R.
  TITLE     Fhod1, an actin-organizing formin family protein, is dispensable
            for cardiac development and function in mice
  JOURNAL   Cytoskeleton (Hoboken) 76 (2), 219-229 (2019)
   PUBMED   31008549
  REMARK    GeneRIF: Fhod1 appears to be dispensable for normal development and
            function of the mouse heart, even if a marginal amount of Fhod1 is
            expressed in the heart.
REFERENCE   4  (bases 1 to 3951)
  AUTHORS   Pan,M.H., Wang,F., Lu,Y., Tang,F., Duan,X., Zhang,Y., Xiong,B. and
            Sun,S.C.
  TITLE     FHOD1 regulates cytoplasmic actin-based spindle migration for mouse
            oocyte asymmetric cell division
  JOURNAL   J Cell Physiol 233 (3), 2270-2278 (2018)
   PUBMED   28708292
  REMARK    GeneRIF: FHOD1 is regulated by ROCK for cytoplasm actin assembly
            and spindle migration during mouse oocyte meiosis.
REFERENCE   5  (bases 1 to 3951)
  AUTHORS   Dutta,P. and Maiti,S.
  TITLE     Expression of multiple formins in adult tissues and during
            developmental stages of mouse brain
  JOURNAL   Gene Expr Patterns 19 (1-2), 52-59 (2015)
   PUBMED   26272686
REFERENCE   6  (bases 1 to 3951)
  AUTHORS   Thomas,S.G., Calaminus,S.D., Machesky,L.M., Alberts,A.S. and
            Watson,S.P.
  TITLE     G-protein coupled and ITAM receptor regulation of the formin FHOD1
            through Rho kinase in platelets
  JOURNAL   J Thromb Haemost 9 (8), 1648-1651 (2011)
   PUBMED   21605332
  REMARK    GeneRIF: Letter: G-protein coupled and ITAM receptor regulation of
            the formin FHOD1 through Rho kinase in platelets.
REFERENCE   7  (bases 1 to 3951)
  AUTHORS   Lin,X., Miller,J.W., Mankodi,A., Kanadia,R.N., Yuan,Y.,
            Moxley,R.T., Swanson,M.S. and Thornton,C.A.
  TITLE     Failure of MBNL1-dependent post-natal splicing transitions in
            myotonic dystrophy
  JOURNAL   Hum Mol Genet 15 (13), 2087-2097 (2006)
   PUBMED   16717059
REFERENCE   8  (bases 1 to 3951)
  AUTHORS   Kanaya,H., Takeya,R., Takeuchi,K., Watanabe,N., Jing,N. and
            Sumimoto,H.
  TITLE     Fhos2, a novel formin-related actin-organizing protein, probably
            associates with the nestin intermediate filament
  JOURNAL   Genes Cells 10 (7), 665-678 (2005)
   PUBMED   15966898
REFERENCE   9  (bases 1 to 3951)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
REFERENCE   10 (bases 1 to 3951)
  AUTHORS   Lake,S., Gullberg,H., Wahlqvist,J., Sjogren,A.M., Kinhult,A.,
            Lind,P., Hellstrom-Lindahl,E. and Stjernschantz,J.
  TITLE     Cloning of the rat and human prostaglandin F2 alpha receptors and
            the expression of the rat prostaglandin F2 alpha receptor
  JOURNAL   FEBS Lett 355 (3), 317-325 (1994)
   PUBMED   7988697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB858085.1, AB041045.1 and AW540395.2.
            
            On Nov 28, 2009 this sequence version replaced NM_177699.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060654.1, AB041045.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               BB858085.1         1-106
            107-3945            AB041045.1         1-3839
            3946-3951           AW540395.2         1-6                 c
FEATURES             Location/Qualifiers
     source          1..3951
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..3951
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /note="formin homology 2 domain containing 1"
                     /db_xref="GeneID:234686"
                     /db_xref="MGI:MGI:2679008"
     exon            1..318
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..3711
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /note="formin homolog overexpressed in spleen 1; formin
                     homology 2 domain-containing protein 1"
                     /codon_start=1
                     /product="FH1/FH2 domain-containing protein 1"
                     /protein_id="NP_808367.2"
                     /db_xref="CCDS:CCDS22600.1"
                     /db_xref="GeneID:234686"
                     /db_xref="MGI:MGI:2679008"
                     /translation="MAGEEERGDGDPVSVVTVRVQYLEDTDPFACANFPEPRRAPTCS
                     LDGALPLSAQIPALHRLLGAPLKLEDCALQVSPSGYYLDPELSLEEQREMLEGFYEEI
                     SKGRKPTLILRTQLSVRVNAILEKLYGSSGPELRRSLFSLKQIFQEDKDLVPEFVHSE
                     GLSCLIRVGAAADHNYQSYILRALGQLMLFVDGMLGVVAHSETVQWLYTLCASLSRLV
                     VKTALKLLLVFVEYSENNAPLFIQAVNAVASATGTLPWANLVSILEEKNGADAELLVY
                     TVTLINKTLAALPDQDSFYDVTDALEQQGMEALVQRFLGTAGTDVDLRTQLTLYESAL
                     RLEDGDMEEAAAAAAAGGRRERRKPSSEEGKRSRRSLEGGGCPVRAPEPGSTGSASPV
                     GSTPSTGSAPPTNPAFSSTGPASGLLRTSVNLFPTISVGPSVDSSCERSVYKARFLEN
                     VAAAETEKQAALAQGRAETLAGATVDDTDGSSGTRELWDSPEPASAPRTPQSPVSRIL
                     LRTQRSLEPEPKKPVSPPSPKAEPIQEPPTCVPKLCIGDLDFSDLGEDEDQDTLNVES
                     VEAGKASPFLSSLSPSLSGGPPPPPPPPPPITGSCPPPPPPPLPPPATGSCPPPPPPP
                     PPPIIGSCPPPPPLAAPFTHSALDGPRHPTKRKTVKLFWRELKLTGGPGCSRSRFGPC
                     PTLWASLEPVSVDTARLEHLFESRAKDVLPTKKAGEGRRTMTVVLDPKRSNAINIGLT
                     TLPPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDVPLGPAEN
                     FLMTLASIGGLAARLQLWAFKLDYESMEREIAEPLFDLKVGMEQLVHNATFRCILATL
                     LAVGNFLNGSQSSGFELSYLEKVSEVKDTVRRQSLLYHLCSLVLQTRPDSSDLYSEIP
                     ALTRCAKVDFEQLTENLGQLECRSQAAEDSLRSLAKHELSPALRARLTHFLAQCTRRV
                     AMLRVVHRRVCNRFHAFLLYLGYTPQAARDVRIMQFCHTLREFALEYRTCRERVLQQQ
                     QKRATYRERNKTRGRMITETEKFSGVAGEAPNNLSVPVAVGSGPGQGDTDNHASMKSL
                     LTSRPEDATHSRRSRGMVQSSSPVSHTAVGPSAASPEETAASGLPTDTSDEIMDLLVQ
                     SVTKSGPRALAARERKRSRGNRKSLRRTLKSGLGDDLVQALGLSKAPGLEV"
     exon            319..425
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..490
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..558
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..664
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..759
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..871
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..966
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1110
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1268
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1448
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1564
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..2259
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2415
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2598
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2718
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2880
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..3071
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..3264
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3427
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..3628
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3948
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3922..3927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /note="hexamer: AATAAA"
     polyA_site      3945
                     /gene="Fhod1"
                     /gene_synonym="FHOS; FHOS1"
                     /note="major polyA site"
ORIGIN      
        1 gagccgcgag cgtccggccc agcctggccc ggccctaaca gcaaagttta gtcgagttga
       61 agttgcagca tttgcagggg acacaagagg cgtccagcgg tagccggtgg cagagccatg
      121 gcgggcgagg aagagcgcgg ggatggggac ccagtatccg tggtaactgt gagagtgcag
      181 tacctggaag acaccgaccc tttcgcttgt gccaacttcc cggaaccacg ccgggccccc
      241 acctgcagcc tggacggggc tctgcccctg agtgcgcaga tccctgctct gcaccgactc
      301 ctgggggcgc ctcttaagct ggaggactgt gcattgcaag tgtctccctc cggatactac
      361 ctggacccgg agctgtccct agaagaacag cgggagatgc tggagggttt ctatgaagag
      421 atcagcaaag ggcggaagcc cacgttaatc ctgcggaccc agctctccgt gagggtcaat
      481 gctatcttgg aaaagctgta tggctccagt ggccccgagc tccgccgatc tctcttctca
      541 ttaaagcaga tattccagga agacaaggac ctggtgcccg aattcgtgca ctcggagggt
      601 ctgagttgcc tgatccgcgt gggtgctgct gcagaccaca actaccagag ctacatcctt
      661 cgagccctgg gccagctgat gctgtttgtg gatgggatgc tgggggtggt ggcccacagc
      721 gagaccgtgc agtggctgta taccctgtgt gctagcctgt cccgcttggt ggtaaagaca
      781 gccctgaagc tgctgctggt gtttgtggag tattccgaga acaacgcgcc gctgttcatc
      841 caggcagtca acgcagtagc cagtgccacc ggtactcttc cctgggccaa cttggtgtcc
      901 atcctggagg agaagaatgg agctgatgca gagttgttgg tgtacactgt cactctcatt
      961 aacaagacgc tggcggcact cccagaccag gactccttct atgatgtgac agatgctctg
     1021 gagcagcagg gcatggaagc gctggtccaa cgtttcttgg gcaccgctgg cactgatgtt
     1081 gacctgcgaa cccagctaac gctctatgag agtgcccttc ggttagagga tggagatatg
     1141 gaagaggctg cagccgccgc tgctgcaggt ggccggcgag agcggcggaa gccatcctcg
     1201 gaggagggca aaaggagccg aagatcacta gaaggtggag gctgccctgt gcgtgcccca
     1261 gaacctggct ctacaggctc cgcctcacca gtaggctcca ccccctccac tggctccgcc
     1321 ccgcctacaa atccagcctt cagctctact ggcccagcct ctggccttct tcgaacctca
     1381 gtgaacctct ttcctaccat ttccgtgggg ccgtcagtgg acagttcctg tgagagaagc
     1441 gtctacaaag cccggttcct ggagaatgtg gcggcagcag agacggagaa gcaggctgct
     1501 ctggcccaag gccgagcgga gacgctggct ggagccacgg tagatgacac tgatggatca
     1561 tcaggcacaa gggaactgtg ggactcccca gagccagcct ctgcacccag gacaccccag
     1621 agccctgttt cccgaatcct gctgcgcacc cagcggagtc ttgagccaga gcccaagaag
     1681 ccagtgtcac caccaagccc taaggctgag cctatccagg agcctcccac ctgtgtcccc
     1741 aagctctgca ttggggactt ggacttctca gacctagggg aggatgaaga ccaggacaca
     1801 ctgaatgtgg aatctgtgga ggctggaaaa gcatctccct tcctgtcatc tctatcgccc
     1861 tcactctctg ggggtccccc tcctccgccc ccacctcctc cacccatcac aggctcctgc
     1921 cccccacctc cgcccccacc tctcccccca cccgccacag gctcctgccc tccacctccg
     1981 cccccacctc ccccacccat cataggctcc tgcccaccgc ctccacccct ggctgctcct
     2041 tttacccact cagcacttga cggcccaagg caccccacca aaaggaagac agtaaaactt
     2101 ttctggcggg aactaaagct gactgggggc cctgggtgct ctagaagccg ctttgggcct
     2161 tgtcctaccc tgtgggcctc gctggaaccc gtctcggtgg acacagcccg cctggaacac
     2221 ctatttgagt ccagagccaa ggatgtgcta ccaaccaaga aagctggtga gggccgccgg
     2281 acaatgaccg tagtgctgga ccccaagcgc agcaatgcca tcaacattgg cctaaccact
     2341 ctgccacccg tgcacgtcat caaggctgcc ctgctcaact tcgatgagtt tgctgtcagc
     2401 aaagatggca ttgagaaact gctgacaatg atgcccacgg aggaagagcg gcagaagatt
     2461 gaggaagccc agctggctaa ccccgatgta cccctcggcc ccgctgagaa tttcctgatg
     2521 acgcttgctt ccattggagg cctggctgcg cgcctacagc tctgggcttt caagctggac
     2581 tatgaaagca tggagcggga aattgcagag ccactgtttg atctgaaagt gggcatggaa
     2641 cagctggtac acaatgccac cttccgctgt attctggcta cccttttggc tgtgggcaac
     2701 ttcctcaatg gttcccagag cagtggcttt gagctgagct acctggagaa ggtgtcagaa
     2761 gtgaaggaca cagtgcgacg gcagtcattg ctctatcatc tctgctccct ggtgctccag
     2821 acccgacctg attcctctga cctctactca gaaattcctg ccctcacccg ctgtgccaag
     2881 gtggactttg aacagctgac tgagaaccta gggcagctgg agtgccggag ccaggctgcc
     2941 gaggacagcc tccggagctt ggctaagcac gagctctccc cagctctgcg tgctcgcctc
     3001 acccacttct tggcccagtg tacccgccgg gtagccatgt taagagtagt gcatcgccga
     3061 gtctgcaata ggttccatgc cttcctgctc tacctgggct acaccccaca ggcagcaagg
     3121 gatgtacgca tcatgcagtt ctgccacaca ctgagagagt ttgcccttga gtatcggact
     3181 tgtcgggaac gggtactgca gcagcagcag aagcgggcta cataccgtga gcgcaacaag
     3241 acccgtggtc gcatgattac cgagacagag aagttctcag gtgtggctgg ggaggccccc
     3301 aataacctgt ctgtcccagt ggctgtgggc agcgggccag gtcagggtga tactgacaat
     3361 catgccagca tgaagagcct gcttaccagc aggccggaag atgccacaca cagccgacgc
     3421 agcagaggta tggtccagag cagttccccc gtctcacaca cagcagtggg gccctccgct
     3481 gcatcccctg aggagactgc agcctccggc ttacccaccg acacgtcaga tgagataatg
     3541 gacctgctgg tgcagtcagt taccaagagc ggtcctagag ccttagctgc tcgggagagg
     3601 aagcgctctc gtggcaaccg aaagtccttg agacggacac tgaagagtgg acttggagat
     3661 gacctggtgc aggcactggg actaagcaaa gctcctggtc tagaggtgtg aggtgctacc
     3721 acgcctggac atgacagcga catgcacaag agatggagtg cggaaagggc ctggaacaga
     3781 aacctggttt cagaagctta tacccagaaa ccagtattgt gaacagtatt aggtgtgtgt
     3841 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtatacac gtacatgtat tttgcatgtg
     3901 tgagttcctt atttggaaca aaataaagtt tacctagcta atctataaaa a
//
