LOCUS       NM_001418980            1905 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus four and a half LIM domains 3 (Fhl3), transcript
            variant 3, mRNA.
ACCESSION   NM_001418980
VERSION     NM_001418980.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1905)
  AUTHORS   Zhang,Y., Li,W., Zhu,M., Li,Y., Xu,Z. and Zuo,B.
  TITLE     FHL3 differentially regulates the expression of MyHC isoforms
            through interactions with MyoD and pCREB
  JOURNAL   Cell Signal 28 (1), 60-73 (2016)
   PUBMED   26499038
  REMARK    GeneRIF: Four and a half LIM domain protein 3 could interact with
            MyoD, cyclic AMP-responsive elements and phosphorylated cAMP
            response element binding protein in vivo
REFERENCE   2  (bases 1 to 1905)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   3  (bases 1 to 1905)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1905)
  AUTHORS   Chung,Y.C., Tsai,Y.J., Shiu,T.Y., Sun,Y.Y., Wang,P.F. and Chen,C.L.
  TITLE     Screening large numbers of expression patterns of transcription
            factors in late stages of the mouse thymus
  JOURNAL   Gene Expr Patterns 11 (1-2), 84-92 (2011)
   PUBMED   20932939
REFERENCE   5  (bases 1 to 1905)
  AUTHORS   Ding,L., Wang,Z., Yan,J., Yang,X., Liu,A., Qiu,W., Zhu,J., Han,J.,
            Zhang,H., Lin,J., Cheng,L., Qin,X., Niu,C., Yuan,B., Wang,X.,
            Zhu,C., Zhou,Y., Li,J., Song,H., Huang,C. and Ye,Q.
  TITLE     Human four-and-a-half LIM family members suppress tumor cell growth
            through a TGF-beta-like signaling pathway
  JOURNAL   J Clin Invest 119 (2), 349-361 (2009)
   PUBMED   19139564
REFERENCE   6  (bases 1 to 1905)
  AUTHORS   Samson,T., Smyth,N., Janetzky,S., Wendler,O., Muller,J.M.,
            Schule,R., von der Mark,H., von der Mark,K. and Wixler,V.
  TITLE     The LIM-only proteins FHL2 and FHL3 interact with alpha- and
            beta-subunits of the muscle alpha7beta1 integrin receptor
  JOURNAL   J Biol Chem 279 (27), 28641-28652 (2004)
   PUBMED   15117962
  REMARK    GeneRIF: FHL2 and FHL3, respectively, are colocalized with
            alpha(7)beta(1) integrin receptor at the periphery of Z-discs,
            suggesting a role in mechanical stabilization of muscle cells
REFERENCE   7  (bases 1 to 1905)
  AUTHORS   Coghill,I.D., Brown,S., Cottle,D.L., McGrath,M.J., Robinson,P.A.,
            Nandurkar,H.H., Dyson,J.M. and Mitchell,C.A.
  TITLE     FHL3 is an actin-binding protein that regulates
            alpha-actinin-mediated actin bundling: FHL3 localizes to actin
            stress fibers and enhances cell spreading and stress fiber
            disassembly
  JOURNAL   J Biol Chem 278 (26), 24139-24152 (2003)
   PUBMED   12704194
  REMARK    GeneRIF: Actin was identified as a FHL3 binding partner; FHL3 is a
            significant regulator of actin cytoskeletal dynamics in skeletal
            myoblasts.
REFERENCE   8  (bases 1 to 1905)
  AUTHORS   Morgan,M.J. and Whawell,S.A.
  TITLE     The structure of the human LIM protein ACT gene and its expression
            in tumor cell lines
  JOURNAL   Biochem Biophys Res Commun 273 (2), 776-783 (2000)
   PUBMED   10873680
REFERENCE   9  (bases 1 to 1905)
  AUTHORS   Chu,P.H., Ruiz-Lozano,P., Zhou,Q., Cai,C. and Chen,J.
  TITLE     Expression patterns of FHL/SLIM family members suggest important
            functional roles in skeletal muscle and cardiovascular system
  JOURNAL   Mech Dev 95 (1-2), 259-265 (2000)
   PUBMED   10906474
REFERENCE   10 (bases 1 to 1905)
  AUTHORS   Morgan,M.J. and Madgwick,A.J.
  TITLE     The LIM proteins FHL1 and FHL3 are expressed differently in
            skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 255 (2), 245-250 (1999)
   PUBMED   10049693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606907.10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.4301861.1,
                                           SRR13422601.147928.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AL606907.10        59249-59393         c
            146-373             AL606907.10        56169-56396         c
            374-550             AL606907.10        54311-54487         c
            551-725             AL606907.10        54042-54216         c
            726-895             AL606907.10        52677-52846         c
            896-1109            AL606907.10        52370-52583         c
            1110-1905           AL606907.10        51489-52284         c
FEATURES             Location/Qualifiers
     source          1..1905
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.88 cM"
     gene            1..1905
                     /gene="Fhl3"
                     /gene_synonym="SLIM2"
                     /note="four and a half LIM domains 3"
                     /db_xref="GeneID:14201"
                     /db_xref="MGI:MGI:1341092"
     exon            1..145
                     /gene="Fhl3"
                     /gene_synonym="SLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            146..373
                     /gene="Fhl3"
                     /gene_synonym="SLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            374..550
                     /gene="Fhl3"
                     /gene_synonym="SLIM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..1264
                     /gene="Fhl3"
                     /gene_synonym="SLIM2"
                     /note="skeletal muscle LIM-protein 2"
                     /codon_start=1
                     /product="four and a half LIM domains protein 3"
                     /protein_id="NP_001405909.1"
                     /db_xref="GeneID:14201"
                     /db_xref="MGI:MGI:1341092"
                     /translation="MSEAFDCAKCNESLYGRKYIQTDSGPYCVPCYDNTFANTCAECQ
                     QLIGHDSRELFYEDRHFHEGCFRCCRCQRSLADEPFTCQDSELLCNECYCTAFSSQCS
                     ACGETVMPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAP
                     RCARCSKTLTQGGVTYRDQPWHRECLVCTGCKTPLAGQQFTSRDDDPYCVACFGELFA
                     PKCSSCKRPITGGSGGGEGAGLGGGKYVSFEDRHWHHSCFSCARCSTSLVGQGFVPDG
                     DQVLCQGCSQAGP"
     exon            551..725
                     /gene="Fhl3"
                     /gene_synonym="SLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..895
                     /gene="Fhl3"
                     /gene_synonym="SLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1109
                     /gene="Fhl3"
                     /gene_synonym="SLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1905
                     /gene="Fhl3"
                     /gene_synonym="SLIM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1886..1891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fhl3"
                     /gene_synonym="SLIM2"
                     /note="hexamer: AATAAA"
     polyA_site      1905
                     /gene="Fhl3"
                     /gene_synonym="SLIM2"
                     /note="major polyA site"
ORIGIN      
        1 actcgcccac acagtcagtc gcagccggct acctcgccgc tgctctctcg gcccccctcc
       61 gcctggccca caggtaggag ccgccgggcg atcggctccc gccccaccca cgccgcgcgc
      121 gcccagctcc cgcgcccgct tcgagtggct aacagcccag gcagtcctca gatgctgggc
      181 cagaggaaac caggacctga atgacagggg agagagaagg aggggctctc tccacccttc
      241 agcatgaccg ctacctgagg actctccact ttgaagactc ccactttggt cgccttatgt
      301 cctgctttgg gtgtgaacca ggtgttctcc ctccttgttg aagggaaagt tcaaactcat
      361 aagccacaaa gagggctcac tgggcaccgc caccatgagc gaggcatttg actgtgcaaa
      421 atgcaacgag tccttgtacg gccgcaaata catccagaca gacagtggcc cctactgcgt
      481 tccgtgctat gacaacacct tcgccaacac ctgtgctgag tgccagcagc tcattgggca
      541 tgattcaagg gaactgttct atgaggaccg ccacttccac gagggctgct tccgctgctg
      601 ccgatgccag cgctcccttg ccgatgagcc cttcacctgt caggacagtg agcttctgtg
      661 taatgagtgt tactgcacag ccttctcgtc ccagtgttct gcctgcgggg agactgtcat
      721 gcctgggtcc cggaagctgg agtatggagg ccagacgtgg catgaacact gctttctgtg
      781 cagtggctgt gagcagccgc tgggctcccg ctccttcgtg cctgacaagg gtgcccacta
      841 ctgcgtgcct tgctatgaga acaaatttgc tcctcggtgt gcccgctgca gcaagacgct
      901 gacccagggt ggagtgacat atcgtgatca gccctggcac cgagagtgcc tggtctgcac
      961 tgggtgcaag acgccccttg cagggcagca gttcacatct cgggatgatg atccttactg
     1021 tgtggcctgc tttggagaac tctttgcacc caagtgcagc agctgcaagc gccccatcac
     1081 aggtgggagc ggcggcggcg agggcgcagg actcggtgga ggcaagtatg tgtccttcga
     1141 agaccgacat tggcaccaca gctgcttttc ctgtgcccgc tgctccacct ccctggtggg
     1201 ccaaggcttt gtaccagacg gagatcaagt tctatgccag ggctgcagcc aagcaggccc
     1261 ctgagtggag gatcctgact ctcctctttc ccaaaccaag agttcaagac tttggcgcct
     1321 tttctgaacc acttctgggg cccaacccct ccctagaacg ggccctcccc caacccccgc
     1381 tccccactca ttgggacttc aggattcagt cacccaattt taacacaccc cagtggtact
     1441 ccccgaccca ggcccccaaa tctgggctgt tgtggaacac ccatgactta agcctttctc
     1501 caagtctgga ttccagaaat gttccccaca tcaaggctct gacaccccag ccctccaaac
     1561 ctgaactctg aggcctaggc ctctttaagt caagacttct agggtagatt tttttttttt
     1621 tttttttttt tttttttttt ttttttagtt tttctgcagg tgcctaagaa gtcttcaaaa
     1681 atagattgta cacccggttt gacctcaccc ccatcccact gctctctctg agctgcagct
     1741 gtatgtatag cagattaggg gctccctggt tagagggttg taaggtacag ggtgctgtcc
     1801 agcctctgag taccatgtta tttcagctcc atgttgccct gcaacaggaa gcaggaaggt
     1861 tgctcgccct gtttccagag attgcaataa agcagtgtga gggga
//
