LOCUS       NM_010212               1537 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus four and a half LIM domains 2 (Fhl2), transcript
            variant 1, mRNA.
ACCESSION   NM_010212
VERSION     NM_010212.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1537)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1537)
  AUTHORS   Van Wauwe,J., Mahy,A., Craps,S., Ekhteraei-Tousi,S., Vrancaert,P.,
            Kemps,H., Dheedene,W., Donate Puertas,R., Trenson,S.,
            Roderick,H.L., Beerens,M. and Luttun,A.
  TITLE     PRDM16 determines specification of ventricular cardiomyocytes by
            suppressing alternative cell fates
  JOURNAL   Life Sci Alliance 7 (12), e202402719 (2024)
   PUBMED   39304345
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1537)
  AUTHORS   Wang,Y., Kuang,Z., Xing,X., Qiu,Y., Zhang,J., Shao,D., Huang,J.,
            Dai,C. and He,W.
  TITLE     Proximal tubular FHL2, a novel downstream target of hypoxia
            inducible factor 1, is a protector against ischemic acute kidney
            injury
  JOURNAL   Cell Mol Life Sci 81 (1), 244 (2024)
   PUBMED   38814462
  REMARK    GeneRIF: Proximal tubular FHL2, a novel downstream target of
            hypoxia inducible factor 1, is a protector against ischemic acute
            kidney injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1537)
  AUTHORS   Li,C., Warren,D.T., Zhou,C., De Silva,S., Wilson,D.G.S.,
            Garcia-Maya,M., Wheeler,M.A., Meinke,P., Sawyer,G., Ehler,E.,
            Wehnert,M., Rao,L., Zhang,Q. and Shanahan,C.M.
  TITLE     Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in
            the cardiomyocyte sarcomere
  JOURNAL   J Biol Chem 300 (5), 107254 (2024)
   PUBMED   38569934
  REMARK    GeneRIF: Nesprin-2 is a novel scaffold protein for telethonin and
            FHL-2 in the cardiomyocyte sarcomere.
REFERENCE   5  (bases 1 to 1537)
  AUTHORS   Sommer,J., Ehnis,H., Seitz,T., Schneider,J., Wild,A.B., Moceri,S.,
            Buechler,C., Bozec,A., Weber,G.F., Merkel,S.,
            Beckervordersandforth,R., Steinkasserer,A., Schule,R., Trebicka,J.,
            Hartmann,A., Bosserhoff,A., von Horsten,S., Dietrich,P. and
            Hellerbrand,C.
  TITLE     Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y
            (NPY) in Macrophages in Visceral Adipose Tissue and Promotes
            Diet-Induced Obesity
  JOURNAL   Int J Mol Sci 24 (19), 14943 (2023)
   PUBMED   37834391
  REMARK    GeneRIF: Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces
            Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and
            Promotes Diet-Induced Obesity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1537)
  AUTHORS   Gisler,S.M., Stagljar,I., Traebert,M., Bacic,D., Biber,J. and
            Murer,H.
  TITLE     Interaction of the type IIa Na/Pi cotransporter with PDZ proteins
  JOURNAL   J Biol Chem 276 (12), 9206-9213 (2001)
   PUBMED   11099500
REFERENCE   7  (bases 1 to 1537)
  AUTHORS   Fimia,G.M., De Cesare,D. and Sassone-Corsi,P.
  TITLE     A family of LIM-only transcriptional coactivators: tissue-specific
            expression and selective activation of CREB and CREM
  JOURNAL   Mol Cell Biol 20 (22), 8613-8622 (2000)
   PUBMED   11046156
REFERENCE   8  (bases 1 to 1537)
  AUTHORS   Chu,P.H., Bardwell,W.M., Gu,Y., Ross,J. Jr. and Chen,J.
  TITLE     FHL2 (SLIM3) is not essential for cardiac development and function
  JOURNAL   Mol Cell Biol 20 (20), 7460-7462 (2000)
   PUBMED   11003643
REFERENCE   9  (bases 1 to 1537)
  AUTHORS   Chu,P.H., Ruiz-Lozano,P., Zhou,Q., Cai,C. and Chen,J.
  TITLE     Expression patterns of FHL/SLIM family members suggest important
            functional roles in skeletal muscle and cardiovascular system
  JOURNAL   Mech Dev 95 (1-2), 259-265 (2000)
   PUBMED   10906474
REFERENCE   10 (bases 1 to 1537)
  AUTHORS   Morgan,M.J. and Madgwick,A.J.
  TITLE     The LIM proteins FHL1 and FHL3 are expressed differently in
            skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 255 (2), 245-250 (1999)
   PUBMED   10049693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161207.4.
            
            On Oct 12, 2022 this sequence version replaced NM_010212.4.
            
            Summary: This gene encodes a member of the four-and-a-half-LIM-only
            protein family. The encoded protein functions as a regulator in
            numerous signaling pathways and cellular processes in development
            and cellular differentiation, including development and maintenance
            of the cardiovascular system and striated muscles. This gene also
            plays a role in bone formation and regulates and bone mineral
            content and bone mineral density. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147024.1, AK133708.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               AC161207.4         153243-153475       c
            234-412             AC161207.4         142617-142795       c
            413-587             AC161207.4         131239-131413       c
            588-757             AC161207.4         121193-121362       c
            758-944             AC161207.4         117785-117971       c
            945-1537            AC161207.4         112614-113206       c
FEATURES             Location/Qualifiers
     source          1..1537
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 22.33 cM"
     gene            1..1537
                     /gene="Fhl2"
                     /gene_synonym="FHL-2; SLIM-3; SLIM3"
                     /note="four and a half LIM domains 2"
                     /db_xref="GeneID:14200"
                     /db_xref="MGI:MGI:1338762"
     exon            1..233
                     /gene="Fhl2"
                     /gene_synonym="FHL-2; SLIM-3; SLIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            234..412
                     /gene="Fhl2"
                     /gene_synonym="FHL-2; SLIM-3; SLIM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..1096
                     /gene="Fhl2"
                     /gene_synonym="FHL-2; SLIM-3; SLIM3"
                     /note="skeletal muscle LIM-protein 3"
                     /codon_start=1
                     /product="four and a half LIM domains protein 2"
                     /protein_id="NP_034342.1"
                     /db_xref="CCDS:CCDS14922.1"
                     /db_xref="GeneID:14200"
                     /db_xref="MGI:MGI:1338762"
                     /translation="MTERFDCHHCNESLYGKKYILKEENPHCVACFEELYANTCEECG
                     TPIGCDCKDLSYKDRHWHEGCFHCSRCGSSLVDKPFAAKEEQLLCTDCYSNEYSSKCQ
                     ECKKTIMPGTRKMEYKGSSWHETCFTCQRCQQPIGTKSFIPKENQNFCVPCYEKQYAL
                     QCVQCKKPITTGGVTYREQPWHKECFVCTACKKQLSGQRFTARDEFPYCLTCFCDLYA
                     KKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCG
                     KDI"
     exon            413..587
                     /gene="Fhl2"
                     /gene_synonym="FHL-2; SLIM-3; SLIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            588..757
                     /gene="Fhl2"
                     /gene_synonym="FHL-2; SLIM-3; SLIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            758..944
                     /gene="Fhl2"
                     /gene_synonym="FHL-2; SLIM-3; SLIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1537
                     /gene="Fhl2"
                     /gene_synonym="FHL-2; SLIM-3; SLIM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1517..1522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fhl2"
                     /gene_synonym="FHL-2; SLIM-3; SLIM3"
                     /note="hexamer: AATAAA"
     polyA_site      1537
                     /gene="Fhl2"
                     /gene_synonym="FHL-2; SLIM-3; SLIM3"
                     /note="major polyA site"
ORIGIN      
        1 actccgcccg ctgagccgcc accgccaccg gtccacagtc cgctgggttc ccttagaccc
       61 cggccccacc gcgcgagtac tactgcggcc gcccaggcca cagccctgct tgggacacaa
      121 ggatcgccac cagaccgctg ccctaggacg cgtcgagagc ctgtggccag cgcactcgga
      181 ccgtggggcg gagacccagg agaccggagc agagctgtgc agacagcatc aggattgctg
      241 aaagacaggt gtcagcatga ctgaacgctt tgactgccac cactgcaatg aatctctgta
      301 cggcaagaag tacattctaa aggaggagaa cccacactgt gtggcctgct ttgaggaact
      361 ctatgccaat acctgtgagg agtgtggaac acccatcggc tgcgactgca aggacttgtc
      421 ctacaaggat cggcactggc atgaaggctg cttccattgc tcccggtgtg gaagctcgct
      481 ggtggacaag ccctttgctg ccaaggagga acagctgctg tgcaccgact gctattccaa
      541 tgaatactcg tccaagtgcc aggaatgcaa gaaaaccatc atgccaggta cccgcaagat
      601 ggaatacaag ggcagcagct ggcacgagac ctgcttcacc tgtcagcgct gccagcagcc
      661 cattggaacc aagagcttca tacctaagga gaatcagaac ttctgcgtgc cctgctatga
      721 gaagcagtat gccctgcagt gcgtgcagtg caaaaagcct atcaccacag gaggtgttac
      781 ttaccgggag cagccctggc acaaggaatg ctttgtgtgc acagcctgca agaagcagct
      841 atctgggcaa cgcttcacag cacgggatga gtttccatac tgcctgacct gcttctgtga
      901 cttgtacgct aagaaatgtg ctgggtgcac caaccccatt agtggtctgg gtggcacaaa
      961 gtacatctct ttcgaggaac gccaatggca caacgactgc tttaactgta agaagtgctc
     1021 cctgtctctg gtgggacgag gcttcctcac agagagagat gacatcctct gtcctgactg
     1081 tggaaaggat atttgaaggc ggcacagaag ccacagcgcg tggcgcagag attcggatgt
     1141 tttctttcat aaccaggcaa tgctgtgttc tgattcccac cagccaccac gaggcttcct
     1201 cttgctgccc tggcttcaca tttgttgaaa ccctttagtt cttttcttct cagtggggac
     1261 aagatccatc cgtaagcccc ggatgggaag atggtttgga attttataga aatgcaaggc
     1321 agattaaatg aaaaagtctt gagtgtcttt ataatgcatc cttccttcac atcctattta
     1381 attttttaag tgcaattaac atgtgttatg aacttgaatg tattttcaag ggagagctgg
     1441 gatttgcagc tttgtgactt cctttttatg taaaacctag aggaagactt atgtgactta
     1501 caataaaatt attcagaata aaacattttg tcaagca
//
