LOCUS       NM_001412088            2050 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus four and a half LIM domains 1 (Fhl1), transcript
            variant 14, mRNA.
ACCESSION   NM_001412088 XM_006527808
VERSION     NM_001412088.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2050)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2050)
  AUTHORS   Ng,W.H., Liu,X., Ling,Z.L., Santos,C.N.O., Magalhaes,L.S.,
            Kueh,A.J., Herold,M.J., Taylor,A., Freitas,J.R., Koit,S., Wang,S.,
            Lloyd,A.R., Teixeira,M.M., Merits,A., Almeida,R.P., King,N.J.C. and
            Mahalingam,S.
  TITLE     FHL1 promotes chikungunya and o'nyong-nyong virus infection and
            pathogenesis with implications for alphavirus vaccine design
  JOURNAL   Nat Commun 14 (1), 6605 (2023)
   PUBMED   37884534
  REMARK    GeneRIF: FHL1 promotes chikungunya and o'nyong-nyong virus
            infection and pathogenesis with implications for alphavirus vaccine
            design.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2050)
  AUTHORS   Broadway-Stringer,S., Jiang,H., Wadmore,K., Hooper,C., Douglas,G.,
            Steeples,V., Azad,A.J., Singer,E., Reyat,J.S., Galatik,F.,
            Ehler,E., Bennett,P., Kalisch-Smith,J.I., Sparrow,D.B., Davies,B.,
            Djinovic-Carugo,K., Gautel,M., Watkins,H. and Gehmlich,K.
  TITLE     Insights into the Role of a Cardiomyopathy-Causing Genetic Variant
            in ACTN2
  JOURNAL   Cells 12 (5), 721 (2023)
   PUBMED   36899856
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2050)
  AUTHORS   Noack,F., Vangelisti,S., Raffl,G., Carido,M., Diwakar,J., Chong,F.
            and Bonev,B.
  TITLE     Multimodal profiling of the transcriptional regulatory landscape of
            the developing mouse cortex identifies Neurog2 as a key epigenome
            remodeler
  JOURNAL   Nat Neurosci 25 (2), 154-167 (2022)
   PUBMED   35132236
REFERENCE   5  (bases 1 to 2050)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2050)
  AUTHORS   Fimia,G.M., De Cesare,D. and Sassone-Corsi,P.
  TITLE     A family of LIM-only transcriptional coactivators: tissue-specific
            expression and selective activation of CREB and CREM
  JOURNAL   Mol Cell Biol 20 (22), 8613-8622 (2000)
   PUBMED   11046156
REFERENCE   7  (bases 1 to 2050)
  AUTHORS   Chu,P.H., Ruiz-Lozano,P., Zhou,Q., Cai,C. and Chen,J.
  TITLE     Expression patterns of FHL/SLIM family members suggest important
            functional roles in skeletal muscle and cardiovascular system
  JOURNAL   Mech Dev 95 (1-2), 259-265 (2000)
   PUBMED   10906474
REFERENCE   8  (bases 1 to 2050)
  AUTHORS   Morgan,M.J. and Madgwick,A.J.
  TITLE     The LIM proteins FHL1 and FHL3 are expressed differently in
            skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 255 (2), 245-250 (1999)
   PUBMED   10049693
REFERENCE   9  (bases 1 to 2050)
  AUTHORS   Greene,W.K., Bahn,S., Masson,N. and Rabbitts,T.H.
  TITLE     The T-cell oncogenic protein HOX11 activates Aldh1 expression in
            NIH 3T3 cells but represses its expression in mouse spleen
            development
  JOURNAL   Mol Cell Biol 18 (12), 7030-7037 (1998)
   PUBMED   9819390
REFERENCE   10 (bases 1 to 2050)
  AUTHORS   Taniguchi,Y., Furukawa,T., Tun,T., Han,H. and Honjo,T.
  TITLE     LIM protein KyoT2 negatively regulates transcription by association
            with the RBP-J DNA-binding protein
  JOURNAL   Mol Cell Biol 18 (1), 644-654 (1998)
   PUBMED   9418910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671998.10.
            
            On Sep 14, 2022 this sequence version replaced XM_006527808.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4977128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AL671998.10        78884-78906
            24-205              AL671998.10        80313-80494
            206-380             AL671998.10        81468-81642
            381-550             AL671998.10        82201-82370
            551-2050            AL671998.10        84168-85667
FEATURES             Location/Qualifiers
     source          1..2050
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 30.06 cM"
     gene            1..2050
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /note="four and a half LIM domains 1"
                     /db_xref="GeneID:14199"
                     /db_xref="MGI:MGI:1298387"
     exon            1..23
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            24..205
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..634
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /note="isoform 7 is encoded by transcript variant 14; four
                     and a half LIM domains protein 1; RBP-associated molecule
                     14-1; skeletal muscle LIM-protein 1"
                     /codon_start=1
                     /product="four and a half LIM domains protein 1 isoform 7"
                     /protein_id="NP_001399017.1"
                     /db_xref="GeneID:14199"
                     /db_xref="MGI:MGI:1298387"
                     /translation="MSEKFDCHYCRDPLQGKKYVQKDGRHCCLKCFDKFCANTCVDCR
                     KPISADAKEVHYKNRYWHDNCFRCAKCLHPLASETFVSKDGKILCNKCATREDSPRCK
                     GCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAK
                     HCVKCNKGLVKAPVWWPMKDNPGTTTASTAKNAP"
     exon            206..380
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..550
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..2050
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2031..2036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /note="hexamer: AATAAA"
     polyA_site      2050
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /note="major polyA site"
ORIGIN      
        1 attcagttgg tggaagagct gcggtccctc cagctataag gtgggcacca tgtcggagaa
       61 gttcgactgt cactactgca gggacccctt gcaggggaag aagtacgtgc agaaggatgg
      121 ccgtcactgc tgcctgaagt gctttgacaa gttctgcgcc aacacctgcg tggactgccg
      181 caagcccata agcgctgatg ccaaggaggt gcattataag aatcgctact ggcacgacaa
      241 ctgcttccgc tgtgccaagt gccttcaccc cttggccagt gagacctttg tgtccaagga
      301 tggcaagatc ctgtgcaaca agtgcgctac tcgggaggac tcccccaggt gcaaagggtg
      361 cttcaaggcc attgtggcag gagaccagaa cgtggagtac aagggcaccg tctggcataa
      421 agactgcttc acctgcagca actgcaagca agtcattggg accggaagct tcttcccgaa
      481 aggggaggac ttctactgtg tgacttgcca tgagaccaag ttcgccaaac attgcgtgaa
      541 gtgcaacaag ggtttggtaa aggctccagt gtggtggcct atgaaggaca atcctggcac
      601 gactactgct tccactgcaa aaaatgctcc gtgaatctgg ccaacaagcg ctttgtattt
      661 cataatgagc aggtgtattg ccctgactgt gccaaaaagc tgtaacttga caggggctcc
      721 tgtcctgtaa aatggcattg gaaccattct ttgtgtcctt tgctccctcc ctccctctgt
      781 accatccata gggcaagagt gggctttcac ctctttaaag ttgctctttc cgtcttttct
      841 cccattttac agtattaatc aacgaaggac acacagtgat catattaaga tttagcaaag
      901 agcaaccttg cagcaaaaat aatttctctg ttgctgcact ggaaaaacaa aaccttagac
      961 tgactcttct gcatgtttct catagagcag aaaagtgcta accatgtagc cacttcacga
     1021 tgtaaacgag aagcataggc gataaagctc ccactgagac acctttgggg ctcagtctgg
     1081 atgcgctgtg cggtcacgtg actgcggtgt aagagttgca gcggctgctc caactccctt
     1141 ctcgccttct ctgggcagtt aagaacttgc cagaatgcat ggtttaactt ccttatcaaa
     1201 actctgacct tccttctgtt cttttgtgct ttcacacgac taacacagat ttccagagaa
     1261 ttaacatttt gaactttgtt gtaattctca agtgactttt cccccatact aacatttgac
     1321 tcccttacgt ggcgtgttct ctgagcgttc ctactttaaa gcatggaaca cacaggtgat
     1381 ttgaagcatc taagcagatc tgagaaaacg agcctgtttc agaacaaact caccacagtg
     1441 actacttcgg aagcttaaca agactaactc tcctgtcctt tttaattttt ttttttaaat
     1501 tttgttttaa tgagtagtaa aatagtttat gggtttggaa acttgcatga caatatttga
     1561 gcctcctcaa acgttcctgc agttttgaga ttcatcctgt agacatgaca aaaactctag
     1621 agccgcagct gagcaggcac agggctgtca tcaaagtagg gacaaggtga agtccttgta
     1681 acataaccgt tgtctgctct ttgtctgcat ccaggaagag tgcaaagtcc ctttgcttgt
     1741 gattcttaga actttccctc cagaattgca gttagactct ggggctgtcg gaggtggtcg
     1801 tcatccttca caggcaggac tgggttttca cccccttctc tgaaacgcag gattgcctcc
     1861 ttaactgtac tctccatttt attacatata taacgagcca atatcaaagt aaagatgtaa
     1921 tgaaaacaca cactcatata ttactgtagg agtggttata gatgccaaca cctcatttcc
     1981 atatttgtca ttagctgttt ccatctactg tttgattgta tccttacaaa aataaagcag
     2041 catagaaaga
//
