LOCUS       NM_001412083            2499 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus four and a half LIM domains 1 (Fhl1), transcript
            variant 9, mRNA.
ACCESSION   NM_001412083 XM_006527801
VERSION     NM_001412083.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2499)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2499)
  AUTHORS   Ng,W.H., Liu,X., Ling,Z.L., Santos,C.N.O., Magalhaes,L.S.,
            Kueh,A.J., Herold,M.J., Taylor,A., Freitas,J.R., Koit,S., Wang,S.,
            Lloyd,A.R., Teixeira,M.M., Merits,A., Almeida,R.P., King,N.J.C. and
            Mahalingam,S.
  TITLE     FHL1 promotes chikungunya and o'nyong-nyong virus infection and
            pathogenesis with implications for alphavirus vaccine design
  JOURNAL   Nat Commun 14 (1), 6605 (2023)
   PUBMED   37884534
  REMARK    GeneRIF: FHL1 promotes chikungunya and o'nyong-nyong virus
            infection and pathogenesis with implications for alphavirus vaccine
            design.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2499)
  AUTHORS   Broadway-Stringer,S., Jiang,H., Wadmore,K., Hooper,C., Douglas,G.,
            Steeples,V., Azad,A.J., Singer,E., Reyat,J.S., Galatik,F.,
            Ehler,E., Bennett,P., Kalisch-Smith,J.I., Sparrow,D.B., Davies,B.,
            Djinovic-Carugo,K., Gautel,M., Watkins,H. and Gehmlich,K.
  TITLE     Insights into the Role of a Cardiomyopathy-Causing Genetic Variant
            in ACTN2
  JOURNAL   Cells 12 (5), 721 (2023)
   PUBMED   36899856
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2499)
  AUTHORS   Noack,F., Vangelisti,S., Raffl,G., Carido,M., Diwakar,J., Chong,F.
            and Bonev,B.
  TITLE     Multimodal profiling of the transcriptional regulatory landscape of
            the developing mouse cortex identifies Neurog2 as a key epigenome
            remodeler
  JOURNAL   Nat Neurosci 25 (2), 154-167 (2022)
   PUBMED   35132236
REFERENCE   5  (bases 1 to 2499)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2499)
  AUTHORS   Fimia,G.M., De Cesare,D. and Sassone-Corsi,P.
  TITLE     A family of LIM-only transcriptional coactivators: tissue-specific
            expression and selective activation of CREB and CREM
  JOURNAL   Mol Cell Biol 20 (22), 8613-8622 (2000)
   PUBMED   11046156
REFERENCE   7  (bases 1 to 2499)
  AUTHORS   Chu,P.H., Ruiz-Lozano,P., Zhou,Q., Cai,C. and Chen,J.
  TITLE     Expression patterns of FHL/SLIM family members suggest important
            functional roles in skeletal muscle and cardiovascular system
  JOURNAL   Mech Dev 95 (1-2), 259-265 (2000)
   PUBMED   10906474
REFERENCE   8  (bases 1 to 2499)
  AUTHORS   Morgan,M.J. and Madgwick,A.J.
  TITLE     The LIM proteins FHL1 and FHL3 are expressed differently in
            skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 255 (2), 245-250 (1999)
   PUBMED   10049693
REFERENCE   9  (bases 1 to 2499)
  AUTHORS   Greene,W.K., Bahn,S., Masson,N. and Rabbitts,T.H.
  TITLE     The T-cell oncogenic protein HOX11 activates Aldh1 expression in
            NIH 3T3 cells but represses its expression in mouse spleen
            development
  JOURNAL   Mol Cell Biol 18 (12), 7030-7037 (1998)
   PUBMED   9819390
REFERENCE   10 (bases 1 to 2499)
  AUTHORS   Taniguchi,Y., Furukawa,T., Tun,T., Han,H. and Honjo,T.
  TITLE     LIM protein KyoT2 negatively regulates transcription by association
            with the RBP-J DNA-binding protein
  JOURNAL   Mol Cell Biol 18 (1), 644-654 (1998)
   PUBMED   9418910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671998.10.
            
            On Sep 14, 2022 this sequence version replaced XM_006527801.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3835354.282275.1,
                                           SRR17253011.3653286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AL671998.10        72034-72118
            86-267              AL671998.10        80313-80494
            268-442             AL671998.10        81468-81642
            443-612             AL671998.10        82201-82370
            613-799             AL671998.10        82788-82974
            800-999             AL671998.10        83563-83762
            1000-2499           AL671998.10        84168-85667
FEATURES             Location/Qualifiers
     source          1..2499
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 30.06 cM"
     gene            1..2499
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /note="four and a half LIM domains 1"
                     /db_xref="GeneID:14199"
                     /db_xref="MGI:MGI:1298387"
     exon            1..85
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1083
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /note="isoform 4 is encoded by transcript variant 9; four
                     and a half LIM domains protein 1; RBP-associated molecule
                     14-1; skeletal muscle LIM-protein 1"
                     /codon_start=1
                     /product="four and a half LIM domains protein 1 isoform 4"
                     /protein_id="NP_001399012.1"
                     /db_xref="GeneID:14199"
                     /db_xref="MGI:MGI:1298387"
                     /translation="MASQRHSGPSSYKVGTMSEKFDCHYCRDPLQGKKYVQKDGRHCC
                     LKCFDKFCANTCVDCRKPISADAKEVHYKNRYWHDNCFRCAKCLHPLASETFVSKDGK
                     ILCNKCATREDSPRCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPK
                     GEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQPWHAECFVCVTCSKKLAGQRFTA
                     VEDQYYCVDCYKNFVAKKCAGCKNPITGKRTVSRVSHPVSKARKSPVCHGKRLPLTLF
                     PSANLRGRHPGGERTCPSWVVVLYRKNRSLAAPRGPGLVKAPVWWPMKDNPGTTTAST
                     AKNAP"
     exon            86..267
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            268..442
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..612
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..799
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..999
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..2499
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2480..2485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /note="hexamer: AATAAA"
     polyA_site      2499
                     /gene="Fhl1"
                     /gene_synonym="FHL-1; KyoT; RAM14-1; SLIM; SLIM-1"
                     /note="major polyA site"
ORIGIN      
        1 gttatcatct ggggttgagg gaagacaggt ctgggtgccg ctcctgaact tggcctctga
       61 gccatggctt ctcaaagaca ctcaggtccc tccagctata aggtgggcac catgtcggag
      121 aagttcgact gtcactactg cagggacccc ttgcagggga agaagtacgt gcagaaggat
      181 ggccgtcact gctgcctgaa gtgctttgac aagttctgcg ccaacacctg cgtggactgc
      241 cgcaagccca taagcgctga tgccaaggag gtgcattata agaatcgcta ctggcacgac
      301 aactgcttcc gctgtgccaa gtgccttcac cccttggcca gtgagacctt tgtgtccaag
      361 gatggcaaga tcctgtgcaa caagtgcgct actcgggagg actcccccag gtgcaaaggg
      421 tgcttcaagg ccattgtggc aggagaccag aacgtggagt acaagggcac cgtctggcat
      481 aaagactgct tcacctgcag caactgcaag caagtcattg ggaccggaag cttcttcccg
      541 aaaggggagg acttctactg tgtgacttgc catgagacca agttcgccaa acattgcgtg
      601 aagtgcaaca aggccatcac atctggagga atcacttacc aggatcagcc ctggcatgcc
      661 gagtgctttg tgtgtgttac ctgctctaag aagctggctg ggcagcgttt caccgctgtg
      721 gaggaccagt attactgcgt ggattgctac aagaactttg tggccaagaa gtgtgctgga
      781 tgcaagaacc ccatcactgg gaaaaggact gtgtcaagag tgagccaccc agtctctaaa
      841 gctaggaagt ccccagtgtg ccacgggaaa cgcttgcctc tcaccctgtt tcccagcgcc
      901 aacctccggg gcaggcatcc gggtggagag aggacttgtc cctcgtgggt ggtggttctt
      961 tatagaaaaa atcgaagctt agcagctcct cgaggcccgg gtttggtaaa ggctccagtg
     1021 tggtggccta tgaaggacaa tcctggcacg actactgctt ccactgcaaa aaatgctccg
     1081 tgaatctggc caacaagcgc tttgtatttc ataatgagca ggtgtattgc cctgactgtg
     1141 ccaaaaagct gtaacttgac aggggctcct gtcctgtaaa atggcattgg aaccattctt
     1201 tgtgtccttt gctccctccc tccctctgta ccatccatag ggcaagagtg ggctttcacc
     1261 tctttaaagt tgctctttcc gtcttttctc ccattttaca gtattaatca acgaaggaca
     1321 cacagtgatc atattaagat ttagcaaaga gcaaccttgc agcaaaaata atttctctgt
     1381 tgctgcactg gaaaaacaaa accttagact gactcttctg catgtttctc atagagcaga
     1441 aaagtgctaa ccatgtagcc acttcacgat gtaaacgaga agcataggcg ataaagctcc
     1501 cactgagaca cctttggggc tcagtctgga tgcgctgtgc ggtcacgtga ctgcggtgta
     1561 agagttgcag cggctgctcc aactcccttc tcgccttctc tgggcagtta agaacttgcc
     1621 agaatgcatg gtttaacttc cttatcaaaa ctctgacctt ccttctgttc ttttgtgctt
     1681 tcacacgact aacacagatt tccagagaat taacattttg aactttgttg taattctcaa
     1741 gtgacttttc ccccatacta acatttgact cccttacgtg gcgtgttctc tgagcgttcc
     1801 tactttaaag catggaacac acaggtgatt tgaagcatct aagcagatct gagaaaacga
     1861 gcctgtttca gaacaaactc accacagtga ctacttcgga agcttaacaa gactaactct
     1921 cctgtccttt ttaatttttt tttttaaatt ttgttttaat gagtagtaaa atagtttatg
     1981 ggtttggaaa cttgcatgac aatatttgag cctcctcaaa cgttcctgca gttttgagat
     2041 tcatcctgta gacatgacaa aaactctaga gccgcagctg agcaggcaca gggctgtcat
     2101 caaagtaggg acaaggtgaa gtccttgtaa cataaccgtt gtctgctctt tgtctgcatc
     2161 caggaagagt gcaaagtccc tttgcttgtg attcttagaa ctttccctcc agaattgcag
     2221 ttagactctg gggctgtcgg aggtggtcgt catccttcac aggcaggact gggttttcac
     2281 ccccttctct gaaacgcagg attgcctcct taactgtact ctccatttta ttacatatat
     2341 aacgagccaa tatcaaagta aagatgtaat gaaaacacac actcatatat tactgtagga
     2401 gtggttatag atgccaacac ctcatttcca tatttgtcat tagctgtttc catctactgt
     2461 ttgattgtat ccttacaaaa ataaagcagc atagaaaga
//
