LOCUS       NM_001308285            1112 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus fragile histidine triad gene (Fhit), transcript
            variant 1, mRNA.
ACCESSION   NM_001308285 XM_006517923
VERSION     NM_001308285.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1112)
  AUTHORS   Karras JR, Schrock MS, Batar B, Zhang J, La Perle K, Druck T and
            Huebner K.
  TITLE     Fhit loss-associated initiation and progression of neoplasia in
            vitro
  JOURNAL   Cancer Sci 107 (11), 1590-1598 (2016)
   PUBMED   27513973
  REMARK    GeneRIF: Fhit loss and subsequent thymidine kinase 1 inactivation,
            combined with selective pressures, leads to neoplasia-associated
            alterations in genes and gene expression patterns in vitro and in
            vivo
REFERENCE   2  (bases 1 to 1112)
  AUTHORS   Paisie CA, Schrock MS, Karras JR, Zhang J, Miuma S, Ouda IM, Waters
            CE, Saldivar JC, Druck T and Huebner K.
  TITLE     Exome-wide single-base substitutions in tissues and derived cell
            lines of the constitutive Fhit knockout mouse
  JOURNAL   Cancer Sci 107 (4), 528-535 (2016)
   PUBMED   26782170
  REMARK    GeneRIF: Fhit-deficiency mutation signature also resembles a C>T
            and T>C mutation signature reported for human papillary kidney
            cancers and a similar signature recently reported for esophageal
            and bladder cancers, cancers that are frequently Fhit deficient.
REFERENCE   3  (bases 1 to 1112)
  AUTHORS   Hu B, Ying X, Wang J, Piriyapongsa J, Jordan IK, Sheng J, Yu F,
            Zhao P, Li Y, Wang H, Ng WL, Hu S, Wang X, Wang C, Zheng X, Li W,
            Curran WJ and Wang Y.
  TITLE     Identification of a tumor-suppressive human-specific microRNA
            within the FHIT tumor-suppressor gene
  JOURNAL   Cancer Res 74 (8), 2283-2294 (2014)
   PUBMED   24556720
REFERENCE   4  (bases 1 to 1112)
  AUTHORS   Miuma S, Saldivar JC, Karras JR, Waters CE, Paisie CA, Wang Y, Jin
            V, Sun J, Druck T, Zhang J and Huebner K.
  TITLE     Fhit deficiency-induced global genome instability promotes mutation
            and clonal expansion
  JOURNAL   PLoS One 8 (11), e80730 (2013)
   PUBMED   24244712
  REMARK    GeneRIF: Fhit deficiency-induced global genome instability promotes
            mutation and clonal expansion
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1112)
  AUTHORS   Gaudio E, Paduano F, Spizzo R, Ngankeu A, Zanesi N, Gaspari M,
            Ortuso F, Lovat F, Rock J, Hill GA, Kaou M, Cuda G, Aqeilan RI,
            Alcaro S, Croce CM and Trapasso F.
  TITLE     Fhit delocalizes annexin a4 from plasma membrane to cytosol and
            sensitizes lung cancer cells to paclitaxel
  JOURNAL   PLoS One 8 (11), e78610 (2013)
   PUBMED   24223161
  REMARK    GeneRIF: Fhit delocalizes annexin A4 from plasma membrane to
            cytosol and sensitizes lung cancer cells to paclitaxel.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1112)
  AUTHORS   Glover TW, Hoge AW, Miller DE, Ascara-Wilke JE, Adam AN, Dagenais
            SL, Wilke CM, Dierick HA and Beer DG.
  TITLE     The murine Fhit gene is highly similar to its human orthologue and
            maps to a common fragile site region
  JOURNAL   Cancer Res 58 (15), 3409-3414 (1998)
   PUBMED   9699673
REFERENCE   7  (bases 1 to 1112)
  AUTHORS   Pekarsky Y, Druck T, Cotticelli MG, Ohta M, Shou J, Mendrola J,
            Montgomery JC, Buchberg AM, Siracusa LD, Manenti G, Fong LY,
            Dragani TA, Croce CM and Huebner K.
  TITLE     The murine Fhit locus: isolation, characterization, and expression
            in normal and tumor cells
  JOURNAL   Cancer Res 58 (15), 3401-3408 (1998)
   PUBMED   9699672
REFERENCE   8  (bases 1 to 1112)
  AUTHORS   Pekarsky Y, Campiglio M, Siprashvili Z, Druck T, Sedkov Y, Tillib
            S, Draganescu A, Wermuth P, Rothman JH, Huebner K, Buchberg AM,
            Mazo A, Brenner C and Croce CM.
  TITLE     Nitrilase and Fhit homologs are encoded as fusion proteins in
            Drosophila melanogaster and Caenorhabditis elegans
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8744-8749 (1998)
   PUBMED   9671749
REFERENCE   9  (bases 1 to 1112)
  AUTHORS   Barnes LD, Garrison PN, Siprashvili Z, Guranowski A, Robinson AK,
            Ingram SW, Croce CM, Ohta M and Huebner K.
  TITLE     Fhit, a putative tumor suppressor in humans, is a dinucleoside
            5',5''-P1,P3-triphosphate hydrolase
  JOURNAL   Biochemistry 35 (36), 11529-11535 (1996)
   PUBMED   8794732
REFERENCE   10 (bases 1 to 1112)
  AUTHORS   Ohta M, Inoue H, Cotticelli MG, Kastury K, Baffa R, Palazzo J,
            Siprashvili Z, Mori M, McCue P, Druck T, Croce CM and Huebner K.
  TITLE     The FHIT gene, spanning the chromosome 3p14.2 fragile site and
            renal carcinoma-associated t(3;8) breakpoint, is abnormal in
            digestive tract cancers
  JOURNAL   Cell 84 (4), 587-597 (1996)
   PUBMED   8598045
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ058331.1, CJ056464.1,
            AC154197.1 and CO040033.1.
            
            [WARNING] On Sep 25, 2023 this sequence was replaced by
            NM_001308285.2.
            
            On Apr 29, 2015 this sequence version replaced XM_006517923.2.
            
            Summary: This gene encodes a member of the HIT family of proteins
            that are characterized by the presence of a histidine triad
            sequence. The encoded protein is a diadenosine triphosphate
            hydrolase enzyme that cleaves the P(1)-P(3)-bis(5'-adenosyl)
            triphosphate (Ap3A) to yield AMP and ADP. This locus is very
            fragile and has been found to be altered in different types of
            cancers. Mice lacking the encoded protein display increased
            susceptibility to spontaneous and induced tumors. Ectopic
            expression of the encoded protein in such knockout mice inhibits
            tumor development. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF047699.1, SRR17784647.584365.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 CJ058331.1         2-4
            4-151               CJ056464.1         2-149
            152-261             AC154197.1         143922-144031       c
            262-522             CJ056464.1         150-410
            523-1112            CO040033.1         1-590               c
FEATURES             Location/Qualifiers
     source          1..1112
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 5.61 cM"
     gene            1..1112
                     /gene="Fhit"
                     /gene_synonym="Fra14A2"
                     /note="fragile histidine triad gene"
                     /db_xref="GeneID:14198"
                     /db_xref="MGI:MGI:1277947"
     exon            1..102
                     /gene="Fhit"
                     /gene_synonym="Fra14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            103..151
                     /gene="Fhit"
                     /gene_synonym="Fra14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            152..261
                     /gene="Fhit"
                     /gene_synonym="Fra14A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..801
                     /gene="Fhit"
                     /gene_synonym="Fra14A2"
                     /EC_number="3.6.1.29"
                     /EC_number="3.6.2.1"
                     /EC_number="2.7.7.51"
                     /note="isoform 1 is encoded by transcript variant 1;
                     bis(5'-adenosyl)-triphosphatase; AP3A hydrolase;
                     dinucleosidetriphosphatase; fragile histidine triad
                     protein; diadenosine 5',5'''-P1,P3-triphosphate hydrolase;
                     AP3Aase; adenylylsulfatase; adenosine
                     5'-monophosphoramidase FHIT; adenylylsulfate-ammonia
                     adenylyltransferase"
                     /codon_start=1
                     /product="bis(5'-adenosyl)-triphosphatase isoform 1"
                     /protein_id="NP_001295214.1"
                     /db_xref="CCDS:CCDS79263.1"
                     /db_xref="GeneID:14198"
                     /db_xref="MGI:MGI:1277947"
                     /translation="MLSLLWNTSPQCNQMQDVGAFKIVFYLIGWTNLKVPWDNLLGHT
                     SARTLHLALRTPRSFYCETMSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVC
                     PLRPVERFRDLHPDEVADLFQVTQRVGTVVEKHFQGTSITFSMQDGPEAGQTVKHVHV
                     HVLPRKAGDFPRNDNIYDELQKHDREEEDSPAFWRSEKEMAAEAEALRVYFQA"
     exon            262..332
                     /gene="Fhit"
                     /gene_synonym="Fra14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            333..451
                     /gene="Fhit"
                     /gene_synonym="Fra14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            452..597
                     /gene="Fhit"
                     /gene_synonym="Fra14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..627
                     /gene="Fhit"
                     /gene_synonym="Fra14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            628..696
                     /gene="Fhit"
                     /gene_synonym="Fra14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            697..795
                     /gene="Fhit"
                     /gene_synonym="Fra14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1100
                     /gene="Fhit"
                     /gene_synonym="Fra14A2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagctccc aggtccaccc cagtggggac acgctcaggc ggcactcctg tcccgtgctc
       61 ccgccctctt gcctttcatt ccagccacca agatcttgga agctttgaag cccagcaaag
      121 aagggaaatc cactgagaag agtcaggaaa ggcacatgaa tgctcagcct actttggaat
      181 acctccccac agtgcaacca aatgcaagac gttggtgcct tcaagatagt attctacctg
      241 ataggttgga ctaatctgaa ggtgccctgg gacaacctgc tcggtcacac atctgcaaga
      301 actctccatc ttgcactgag gaccccaagg agcttttact gtgagaccat gtcatttaga
      361 tttggccaac atctcatcaa gccctctgtg gtttttctca aaactgaact gtccttcgcc
      421 ctggtgaata ggaaacccgt tgtacctggc catgtcctcg tgtgcccgct gaggccagta
      481 gagcgcttcc gtgacctaca tcctgatgaa gtggccgatt tgtttcaagt gacccagaga
      541 gttgggacag tggtggagaa gcatttccag gggacctcca tcaccttctc catgcaagat
      601 ggtcctgaag ctgggcagac tgtgaagcat gtacatgtcc acgttcttcc caggaaggca
      661 ggggacttcc cccggaatga caacatctat gatgagctcc agaaacatga cagagaagaa
      721 gaggactcgc cagccttttg gagatctgag aaggagatgg ctgcagaggc ggaggctctg
      781 cgggtctact ttcaggcctg agagtaactc aaacgattcc caaggcataa gaaaatggac
      841 cccattcttc tggagtcttc gacattggaa atgaagctaa ccactcttta ttgtacccca
      901 cgaccccaca gccttgtaca aagaacttta ttgcatgtgt ggaagccact agtattatgc
      961 ttccatcacg atgacaaata ggctagcttc ccaaacagtg gcattgacag cctgccaccg
     1021 ttcctcagtt ctgtacttag aatagtaaca tttccaaact gtccctgagc ctagatgaaa
     1081 ataaagtggt tgctaaaata aaaaaaaaaa aa
//
