LOCUS       NM_001205355            6001 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus FH2 domain containing 1 (Fhdc1), transcript variant 1,
            mRNA.
ACCESSION   NM_001205355
VERSION     NM_001205355.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6001)
  AUTHORS   Copeland,S.J., McRae,A., Guarguaglini,G., Trinkle-Mulcahy,L. and
            Copeland,J.W.
  TITLE     Actin-dependent regulation of cilia length by the inverted formin
            FHDC1
  JOURNAL   Mol Biol Cell 29 (13), 1611-1627 (2018)
   PUBMED   29742020
  REMARK    GeneRIF: FHDC1 plays a role in coordinating cytoskeletal dynamics
            during normal cilia assembly.
REFERENCE   2  (bases 1 to 6001)
  AUTHORS   Copeland,S.J., Thurston,S.F. and Copeland,J.W.
  TITLE     Actin- and microtubule-dependent regulation of Golgi morphology by
            FHDC1
  JOURNAL   Mol Biol Cell 27 (2), 260-276 (2016)
   PUBMED   26564798
REFERENCE   3  (bases 1 to 6001)
  AUTHORS   Dutta,P. and Maiti,S.
  TITLE     Expression of multiple formins in adult tissues and during
            developmental stages of mouse brain
  JOURNAL   Gene Expr Patterns 19 (1-2), 52-59 (2015)
   PUBMED   26272686
REFERENCE   4  (bases 1 to 6001)
  AUTHORS   Young,K.G., Thurston,S.F., Copeland,S., Smallwood,C. and
            Copeland,J.W.
  TITLE     INF1 is a novel microtubule-associated formin
  JOURNAL   Mol Biol Cell 19 (12), 5168-5180 (2008)
   PUBMED   18815276
REFERENCE   5  (bases 1 to 6001)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102140.15.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173244.1, BC137632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AC102140.15        183419-183561       c
            144-781             AC102140.15        178210-178847       c
            782-843             AC102140.15        169492-169553       c
            844-946             AC102140.15        168342-168444       c
            947-1032            AC102140.15        161256-161341       c
            1033-1133           AC102140.15        161065-161165       c
            1134-1204           AC102140.15        159058-159128       c
            1205-1312           AC102140.15        158857-158964       c
            1313-1383           AC102140.15        157587-157657       c
            1384-1501           AC102140.15        155440-155557       c
            1502-1666           AC102140.15        152820-152984       c
            1667-6001           AC102140.15        146266-150600       c
FEATURES             Location/Qualifiers
     source          1..6001
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 37.67 cM"
     gene            1..6001
                     /gene="Fhdc1"
                     /gene_synonym="6330505N24Rik; Gm126"
                     /note="FH2 domain containing 1"
                     /db_xref="GeneID:229474"
                     /db_xref="MGI:MGI:2684972"
     exon            1..143
                     /gene="Fhdc1"
                     /gene_synonym="6330505N24Rik; Gm126"
                     /inference="alignment:Splign:2.1.0"
     exon            144..781
                     /gene="Fhdc1"
                     /gene_synonym="6330505N24Rik; Gm126"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..3730
                     /gene="Fhdc1"
                     /gene_synonym="6330505N24Rik; Gm126"
                     /note="inverted formin-1"
                     /codon_start=1
                     /product="FH2 domain-containing protein 1"
                     /protein_id="NP_001192284.1"
                     /db_xref="CCDS:CCDS17438.1"
                     /db_xref="GeneID:229474"
                     /db_xref="MGI:MGI:2684972"
                     /translation="MHVMNCVSLASDKENGTLATAAAFMTGQTSPSASPPPPPPPPPP
                     PPCPHSGEGFSPSPPPPLPPPLPGGPPIPPPPPPGLPSVSYLNGYSSLGKKKRMRSFF
                     WKTIPEEQVRGKTNIWTLAAKQQHQYQIDKKTIEELFGQQEDTSKASLPKRGGALNSS
                     FRDAREEVTVLDAKRSMNIGIFLKQFKKSPQSIVEDIYQGKSEHYGSETLREILKLLP
                     ESEEVKKLKAFNGDVSKLSLADSFLHCLIQVPNYSLRIEAMVLKKEFLPSCSSLFKDI
                     RTLRAATKELMLCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKP
                     GMNLLHFVAQEAQKQDAILLNFSEKLQHVQETSRLSLDITEAELHSLFVRTKSLQENI
                     QLDQELCQQMEDFLQFAVEKLAELELWKRELQGEAHTLIDFFCEDKETMKLDECFQIF
                     RDFCTRFNKAVKDNHDREEQERKQLQRQKEMEQKRYSWSTGELGSFGRSSSENDVQML
                     AKTGTEDLPSFLKPRPNSPSYRPPNTRRSRLSLGISADRELLTFLESATSSPEDPNKF
                     NSLPRSSPRQARPTIAWMEPREQQSHGPNFTHEPQASKIQEKAPPPAWQNQLPTTWRE
                     EPASPLPLAGRSRPSLRKRNSEPVGLGPTQSPPLLPLDLGVREHELVTGLTQFDLQSP
                     KSLEEGSQLTLNDFCPTKLPSPGDRSSQPFAAGGDSLPPKDTDTQEVLSPAGEDDRTI
                     SDEPSSEALVSVVVTDTEDKDAGPLLYVSDTTDCSLTLDCSEGMDSRAGGDKQEEEKE
                     GDGSVSSGAGEAGSSQVSSNSVSSPPGEVPAPKSSKSELSCQGGLPKDRPSRGKDAIA
                     PKRNSFKEASVGASKPVSARRSQGVTTKPVRTLNSSENEHMRKVVPISKSSRGAGPWK
                     RPEPTPKATPRETPSSTDTPLSRRSSVRGTSDTSPRRPQVSGSGAEEPRLPRSSGSIS
                     GRPGKDAPLQPRASFRKPSAKPLRNIPRQKPEENKVSSPNSPDPESPKEEPKAPQATG
                     VSRALPPIPSFARNTVASSSRSLRTDAPPAARTTGLTRTVSQRQLRVKGGSEDSASKD
                     IGTLKRASSARASKKCPESAGGSSANVETSLKGRGTTERSSLRLKDSGQATLGRILRP
                     LQK"
     exon            782..843
                     /gene="Fhdc1"
                     /gene_synonym="6330505N24Rik; Gm126"
                     /inference="alignment:Splign:2.1.0"
     exon            844..946
                     /gene="Fhdc1"
                     /gene_synonym="6330505N24Rik; Gm126"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1032
                     /gene="Fhdc1"
                     /gene_synonym="6330505N24Rik; Gm126"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1133
                     /gene="Fhdc1"
                     /gene_synonym="6330505N24Rik; Gm126"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1204
                     /gene="Fhdc1"
                     /gene_synonym="6330505N24Rik; Gm126"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1312
                     /gene="Fhdc1"
                     /gene_synonym="6330505N24Rik; Gm126"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1383
                     /gene="Fhdc1"
                     /gene_synonym="6330505N24Rik; Gm126"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1501
                     /gene="Fhdc1"
                     /gene_synonym="6330505N24Rik; Gm126"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1666
                     /gene="Fhdc1"
                     /gene_synonym="6330505N24Rik; Gm126"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..6001
                     /gene="Fhdc1"
                     /gene_synonym="6330505N24Rik; Gm126"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4138..4143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fhdc1"
                     /gene_synonym="6330505N24Rik; Gm126"
                     /note="hexamer: AATAAA"
     polyA_site      4162
                     /gene="Fhdc1"
                     /gene_synonym="6330505N24Rik; Gm126"
                     /note="major polyA site"
ORIGIN      
        1 cggcctctga gctagtgcgg ggaccgccca ttcgaagctc gtctgctgtc ccgggatcct
       61 gggctgcgca gctgcgggac gctggtagcc tcggggggct tgggctaagc gcctcgggag
      121 ccggcggagc caagggcctt ttggtctgga agctgacatg cagctcggtt gccttctctt
      181 ctggcaacag acttatgagc caagaagtcc gactggagtt tgatgtttgt gtctgcttct
      241 ccaaggttaa ggaattagct ccttagaagg caacagtact atgcatgtta tgaattgtgt
      301 ctccctggcc agcgataaag aaaatgggac tcttgccaca gcagctgcat tcatgactgg
      361 gcagacgtca ccctctgcat ctcctccacc tcctcctcca ccgcctccac ctccaccttg
      421 tccacattca ggggagggct tttccccctc ccctcctcct cctctgccac ctccacttcc
      481 tgggggacct cccatacccc ctcctcctcc tccaggactc ccctcagttt cttacctgaa
      541 tggctacagc tccctgggta agaagaaacg aatgcggagc tttttctgga aaaccattcc
      601 agaggagcaa gttcgaggca agaccaacat ctggacctta gcagctaagc agcagcatca
      661 gtaccagatc gacaagaaga ccattgagga gctttttggg cagcaagaag acacctccaa
      721 ggcttctctt cccaagagag gaggagcttt gaattcatcc ttcagagatg cccgggaaga
      781 ggttaccgtc ttggatgcaa agcgaagtat gaacattggc atatttctta agcagtttaa
      841 aaagtctcct cagtccatcg tagaggatat ctatcaagga aagagcgagc attacggatc
      901 agagacgctt cgagaaatcc ttaagctttt gccggagtca gaagaggtaa agaaattaaa
      961 ggcatttaat ggcgatgtat ccaagctctc gctggcagat tcctttctgc actgcttgat
     1021 tcaggtgcca aactattcac ttcggattga agccatggtg ctaaaaaagg agtttttgcc
     1081 atcttgttcc tctctgttca aagacataag gactctgaga gcagctacaa aagagctgat
     1141 gttatgtgag gagctacatt caatattaca cttggtgctc caggctggga atatcatgaa
     1201 tgccggaggg tatgccggca atgccgtagg atttaaactg tcttctctac tcaaattggc
     1261 ggacacgaag gcaaacaaac ctggaatgaa tcttctgcat tttgtagctc aggaagccca
     1321 gaagcaagat gccatccttc taaacttctc tgagaagttg cagcacgtgc aagagacatc
     1381 gagattatct ctggatatca ccgaggcaga gctgcactct ctctttgtca gaacgaaatc
     1441 gctgcaggaa aacatccagc ttgaccagga gctgtgccag cagatggaag acttcctcca
     1501 gtttgctgtg gagaagttgg cggagctgga actctggaaa cgggagctgc agggtgaagc
     1561 tcacaccctt atagactttt tctgcgaaga caaagaaacc atgaaactgg atgaatgctt
     1621 ccagatattc agagacttct gtaccagatt caacaaagca gttaaggaca atcatgaccg
     1681 ggaggaacag gagcggaagc agctacagag gcagaaggag atggaacaga agcggtattc
     1741 ctggtcaact ggggaactcg ggagctttgg caggagcagc agtgagaatg atgtgcagat
     1801 gctagctaag acaggcacag aagacctgcc ctccttcctg aagcccaggc ccaacagccc
     1861 ctcctaccgg ccccccaaca cacgtcgctc ccgcctctcc ctgggcatct ctgcggaccg
     1921 ggagcttttg accttcctgg agagtgccac cagcagtcca gaggacccca acaaattcaa
     1981 cagtttgccc cggagcagtc cccgacaagc tcggcccacc atcgcctgga tggaacccag
     2041 agaacaacag agccatggcc ctaactttac acatgaacct caggcctcaa agatccagga
     2101 gaaagcccct ccccctgctt ggcaaaatca gcttccgaca acctggcggg aggagcctgc
     2161 ttctcccctc ccactggctg ggcggagcag gccgagcctc cgaaaaagga acagtgaacc
     2221 tgtgggcttg ggtcccacac aaagccctcc actcttacca ttggatctgg gtgttaggga
     2281 gcatgagttg gtcacagggc tgacccagtt tgacctccag agtcccaaga gcctggagga
     2341 aggatcccaa ctgactctga atgacttctg tcccacaaag ctgccatctc caggggatag
     2401 gagctcacag ccctttgctg ctggcggtga cagtctccca cccaaggaca cagacaccca
     2461 ggaggttctc agcccagctg gggaggatga caggaccatc tctgatgaac ccagcagtga
     2521 ggctctcgtg tctgtggttg tcaccgacac tgaagataag gatgctggac ctctgttata
     2581 tgtctcagat accacagact gctcactgac tctggactgc tccgagggaa tggactccag
     2641 agccggggga gacaagcaag aggaagagaa ggaaggggat ggctcagtgt cctctggggc
     2701 tggagaggca ggaagcagcc aggtttcctc caactctgtt tccagccccc ctggggaggt
     2761 tcctgctcca aaatccagta agagtgagct gagctgccaa ggtggccttc cgaaggacag
     2821 acccagcaga gggaaggatg ctatagcacc aaagagaaat tccttcaaag aggcttcagt
     2881 aggggcttca aagcctgtca gtgcacggcg cagccaaggg gtaacaacca agcctgtgcg
     2941 aaccttgaac tcctccgaga acgaacatat gcgcaaagtg gtccctatct ccaagtccag
     3001 caggggagcc gggccctgga agcggccgga accgacaccc aaggctaccc ctcgggagac
     3061 acccagcagc acagacacac cactatcacg aaggagctca gtgagaggaa cttcggacac
     3121 ttcgcccagg aggccccagg tgagtggatc tggggcagag gagcccaggc tgccccgctc
     3181 gagtggcagc atcagtggac ggccagggaa ggacgccccg ctgcagccca gagcctcgtt
     3241 caggaagcct agcgccaagc ccctcagaaa catccccagg cagaaacctg aagaaaacaa
     3301 ggtcagcagc cccaactctc ctgaccccga gagtcccaag gaagagccca aggctcctca
     3361 ggctacgggt gtctctcgag cccttccccc catcccaagt tttgctcgaa atacggtggc
     3421 ctcgtcatct cggagcctgc gaacggatgc tccacccgcg gccagaacca ctggcctcac
     3481 caggacagtc tcccagcggc agcttagggt caaaggtggc tccgaggatt ctgcctccaa
     3541 ggacattggc actttgaaga gggccagcag tgctcgggcc tccaagaagt gtcctgaatc
     3601 tgctgggggt tcaagtgcca atgtagaaac ctcactgaag ggcagaggga cgacggaaag
     3661 atcctctctc agactgaagg actcggggca ggccaccctc gggaggatcc tccgtcccct
     3721 gcagaaatga tgacgcctgt ctgcatttct gccttgtggg atgttagctg ctgggactgg
     3781 ctgctgcggg gggaggacac agaggccagt cttaaacatc ttgttacaca tcgagcaaca
     3841 cactggtgcc acctgcttaa aggtcacgtc actaaaggta caaggagagc tatagcctgc
     3901 tgtgcagact tctgcttcga aatcaaagct gagagtatcc ttattctgca cagtactttg
     3961 tcaggggctg gcacctcctg tcactcatac tcaggaccct atccctaact cctgccccga
     4021 gacaaagatc caataatagt ctggacatgt aagatgacaa ttcttatgta acaagtaaaa
     4081 aaaaaaaaat tctggccagt ttttatatat caaagactta ttttttaata ttataaaaat
     4141 aaaaaagatg ttttagttcc tttttcagag tgaaatgcct cccaggaatg gggggattat
     4201 ccttaatatg aaactgtttg taccttcatc cccaccccct gcctcggggt tccatcagcg
     4261 tgtatgtggg agaacacaca ccatacctag ccaggggtgg cctctcacaa gctcttgggt
     4321 ggttgtacgg ttgaggctgt ctccttgaga actttctggc tagctaatgt gtgggttctc
     4381 ctcaaatgac tctgggtgag gatttcatgt gaataggagg gacgtcagat ttgtatgggt
     4441 aaaaatctga tgttactgtg agtttaaggg ggccccaagg gtgtgaggcc catggcgggg
     4501 agcccatggc tatagggaag ttttccctga agataggagc aactgtgtag ggtgctggat
     4561 agggtgcttg gtgtagaaga cagcaagggc tgcccagctg agtaggtcct tcccatgtgt
     4621 gcaatggtgg ccactcgctt ctgttagctc cgggtggaga gggaaatgac cctttttgtg
     4681 ggtcaggctt ccttctcttc tggggcctca gtaccccacc cccacctgct attctatttg
     4741 attttgcttt tagagacatt gtgagaccta gtctaggctg gcctcttact tgcaatcctc
     4801 tgcctcagct tctgagtgct aggataacag gtacaaggca ccaggcccag cctagggata
     4861 ctgcttggtg tcagcctgtc ttccttggta cagcgcttct caagtccaac tgagagaagc
     4921 ccagtcatgg ttgtttattt taaatagact cttacccccc aagaaacact gacttctgac
     4981 ttcaggaatc ttaacactgg ggaaatctgt gcaggagata ggcatcgtgc aaacagaagt
     5041 tcttacccaa tgctcttttt actacttctc tattaaaccc aggaaataga gaagaaagtg
     5101 gggggggaag cttgaaataa aagccctgcc cccttctttc tgagtcactt cttagtgaaa
     5161 tctcacttta gatcagacac tggtgactgg gtgggctagg tcagcgtgtc acactgtgag
     5221 gtgactgcgg aggctgctat ggtctctcct ttcgggaagc ctctccatct ttgcctggga
     5281 actgagctgc tgtccctgag ctgcagcagt tgaacagtac agtggcagag ataggctgca
     5341 gtcaccacct cttgttaaaa acagccctga gcagcgatgt ctgggcagct aggaagccct
     5401 cagcaatctg tccccctctg gaaccctcca gaaccagaag gcctgtgggt gggtgggaac
     5461 ggatgagaga cgacacgtgc tgacaggttt gtggatggtg aattgagtag ccccgtggga
     5521 gggcccaggg acccatcctg tgccgtattc caacaccgct ttcgttcggt acaagcgtct
     5581 actctcccta agtgtctgtc tcccagccca tagaagtgag tccagccctt catgatggtt
     5641 tccaggaatc gagctaccca gtcaccctgt gtctgtttct gacgtggctt ctaggaccct
     5701 cagcagaggc tggggagcct ccggagaagc ctgttggtat ggtgctgtca gatcacattg
     5761 gctgcgtgct tgggaaagca gtggtgtcgc cggccctgtg cacacgtggg tgggcaggtg
     5821 ggcagtctct tactaccttt tatacactgt aagtttggga gaatcatcta tgcaacagag
     5881 gaatgtcaat gcctttctac atgcgtttgt tgaggatgcg ctgaatgcat tttaaggtcc
     5941 ttttctacgt actttatgga acaggtagtc ttaataaagt tgtttgtagg agttatacct
     6001 a
//
