LOCUS       NM_010209               1644 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Mus musculus fumarate hydratase 1 (Fh1), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_010209
VERSION     NM_010209.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1644)
  AUTHORS   Luo,H.Y., Mu,W.J., Chen,M., Zhu,J.Y., Li,Y., Li,S., Yan,L.J.,
            Li,R.Y., Yin,M.T., Li,X., Chen,H.M. and Guo,L.
  TITLE     Hepatic Klf10-Fh1 axis promotes exercise-mediated amelioration of
            NASH in mice
  JOURNAL   Metabolism 155, 155916 (2024)
   PUBMED   38615945
  REMARK    GeneRIF: Hepatic Klf10-Fh1 axis promotes exercise-mediated
            amelioration of NASH in mice.
REFERENCE   2  (bases 1 to 1644)
  AUTHORS   Ayyangar,U., Karkhanis,A., Tay,H., Afandi,A.F.B., Bhattacharjee,O.,
            Ks,L., Lee,S.H., Chan,J. and Raghavan,S.
  TITLE     Metabolic rewiring of macrophages by epidermal-derived lactate
            promotes sterile inflammation in the murine skin
  JOURNAL   EMBO J 43 (7), 1113-1134 (2024)
   PUBMED   38418556
REFERENCE   3  (bases 1 to 1644)
  AUTHORS   Wongkittichote,P., Cunningham,G., Summar,M.L., Pumbo,E., Forny,P.,
            Baumgartner,M.R. and Chapman,K.A.
  TITLE     Tricarboxylic acid cycle enzyme activities in a mouse model of
            methylmalonic aciduria
  JOURNAL   Mol Genet Metab 128 (4), 444-451 (2019)
   PUBMED   31648943
REFERENCE   4  (bases 1 to 1644)
  AUTHORS   Mayeuf-Louchart,A., Lancel,S., Sebti,Y., Pourcet,B., Loyens,A.,
            Delhaye,S., Duhem,C., Beauchamp,J., Ferri,L., Thorel,Q.,
            Boulinguiez,A., Zecchin,M., Dubois-Chevalier,J., Eeckhoute,J.,
            Vaughn,L.T., Roach,P.J., Dani,C., Pederson,B.A., Vincent,S.D.,
            Staels,B. and Duez,H.
  TITLE     Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown
            Adipocyte Differentiation
  JOURNAL   Cell Rep 29 (6), 1410-1418 (2019)
   PUBMED   31693883
REFERENCE   5  (bases 1 to 1644)
  AUTHORS   Knudsen,J.G., Hamilton,A., Ramracheya,R., Tarasov,A.I.,
            Brereton,M., Haythorne,E., Chibalina,M.V., Spegel,P., Mulder,H.,
            Zhang,Q., Ashcroft,F.M., Adam,J. and Rorsman,P.
  TITLE     Dysregulation of Glucagon Secretion by Hyperglycemia-Induced
            Sodium-Dependent Reduction of ATP Production
  JOURNAL   Cell Metab 29 (2), 430-442 (2019)
   PUBMED   30415925
REFERENCE   6  (bases 1 to 1644)
  AUTHORS   Pollard,P.J., Spencer-Dene,B., Shukla,D., Howarth,K., Nye,E.,
            El-Bahrawy,M., Deheragoda,M., Joannou,M., McDonald,S., Martin,A.,
            Igarashi,P., Varsani-Brown,S., Rosewell,I., Poulsom,R., Maxwell,P.,
            Stamp,G.W. and Tomlinson,I.P.
  TITLE     Targeted inactivation of fh1 causes proliferative renal cyst
            development and activation of the hypoxia pathway
  JOURNAL   Cancer Cell 11 (4), 311-319 (2007)
   PUBMED   17418408
REFERENCE   7  (bases 1 to 1644)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   8  (bases 1 to 1644)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 1644)
  AUTHORS   Alam,N.A., Rowan,A.J., Wortham,N.C., Pollard,P.J., Mitchell,M.,
            Tyrer,J.P., Barclay,E., Calonje,E., Manek,S., Adams,S.J.,
            Bowers,P.W., Burrows,N.P., Charles-Holmes,R., Cook,L.J., Daly,B.M.,
            Ford,G.P., Fuller,L.C., Hadfield-Jones,S.E., Hardwick,N.,
            Highet,A.S., Keefe,M., MacDonald-Hull,S.P., Potts,E.D., Crone,M.,
            Wilkinson,S., Camacho-Martinez,F., Jablonska,S., Ratnavel,R.,
            MacDonald,A., Mann,R.J., Grice,K., Guillet,G., Lewis-Jones,M.S.,
            McGrath,H., Seukeran,D.C., Morrison,P.J., Fleming,S., Rahman,S.,
            Kelsell,D., Leigh,I., Olpin,S. and Tomlinson,I.P.
  TITLE     Genetic and functional analyses of FH mutations in multiple
            cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and
            renal cancer, and fumarate hydratase deficiency
  JOURNAL   Hum Mol Genet 12 (11), 1241-1252 (2003)
   PUBMED   12761039
REFERENCE   10 (bases 1 to 1644)
  AUTHORS   Fu,X. and Kamps,M.P.
  TITLE     E2a-Pbx1 induces aberrant expression of tissue-specific and
            developmentally regulated genes when expressed in NIH 3T3
            fibroblasts
  JOURNAL   Mol Cell Biol 17 (3), 1503-1512 (1997)
   PUBMED   9032278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU526396.1, AK147000.1 and BQ174129.1.
            
            On Apr 15, 2009 this sequence version replaced NM_010209.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006048.1, AK147000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BU526396.1         4-10
            8-1626              AK147000.1         2-1620
            1627-1644           BQ174129.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1644
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 81.58 cM"
     gene            1..1644
                     /gene="Fh1"
                     /gene_synonym="Fh; Fh-1"
                     /note="fumarate hydratase 1"
                     /db_xref="GeneID:14194"
                     /db_xref="MGI:MGI:95530"
     exon            1..185
                     /gene="Fh1"
                     /gene_synonym="Fh; Fh-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1586
                     /gene="Fh1"
                     /gene_synonym="Fh; Fh-1"
                     /EC_number="4.2.1.2"
                     /note="fumarate hydratase, mitochondrial; EF-3; fumarase"
                     /codon_start=1
                     /product="fumarate hydratase, mitochondrial precursor"
                     /protein_id="NP_034339.2"
                     /db_xref="CCDS:CCDS15547.1"
                     /db_xref="GeneID:14194"
                     /db_xref="MGI:MGI:95530"
                     /translation="MYRALRLLARSRRLLRVPSAGAAVSGEATTLPRCAPNVARMASQ
                     NSFRVEFDTFGELKVPTDKYYGAQTVRSTMNFKIGGATERMPIPVIQAFGILKRAAAE
                     VNQEYGLDPKIASAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIE
                     MLGGELGSKKPVHPNDHVNKSQSSNDTFPTAMHIAAAVEVHKVLLPGLQKLHDALSAK
                     SKEFAQVIKIGRTHTQDAVPLTLGQEFSGYVQQVQYAMVRIKAAMPRIYELAAGGTAV
                     GTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTAACSLMK
                     IANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVT
                     VGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTDNCVVGIQANTERINKLMNESL
                     MLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK"
     exon            186..320
                     /gene="Fh1"
                     /gene_synonym="Fh; Fh-1"
                     /inference="alignment:Splign:2.1.0"
     exon            321..431
                     /gene="Fh1"
                     /gene_synonym="Fh; Fh-1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..608
                     /gene="Fh1"
                     /gene_synonym="Fh; Fh-1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..791
                     /gene="Fh1"
                     /gene_synonym="Fh; Fh-1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..957
                     /gene="Fh1"
                     /gene_synonym="Fh; Fh-1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1161
                     /gene="Fh1"
                     /gene_synonym="Fh; Fh-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1289
                     /gene="Fh1"
                     /gene_synonym="Fh; Fh-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1443
                     /gene="Fh1"
                     /gene_synonym="Fh; Fh-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1632
                     /gene="Fh1"
                     /gene_synonym="Fh; Fh-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1607..1612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fh1"
                     /gene_synonym="Fh; Fh-1"
                     /note="hexamer: AATAAA"
     regulatory      1616..1621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fh1"
                     /gene_synonym="Fh; Fh-1"
                     /note="hexamer: AAGAAA"
     polyA_site      1625
                     /gene="Fh1"
                     /gene_synonym="Fh; Fh-1"
     polyA_site      1632
                     /gene="Fh1"
                     /gene_synonym="Fh; Fh-1"
                     /note="major polyA site"
ORIGIN      
        1 ggaatctgac gtattagggg gcgtggctca ggctcagctt tccacccccg tacagcagca
       61 ccatgtaccg cgcactccgt ctcctcgcgc gctcgcgtcg cctcctgcgg gttccgtccg
      121 ccggtgctgc agtgtctggg gaagcgacca ccctcccgcg gtgtgctccg aacgtcgcgc
      181 gaatggcaag ccaaaattcc ttccgtgtag agttcgacac ctttggtgaa ttgaaggttc
      241 caaccgataa gtattatggt gctcagaccg taagatctac gatgaacttt aagattggag
      301 gtgctacgga acgtatgcca atcccagtca ttcaagcttt cggcatcttg aagcgagctg
      361 ctgctgaagt aaaccaggag tatggtctcg atccaaagat tgctagtgca ataatgaagg
      421 ccgcagatga ggtagctgaa ggtaaattaa atgatcactt tcctctggtg gtttggcaga
      481 ctggatcagg aacccagaca aacatgaatg taaatgaagt cattagcaac agagcaattg
      541 aaatgttagg aggtgaactt ggcagcaaga agcctgtgca ccccaatgat catgttaaca
      601 aaagccagag ctcgaatgac acctttccca cagcaatgca tattgctgct gcagtggaag
      661 ttcacaaggt cctgttgcca gggttacaga agctccatga tgctctcagt gcaaaatcca
      721 aagagtttgc gcaggtcatc aaaattgggc gaactcacac gcaggatgct gtccctctta
      781 ctcttggaca ggaattcagt ggttacgttc agcaagtcca gtatgcgatg gtgagaataa
      841 aagccgccat gccaagaatc tacgagctcg ctgctggagg cactgctgtg gggacggggt
      901 taaacaccag gatcggtttc gcagaaaagg tggccgcaaa agtagcagca ctcacaggtt
      961 tgccttttgt cactgccccg aataagtttg aagctctggc tgctcatgat gctctggttg
     1021 agcttagtgg agccatgaac actgccgcct gcagtctaat gaagatagcg aatgatattc
     1081 gcttcctggg ttctggtcct cggtcaggtt tgggagagct gatcttgcct gaaaacgagc
     1141 cagggagcag catcatgcca ggaaaggtga accctactca gtgtgaagcg atgaccatgg
     1201 ttgcagccca agtcatgggg aatcacgttg ctgttaccgt tggaggcagc aatggacatt
     1261 ttgaactgaa tgtgtttaaa ccaatgatga ttaagaatgt gctgcactca gccaggctac
     1321 tgggagatgc ttcagtgtcc ttcacagaca actgtgtggt cgggatccag gccaacacag
     1381 agcggatcaa caagctaatg aatgagtctt taatgttggt cacagctctt aatccacata
     1441 tagggtatga caaagcagca aagattgcca agaccgcaca caagaacgga tcaaccttaa
     1501 aggaaacggc tattgaactt ggctatctca cagcagagca gtttgatgag tgggtgaaac
     1561 ccaaggatat gctgggtcca aagtgacttc aataaattta tattaaaata aacttaagaa
     1621 atttacaaac aaaaaaaaaa aaaa
//
