LOCUS       NM_010208               3353 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus FGR proto-oncogene, Src family tyrosine kinase (Fgr),
            mRNA.
ACCESSION   NM_010208
VERSION     NM_010208.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3353)
  AUTHORS   Futosi,K., Bajza,B., Deli,D., Erdelyi,A., Tusnady,S. and Mocsai,A.
  TITLE     Analysis of intracellular tyrosine phosphorylation in circulating
            neutrophils as a rapid assay for the in vivo effect of oral
            tyrosine kinase inhibitors
  JOURNAL   Front Pharmacol 14, 1056154 (2023)
   PUBMED   37089957
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3353)
  AUTHORS   Huang,T., Fu,G., Gao,J., Zhang,Y., Cai,W., Wu,S., Jia,S., Xia,S.,
            Bachmann,T., Bekker,A. and Tao,Y.X.
  TITLE     Fgr contributes to hemorrhage-induced thalamic pain by activating
            NF-kappaB/ERK1/2 pathways
  JOURNAL   JCI Insight 5 (20), 139987 (2020)
   PUBMED   33055425
  REMARK    GeneRIF: Fgr contributes to hemorrhage-induced thalamic pain by
            activating NF-kappaB/ERK1/2 pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3353)
  AUTHORS   Acin-Perez,R., Iborra,S., Marti-Mateos,Y., Cook,E.C.L.,
            Conde-Garrosa,R., Petcherski,A., Munoz,M.D.M., Martinez de Mena,R.,
            Krishnan,K.C., Jimenez,C., Bolanos,J.P., Laakso,M., Lusis,A.J.,
            Shirihai,O.S., Sancho,D. and Enriquez,J.A.
  TITLE     Fgr kinase is required for proinflammatory macrophage activation
            during diet-induced obesity
  JOURNAL   Nat Metab 2 (9), 974-988 (2020)
   PUBMED   32943786
  REMARK    GeneRIF: Fgr kinase is required for proinflammatory macrophage
            activation during diet-induced obesity.
REFERENCE   4  (bases 1 to 3353)
  AUTHORS   Ma,J., Abram,C.L., Hu,Y. and Lowell,C.A.
  TITLE     CARD9 mediates dendritic cell-induced development of Lyn
            deficiency-associated autoimmune and inflammatory diseases
  JOURNAL   Sci Signal 12 (602) (2019)
   PUBMED   31594855
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3353)
  AUTHORS   Abe,K., Cox,A., Takamatsu,N., Velez,G., Laxer,R.M., Tse,S.M.L.,
            Mahajan,V.B., Bassuk,A.G., Fuchs,H., Ferguson,P.J. and Hrabe de
            Angelis,M.
  TITLE     Gain-of-function mutations in a member of the Src family kinases
            cause autoinflammatory bone disease in mice and humans
  JOURNAL   Proc Natl Acad Sci U S A 116 (24), 11872-11877 (2019)
   PUBMED   31138708
REFERENCE   6  (bases 1 to 3353)
  AUTHORS   Goodwin,R.G., Anderson,D., Jerzy,R., Davis,T., Brannan,C.I.,
            Copeland,N.G., Jenkins,N.A. and Smith,C.A.
  TITLE     Molecular cloning and expression of the type 1 and type 2 murine
            receptors for tumor necrosis factor
  JOURNAL   Mol Cell Biol 11 (6), 3020-3026 (1991)
   PUBMED   1645445
REFERENCE   7  (bases 1 to 3353)
  AUTHORS   Christy,B.A., Sanders,L.K., Lau,L.F., Copeland,N.G., Jenkins,N.A.
            and Nathans,D.
  TITLE     An Id-related helix-loop-helix protein encoded by a growth
            factor-inducible gene
  JOURNAL   Proc Natl Acad Sci U S A 88 (5), 1815-1819 (1991)
   PUBMED   2000388
REFERENCE   8  (bases 1 to 3353)
  AUTHORS   King,F.J. and Cole,M.D.
  TITLE     Molecular cloning and sequencing of the murine c-fgr gene
  JOURNAL   Oncogene 5 (3), 337-344 (1990)
   PUBMED   2179817
REFERENCE   9  (bases 1 to 3353)
  AUTHORS   Ceci,J.D., Siracusa,L.D., Jenkins,N.A. and Copeland,N.G.
  TITLE     A molecular genetic linkage map of mouse chromosome 4 including the
            localization of several proto-oncogenes
  JOURNAL   Genomics 5 (4), 699-709 (1989)
   PUBMED   2574141
REFERENCE   10 (bases 1 to 3353)
  AUTHORS   Parker,R.C., Mardon,G., Lebo,R.V., Varmus,H.E. and Bishop,J.M.
  TITLE     Isolation of duplicated human c-src genes located on chromosomes 1
            and 20
  JOURNAL   Mol Cell Biol 5 (4), 831-838 (1985)
   PUBMED   2581127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY204076.1, AK155902.1, AK038141.1 and AI661913.1.
            
            On Apr 1, 2008 this sequence version replaced NM_010208.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157640.1, AK038141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BY204076.1         2-26
            26-1986             AK155902.1         2-1962
            1987-3337           AK038141.1         1893-3243
            3338-3353           AI661913.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..3353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.11 cM"
     gene            1..3353
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /note="FGR proto-oncogene, Src family tyrosine kinase"
                     /db_xref="GeneID:14191"
                     /db_xref="MGI:MGI:95527"
     exon            1..176
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /inference="alignment:Splign:2.1.0"
     exon            177..239
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /inference="alignment:Splign:2.1.0"
     exon            240..439
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..1803
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /EC_number="2.7.10.2"
                     /note="proto-oncogene tyrosine-protein kinase Fgr;
                     p55-Fgr; proto-oncogene c-Fgr; Gardner-Rasheed feline
                     sarcoma viral (Fgr) oncogene homolog"
                     /codon_start=1
                     /product="tyrosine-protein kinase Fgr"
                     /protein_id="NP_034338.3"
                     /db_xref="CCDS:CCDS18739.1"
                     /db_xref="GeneID:14191"
                     /db_xref="MGI:MGI:95527"
                     /translation="MGCVFCKKLEPASKEDVGLEGDFRSQTAEERYFPDPTQGRTSSV
                     FPQPTSPAFLNTGNMRSISGTGVTIFVALYDYEARTGDDLTFTKGEKFHILNNTEYDW
                     WEARSLSSGHRGYVPSNYVAPVDSIQAEEWYFGKISRKDAERQLLSSGNPQGAFLIRE
                     SETTKGAYSLSIRDWDQNRGDHIKHYKIRKLDTGGYYITTRAQFDSIQDLVRHYMEVN
                     DGLCYLLTAPCTTTKPQTLGLAKDAWEIDRNSIALERRLGTGCFGDVWLGTWNCSTKV
                     AVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYAVVSEEPIYIVTEFMCYGSLLDFL
                     KDREGQNLMLPHLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGEYLICKIADFGLA
                     RLIEDNEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVPYPGM
                     NNREVLEQVEHGYHMPCPPGCPASLYEVMEQAWRLDPEERPTFEYLQSFLEDYFTSTE
                     PQYQPGDQT"
     exon            440..542
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /inference="alignment:Splign:2.1.0"
     exon            543..641
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /inference="alignment:Splign:2.1.0"
     exon            642..745
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /inference="alignment:Splign:2.1.0"
     exon            746..895
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1051
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1231
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1308
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1462
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1594
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..3353
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2207..2212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /note="hexamer: TATAAA"
     polyA_site      2236
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /note="major polyA site"
     regulatory      2694..2699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /note="hexamer: AATAAG"
     polyA_site      2716
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /note="major polyA site"
     regulatory      3247..3252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
                     /note="hexamer: AATAAA"
     polyA_site      3273
                     /gene="Fgr"
                     /gene_synonym="Ali18; Mhdaali18"
ORIGIN      
        1 agtcaccaaa ataagagaag tccgagacgg cttcctcctc cctccccaga gtaggtagta
       61 ggggcagagg cgggtagcac ctcactttac cccccacatc gcctctcctg gttgctggaa
      121 gttagggttg gctcgcccca gatcgagtca cccgcagctg gctcccttga gaccaggttt
      181 ccggcacctc ccagggatca tgcatcagtc ctattgaccc aggagtaggg gtctgtgggg
      241 gcatctggaa tgggctgtgt gttctgcaag aagttggagc ctgcatccaa ggaggatgtg
      301 ggcctggaag gggacttccg gagccaaacg gctgaagaac gctatttccc tgaccccact
      361 caaggccgga cttcgtccgt ctttcctcag cccaccagcc ctgctttcct caacactggc
      421 aacatgagaa gcatctcagg gaccggagtg accatattcg tcgccctgta cgactatgag
      481 gccaggacag gggatgacct caccttcacc aaaggcgaga agttccacat cctgaacaat
      541 acggagtatg actggtggga ggctcgctcc ctgagctccg gacacagagg ctatgttccc
      601 agcaactatg ttgctcctgt ggattccatc caggctgaag agtggtactt cggaaagatc
      661 agtagaaagg atgcagagag gcagcttctg tcctctggta acccccaggg ggcctttctc
      721 attcgggaaa gcgagaccac caaaggggcc tactccctgt ccatccgtga ctgggaccag
      781 aacagaggcg atcacataaa gcattataag atccgaaagc tggacacggg cggctactac
      841 atcaccacac gggcccagtt tgactccata caggacctag tgcggcacta catggaagtg
      901 aatgatggtc tgtgctactt gcttacggcg ccttgtacca ccactaagcc ccagactcta
      961 ggcctggcca aggatgcctg ggagatcgac cggaactcca tagcactgga acgcaggctg
     1021 ggcaccggct gctttggaga tgtgtggctg ggcacatgga actgcagcac aaaggtggca
     1081 gtgaagacgc tgaagccggg caccatgtcc ccgaaggcat tcctggagga ggcacagatc
     1141 atgaagctgc tgaggcacga caagctggtg cagctgtatg cggtggtgtc ggaggaaccc
     1201 atttatattg tgacagagtt catgtgctat ggtagcttgc tggatttcct aaaggatcga
     1261 gaaggtcaga acttgatgct gccccatcta gtggacatgg ctgcccaggt agccgagggc
     1321 atggcctaca tggaacgcat gaactatatc caccgagact tgagggcagc caacatcctg
     1381 gtgggggaat acctaatatg caagatcgct gacttcgggc tggcacgcct catagaggac
     1441 aatgagtata acccccaaca aggaaccaag ttccccatca agtggacagc cccagaggcc
     1501 gccctctttg gcagattcac tgtcaaatca gacgtgtggt cctttgggat tctgctcact
     1561 gaactgatca ccaagggcag agttccctac ccaggtatga acaaccggga agtgttggaa
     1621 caggtggagc atggctacca catgccgtgc cctccaggat gtcctgcatc cctgtatgag
     1681 gtcatggagc aggcgtggcg cctggatcca gaggagaggc ccacctttga gtacctgcag
     1741 tctttcctgg aagactattt cacctccaca gaaccacagt accagcctgg agaccagaca
     1801 tagcctgact gggcatcact gaccctctgg gagtatgtac ttgctcttgc caatcccccg
     1861 gggcactctg gtcccagtgc ccaagacttg gaacccctgt ggaatcctag cacaggatca
     1921 gagaaggtcc gacgctctga agccatttta tagagggtgc aaatggagac gagaaactca
     1981 tctcttacct cctctgaccc caagtgttca tttttccctt cccacccatg ccccatccaa
     2041 aaatctaggg catcccactc atttcacaga tgaagtaagt ggatgctcag agctcctctc
     2101 tcgaacactc tgaccccagt accacttttc ctgtcccatt aggctccgac ataccgttag
     2161 tctctctccc catctcctaa aaatactcat cctttgtcta gttatttata aaactgtatt
     2221 tctcttcttc cacttatccc ttattcctgc tttcctacct cctatcagcc tgctccagcc
     2281 cagaccctaa gaatttaatt cttagcatct cttgggtttc tctacattac aaaagccttc
     2341 agactggatg ctccggtccg ggcccaggtc tgagggagag agctgttgaa tgctcaccac
     2401 ccctctgagg gacgtgtatg tgtgtattca ttatgtaaga acaacgatga tatgcacacc
     2461 aggctagaac aatttcctga gccatctatg gagaggggtg gtagtctgca ggaggcgaac
     2521 aggatagctt tggctatttg tggggagggc ggagtggggt ggttagcagt tccctcttac
     2581 ctactaagtg ccagataccc agcacgtggg gcttcagggc acccctatgt cccactgttc
     2641 acccacatgt cagttcacca tgagttgaga gacccagaaa gcaggtgatt gcaaataaga
     2701 caaatgtggt tttgaatctt cgtacagcta attctttacc tgatttcagc ctacttccca
     2761 accatcacag gcacactggc acagtcttag gcctcccatg gcagaggcat ggagaagaat
     2821 acaacaaact ctctacagct ctcaggctcc ccagaacaca gcaagaggag gatgaaggcc
     2881 tagctcatac cacctcactg gggagtaggg tgggctcttc cccaccccag ggagcttttg
     2941 gagacctttg gagatatttt tattatagtg actggaagca cctactggct gggatcggag
     3001 atggtagacc atctttgatg tacttcttgg atcctctgtg gagaaactgg tagctgacat
     3061 gcctctttgg aaaccaggag aacaggatat atggagtctc acctctcctg tcaggaagtg
     3121 tttattggcc ctctggctta ttgctgggag agaggaaagg agcctgggag tttggagtca
     3181 ctaatgcact aggcaattac taagaattga ctctgatggg cccttcactg agcaggaccc
     3241 tgagcaaata aaaatgagta agagctattc ctatcctgga ggctttccct tgggtggaga
     3301 aataatgaat gaataaataa acatatactt accttttaag aaaaaaaaaa aaa
//
