LOCUS       NM_008013               3769 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus fibrinogen-like protein 2 (Fgl2), mRNA.
ACCESSION   NM_008013
VERSION     NM_008013.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3769)
  AUTHORS   Bennion,K.B., Liu,D., Dawood,A.S., Wyatt,M.M., Alexander,K.L.,
            Abdel-Hakeem,M.S., Paulos,C.M. and Ford,M.L.
  TITLE     CD8+ T cell-derived Fgl2 regulates immunity in a cell-autonomous
            manner via ligation of FcgammaRIIB
  JOURNAL   Nat Commun 15 (1), 5280 (2024)
   PUBMED   38902261
  REMARK    GeneRIF: CD8[+] T cell-derived Fgl2 regulates immunity in a
            cell-autonomous manner via ligation of FcgammaRIIB.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3769)
  AUTHORS   Galpin,K.J.C., Rodriguez,G.M., Maranda,V., Cook,D.P., Macdonald,E.,
            Murshed,H., Zhao,S., McCloskey,C.W., Chruscinski,A., Levy,G.A.,
            Ardolino,M. and Vanderhyden,B.C.
  TITLE     FGL2 promotes tumour growth and attenuates infiltration of
            activated immune cells in melanoma and ovarian cancer models
  JOURNAL   Sci Rep 14 (1), 787 (2024)
   PUBMED   38191799
  REMARK    GeneRIF: FGL2 promotes tumour growth and attenuates infiltration of
            activated immune cells in melanoma and ovarian cancer models.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3769)
  AUTHORS   Wu,L., Liu,X., Lei,J., Zhang,N., Zhao,H., Zhang,J., Deng,H. and
            Li,Y.
  TITLE     Fibrinogen-like protein 2 promotes tumor immune suppression by
            regulating cholesterol metabolism in myeloid-derived suppressor
            cells
  JOURNAL   J Immunother Cancer 11 (12), e008081 (2023)
   PUBMED   38056898
  REMARK    GeneRIF: Fibrinogen-like protein 2 promotes tumor immune
            suppression by regulating cholesterol metabolism in myeloid-derived
            suppressor cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3769)
  AUTHORS   Zhou,H.Y., Feng,X., Wang,L.W., Zhou,R., Sun,H., Chen,X., Lu,R.B.,
            Huang,Y., Guo,Q. and Luo,X.H.
  TITLE     Bone marrow immune cells respond to fluctuating nutritional stress
            to constrain weight regain
  JOURNAL   Cell Metab 35 (11), 1915-1930 (2023)
   PUBMED   37703873
REFERENCE   5  (bases 1 to 3769)
  AUTHORS   Hu,X., Wan,X., Diao,Y., Shen,Z., Zhang,Z., Wang,P., Hu,D., Wang,X.,
            Yan,W., Yu,C., Luo,X., Wang,H. and Ning,Q.
  TITLE     Fibrinogen-like protein 2 regulates macrophage glycolytic
            reprogramming by directly targeting PKM2 and exacerbates alcoholic
            liver injury
  JOURNAL   Int Immunopharmacol 124 (Pt B), 110957 (2023)
   PUBMED   37734200
  REMARK    GeneRIF: Fibrinogen-like protein 2 regulates macrophage glycolytic
            reprogramming by directly targeting PKM2 and exacerbates alcoholic
            liver injury.
REFERENCE   6  (bases 1 to 3769)
  AUTHORS   Wightman,P.J., Hayward,B.E. and Bonthron,D.T.
  TITLE     The genes encoding glucokinase regulatory protein and
            ketohexokinase co-localize to mouse chromosome 5
  JOURNAL   Mamm Genome 8 (9), 700-701 (1997)
   PUBMED   9271679
REFERENCE   7  (bases 1 to 3769)
  AUTHORS   Qureshi,S.T., Clermont,S., Leibowitz,J., Fung,L.S., Levy,G. and
            Malo,D.
  TITLE     Mouse hepatitis virus-3 induced prothrombinase (Fgl2) maps to
            proximal chromosome 5
  JOURNAL   Genomics 29 (1), 307-309 (1995)
   PUBMED   8530097
REFERENCE   8  (bases 1 to 3769)
  AUTHORS   Parr,R.L., Fung,L., Reneker,J., Myers-Mason,N., Leibowitz,J.L. and
            Levy,G.
  TITLE     Association of mouse fibrinogen-like protein with murine hepatitis
            virus-induced prothrombinase activity
  JOURNAL   J Virol 69 (8), 5033-5038 (1995)
   PUBMED   7609073
REFERENCE   9  (bases 1 to 3769)
  AUTHORS   Lafuse,W.P., Castle,L., Brown,D. and Zwilling,B.S.
  TITLE     The cytotoxic T lymphocyte gene FIBLP with homology to fibrinogen
            beta and gamma subunits is also induced in mouse macrophages by
            IFN-gamma
  JOURNAL   Cell Immunol 163 (2), 187-190 (1995)
   PUBMED   7606791
REFERENCE   10 (bases 1 to 3769)
  AUTHORS   Koyama,T., Hall,L.R., Haser,W.G., Tonegawa,S. and Saito,H.
  TITLE     Structure of a cytotoxic T-lymphocyte-specific gene shows a strong
            homology to fibrinogen beta and gamma chains
  JOURNAL   Proc Natl Acad Sci U S A 84 (6), 1609-1613 (1987)
   PUBMED   3550794
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009500.1, AK036402.1, W13307.1, AK036784.1, CB599038.1 and
            BB016276.1.
            
            On May 7, 2009 this sequence version replaced NM_008013.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028893.1, AK036402.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-601               AK009500.1         33-633
            602-2439            AK036402.1         573-2410
            2440-2732           W13307.1           105-397
            2733-3535           AK036784.1         2704-3506
            3536-3757           CB599038.1         318-539
            3758-3769           BB016276.1         235-246
FEATURES             Location/Qualifiers
     source          1..3769
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 9.83 cM"
     gene            1..3769
                     /gene="Fgl2"
                     /gene_synonym="musfiblp"
                     /note="fibrinogen-like protein 2"
                     /db_xref="GeneID:14190"
                     /db_xref="MGI:MGI:103266"
     exon            1..636
                     /gene="Fgl2"
                     /gene_synonym="musfiblp"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1343
                     /gene="Fgl2"
                     /gene_synonym="musfiblp"
                     /note="fibroleukin; associated with MHV-3 induced
                     prothrombinase activity; cytotoxic T-lymphocyte-specific
                     protein"
                     /codon_start=1
                     /product="fibroleukin precursor"
                     /protein_id="NP_032039.2"
                     /db_xref="CCDS:CCDS19103.1"
                     /db_xref="GeneID:14190"
                     /db_xref="MGI:MGI:103266"
                     /translation="MRLPGWLWLSSAVLAACRAVEEHNLTEGLEDASAQAACPARLEG
                     SGRCEGSQCPFQLTLPTLTIQLPRQLGSMEEVLKEVRTLKEAVDSLKKSCQDCKLQAD
                     DHRDPGGNGGNGAETAEDSRVQELESQVNKLSSELKNAKDQIQGLQGRLETLHLVNMN
                     NIENYVDNKVANLTVVVNSLDGKCSKCPSQEHMQSQPVQHLIYKDCSDHYVLGRRSSG
                     AYRVTPDHRNSSFEVYCDMETMGGGWTVLQARLDGSTNFTREWKDYKAGFGNLEREFW
                     LGNDKIHLLTKSKEMILRIDLEDFNGLTLYALYDQFYVANEFLKYRLHIGNYNGTAGD
                     ALRFSRHYNHDLRFFTTPDRDNDRYPSGNCGLYYSSGWWFDSCLSANLNGKYYHQKYK
                     GVRNGIFWGTWPGINQAQPGGYKSSFKQAKMMIRPKNFKP"
     exon            637..3769
                     /gene="Fgl2"
                     /gene_synonym="musfiblp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3734..3739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgl2"
                     /gene_synonym="musfiblp"
                     /note="hexamer: AATAAA"
     polyA_site      3757
                     /gene="Fgl2"
                     /gene_synonym="musfiblp"
                     /note="major polyA site"
ORIGIN      
        1 ggctattaaa gcgcctggtc aggctgggct gccgcactgc aaggatgagg cttcctggtt
       61 ggttgtggct gagttctgcc gtcctcgctg cctgccgagc ggtggaggag cacaacctga
      121 ctgaggggct ggaggatgcc agcgcccagg ctgcctgccc cgcgaggctg gagggcagcg
      181 ggaggtgcga ggggagccag tgccccttcc agctcaccct gcccacgctg accatccagc
      241 tcccgcggca gcttggcagc atggaggagg tgctcaaaga agtgcggacc ctcaaggaag
      301 cagtggacag tctgaagaaa tcctgccagg actgtaagtt gcaggctgac gaccatcgag
      361 atcccggcgg gaatggaggg aatggagcag agacagccga ggacagtaga gtccaggaac
      421 tggagagtca ggtgaacaag ctgtcctcag agctgaagaa tgcaaaggac cagatccagg
      481 ggctgcaggg gcgcctggag acgctccatc tggtaaatat gaacaacatt gagaactacg
      541 tggacaacaa agtggcaaat ctaaccgttg tggtcaacag tttggatggc aagtgttcca
      601 agtgtcccag ccaagaacac atgcagtcac agccggttca acatctaata tacaaagatt
      661 gttccgacca ctacgtgcta ggaaggagaa gcagtggggc ctacagagtt acccctgatc
      721 acagaaacag cagctttgag gtctactgtg acatggagac catgggtgga ggctggacgg
      781 tgctgcaggc tcgccttgat ggcagcacca acttcaccag agagtggaaa gactacaaag
      841 ccggctttgg aaaccttgaa cgagaatttt ggttgggcaa cgataaaatt catcttctga
      901 ccaagagtaa ggaaatgatt ttgagaatag atcttgaaga ctttaatggt ctcacacttt
      961 atgccttgta tgatcagttt tatgtggcta atgaatttct caaataccga ttacacatcg
     1021 gtaactacaa tggcacggca ggggatgcct tgcgtttcag tcgacactac aaccatgacc
     1081 tgaggttttt cacaacccca gacagagaca acgatcggta cccctctggg aactgtgggc
     1141 tctattacag ctcaggctgg tggtttgatt catgtctctc tgccaactta aatggcaaat
     1201 attaccacca gaaatacaaa ggtgtccgta atgggatttt ctggggcacc tggcctggta
     1261 taaaccaggc acagccaggt ggctacaagt cctccttcaa acaggccaag atgatgatta
     1321 ggcccaagaa tttcaagcca taaattgcta gtgttcatct ctctgggcac tcactatcta
     1381 agaggacgat gaattccttc agccctttac catatgtctc agtttatatt cctttcctat
     1441 ggctaaacat ttcctttaaa gctttacagc ttttagaata aagctgaaaa gatctaaaaa
     1501 gactcctatg ttgctgttat atgaggaatg cttgaaagca ctggaaatat tgacaattat
     1561 acattataat tgcaaaacct ttcattttta ttagttgaaa agtttcctaa tatttttatt
     1621 atttttataa taaaaactaa attattcagc aagctagatt ctatatacgc aagttttatt
     1681 ttcactaggg ctaaatatac acatttgaga atataccagt ccttccaggt acaactgaaa
     1741 gccaagaact gtagtattat ctttcgtcta agaagaactt aaagcatttt agttctcaag
     1801 aagaagggca gggatgggat tgggggccag ggacaatatg tatagctaaa tgtattcatc
     1861 taatgcaaaa tatggcatta aaatacctaa aaatgtggta gcataatata tgtctcttcc
     1921 ctctccaatt gaaaaataat gttaccctgt agactttggt ttagtggtaa ttcacttact
     1981 gtttatagcc tgttagaccg cgatacaaaa gctgctttat cctctccctc tgctctctgt
     2041 gcacaatggt ttgtgatgta aggtgctaga ctactgtaag gtttccttgg ggaaaggcat
     2101 ggtaagggaa aacacactgg tttatatttt gaaagccaat cctaatccca aagcaatact
     2161 gttgtcgagg agtcaacgtt ctaggaagct gacttttcta gaacaaatgt atttattagg
     2221 atgaattttg gaattttagt ttaaatatta tacattttaa tcctaagcag tcaattgctt
     2281 atttcattct tagaaattca aagaatatat acaattttag ccaaatgtga gtccctggaa
     2341 ttccttactt gtggatgtca agggtcacat taaaaggctc tgggggcagt ttcactcact
     2401 ttattcttgt gaaaaggggt cactcagaga gaaacaaccc agccgcacac ttaaacgtgc
     2461 tcttgggtgg aatctgaagt gccgcatgca gtcagtcacg tggagtaact gactgtacaa
     2521 catgcactgt ctaagcaata actttgatct ttaagttttg gtgtagcttc taatatacta
     2581 accaagcttt tgaaatatat gcacaaagat tccaccttag ttatttttaa aacataacta
     2641 gggaggatat ttattgtctt gactacttaa actttcaaac atgtagccac tgtaaaaaaa
     2701 aaaaaacttt acaaagagca agatactatt tttgaaacat gcaacatgaa gttttcaggt
     2761 gaatacagtg acaactaagc tattaataat ataattaaat tgccagcgta agctaaatgc
     2821 atgctgaatt aaatgaccaa aatataacgt agattttaaa gcctttacct acttggtaaa
     2881 acagtgaatg taagtggcag taaccaatct tatttctttt tgctttttaa aaaagactaa
     2941 gaagattttg atattataca attcatgtgt ttcaaatcct gtttattata tgtagccata
     3001 taagtctaat gacatttcca taatgaaaat tgatttacca tagcaaaaat actatgtgtt
     3061 catcctgagt gtgtctttct cagggtaaca atgaatccat gtaaatactt tatctttgca
     3121 cttccaatgg atccaaatgt tgttttctat tatagtctat gatattcttc taataattct
     3181 ttaacacaga aatttatttt tgaatcattt tctgtcactc atttaaaaat atattgtaga
     3241 ctttgataat ctctaatctg tttattgaaa tagtccttag ccttaacaat tcactgatat
     3301 atgctgatgt tcattaatgt acactatttg ccaatatgta tttttagagt cttggcttca
     3361 tttgggtggc tagcactgat cttaatgatc actttattgc tgaacatcat tattctttaa
     3421 aaatgccaag tggaactaat ttcttaggaa tccagttgat ttgcctgtca cgaaacgaga
     3481 aagccatctc tctgaaaagt agtaacgcag caaatgtcct cagttctctg gtggacagag
     3541 ctcgtgtgcg aggctcaagg agcattagaa tcccaggatg ggctggacct ggatttttca
     3601 gtagctgccc ctcactcttc gataagtttt caagataggt ggatatatgc aatttccatg
     3661 aactcttgtt taagatttat tttcattgat gtataattaa ggttatgttt aatgtttctt
     3721 taaagccttg taaaataaaa gttaatcttt atatctatcc ttcgatgtg
//
