LOCUS       NM_145594               1120 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus fibrinogen-like protein 1 (Fgl1), mRNA.
ACCESSION   NM_145594
VERSION     NM_145594.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1120)
  AUTHORS   Sardo,U., Perrier,P., Cormier,K., Sotin,M., Personnaz,J.,
            Medjbeur,T., Desquesnes,A., Cannizzo,L., Ruiz-Martinez,M.,
            Thevenin,J., Billore,B., Jung,G., Abboud,E., Peyssonnaux,C.,
            Nemeth,E., Ginzburg,Y.Z., Ganz,T. and Kautz,L.
  TITLE     The hepatokine FGL1 regulates hepcidin and iron metabolism during
            anemia in mice by antagonizing BMP signaling
  JOURNAL   Blood 143 (13), 1282-1292 (2024)
   PUBMED   38232308
  REMARK    GeneRIF: The hepatokine FGL1 regulates hepcidin and iron metabolism
            during anemia in mice by antagonizing BMP signaling.
REFERENCE   2  (bases 1 to 1120)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1120)
  AUTHORS   Tian,T., Xie,X., Yi,W., Zhou,Y., Xu,Y., Wang,Z., Zhang,J., Lin,M.,
            Zhang,R., Lv,Z., Li,X., Lv,L. and Xu,Y.
  TITLE     FBXO38 mediates FGL1 ubiquitination and degradation to enhance
            cancer immunity and suppress inflammation
  JOURNAL   Cell Rep 42 (11), 113362 (2023)
   PUBMED   37938970
  REMARK    GeneRIF: FBXO38 mediates FGL1 ubiquitination and degradation to
            enhance cancer immunity and suppress inflammation.
REFERENCE   4  (bases 1 to 1120)
  AUTHORS   Huang,J., Huang,Q., Xue,J., Liu,H., Guo,Y., Chen,H. and Zhou,L.
  TITLE     Fibrinogen like protein-1 knockdown suppresses the proliferation
            and metastasis of TU-686 cells and sensitizes laryngeal cancer to
            LAG-3 blockade
  JOURNAL   J Int Med Res 50 (9), 3000605221126874 (2022)
   PUBMED   36173010
  REMARK    GeneRIF: Fibrinogen like protein-1 knockdown suppresses the
            proliferation and metastasis of TU-686 cells and sensitizes
            laryngeal cancer to LAG-3 blockade.
REFERENCE   5  (bases 1 to 1120)
  AUTHORS   Tsai,H.I., Wu,Y., Liu,X., Xu,Z., Liu,L., Wang,C., Zhang,H.,
            Huang,Y., Wang,L., Zhang,W., Su,D., Khan,F.U., Zhu,X., Yang,R.,
            Pang,Y., Eriksson,J.E., Zhu,H., Wang,D., Jia,B., Cheng,F. and
            Chen,H.
  TITLE     Engineered Small Extracellular Vesicles as a FGL1/PD-L1
            Dual-Targeting Delivery System for Alleviating Immune Rejection
  JOURNAL   Adv Sci (Weinh) 9 (3), e2102634 (2022)
   PUBMED   34738731
  REMARK    GeneRIF: Engineered Small Extracellular Vesicles as a FGL1/PD-L1
            Dual-Targeting Delivery System for Alleviating Immune Rejection.
REFERENCE   6  (bases 1 to 1120)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   7  (bases 1 to 1120)
  AUTHORS   Baur,J.A., Pearson,K.J., Price,N.L., Jamieson,H.A., Lerin,C.,
            Kalra,A., Prabhu,V.V., Allard,J.S., Lopez-Lluch,G., Lewis,K.,
            Pistell,P.J., Poosala,S., Becker,K.G., Boss,O., Gwinn,D., Wang,M.,
            Ramaswamy,S., Fishbein,K.W., Spencer,R.G., Lakatta,E.G., Le
            Couteur,D., Shaw,R.J., Navas,P., Puigserver,P., Ingram,D.K., de
            Cabo,R. and Sinclair,D.A.
  TITLE     Resveratrol improves health and survival of mice on a high-calorie
            diet
  JOURNAL   Nature 444 (7117), 337-342 (2006)
   PUBMED   17086191
REFERENCE   8  (bases 1 to 1120)
  AUTHORS   Yan,J., Ying,H., Gu,F., He,J., Li,Y.L., Liu,H.M. and Xu,Y.H.
  TITLE     Cloning and characterization of a mouse liver-specific gene
            mfrep-1, up-regulated in liver regeneration
  JOURNAL   Cell Res 12 (5-6), 353-361 (2002)
   PUBMED   12528893
REFERENCE   9  (bases 1 to 1120)
  AUTHORS   Parr,R.L., Fung,L., Reneker,J., Myers-Mason,N., Leibowitz,J.L. and
            Levy,G.
  TITLE     Association of mouse fibrinogen-like protein with murine hepatitis
            virus-induced prothrombinase activity
  JOURNAL   J Virol 69 (8), 5033-5038 (1995)
   PUBMED   7609073
REFERENCE   10 (bases 1 to 1120)
  AUTHORS   Yamamoto,T., Gotoh,M., Sasaki,H., Terada,M., Kitajima,M. and
            Hirohashi,S.
  TITLE     Molecular cloning and initial characterization of a novel
            fibrinogen-related gene, HFREP-1
  JOURNAL   Biochem Biophys Res Commun 193 (2), 681-687 (1993)
   PUBMED   8390249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156554.13 and AF478470.1.
            
            On Nov 3, 2009 this sequence version replaced NM_145594.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021946.1, AF478470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC156554.13        42280-42282
            4-1117              AF478470.1         14-1127
            1118-1120           AC156554.13        66000-66002
FEATURES             Location/Qualifiers
     source          1..1120
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 23.89 cM"
     gene            1..1120
                     /gene="Fgl1"
                     /gene_synonym="Mfire1"
                     /note="fibrinogen-like protein 1"
                     /db_xref="GeneID:234199"
                     /db_xref="MGI:MGI:102795"
     exon            1..71
                     /gene="Fgl1"
                     /gene_synonym="Mfire1"
                     /inference="alignment:Splign:2.1.0"
     exon            72..151
                     /gene="Fgl1"
                     /gene_synonym="Mfire1"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1033
                     /gene="Fgl1"
                     /gene_synonym="Mfire1"
                     /note="MFIRE-1; fibrinogen-related protein 1; mfrep-1;
                     liver fibrinogen-related protein-1"
                     /codon_start=1
                     /product="fibrinogen-like protein 1 precursor"
                     /protein_id="NP_663569.2"
                     /db_xref="CCDS:CCDS22260.1"
                     /db_xref="GeneID:234199"
                     /db_xref="MGI:MGI:102795"
                     /translation="MGKIYSFVLVAIALMMGREGWALESENCLREQVRLRAQVHQLET
                     RVKQQQTMIAQLLHEKEVQFLDKGSENSFIDLGGKKQYADCSEIYNDGFKQSGFYKIK
                     PLQSLAEFSVYCDMSDGGGWTVIQRRSDGSENFNRGWNDYENGFGNFVQNNGEYWLGN
                     KNINLLTIQGDYTLKIDLTDFEKNSSFAQYQSFKVGDKKSFYELNIGEYSGTAGDSLS
                     GTFHPEVQWWASHQRMKFSTWDRDNDNYQGNCAEEEQSGWWFNRCHSANLNGVYYRGS
                     YRAETDNGVVWYTWHGWWYSLKSVVMKIRPSDFIPNII"
     exon            152..338
                     /gene="Fgl1"
                     /gene_synonym="Mfire1"
                     /inference="alignment:Splign:2.1.0"
     exon            339..498
                     /gene="Fgl1"
                     /gene_synonym="Mfire1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..596
                     /gene="Fgl1"
                     /gene_synonym="Mfire1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..685
                     /gene="Fgl1"
                     /gene_synonym="Mfire1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..873
                     /gene="Fgl1"
                     /gene_synonym="Mfire1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1120
                     /gene="Fgl1"
                     /gene_synonym="Mfire1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1083..1088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgl1"
                     /gene_synonym="Mfire1"
                     /note="hexamer: AATAAA"
     polyA_site      1120
                     /gene="Fgl1"
                     /gene_synonym="Mfire1"
                     /note="major polyA site"
ORIGIN      
        1 gttagaagtt cctgggaggc tctgtgtgga tggactgagc ctagctaagt cctgattcat
       61 tttgacttga gttctctcag tgggaagaat gggaaagatt tacagcttcg tcctggtcgc
      121 cattgctctg atgatgggaa gggaaggttg ggccctcgag agtgagaact gcttgcggga
      181 gcaggtgagg ctcagggctc aggtgcacca gcttgagacc cgggtcaaac aacaacagac
      241 catgattgca cagctcttgc atgagaagga agtccagttt ctggataaag gatcggagaa
      301 cagtttcatt gaccttggag gcaagaagca gtatgcagat tgttcagaga tttacaatga
      361 cggatttaag cagagtggat tttacaaaat caaacctctt cagagcctgg cagaattctc
      421 tgtttattgt gacatgtctg atggaggggg atggactgta attcagagac gatctgatgg
      481 cagtgagaac tttaacaggg gttggaatga ctatgaaaat ggctttggaa actttgtcca
      541 aaacaatggc gaatactggc tgggtaacaa aaacattaac ttgctaacta ttcaaggaga
      601 ctacacttta aaaatcgacc tgacagattt tgagaaaaac agcagcttcg cacaatacca
      661 aagttttaaa gttggtgata aaaagtcttt ttatgaacta aatattggag aatattctgg
      721 cacagctgga gattccctgt caggaacttt tcatcctgaa gtacagtggt gggctagtca
      781 ccaaaggatg aagttcagca cgtgggacag agataacgac aattaccaag gaaactgtgc
      841 tgaggaagag cagtctggct ggtggtttaa caggtgtcac tctgcaaacc tgaacggtgt
      901 ttactaccgt ggttcctaca gggcagaaac ggataatggt gttgtgtggt acacctggca
      961 tgggtggtgg tattccttga aatctgtggt tatgaaaatt aggccaagtg attttattcc
     1021 aaatattatt tagttgccct cattgggatc tcctttctgt aattcatctt ggtttacttg
     1081 aaaataaata tttgaaaaag atataattct gaataacaca
//
