LOCUS       NM_001113412            1904 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus FGGY carbohydrate kinase domain containing (Fggy),
            transcript variant 1, mRNA.
ACCESSION   NM_001113412
VERSION     NM_001113412.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1904)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1904)
  AUTHORS   Smith,A.L., Gjoka,E., Izhar,M., Novo,K.J., Mason,B.C., De Las
            Casas,A. and Waddell,D.S.
  TITLE     FGGY carbohydrate kinase domain containing is expressed and
            alternatively spliced in skeletal muscle and attenuates MAP kinase
            and Akt signaling
  JOURNAL   Gene 800, 145836 (2021)
   PUBMED   34280510
  REMARK    GeneRIF: FGGY carbohydrate kinase domain containing is expressed
            and alternatively spliced in skeletal muscle and attenuates MAP
            kinase and Akt signaling.
REFERENCE   3  (bases 1 to 1904)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1904)
  AUTHORS   Taylor,J.A., Shioda,K., Mitsunaga,S., Yawata,S., Angle,B.M.,
            Nagel,S.C., Vom Saal,F.S. and Shioda,T.
  TITLE     Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring
            Bimodal DNA Methylation at Proximal Promoter of fggy, an
            Obesity-Relevant Gene Encoding a Carbohydrate Kinase, in Gonadal
            White Adipose Tissues of CD-1 Mice
  JOURNAL   Endocrinology 159 (2), 779-794 (2018)
   PUBMED   29220483
  REMARK    GeneRIF: The strength of Fggy mRNA expression significantly
            correlated with increased whole body weight and gonadal fat weight
            of males but not females.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY073369.1, AK138439.1, AK009249.1 and BX519665.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY073369.1         2-5
            5-830               AK138439.1         2-827
            831-1883            AK009249.1         1-1053
            1884-1904           BX519665.1         410-430
FEATURES             Location/Qualifiers
     source          1..1904
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 43.83 cM"
     gene            1..1904
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /note="FGGY carbohydrate kinase domain containing"
                     /db_xref="GeneID:75578"
                     /db_xref="MGI:MGI:1922828"
     exon            1..85
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            86..301
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1756
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /EC_number="2.7.1.47"
                     /note="isoform a is encoded by transcript variant 1; FGGY
                     carbohydrate kinase domain-containing protein;
                     D-ribulokinase FGGY"
                     /codon_start=1
                     /product="FGGY carbohydrate kinase domain-containing
                     protein isoform a"
                     /protein_id="NP_001106883.1"
                     /db_xref="CCDS:CCDS51233.1"
                     /db_xref="GeneID:75578"
                     /db_xref="MGI:MGI:1922828"
                     /translation="MMSGRDQEPSRYYVGIDVGTGSVRAALVDQRGLLLAFAEQPIKK
                     WEPQFNHHEQSSEDIWAACCLVTKEVVQGIDAHRIRGLGFDATCSLVVLDKEFHPLPV
                     NHEGDSSRNVIMWLDHRAVSQVHRINETKHRVLQYVGGVMSVEMQAPKLLWLKENLRE
                     ICWDKAGHFFDLPDFLSWKATGVTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDLID
                     DNYSKIGNLVLLPGAALGIGLTPEAARELGLPSGIAVAASLIDAHAGGLGVIGADVRG
                     HGLTCEGQPVTSRLAVICGTSSCHMGISKDPVFVPGVWGPYYSAMVPGFWLNEGGQSV
                     TGKLIDHMVQGHPAFPELQAKATARCQSIYAYLNSHLDLIKKAQPVGFLTVDLHVWPD
                     FHGNRSPLADLTLKGMVTGLTLSQDLDDLAILYLATVQAIAFGTRFIIETMEAAGHSL
                     STLFLCGGLSKNPLFVQMHADITGMPVVLSQEVESVLVGAAILGACASGDFTSVQEAM
                     ARMSKVGKVVFPEHADKKYYDKKYQVFLRMVEHQKEYSAIMNGS"
     exon            302..413
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            414..565
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            566..654
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            655..770
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            771..899
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1003
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1111
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1173
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1321
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1396
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1517
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1612
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1674
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1891
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1864..1869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1891
                     /gene="Fggy"
                     /gene_synonym="2310009E04Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtttggaccg ccctgctggg tgcggtgcgg ctgtgcatgg tggcctgctg gcctgctagc
       61 tagaatgtga tttcatattg gacaagtaga ggggaccatg atgtctggca gagaccagga
      121 accaagtcgc tactatgtgg gcatcgatgt gggaacaggt agtgtccgtg cggctctagt
      181 ggaccagaga gggctccttt tggctttcgc agagcagcca attaagaagt gggagcctca
      241 attcaaccac cacgagcagt cctcagagga tatctgggcg gcatgctgcc ttgtcacaaa
      301 ggaagttgtt caagggattg atgcacatcg aatccgagga cttggttttg atgccacgtg
      361 ttctctggtt gtcttggata aagagttcca tcctttacca gtaaaccatg aaggggactc
      421 ctctcgaaac gttatcatgt ggctggacca ccgggctgtc agccaggtcc acaggattaa
      481 tgagaccaag cacagagtcc ttcagtatgt gggtggtgtg atgtctgtgg agatgcaggc
      541 tccaaagctc ctgtggctga aggagaactt gagagagatt tgctgggata aggcgggaca
      601 tttctttgat ctcccagact tcttatcatg gaaggcaaca ggtgtcacag cacggtctct
      661 ctgctccttg gtgtgcaaat ggacatactc agcagagaaa ggttgggatg acagcttctg
      721 gaagatgatt ggactggaag atctcattga tgataattac agcaaaatag gaaacctcgt
      781 gttgcttcct ggagctgctc ttggaattgg gctcacacca gaagcagcca gagagctggg
      841 tcttccttca ggaattgcag tggcagcctc actcattgat gcccatgcag gaggactagg
      901 agtgattggg gcagatgtga gaggtcacgg gcttacctgt gagggacagc cagtgacgtc
      961 aaggctggct gtcatctgtg gaacatcatc ttgtcacatg gggatcagca aagatccagt
     1021 gtttgtacca ggtgtctggg gaccttatta ttcagccatg gtccctgggt tctggttgaa
     1081 tgaaggtggt cagagtgtga ctggaaaatt gatagaccat atggtgcagg gccatcctgc
     1141 ctttcctgaa ctacaagcca aggccacagc cagatgccag agtatatatg catatttgaa
     1201 tagtcacctg gatctgatta agaaggctca gcctgtgggt ttcctcactg ttgatttaca
     1261 tgtttggcca gatttccatg gcaaccggtc tcccttagca gatctgactc tgaagggcat
     1321 ggtcactgga ttgacgctgt ctcaggacct tgatgatctt gccatcctct acctggccac
     1381 tgttcaagcc attgcttttg ggactcgctt catcattgaa acaatggagg cagcagggca
     1441 ctctctcagt accctcttct tatgtggagg cctaagcaag aatccgcttt ttgtgcaaat
     1501 gcatgctgac attactggca tgcctgtggt cctgtcacaa gaggtggagt ctgtcctcgt
     1561 gggagctgct attctgggtg cctgtgcctc aggggacttc acttctgtgc aggaggcaat
     1621 ggcaaggatg agcaaagtgg ggaaagtcgt gtttccggaa catgctgata aaaaatatta
     1681 tgacaagaaa tatcaagtgt ttctgagaat ggttgagcac cagaaggagt attcagcaat
     1741 catgaatgga agctgaacat acctgtccgt acagacgctg tgccattcac tggggccctc
     1801 tgtgtgttca tcttatgctc agtgcccctt gggtataatt ttggcattcc tgtcttatta
     1861 tctaataaaa acttcgagca ggcaaacaca aaaaaaaaaa aaaa
//
