LOCUS       NM_133862               1722 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus fibrinogen gamma chain (Fgg), transcript variant 1,
            mRNA.
ACCESSION   NM_133862
VERSION     NM_133862.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1722)
  AUTHORS   Miller,S.R., Luxem,K., Lauderdale,K., Nambiar,P., Honma,P.S.,
            Ly,K.K., Bangera,S., Bullock,M., Shin,J., Kaliss,N., Qiu,Y.,
            Cai,C., Shen,K., Mallen,K.D., Yan,Z., Mendiola,A.S., Saito,T.,
            Saido,T.C., Pico,A.R., Thomas,R., Roberson,E.D., Akassoglou,K.,
            Bauer,P., Remy,S. and Palop,J.J.
  TITLE     Machine learning reveals prominent spontaneous behavioral changes
            and treatment efficacy in humanized and transgenic Alzheimer's
            disease models
  JOURNAL   Cell Rep 43 (11), 114870 (2024)
   PUBMED   39427315
REFERENCE   2  (bases 1 to 1722)
  AUTHORS   Ryu,J.K., Yan,Z., Montano,M., Sozmen,E.G., Dixit,K.,
            Suryawanshi,R.K., Matsui,Y., Helmy,E., Kaushal,P., Makanani,S.K.,
            Deerinck,T.J., Meyer-Franke,A., Rios Coronado,P.E., Trevino,T.N.,
            Shin,M.G., Tognatta,R., Liu,Y., Schuck,R., Le,L., Miyajima,H.,
            Mendiola,A.S., Arun,N., Guo,B., Taha,T.Y., Agrawal,A.,
            MacDonald,E., Aries,O., Yan,A., Weaver,O., Petersen,M.A., Meza
            Acevedo,R., Alzamora,M.D.P.S., Thomas,R., Traglia,M.,
            Kouznetsova,V.L., Tsigelny,I.F., Pico,A.R., Red-Horse,K.,
            Ellisman,M.H., Krogan,N.J., Bouhaddou,M., Ott,M., Greene,W.C. and
            Akassoglou,K.
  TITLE     Fibrin drives thromboinflammation and neuropathology in COVID-19
  JOURNAL   Nature 633 (8031), 905-913 (2024)
   PUBMED   39198643
REFERENCE   3  (bases 1 to 1722)
  AUTHORS   Poole,L.G., Schmitt,L.R., Schulte,A., Groeneveld,D.J., Cline,H.M.,
            Sang,Y., Hur,W.S., Wolberg,A.S., Flick,M.J., Hansen,K.C. and
            Luyendyk,J.P.
  TITLE     Altered fibrinogen gamma-chain cross-linking in mutant
            fibrinogen-gammaDelta5 mice drives acute liver injury
  JOURNAL   J Thromb Haemost 21 (8), 2175-2188 (2023)
   PUBMED   37062522
  REMARK    GeneRIF: Altered fibrinogen gamma-chain cross-linking in mutant
            fibrinogen-gamma[Delta5] mice drives acute liver injury.
REFERENCE   4  (bases 1 to 1722)
  AUTHORS   Mendiola,A.S., Yan,Z., Dixit,K., Johnson,J.R., Bouhaddou,M.,
            Meyer-Franke,A., Shin,M.G., Yong,Y., Agrawal,A., MacDonald,E.,
            Muthukumar,G., Pearce,C., Arun,N., Cabriga,B., Meza-Acevedo,R.,
            Alzamora,M.D.P.S., Zamvil,S.S., Pico,A.R., Ryu,J.K., Krogan,N.J.
            and Akassoglou,K.
  TITLE     Defining blood-induced microglia functions in neurodegeneration
            through multiomic profiling
  JOURNAL   Nat Immunol 24 (7), 1173-1187 (2023)
   PUBMED   37291385
REFERENCE   5  (bases 1 to 1722)
  AUTHORS   Brutsch,S.M., Madzharova,E., Pantasis,S., Wustemann,T., Gurri,S.,
            Steenbock,H., Gazdhar,A., Kuhn,G., Angel,P., Bellusci,S.,
            Brinckmann,J., Auf dem Keller,U., Werner,S. and Bordoli,M.R.
  TITLE     Mesenchyme-derived vertebrate lonesome kinase controls lung
            organogenesis by altering the matrisome
  JOURNAL   Cell Mol Life Sci 80 (4), 89 (2023)
   PUBMED   36920550
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1722)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   7  (bases 1 to 1722)
  AUTHORS   Ludwig,T., Ruther,U., Metzger,R., Copeland,N.G., Jenkins,N.A.,
            Lobel,P. and Hoflack,B.
  TITLE     Gene and pseudogene of the mouse cation-dependent mannose
            6-phosphate receptor. Genomic organization, expression, and
            chromosomal localization
  JOURNAL   J Biol Chem 267 (17), 12211-12219 (1992)
   PUBMED   1376319
REFERENCE   8  (bases 1 to 1722)
  AUTHORS   Lock,L.F., Pines,J., Hunter,T., Gilbert,D.J., Gopalan,G.,
            Jenkins,N.A., Copeland,N.G. and Donovan,P.J.
  TITLE     A single cyclin A gene and multiple cyclin B1-related sequences are
            dispersed in the mouse genome
  JOURNAL   Genomics 13 (2), 415-424 (1992)
   PUBMED   1535334
REFERENCE   9  (bases 1 to 1722)
  AUTHORS   Haefliger,J.A., Bruzzone,R., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Paul,D.L.
  TITLE     Four novel members of the connexin family of gap junction proteins.
            Molecular cloning, expression, and chromosome mapping
  JOURNAL   J Biol Chem 267 (3), 2057-2064 (1992)
   PUBMED   1370487
REFERENCE   10 (bases 1 to 1722)
  AUTHORS   Nadeau,J.H., Bedigian,H.G., Bouchard,G., Denial,T., Kosowsky,M.,
            Norberg,R., Pugh,S., Sargeant,E., Turner,R. and Paigen,B.
  TITLE     Multilocus markers for mouse genome analysis: PCR amplification
            based on single primers of arbitrary nucleotide sequence
  JOURNAL   Mamm Genome 3 (2), 55-64 (1992)
   PUBMED   1617215
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY793963.1, AK149448.1,
            AC138394.7 and BP772517.1.
            
            On Nov 17, 2015 this sequence version replaced NM_133862.1.
            
            Summary: This gene encodes the gamma subunit of the coagulation
            factor fibrinogen, which is a component of the blood clot. Mice
            lacking the encoded protein did not possess detectable amounts of
            plasma fibrinogen. Pregnant mice lacking the encoded protein die
            due to heavy bleeding during delivery. This gene is located
            adjacent to the genes encoding fibrinogen alpha and gamma subunits
            on chromosome 3. Alternate splicing of this gene results in
            multiple transcript variants encoding distinct isoforms. [provided
            by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019506.1, AK149448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               BY793963.1         2-138
            138-759             AK149448.1         3-624
            760-760             AC138394.7         85733-85733
            761-1699            AK149448.1         626-1564
            1700-1722           BP772517.1         25-47               c
FEATURES             Location/Qualifiers
     source          1..1722
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 36.94 cM"
     gene            1..1722
                     /gene="Fgg"
                     /gene_synonym="3010002H13Rik"
                     /note="fibrinogen gamma chain"
                     /db_xref="GeneID:99571"
                     /db_xref="MGI:MGI:95526"
     exon            1..259
                     /gene="Fgg"
                     /gene_synonym="3010002H13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1495
                     /gene="Fgg"
                     /gene_synonym="3010002H13Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; fibrinogen, gamma polypeptide"
                     /codon_start=1
                     /product="fibrinogen gamma chain isoform 1 precursor"
                     /protein_id="NP_598623.1"
                     /db_xref="CCDS:CCDS38462.1"
                     /db_xref="GeneID:99571"
                     /db_xref="MGI:MGI:95526"
                     /translation="MSWSLQPPSFLLCCLLLLFSPTGLAYVATRDNCCILDERFGSFC
                     PTTCGIADFLSSYQTDVDNDLRTLEDILFRAENRTTEAKELIKAIQVYYNPDQPPKPG
                     MIDSATQKSKKMVEEIVKYEALLLTHETSIRYLQEIYNSNNQKITNLKQKVAQLEAQC
                     QEPCKDSVQIHDTTGKDCQEIANKGAKESGLYFIRPLKAKQQFLVYCEIDGSGNGWTV
                     LQKRIDGSLDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISMQSTIPYALRIQLK
                     DWNGRTSTADYAMFRVGPESDKYRLTYAYFIGGDAGDAFDGYDFGDDPSDKFFTSHNG
                     MQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYHQGGTYSKSSTTNGFDDGI
                     IWATWKSRWYSMKETTMKIIPFNRLSIGEGQQHHMGGSKQAGDV"
     exon            260..304
                     /gene="Fgg"
                     /gene_synonym="3010002H13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            305..488
                     /gene="Fgg"
                     /gene_synonym="3010002H13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            489..582
                     /gene="Fgg"
                     /gene_synonym="3010002H13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            583..713
                     /gene="Fgg"
                     /gene_synonym="3010002H13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            714..847
                     /gene="Fgg"
                     /gene_synonym="3010002H13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1032
                     /gene="Fgg"
                     /gene_synonym="3010002H13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1310
                     /gene="Fgg"
                     /gene_synonym="3010002H13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1480
                     /gene="Fgg"
                     /gene_synonym="3010002H13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1702
                     /gene="Fgg"
                     /gene_synonym="3010002H13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1675..1680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fgg"
                     /gene_synonym="3010002H13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1695
                     /gene="Fgg"
                     /gene_synonym="3010002H13Rik"
                     /note="major polyA site"
ORIGIN      
        1 agagcacgag tgagagccag aatgagcaga aagagctcac atttctggta aagagaccct
       61 gtgaccagtt ccagccaccc ttagtcccgc ccagactgag agctcacata aaggaccaag
      121 gagaagccca agaggtcaca gtgctggctg taaagagctg ggagcacctg gtcacccaga
      181 caccatgagt tggtctttgc agcccccgag tttccttctt tgctgcctgc ttttactgtt
      241 ctctccaacg ggcctggcat atgtggctac cagagataac tgttgcatcc tagatgagag
      301 attcggtagt ttctgcccaa ccacctgtgg tatcgcagat ttcctgtctt cttaccaaac
      361 cgacgtggac aatgatctcc gaacgctgga agacatctta ttccgggctg aaaacagaac
      421 cacagaagcc aaagaactga tcaaagcaat tcaggtttac tacaacccag accaaccccc
      481 aaagccaggt atgatagaca gtgccactca gaagtctaag aagatggtag aagaaattgt
      541 gaaatacgaa gcgctgctgt taacccacga gacaagcatt cggtatttac aggaaatcta
      601 taattcaaat aaccagaaga tcacaaacct aaaacagaag gtagcccagc ttgaagccca
      661 gtgccaggag ccttgcaagg actctgtgca aatccatgac acaactggaa aagattgtca
      721 ggaaattgcc aacaagggcg ccaaagaaag tggactttac ttcattcgac ctttgaaagc
      781 taagcagcag ttcttagtgt actgtgaaat cgacggatct ggaaatggtt ggaccgtatt
      841 gcagaagagg attgatggca gtttggattt caagaagaac tggattcagt ataaagaagg
      901 atttggacac ctgtcgccta ctggcaccac agagttttgg ctgggaaatg agaagattca
      961 tttgataagc atgcagtcca caattccata tgcactgaga atacagctca aagactggaa
     1021 tggcagaacc agcactgcgg actatgccat gttcagggtg ggtcccgagt ctgacaaata
     1081 ccgcctgacc tatgcctact tcattggtgg agatgccggg gatgccttcg acggctacga
     1141 tttcggcgat gaccccagtg acaagttttt cacatcccac aacggcatgc agttcagtac
     1201 ctgggacaac gacaacgata agtttgaagg caactgtgcg gaacaggatg gatccggctg
     1261 gtggatgaac aaatgtcacg caggccacct caatggagtt tatcaccaag gtggtactta
     1321 ctcaaaatca tctactacta atggtttcga cgacggcatt atttgggcga cctggaaaag
     1381 ccgctggtat tctatgaagg aaaccaccat gaagataatt cccttcaaca gactctccat
     1441 cggagaagga cagcagcatc acatgggggg atccaaacag gctggagacg tttaaagaac
     1501 atttcaaagc tggtttgctt ttttaaagga ctttatccaa gcagagaact atactatttt
     1561 tcctatggga caatggactt tcaggacctc acttcatttt cagagttaat gggatccatg
     1621 gtgcaaactc cattagcagt tttatgctgg cgataattta tctacgtgca ttgcaataaa
     1681 catttcgttt cctaagatga gaaaaaaaaa aaaaaaaaaa aa
//
