LOCUS       NM_054071               2656 bp    mRNA    linear   ROD 10-NOV-2023
DEFINITION  Mus musculus fibroblast growth factor receptor-like 1 (Fgfrl1),
            transcript variant 1, mRNA.
ACCESSION   NM_054071 XM_910983
VERSION     NM_054071.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2656)
  AUTHORS   Zhou C, Chen D, Ren J, Huang D, Li R, Luo H, Guan C, Cao Y and Wang
            W.
  TITLE     FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme
            proliferation and differentiation via Lhx8/Suv39h1 complex
  JOURNAL   J Cell Mol Med 25 (6), 3051-3062 (2021)
   PUBMED   33580754
REFERENCE   2  (bases 1 to 2656)
  AUTHORS   Zhuang L, Vogel M, Villiger PM and Trueb B.
  TITLE     Dissecting the Interaction of FGF8 with Receptor FGFRL1
  JOURNAL   Biomolecules 10 (10), 1399 (2020)
   PUBMED   33019532
  REMARK    GeneRIF: Dissecting the Interaction of FGF8 with Receptor FGFRL1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2656)
  AUTHORS   Gerber SD, Beauchamp P, Zhuang L, Villiger PM and Trueb B.
  TITLE     Functional domains of the FgfrL1 receptor
  JOURNAL   Dev Biol 461 (1), 43-54 (2020)
   PUBMED   31923383
  REMARK    GeneRIF: Functional domains of the FgfrL1 receptor.
REFERENCE   4  (bases 1 to 2656)
  AUTHORS   Regeenes R, Silva PN, Chang HH, Arany EJ, Shukalyuk AI, Audet J,
            Kilkenny DM and Rocheleau JV.
  TITLE     Fibroblast growth factor receptor 5 (FGFR5) is a co-receptor for
            FGFR1 that is up-regulated in beta-cells by cytokine-induced
            inflammation
  JOURNAL   J Biol Chem 293 (44), 17218-17228 (2018)
   PUBMED   30217817
  REMARK    GeneRIF: FGFR5 as a co-receptor that is up-regulated by
            inflammation and promotes FGFR1-induced survival.
REFERENCE   5  (bases 1 to 2656)
  AUTHORS   Kahkonen TE, Ivaska KK, Jiang M, Buki KG, Vaananen HK and Harkonen
            PL.
  TITLE     Role of fibroblast growth factor receptors (FGFR) and FGFR like-1
            (FGFRL1) in mesenchymal stromal cell differentiation to osteoblasts
            and adipocytes
  JOURNAL   Mol Cell Endocrinol 461, 194-204 (2018)
   PUBMED   28923346
  REMARK    GeneRIF: FGFR1 and FGFR2 regulate FGFRL1 expression.
REFERENCE   6  (bases 1 to 2656)
  AUTHORS   Trueb B and Taeschler S.
  TITLE     Expression of FGFRL1, a novel fibroblast growth factor receptor,
            during embryonic development
  JOURNAL   Int J Mol Med 17 (4), 617-620 (2006)
   PUBMED   16525717
  REMARK    GeneRIF: FGFRL1 expression is very low in mouse embryos of day 6
            but steadily increases until birth.
REFERENCE   7  (bases 1 to 2656)
  AUTHORS   Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber
            G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong
            WH and Cepko CL.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 2656)
  AUTHORS   Trueb B, Zhuang L, Taeschler S and Wiedemann M.
  TITLE     Characterization of FGFRL1, a novel fibroblast growth factor (FGF)
            receptor preferentially expressed in skeletal tissues
  JOURNAL   J Biol Chem 278 (36), 33857-33865 (2003)
   PUBMED   12813049
REFERENCE   9  (bases 1 to 2656)
  AUTHORS   Wiedemann M and Trueb B.
  TITLE     The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein
  JOURNAL   Biochim Biophys Acta 1520 (3), 247-250 (2001)
   PUBMED   11566361
REFERENCE   10 (bases 1 to 2656)
  AUTHORS   Sleeman M, Fraser J, McDonald M, Yuan S, White D, Grandison P,
            Kumble K, Watson JD and Murison JG.
  TITLE     Identification of a new fibroblast growth factor receptor, FGFR5
  JOURNAL   Gene 271 (2), 171-182 (2001)
   PUBMED   11418238
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123743.11.
            
            [WARNING] On Nov 27, 2023 this sequence was replaced by
            NM_054071.3.
            
            On Aug 18, 2009 this sequence version replaced NM_054071.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF321300.1, SRR7652917.442960.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               AC123743.11        104376-104679       c
            305-528             AC123743.11        103790-104013       c
            529-801             AC123743.11        95350-95622         c
            802-882             AC123743.11        94161-94241         c
            883-1167            AC123743.11        93769-94053         c
            1168-1521           AC123743.11        93336-93689         c
            1522-2656           AC123743.11        91958-93092         c
FEATURES             Location/Qualifiers
     source          1..2656
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.24 cM"
     gene            1..2656
                     /gene="Fgfrl1"
                     /gene_synonym="FGFR5; FGFR5beta; FGFR5gamma"
                     /note="fibroblast growth factor receptor-like 1"
                     /db_xref="GeneID:116701"
                     /db_xref="MGI:MGI:2150920"
     exon            1..304
                     /gene="Fgfrl1"
                     /gene_synonym="FGFR5; FGFR5beta; FGFR5gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            305..528
                     /gene="Fgfrl1"
                     /gene_synonym="FGFR5; FGFR5beta; FGFR5gamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             462..2051
                     /gene="Fgfrl1"
                     /gene_synonym="FGFR5; FGFR5beta; FGFR5gamma"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; FGF receptor-like protein 1; fibroblast growth
                     factor receptor 5"
                     /codon_start=1
                     /product="fibroblast growth factor receptor-like 1 isoform
                     1 precursor"
                     /protein_id="NP_473412.1"
                     /db_xref="CCDS:CCDS19518.1"
                     /db_xref="GeneID:116701"
                     /db_xref="MGI:MGI:2150920"
                     /translation="MTRSPALLLLLLGALPSAEAARGPPRMADKVVPRQVARLGRTVR
                     LQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKEVEAEDAGVYVCKATNGFG
                     SLSVNYTLIIMDDISPGKESPGPGGSSGGQEDPASQQWARPRFTQPSKMRRRVIARPV
                     GSSVRLKCVASGHPRPDIMWMKDDQTLTHLEASEHRKKKWTLSLKNLKPEDSGKYTCR
                     VSNKAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQW
                     LKRVEYGSEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLISRARQDDAGMYIC
                     LGANTMGYSFRSAFLTVLPDPKPPGPPMASSSSSTSLPWPVVIGIPAGAVFILGTVLL
                     WLCQTKKKPCAPASTLPVPGHRPPGTSRERSGDKDLPSLAVGICEEHGSAMAPQHILA
                     SGSTAGPKLYPKLYTDVHTHTHTHTCTHTLSCGGQGSSTPACPLSVLNTANLQALCPE
                     VGIWGPRQQVGRIENNGGRVS"
     exon            529..801
                     /gene="Fgfrl1"
                     /gene_synonym="FGFR5; FGFR5beta; FGFR5gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            802..882
                     /gene="Fgfrl1"
                     /gene_synonym="FGFR5; FGFR5beta; FGFR5gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1167
                     /gene="Fgfrl1"
                     /gene_synonym="FGFR5; FGFR5beta; FGFR5gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1521
                     /gene="Fgfrl1"
                     /gene_synonym="FGFR5; FGFR5beta; FGFR5gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..2656
                     /gene="Fgfrl1"
                     /gene_synonym="FGFR5; FGFR5beta; FGFR5gamma"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagagttga caaagccccg cagggaagga cgcctcgcgg cgcggcgccc cgggcccctc
       61 gccccgccgc ccctcttccc cgccctcgcc aagcctcgcc gtttatccgc gcggacagcg
      121 cgccccgcgc cccagcccgg ccccagccgc cagcgcccag gtagcgccgc cccgcccagg
      181 ccgggcccgg gggcgcgggg ggcgggatgc ggcgcccggg gcagcgatga ccgcgtcgcg
      241 ctgctcaggg gcccggctct gaccccgttg cctgctgcgc gcccccgcgc tgatccctgt
      301 cgagcgtcta cgcgcctcgc ttcctttgcc tggagctcgg cgccgagggg ggccggaccc
      361 tggctctgcg gccgcgacct gggtcttgcg ggcctgagcc ctgagtggcg tccagtccag
      421 ctcccagtga ccgcgcccct gcttcaggtc cgaccggcga gatgacgcgg agccccgcgc
      481 tgctgctgct gctattgggg gccctcccgt cggctgaggc ggcgcgagga cccccaagaa
      541 tggcagacaa agtggtccca cggcaggtgg cccgcctggg ccgcactgtg cggctacagt
      601 gcccagtgga gggggaccca ccaccgttga ccatgtggac caaagatggc cgcacaatcc
      661 acagtggctg gagccgcttc cgtgtgctgc cccagggtct gaaggtgaag gaggtggagg
      721 ccgaggatgc cggtgtttat gtgtgcaagg ccaccaatgg ctttggcagc ctcagcgtca
      781 actacactct catcatcatg gatgatatta gtccagggaa ggagagccct gggccaggtg
      841 gttcttcggg gggccaggag gacccagcca gccagcagtg ggcacggcct cgcttcacac
      901 agccctccaa gatgaggcgc cgagtgattg cacggcctgt gggtagctct gtgcggctca
      961 agtgtgtggc cagtgggcac ccacggccag acatcatgtg gatgaaggat gaccagacct
     1021 tgacgcatct agaggctagt gaacacagaa agaagaagtg gacactgagc ttgaagaacc
     1081 tgaagcctga agacagtggc aagtacacgt gccgtgtatc taacaaggcc ggtgccatca
     1141 acgccaccta caaagtggat gtaatccagc ggactcgttc caagcctgtg ctcacaggga
     1201 cacaccctgt gaacacaacg gtggacttcg gtgggacaac gtccttccag tgcaaggtgc
     1261 gcagtgacgt gaagcctgtg atccagtggc tgaagcgggt ggagtacggc tccgagggac
     1321 gccacaactc caccattgat gtgggtggcc agaagtttgt ggtgttgccc acgggtgatg
     1381 tgtggtcacg gcctgatggc tcctacctca acaagctgct catctctcgg gcccgccagg
     1441 atgatgctgg catgtacatc tgcctaggtg caaataccat gggctacagt ttccgtagcg
     1501 ccttcctcac tgtattacca gaccccaaac ctccagggcc tcctatggct tcttcatcgt
     1561 catccacaag cctgccatgg cctgtggtga tcggcatccc agctggtgct gtcttcatcc
     1621 taggcactgt gctgctctgg ctttgccaga ccaagaagaa gccatgtgcc ccagcatcta
     1681 cacttcctgt gcctgggcat cgtcccccag ggacatcccg agaacgcagt ggtgacaagg
     1741 acctgccctc attggctgtg ggcatatgtg aggagcatgg atccgccatg gccccccagc
     1801 acatcctggc ctctggctca actgctggcc ccaagctgta ccccaagcta tacacagatg
     1861 tgcacacaca cacacataca cacacctgca ctcacacgct ctcatgtgga gggcaaggtt
     1921 catcaacacc agcatgtcca ctatcagtgc taaatacagc gaatctccaa gcactgtgtc
     1981 ctgaggtagg catttggggg ccaaggcaac aggttgggag aattgagaac aatggaggaa
     2041 gagtatctta gggtgcctta tggtggacac tcacaaactt ggccatatag atgtatgtac
     2101 taccagatga acagccagcc agattcacac acgcacatgt ttaaacgtgt aaacgtgtgc
     2161 acaactgcac acacaacctg agaaaccttc aggaggattt gtggtgtgac tttgcagtga
     2221 catgtagcga tggctagttg aaggaatctc cctcatgtct tagtggtcat ggccacttcc
     2281 ccacccctgc ccatctgtgt tcctgcctgg ccttggtgtg cttccgtgtg ccctgggtat
     2341 caggagccta tcatcaacct gactggggtg agcagtgcag ccatgcctgg aggtttgagc
     2401 caccctcccc ttgctagaga gaagggcctc aatatttata tttaagaaat gaaataatat
     2461 taataataat gtaaggaggg ctgggacaca gggactctgg ccttccctgg ggcctgggac
     2521 ctgcctggcc ttgtggttac attgggtacc ctcactgtcc atggctgcct ggtctctgta
     2581 attttatata gagtttgagc tgaagcctcg tatatttaat ttattttgtt aaacaagaaa
     2641 ttgcctcctt ttctca
//
